{"title":"Editor's note: 2025-the year in review for Diagnostic & Interventional Imaging","authors":"Philippe Soyer","doi":"10.1016/j.diii.2026.01.005","DOIUrl":"10.1016/j.diii.2026.01.005","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 2","pages":"Pages 43-44"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transarterial radioembolization challenges immunotherapy as first-line care for hepatocellular carcinoma with portal vein tumor thrombosis","authors":"Anna Pellat , Maxime Barat","doi":"10.1016/j.diii.2025.09.005","DOIUrl":"10.1016/j.diii.2025.09.005","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 1-2"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christos Gkizas , Benjamin Longere , Saad Bechrouri , Helene Ridon , Aimee Rodriguez Musso , Mehdi Haidar , Cedric Croisille , David Montaigne , Pascal De Groote , Francois Pontana
{"title":"Photon-counting CT myocardial extracellular volume: A non-invasive biomarker for fibrosis in patients with hypertrophic cardiomyopathy","authors":"Christos Gkizas , Benjamin Longere , Saad Bechrouri , Helene Ridon , Aimee Rodriguez Musso , Mehdi Haidar , Cedric Croisille , David Montaigne , Pascal De Groote , Francois Pontana","doi":"10.1016/j.diii.2025.09.001","DOIUrl":"10.1016/j.diii.2025.09.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the diagnostic performance of myocardial extracellular volume (ECV) quantification using dual-source photon-counting detector computed tomography (PCCT) compared to cardiac magnetic resonance imaging (MRI) for assessing the severity of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM).</div></div><div><h3>Materials and methods</h3><div>Patients with HCM due to sarcomere mutations underwent cardiac computed tomography angiography (CCTA) using a first-generation PCCT scanner, followed by comprehensive cardiac MRI. The CCTA protocol included a late iodine enhancement acquisition in spectral mode, 5 min after contrast media injection. ECV was calculated from the iodine ratio of the myocardium and blood pool on late iodine enhancement PCCT images. Cardiac MRI biomarkers included T1 mapping, ECV, and late gadolinium enhancement percentage (LGE). Diagnostic capabilities of PCCT were estimated using sensitivity, specificity, accuracy, interobserver agreement for myocardial fibrosis, area under the receiver operating characteristic curve (AUC) analyses for optimal thresholds, and correlations between tissue characteristics, functional capacity, and biomarkers.</div></div><div><h3>Results</h3><div>Thirty patients were retrospectively included. There were 22 men and eight women with a mean age of 59 ± 13.8 (standard deviation [SD]). The mean dose length product of late enhancement PCCT scanning was 105 ± 45 (SD) mGy.cm. No significant differences were found between global PCCT-derived ECV (30.0 ± 4.8 [SD] %) and MRI-derived ECV (30.62 ± 4.2 [SD] %) (<em>P</em> = 0.59). Linear regression revealed a strong segmental correlation between PCCT and MRI (basal, <em>r</em> = 0.89; mid-ventricular, <em>r</em> = 0.85; apical, <em>r</em> = 0.85; <em>P</em> < 0.001). An optimal PCCT-derived ECV threshold of 33.4 % allowed the diagnosis of LGE ≥ 15 % with 80 % sensitivity, 76 % specificity, and an AUC of 0.77, not significantly different from MRI-derived ECV (threshold 33.9 %; sensitivity, 80 %; specificity, 76 %, AUC, 0.80; <em>P</em> = 0.176). PCCT-derived ECV correlated with peak VO₂ (<em>r</em> = -0.76) and NT-proBNP levels (<em>r</em> = 0.59).</div></div><div><h3>Conclusion</h3><div>PCCT-derived ECV shows promise for quantifying myocardial fibrosis in HCM, offering a valuable non-invasive alternative to cardiac MRI, especially for patients with contraindications or those requiring combined CCTA and myocardial assessment.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 17-24"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul Calame, Loic Demir, Romain Moinet, Marine Julien, Eric Delabrousse
{"title":"Clarifying the role of dual-energy CT in the diagnosis of radiolucent gallstone of the common bile duct","authors":"Paul Calame, Loic Demir, Romain Moinet, Marine Julien, Eric Delabrousse","doi":"10.1016/j.diii.2025.10.008","DOIUrl":"10.1016/j.diii.2025.10.008","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 38-40"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jules Grégory , Laure Fournier , Bo Gong , Augustin Lecler
{"title":"Beyond algorithms: How agent-based artificial intelligence is changing the future of radiology","authors":"Jules Grégory , Laure Fournier , Bo Gong , Augustin Lecler","doi":"10.1016/j.diii.2025.11.009","DOIUrl":"10.1016/j.diii.2025.11.009","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 5-6"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youngsu Park , Yuri Cho , Seung Up Kim , Aryoung Kim , Hyunjae Shin , Hyo-Cheol Kim , In Joon Lee , Gyoung Min Kim , Dongho Hyun , Yunmi Ko , Jeayeon Park , Jae Woong Yoon , Gyung Sun Lim , Moon Haeng Hur , Yun Bin Lee , Eun Ju Cho , Jeong-Hoon Lee , Su Jong Yu , Jung-Hwan Yoon , Jin Wook Chung , Yoon Jun Kim
{"title":"Transarterial radioembolization versus atezolizumab-bevacizumab for the treatment of hepatocellular carcinoma with portal vein tumor thrombosis","authors":"Youngsu Park , Yuri Cho , Seung Up Kim , Aryoung Kim , Hyunjae Shin , Hyo-Cheol Kim , In Joon Lee , Gyoung Min Kim , Dongho Hyun , Yunmi Ko , Jeayeon Park , Jae Woong Yoon , Gyung Sun Lim , Moon Haeng Hur , Yun Bin Lee , Eun Ju Cho , Jeong-Hoon Lee , Su Jong Yu , Jung-Hwan Yoon , Jin Wook Chung , Yoon Jun Kim","doi":"10.1016/j.diii.2025.09.002","DOIUrl":"10.1016/j.diii.2025.09.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to compare transarterial radioembolization (TARE) and atezolizumab plus bevacizumab (Atezo/Bev) in treatment-naïve patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) without extrahepatic metastasis.</div></div><div><h3>Material and methods</h3><div>This multicenter retrospective study evaluated 213 patients initially treated with TARE or Atezo/Bev between 2016 and 2023. The primary outcome was overall survival, and the secondary outcomes were progression-free survival, objective response rate, and safety. Baseline characteristics were adjusted using inverse probability treatment weighting or propensity score matching.</div></div><div><h3>Results</h3><div>Deaths occurred in 36 out of 125 patients (28.8 %) in the TARE group and 57 out of 88 patients (64.8 %) in the Atezo/Bev group. The median overall survival was significantly longer in the TARE group (27.5 months) than in the Atezo/Bev group (8.6 months) (<em>P</em> < 0.01), consistent across analyses before matching (hazard ratio [HR], 0.38; 95% confidence interval [CI]: 0.25–0.58; <em>P</em> < 0.01), after inverse probability treatment weighting (HR, 0.49; 95 % CI: 0.28–0.85; <em>P</em> = 0.01), and after propensity score matching (HR, 0.40; 95% CI: 0.22–0.74; <em>P</em> < 0.01). In the PVTT subgroup involving segmental to lobar branches (Vp1–3), TARE demonstrated prolonged overall survival (HR, 0.36; 95 % CI: 0.20–0.63; <em>P</em> < 0.01), with no significant difference in patients with Vp4. The TARE and Atezo/Bev groups exhibited similar progression-free survival. No significant differences in objective response rate were found between TARE group (22.2–30.9 %) and Atezo/Bev group (30.6–30.9 %). Adverse events were less frequent in the TARE group than in the Atezo/Bev group. The incidence of grade ≥ 2 ascites and variceal bleeding were significantly lower in the TARE group (12.0 % and 1.7 %, respectively) than in the Atezo/Bev group (20.5 % and 8 %, respectively) (both <em>P</em> < 0.05). No significant differences in Child–Pugh score aggravation of ≥ 2 were observed between the TARE group (14.4 %) and the Atezo/Bev group (25 %) (<em>P</em> = 0.08).</div></div><div><h3>Conclusion</h3><div>For patients with preserved liver function and locally advanced HCC involving segmental or lobar PVTT, TARE may be preferable to Atezo/Bev.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 25-37"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eleftherios Tzanis , Lisa C. Adams , Tugba Akinci D’Antonoli , Keno K. Bressem , Renato Cuocolo , Burak Kocak , Christina Malamateniou , Michail E. Klontzas
{"title":"Agentic systems in radiology: Principles, opportunities, privacy risks, regulation, and sustainability concerns","authors":"Eleftherios Tzanis , Lisa C. Adams , Tugba Akinci D’Antonoli , Keno K. Bressem , Renato Cuocolo , Burak Kocak , Christina Malamateniou , Michail E. Klontzas","doi":"10.1016/j.diii.2025.10.002","DOIUrl":"10.1016/j.diii.2025.10.002","url":null,"abstract":"<div><div>The rapid rise of transformer-based large language models (LLMs) has introduced new opportunities for automation and decision support in radiology, particularly in applications such as report generation, protocol optimization, and structured interpretation. Despite their impressive performance in producing contextually coherent text, conventional LLMs remain limited by their inability to interact autonomously with external systems, retrieve data, or execute code, restricting their role in real-world clinical and research workflows. To address these limitations, agentic systems have emerged as a new paradigm. By embedding LLMs within frameworks that enable reasoning, planning, and action, agentic systems extend LLM capabilities to dynamic interaction with users, tools, and data sources. This review provides a comprehensive overview of the foundations, architectures, and operational mechanisms of agentic systems, focusing on their applications in medical imaging and radiology. It summarizes key developments in the literature, including recent multi-agent frameworks for automated radiomics pipelines, and discusses the potential benefits of these systems in enhancing the reproducibility, interpretability, and accessibility of AI-driven workflows. The review critically examines current regulatory considerations, ethical implications, and sustainability challenges to highlight essential gaps that must be addressed for the safe and responsible clinical integration of these systems.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 7-16"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contribution of a new super-resolution deep-learning image reconstruction algorithm coupled with an extended matrix to cardiac CT image quality","authors":"Joël Greffier , Djamel Dabli , Fabien de Oliveira , Jean-Paul Beregi , Mickaël Ohana","doi":"10.1016/j.diii.2025.06.004","DOIUrl":"10.1016/j.diii.2025.06.004","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 12","pages":"Pages 438-440"},"PeriodicalIF":8.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}