Diagnostic and Interventional Imaging最新文献

{"title":"Robotic-assisted CT-guided percutaneous thermal ablation of abdominal tumors: An analysis of 41 patients","authors":"Baptiste Bonnet ,&nbsp;Thierry de Baère ,&nbsp;Paul Beunon ,&nbsp;Adlane Feddal ,&nbsp;Lambros Tselikas ,&nbsp;Frédéric Deschamps","doi":"10.1016/j.diii.2024.01.005","DOIUrl":"10.1016/j.diii.2024.01.005","url":null,"abstract":"<div><h3>Purpose</h3><p>Robotic assistance is rapidly evolving and may help physicians optimize needle guidance during percutaneous interventions. The purpose of the study was to report feasibility, safety, accuracy, immediate clinical success and short-term local tumor control after robotic-assisted computed tomography (CT)-guided thermal ablation of abdominal tumors.</p></div><div><h3>Materials and methods</h3><p>Forty-one patients who underwent percutaneous thermal ablation of abdominal tumors using robotic-assisted CT-guided were included. All ablations were performed with robotic assistance, using an optically-monitored robotic system with a needle guide sent to preplanned trajectories defined on three-dimensional-volumetric CT acquisitions with respiration monitoring. Endpoints were technical success, safety, distance from needle tip to planned trajectory and number of needle adjustments, and complete ablation rate.</p></div><div><h3>Results</h3><p>Forty-one patients (31 men; mean age, 66.7 ± 9.9 [standard deviation (SD)] years [age range: 41–84 years]) were treated for 48 abdominal tumors, with 79 planned needles. Lesions treated were located in the liver (23/41; 56%), kidney (14/41;34%), adrenal gland (3/41; 7%) or retroperitoneum (1/41; 2%). Technical success was achieved in 39/41 (95%) patients, and 76/79 (96%) needle insertions. The mean lateral distance between the needle tip and planned trajectory was 3.2 ± 4.5 (SD) mm (range: 0–20 mm) before adjustments, and the mean three-dimensional distance was 1.6 ± 2.6 (SD) mm (range: 0–13 mm) after 29 manual depth adjustments (29/78; 37%) and 33 lateral adjustments (33/78; 42%). Two (2/79; 3%) needles required complete manual reinsertion. One grade 3 complication was reported in one patient (1/41; 2%). The overall clinical success rate was 100%. The 3-month local tumor control rate (progression free survival) was 95% (38/41).</p></div><div><h3>Conclusion</h3><p>These results provide further evidence on the use of robotic-assisted needle insertion regarding feasibility, safety, and accuracy, resulting in effective percutaneous thermal ablation of abdominal tumors.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211568424000172/pdfft?md5=3540210314c1be55dde8740f2f9d66c3&pid=1-s2.0-S2211568424000172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139898308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-high-resolution CT of the temporal bone: Comparison between deep learning reconstruction and hybrid and model-based iterative reconstruction","authors":"Achille Beysang ,&nbsp;Nicolas Villani ,&nbsp;Fatma Boubaker ,&nbsp;Ulysse Puel ,&nbsp;Michael Eliezer ,&nbsp;Gabriela Hossu ,&nbsp;Karim Haioun ,&nbsp;Alain Blum ,&nbsp;Pedro Augusto Gondim Teixeira ,&nbsp;Cécile Parietti-Winkler ,&nbsp;Romain Gillet","doi":"10.1016/j.diii.2024.02.001","DOIUrl":"10.1016/j.diii.2024.02.001","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to evaluate the ability of ultra-high-resolution computed tomography (UHR-CT) to assess stapes and chorda tympani nerve anatomy using a deep learning (DLR), a model-based, and a hybrid iterative reconstruction algorithm compared to simulated conventional CT.</p></div><div><h3>Materials and methods</h3><p>CT acquisitions were performed with a Mercury 4.0 phantom. Images were acquired with a 1024 × 1024 matrix and a 0.25 mm slice thickness and reconstructed using DLR, model-based, and hybrid iterative reconstruction algorithms. To simulate conventional CT, images were also reconstructed with a 512 × 512 matrix and a 0.5 mm slice thickness. Spatial resolution, noise power spectrum, and objective high-contrast detectability were compared. Three radiologists evaluated the clinical acceptability of these algorithms by assessing the thickness and image quality of the stapes footplate and superstructure elements, as well as the image quality of the chorda tympani nerve bony and tympanic segments using a 5-point confidence scale on 13 temporal bone CT examinations reconstructed with the four algorithms.</p></div><div><h3>Results</h3><p>UHR-CT provided higher spatial resolution than simulated conventional CT at the penalty of higher noise. DLR and model-based iterative reconstruction provided better noise reduction than hybrid iterative reconstruction, and DLR had the highest detectability index, regardless of the dose level. All stapedial structure thicknesses were thinner using UHR-CT by comparison with conventional simulated CT (<em>P</em> &lt; 0.009). DLR showed the best visualization scores compared to the other reconstruction algorithms (<em>P</em> &lt; 0.032).</p></div><div><h3>Conclusion</h3><p>UHR-CT with DLR results in less noise than UHR-CT with hybrid iterative reconstruction and significantly improves stapes and tympanic chorda tympani nerve depiction compared to simulated conventional CT and UHR-CT with iterative reconstruction.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211568424000366/pdfft?md5=e3ddcd3dea6038967becaee1d307a882&pid=1-s2.0-S2211568424000366-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139898309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging techniques in balloon pulmonary angioplasty: A bright future ahead","authors":"Sebastian Mafeld","doi":"10.1016/j.diii.2024.03.001","DOIUrl":"10.1016/j.diii.2024.03.001","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal image quality and dose reduction with energy-integrating or photon-counting detectors dual-source CT: A phantom study","authors":"","doi":"10.1016/j.diii.2024.05.002","DOIUrl":"10.1016/j.diii.2024.05.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to assess image-quality and dose reduction potential using a photon-counting computed tomography (PCCT) system by comparison with two different dual-source CT (DSCT) systems using two phantoms.</div></div><div><h3>Materials and methods</h3><div>Acquisitions on phantoms were performed using two DSCT systems (DSCT1 [Somatom Force] and DSCT2 [Somatom Pro.Pulse]) and one PCCT system (Naeotom Alpha) at four dose levels (13/6/3.4/1.8 mGy). Noise power spectrum (NPS) and task-based transfer function (TTF) were computed to assess noise magnitude and noise texture and spatial resolution (f₅₀), respectively. Detectability indexes (d’) were computed to model the detection of abdominal lesions: one unenhanced high-contrast task, one contrast-enhanced high-contrast task and one unenhanced low-contrast task. Image quality was subjectively assessed on an anthropomorphic phantom by two radiologists.</div></div><div><h3>Results</h3><div>For all dose levels, noise magnitude values were lower with PCCT than with DSCTs. For all CT systems, similar noise texture values were found at 13 and 6 mGy, but the greatest noise texture values were found for DSCT2 and the lowest for PCCT at 3.4 and 1.8 mGy. For high-contrast inserts, similar or lower f₅₀ values were found with PCCT than with DSCT1 and the opposite pattern was found for the low-contrast insert. For the three simulated lesions, d’ values were greater with PCCT than with DSCTs. Abdominal images were rated satisfactory for clinical use by the radiologists for all dose levels with PCCT and for 13 and 6 mGy with DSCTs.</div></div><div><h3>Conclusion</h3><div>By comparison with DSCTs, PCCT reduces image-noise and improves detectability of simulated abdominal lesions without altering the spatial resolution and image texture. Image-quality obtained with PCCT seem to indicate greater potential for dose optimization than those obtained with DSCTs.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cutting edge: Promising oncology radiotracers in clinical development","authors":"","doi":"10.1016/j.diii.2024.04.004","DOIUrl":"10.1016/j.diii.2024.04.004","url":null,"abstract":"<div><div><span>Molecular imaging moves forward with the development of new imaging agents<span>, and among these are new radiotracers for nuclear medicine applications, particularly positron emission tomography (PET). A number of new targets are becoming accessible for use in oncologic applications. In this review, major new radiotracers in clinical development are discussed. Prominent among these is the family of fibroblast-activation protein-targeted agents that interact with the tumor microenvironment and may show superiority to 2-deoxy-2-[18F]fluoro-</span></span><span>d</span><span>-glucose in a subset of different tumor histologies. Additionally, carbonic anhydrase IX (CAIX) inhibitors are directed at clear cell renal cell carcinoma, which has long lacked an effective PET imaging agent. Those CAIX agents may also have utility in hypoxic tumors. Pentixafor, which binds to a transmembrane receptor, may similarly allow for visualization by PET of low-grade lymphomas, as well as being a second agent for multiple myeloma that opens theranostic possibilities. There are new adrenergic agents aimed at providing a PET-visible replacement to the single-photon-emitting radiotracer meta-[123I]iodobenzylguanidine (MIBG). Finally, in response to a major development in oncologic chemotherapy, there are new radiotracers targeted at assessing the suitability or use of immunotherapeutic agents. All of these and the existing evidence for their utility are discussed.</span></div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation dose reduction and image quality improvement with ultra-high resolution temporal bone CT using deep learning-based reconstruction: An anatomical study","authors":"","doi":"10.1016/j.diii.2024.05.001","DOIUrl":"10.1016/j.diii.2024.05.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the achievable radiation dose reduction of an ultra-high resolution computed tomography (UHR-CT) scanner using deep learning reconstruction (DLR) while maintaining temporal bone image quality equal to or better than high-resolution CT (HR-CT).</div></div><div><h3>Materials and methods</h3><div>UHR-CT acquisitions were performed with variable tube voltages and currents at eight different dose levels (volumic CT dose index [CTDIvol] range: 4.6–79 mGy), 1024² matrix, and 0.25 mm slice thickness and reconstructed using DLR and hybrid iterative reconstruction (HIR) algorithms. HR-CT images were acquired using a standard protocol (120 kV/220 mAs; CTDI vol, 54.2 mGy, 512² matrix, and 0.5 mm slice thickness). Two radiologists rated the image quality of seven structures using a five point confidence scale on six cadaveric temporal bone CTs. A global image quality score was obtained for each CT protocol by summing the image quality scores of all structures.</div></div><div><h3>Results</h3><div>With DLR, UHR-CT at 120 kV/220 mAs (CTDIvol, 50.9 mGy) and 140 kV/220 mAs (CTDIvol, 79 mGy) received the highest global image quality scores (4.88 ± 0.32 [standard deviation (SD)] [range: 4–5] and 4.85 ± 0.35 [range: 4–5], respectively; <em>P</em> = 0.31), while HR-CT at 120 kV/220 mAs and UHR-CT at 120 kV/20 mAs received the lowest (<em>i.e</em>., 3.14 ± 0.75 [SD] [range: 2–5] and 2.97 ± 0.86 [SD] [range: 1–5], respectively; <em>P</em> = 0.14). All the DLR protocols had better image quality scores than HR-CT with HIR.</div></div><div><h3>Conclusion</h3><div>UHR-CT with DLR can be performed with up to a tenfold reduction in radiation dose compared to HR-CT with HIR while maintaining or improving image quality.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous right coronary artery originating from the pulmonary artery","authors":"Taha M. Ahmed,&nbsp;Elliot K. Fishman","doi":"10.1016/j.diii.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.diii.2024.04.002","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140818637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal aortic calcium and geometry in patients with essential hypertension","authors":"Damian Craiem ,&nbsp;Federico Guilenea ,&nbsp;Jean-Batiste de Freminville ,&nbsp;Michel Azizi ,&nbsp;Mariano E. Casciaro ,&nbsp;Umit Gencer ,&nbsp;Anne-Sophie Jannot ,&nbsp;Laurence Amar ,&nbsp;Gilles Soulat ,&nbsp;Elie Mousseaux","doi":"10.1016/j.diii.2023.12.005","DOIUrl":"10.1016/j.diii.2023.12.005","url":null,"abstract":"<div><h3>Purpose</h3><p>Abdominal aorta calcium (AAC) burden and dilatation are associated with an increased risk of mortality. The purpose of this study was to investigate determinants of AAC and abdominal aorta size in patients with essential hypertension.</p></div><div><h3>Materials and methods</h3><p>Patients with uncomplicated essential hypertension who had undergone non-enhanced abdominal CT to rule out secondary hypertension in addition to biological test were recruited between 2010 and 2018. A semi-automatic system was designed to estimate the aortic size (diameter, length, volume) and quantify the AAC from mesenteric artery to bifurcation using the Agatston score. Determinants of aortic size and those related to AAC were searched for using uni- and multivariables analyses.</p></div><div><h3>Results</h3><p><span>Among 293 randomly selected patients with hypertension (age 52 ± 11 [SD] years) included, 23% had resistant hypertension. Mean abdominal aorta diameter was 20.1 ± 2.1 (SD) mm. Eight (3%) patients had abdominal aorta aneurysm ≥ 30 mm and 58 (20%) had dilated abdominal aorta ≥ 27 mm. Median AAC score was 38 and calcifications were detected in the infra- and supra-renal abdominal aortic portions in 59% and 26% of the patients, respectively. After adjustment for age, male sex and body surface area, abdominal aorta diameter was positively associated with diastolic blood pressure (</span><em>P</em> = 0.0019). Smoking was the single variable associated with calcified abdominal aorta (<em>P</em> &lt; 0.001) after adjustment for cofactors. In patients with calcifications of abdominal aorta, the score increased with smoking history (<em>P</em> &lt; 0.001), statins treatment (<em>P</em> &lt; 0.01), greater number of anti-hypertensive drugs (<em>P</em> &lt; 0.01), larger abdominal aorta (<em>P</em> &lt; 0.05) and greater systolic blood pressure (<em>P</em> &lt; 0.05). Patients with resistant hypertension had more AAC in the supra-renal abdominal aorta portion than those without resistant hypertension (<em>P</em> &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>In patients with essential hypertension, abdominal aorta dilation is related with diastolic blood pressure while AAC is associated with smoking history and resistant hypertension when located to the supra-renal abdominal aorta portion.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139035538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-lesion iodine map histogram analysis versus single-slice spectral CT parameters for determining novel International Association for the Study of Lung Cancer grade of invasive non-mucinous pulmonary adenocarcinomas","authors":"Liangna Deng ,&nbsp;Jingjing Yang ,&nbsp;Mingtao Zhang ,&nbsp;Kaibo Zhu ,&nbsp;Mengyuan Jing ,&nbsp;Yuting Zhang ,&nbsp;Bin Zhang ,&nbsp;Tao Han ,&nbsp;Junlin Zhou","doi":"10.1016/j.diii.2023.12.001","DOIUrl":"10.1016/j.diii.2023.12.001","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to evaluate and compare the performances of whole-lesion iodine map histogram analysis to those of single-slice spectral computed tomography (CT) parameters in discriminating between low-to-moderate grade invasive non-mucinous pulmonary adenocarcinoma (INMA) and high-grade INMA according to the novel International Association for the Study of Lung Cancer grading system of INMA.</p></div><div><h3>Materials and methods</h3><p>Sixty-one patients with INMA (34 with low-to-moderate grade [<em>i.e.</em>, grade I and grade II] and 27 with high grade [<em>i.e.</em>, grade III]) were evaluated with spectral CT. There were 28 men and 33 women, with a mean age of 56.4 ± 10.5 (standard deviation) years (range: 29–78 years). The whole-lesion iodine map histogram parameters (mean, standard deviation, variance, skewness, kurtosis, entropy, and 1st, 10th, 25th, 50th, 75th, 90th, and 99th percentile) were measured for each INMA. In other sessions, by placing regions of interest at representative levels of the tumor and normalizing them, spectral CT parameters (iodine concentration and normalized iodine concentration) were obtained. Discriminating capabilities of spectral CT and histogram parameters were assessed and compared using area under the ROC curve (AUC) and logistic regression models.</p></div><div><h3>Results</h3><p>The 1st, 10th, and 25th percentiles of the iodine map histogram analysis, and iodine concentration and normalized iodine concentration of single-slice spectral CT parameters were significantly different between high-grade and low-to-moderate grade INMAs (<em>P</em> &lt; 0.001 to <em>P</em> = 0.002). The 1st percentile of histogram parameters (AUC, 0.84; 95% confidence interval [CI]: 0.73–0.92) and iodine concentration (AUC, 0.78; 95% CI: 0.66–0.88) from single-slice spectral CT parameters had the best performance for discriminating between high-grade and low-to-moderate grade INMAs. At ROC curve analysis no significant differences in AUC were found between histogram parameters (AUC = 0.86; 95% CI: 0.74–0.93) and spectral CT parameters (AUC = 0.81; 95% CI: 0.74–0.93) (<em>P</em> = 0.60).</p></div><div><h3>Conclusion</h3><p>Both whole-lesion iodine map histogram analysis and single-slice spectral CT parameters help discriminate between low-to-moderate grade and high-grade INMAs according to the novel International Association for the Study of Lung Cancer grading system, with no differences in diagnostic performances.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138562840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary fibrosis is uncommon in primary Sjögren disease","authors":"Salim Aymeric Si-Mohamed,&nbsp;Vincent Cottin","doi":"10.1016/j.diii.2024.03.002","DOIUrl":"10.1016/j.diii.2024.03.002","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}