François Cornud , Eric M Walser , Katelijne CC de Bie , Arnaud Lefevre , Marc Galiano
{"title":"Laser-focused ablative therapy for prostate cancer and benign prostatic hyperplasia: A review of current applications and future directions","authors":"François Cornud , Eric M Walser , Katelijne CC de Bie , Arnaud Lefevre , Marc Galiano","doi":"10.1016/j.diii.2025.04.001","DOIUrl":"10.1016/j.diii.2025.04.001","url":null,"abstract":"<div><div>Focal Laser ablation (FLA), or interstitial Laser thermotherapy, is a promising minimally invasive approach for the treatment of localized prostate cancer and benign prostatic hyperplasia. This technique is gaining popularity among patients due to its ability to preserve pre-treatment quality of life. The examination is performed under magnetic resonance imaging (in bore) or ultrasound guidance, via a percutaneous transrectal or transperineal route. Under transperineal ultrasound guidance, FLA can use up to four Laser fibers to create confluent zones of tissue ablation, enabling treatment of larger prostate- or tumor volumes. Primary indications for FLA include intermediate-risk localized prostate cancer and benign prostatic hyperplasia refractory to medical treatment due to ineffectiveness or side effects. The intervention is typically performed under light sedation or under locoregional anesthesia. FLA lasts approximately 10 min, with a total intervention time of < 60 min on an outpatient basis. Patients are often discharged with either a suprapubic or bladder catheter to prevent urinary retention, especially if the ablated area is close to the urethra. Minor complications are rare and limited to transient voiding dysfunction, urinary tract infection, or hematuria. Major complications, such as rectoprostatic fistula, are avoided by rectoprostatic hydrodissection. FLA is an effective, well-tolerated option in the minimally invasive treatment of prostate disease, offering rapid treatment times, low complication rates, and preservation of quality of life for appropriately selected patients. However, variability in recurrence rates following FLA for prostate cancer highlights the need for further investigation into optimal patient selection for this treatment.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 9","pages":"Pages 289-298"},"PeriodicalIF":8.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antoine Pelcat , Alice Le Berre , Wagih Ben Hassen , Clement Debacker , Sylvain Charron , Bertrand Thirion , Laurence Legrand , Guillaume Turc , Catherine Oppenheim , Joseph Benzakoun
{"title":"Generative T2*-weighted images as a substitute for true T2*-weighted images on brain MRI in patients with acute stroke","authors":"Antoine Pelcat , Alice Le Berre , Wagih Ben Hassen , Clement Debacker , Sylvain Charron , Bertrand Thirion , Laurence Legrand , Guillaume Turc , Catherine Oppenheim , Joseph Benzakoun","doi":"10.1016/j.diii.2025.03.004","DOIUrl":"10.1016/j.diii.2025.03.004","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to validate a deep learning algorithm that generates T2*-weighted images from diffusion-weighted (DW) images and to compare its performance with that of true T2*-weighted images for hemorrhage detection on MRI in patients with acute stroke.</div></div><div><h3>Materials and methods</h3><div>This single-center, retrospective study included DW- and T2*-weighted images obtained less than 48 hours after symptom onset in consecutive patients admitted for acute stroke. Datasets were divided into training (60 %), validation (20 %), and test (20 %) sets, with stratification by stroke type (hemorrhagic/ischemic). A generative adversarial network was trained to produce generative T2*-weighted images using DW images. Concordance between true T2*-weighted images and generative T2*-weighted images for hemorrhage detection was independently graded by two readers into three categories (parenchymal hematoma, hemorrhagic infarct or no hemorrhage), and discordances were resolved by consensus reading. Sensitivity, specificity and accuracy of generative T2*-weighted images were estimated using true T2*-weighted images as the standard of reference.</div></div><div><h3>Results</h3><div>A total of 1491 MRI sets from 939 patients (487 women, 452 men) with a median age of 71 years (first quartile, 57; third quartile, 81; range: 21–101) were included. In the test set (n = 300), there were no differences between true T2*-weighted images and generative T2*-weighted images for intraobserver reproducibility (κ = 0.97 [95 % CI: 0.95–0.99] vs. 0.95 [95 % CI: 0.92–0.97]; <em>P</em> = 0.27) and interobserver reproducibility (κ = 0.93 [95 % CI: 0.90–0.97] vs. 0.92 [95 % CI: 0.88–0.96]; <em>P</em> = 0.64). After consensus reading, concordance between true T2*-weighted images and generative T2*-weighted images was excellent (κ = 0.92; 95 % CI: 0.91–0.96). Generative T2*-weighted images achieved 90 % sensitivity (73/81; 95 % CI: 81–96), 97 % specificity (213/219; 95 % CI: 94–99) and 95 % accuracy (286/300; 95 % CI: 92–97) for the diagnosis of any cerebral hemorrhage (hemorrhagic infarct or parenchymal hemorrhage).</div></div><div><h3>Conclusion</h3><div>Generative T2*-weighted images and true T2*-weighted images have non-different diagnostic performances for hemorrhage detection in patients with acute stroke and may be used to shorten MRI protocols.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 264-271"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SIAD (Societé d'Imagerie Abdominale et Digestive) and AFEF (Association Française pour l'Etude du Foie) best practice position paper on the implementation of ultrasound elastography in clinical practice","authors":"Lucia Parlati , Christophe Aubé , Maïté Lewin , Jérôme Boursier , Maxime Ronot , Anita Paisant","doi":"10.1016/j.diii.2025.03.010","DOIUrl":"10.1016/j.diii.2025.03.010","url":null,"abstract":"<div><h3>Purpose</h3><div>The diagnosis of liver fibrosis is critical in managing chronic liver diseases. The EASL guidelines now recognize ultrasound elastography as a valuable, non-invasive method for assessing liver fibrosis. However, there is a lack of uniform use and reporting of the technique. The purpose of this position paper was to provide guidance on using ultrasound elastography techniques and interpreting results in clinical practice.</div></div><div><h3>Materials and methods</h3><div>A French national consensus panel of experts in radiology and hepatology, convened by SIAD (Société d'Imagerie Abdominale et Digestive) and AFEF (Association Française pour l'Etude du Foie), developed a position statement paper on best practices in ultrasound elastography. They were established using an online Delphi methodology that included an online panel discussion and item preparation. Consensus was achieved when ≥ 80 % of the participants agreed with a specific recommendation.</div></div><div><h3>Results</h3><div>The accuracy and reliability of ultrasound elastography results could be significantly affected by a variety of operator-related and patient-related factors. Standard recommendations have been established in two areas, including recommendations for measurements and factors affecting results and reliability, and guidelines for standardized reporting of ultrasound elastography results.</div></div><div><h3>Conclusion</h3><div>This position paper is a comprehensive and accessible guide for clinicians that outlines best practices and standardized protocols to improve the reliability of ultrasound elastography assessments.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 272-279"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual diagnostic capabilities of photon-counting CT: From coronary artery evaluation to myocardial characterization","authors":"Jan M. Brendel , Aurelien Bustin , Gilles Soulat","doi":"10.1016/j.diii.2025.04.002","DOIUrl":"10.1016/j.diii.2025.04.002","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 241-242"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christos Gkizas , Benjamin Longere , Olga Sliwicka , Aimee Rodriguez Musso , Gilles Lemesle , Cedric Croisille , Mehdi Haidar , Francois Pontana
{"title":"Photon-counting CT-derived extracellular volume in acute myocarditis: Comparison with cardiac MRI","authors":"Christos Gkizas , Benjamin Longere , Olga Sliwicka , Aimee Rodriguez Musso , Gilles Lemesle , Cedric Croisille , Mehdi Haidar , Francois Pontana","doi":"10.1016/j.diii.2025.03.001","DOIUrl":"10.1016/j.diii.2025.03.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the feasibility and the accuracy of myocardial late iodine enhancement for extracellular volume (ECV) quantification using dual-source photon-counting detector computed tomography (PCD-CT) in patients with suspected acute myocarditis by comparison with cardiac MRI.</div></div><div><h3>Materials and methods</h3><div>Patients with clinical suspicion of myocarditis who were referred for coronary CT angiography (CCTA) to exclude coronary artery disease were included in this retrospective study. All patients underwent CCTA examination using a first-generation PCD-CT, which included slate iodine enhancement images. ECV was calculated from the iodine ratio of the myocardium to the blood pool on late iodine enhancement PCD-CT images. A comprehensive cardiac MRI protocol was used as the reference method to confirm myocarditis according to the Lake Louise 2018 criteria. All subjects underwent CCTA using PCD-CT and cardiac MRI within 24 h. The mean dose-length product of late enhancement PCD-CT scanning was calculated. Correlations between ECV PCD-CT (endocardial, epicardial, midcardial, and global), cardiac MRI-LGE, and right and left ventricular ejection fractions were assessed using Pearson correlation test. ECV values derived from PCD-CT and those from cardiac MRI were compared using Bland Altman plots and linear regression analysis. Areas under the receiver operating characteristic curves (AUCs) were used to determine the optimal thresholds of ECV-PCD-CT and ECV-MRI for differentiating patients with myocarditis from those not meeting the Lake Louise criteria.</div></div><div><h3>Results</h3><div>Thirty-two patients were included. There were 19 men and 13 women with a mean age of 35.9 ± 15.0 (standard deviation [SD]) years; age range: 21–51). The mean dose-length product of late enhancement PCD-CT scanning was 96 ± 32 (SD) mGy.cm. No significant differences in mean global ECV were found between ECV calculated with the PCD-CT (29.4 ± 4.5 [SD] %) and that calculated with cardiac MRI (30.0 ± 4.1 [SD] %) (<em>P</em> = 0.69). ECV-CT was greater in patients with cardiac MRI-confirmed myocarditis (31.65 ± 3.6 [SD] %) by comparison with those with normal findings (25.6 ± 3.2 [SD] %) (<em>P</em> < 0.01). ECV-CT strongly correlated with LGE mass (<em>r</em> = 0.82) and showed strong segmental correlation with ECV-MRI (basal: <em>r</em> = 0.95; mid-ventricular: <em>r</em> = 0.91). An ECV-CT threshold of 26.9 % yielded an AUC of 0.95 (95 % CI: 0.84–1.00) for the diagnosis of myocarditis.</div></div><div><h3>Conclusion</h3><div>Calculation of ECV using iodine maps derived from late iodine enhancement cardiac PCD-CT images is both feasible and accurate at low radiation doses. PCD-CT appears as a promising non-invasive imaging modality for the diagnostic and prognostic assessment of acute myocarditis in the setting of chest pain.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 255-263"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unicentric Castleman disease: CT and cinematic rendering imaging features","authors":"Taha M. Ahmed, Elliot K. Fishman","doi":"10.1016/j.diii.2025.05.001","DOIUrl":"10.1016/j.diii.2025.05.001","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 280-281"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac magnetic resonance imaging in the follow-up of patients with Fabry cardiomyopathy","authors":"Jules Senlis , Fabien Labombarda , Julien Burel , Arthur Flouriot , Sébastien Normant , Matthieu Demeyere , Olivier Lairez , Soraya El Ghannudi , Alexis Jacquier , Olivier Ghekiere , Farah Cadour , Jean-Nicolas Dacher","doi":"10.1016/j.diii.2025.02.002","DOIUrl":"10.1016/j.diii.2025.02.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the role of cardiac magnetic resonance imaging (MRI) in the follow-up of patients with Fabry disease. Our hypothesis was that LV functional parameters and native myocardial T1 and T2 values could be used to monitor treatment efficacy.</div></div><div><h3>Materials and methods</h3><div>This prospective, observational, multicenter study included patients with Fabry disease who underwent two cardiac MRI examinations performed at 1.5 T 24 months apart at five University Hospitals between March 2017 and December 2022. Changes in cardiac MRI parameters were compared between two groups of patients according to whether or not they were receiving specific treatment.</div></div><div><h3>Results</h3><div>Twenty-six patients with Fabry disease were enrolled. There were 17 women and 9 men, with a mean age of 45.3 ± 17.4 (standard deviation [SD]) years. Both treated and untreated patients showed an increase in native T1 values over time, but the T1 increase was higher in treated patients (global T1, +39.4 ± 28.9 [SD] ms) than in untreated ones (global T1, +14.5 ± 30.3 [SD] ms) (<em>P</em> = 0.04). T2 values decreased in treated patients (global T2, -2.11 [SD] ms ± 3.36 but increased in untreated ones (global T2, +0.57 ± 1.63 [SD] ms) (<em>P</em> = 0.02). No significant changes in extracellular cardiac volume, left ventricular functional parameters, late gadolinium enhancement or left atrial volume were observed. However, LV mass index increased in untreated patients and decreased in treated patients. Intra- and interobserver reproducibility of T1 measurements showed mean biases of -0.18 ms (limit of agreement:11.61, 11.24) and -0.64 ms (limit of agreement:23.82; 22.54), respectively.</div></div><div><h3>Conclusion</h3><div>Variations in native myocardial T1 values at cardiac MRI are significantly greater in patients with Fabry disease receiving treatment than in untreated patients, suggesting an effect of treatment on lipid storage. In addition, changes in T2 values suggest an anti-inflammatory effect of the treatment.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 247-254"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac MRI in Fabry disease: T1 mapping as a quantitative biomarker for treatment monitoring","authors":"Jean-Francois Deux , Paul Habert","doi":"10.1016/j.diii.2025.04.005","DOIUrl":"10.1016/j.diii.2025.04.005","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 7","pages":"Pages 243-244"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}