Ha-Long Nguyen , Ricardo Holderbaum Do Amaral , Sophie Lerouge , An-Katrien De Roo , Fatemeh Zehtabi , Miikka Vikkula , Gilles Soulez
{"title":"Injectable chitosan hydrogel effectively controls lesion growth in a venous malformation murine model","authors":"Ha-Long Nguyen , Ricardo Holderbaum Do Amaral , Sophie Lerouge , An-Katrien De Roo , Fatemeh Zehtabi , Miikka Vikkula , Gilles Soulez","doi":"10.1016/j.diii.2024.07.004","DOIUrl":"10.1016/j.diii.2024.07.004","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the safety and efficacy of intralesional injection of chitosan hydrogel (CH) combined with sodium tetradecyl sulfate (STS) to sclerose and embolize venous malformations (VMs) by comparison with 3% STS foam and placebo in a mouse model.</div></div><div><h3>Materials and methods</h3><div>Subcutaneous VMs were created by injecting HUVEC_TIE2-L914F cells, mixed with matrigel, into the back of athymic mice (Day [D] 0). After VM-like lesions were established at D10, 70 lesions were randomly assigned to one of six treatment groups (untreated, saline, 3% STS-foam, CH, 1% STS-CH, 3% STS-CH). For 3% STS-foam, the standard Tessari technique was performed. VMs were regularly evaluated every 2–3 days to measure lesion size until the time of collection at D30 (primary endpoint). At D30, VM lesions including the matrigel plugs were culled and evaluated by histological analysis to assess vessel size, chitosan distribution and endothelial expression. One-way analysis of variance (ANOVA) test was performed to compare quantitative variables with normal distribution, otherwise Kruskal-Wallis test followed by pairwise comparisons by a Wilcoxon rank sum test was performed.</div></div><div><h3>Results</h3><div>All VMs were successfully punctured and injected. Six VMs injected with 3% STS-CH showed early skin ulceration with an extrusion of the matrigel plug and were excluded from final analysis. In the remaining 64 VMs, skin ulceration occurred on 26 plugs, resulting in the loss of three 3% STS-foam and one 1% STS-CH plugs. Both chitosan formulations effectively controlled growth of VMs by the end of follow-up compared to untreated or 3% STS-foam groups (<em>P</em> < 0.05). Vessel sizes were smaller with both CH formulations compared to untreated and saline groups (<em>P</em> < 0.05). Additionally, there were smaller vascular channels within the 1% STS-CH group compared to the 3% STS-foam group (<em>P</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>Chitosan's ability to control the growth of VMs suggests a promising therapeutic effect that outperforms the gold standard (STS-foam) on several variables.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 11","pages":"Pages 430-438"},"PeriodicalIF":4.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Douraied Ben Salem, Philippe Soyer, Hélène Vernhet Kovaczick
{"title":"The effect of radiology on climate change: Can AI help us move toward a green future?","authors":"Douraied Ben Salem, Philippe Soyer, Hélène Vernhet Kovaczick","doi":"10.1016/j.diii.2024.07.011","DOIUrl":"10.1016/j.diii.2024.07.011","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 11","pages":"Pages 415-416"},"PeriodicalIF":4.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Idiopathic intracranial hypertension: A complex condition in which physiological and anatomical concepts collide","authors":"","doi":"10.1016/j.diii.2024.06.009","DOIUrl":"10.1016/j.diii.2024.06.009","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 11","pages":"Pages 413-414"},"PeriodicalIF":4.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chitosan hydrogel to improve the efficacy of sclerotherapy for venous malformations: From preclinical experiment to clinical application","authors":"Romaric Loffroy , Pierre-Olivier Comby","doi":"10.1016/j.diii.2024.09.013","DOIUrl":"10.1016/j.diii.2024.09.013","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 11","pages":"Pages 417-418"},"PeriodicalIF":4.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xu Bai , Cheng Peng , Baichuan Liu , Shaopeng Zhou , Haili Liu , Yijian Chen , Huiping Guo , Yuwei Hao , Xin Liu , Jian Zhao , Xiaohui Ding , Lin Li , Xu Zhang , Huiyi Ye , Xin Ma , Haiyi Wang
{"title":"Diagnostic and prognostic value of MRI-based Node-RADS for the assessment of regional lymph node metastasis in renal cell carcinoma","authors":"Xu Bai , Cheng Peng , Baichuan Liu , Shaopeng Zhou , Haili Liu , Yijian Chen , Huiping Guo , Yuwei Hao , Xin Liu , Jian Zhao , Xiaohui Ding , Lin Li , Xu Zhang , Huiyi Ye , Xin Ma , Haiyi Wang","doi":"10.1016/j.diii.2024.10.005","DOIUrl":"10.1016/j.diii.2024.10.005","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to assess the capabilities of MRI-based Node Reporting and Data System (Node-RADS) in diagnosing regional lymph node metastasis (RLNM) and to estimate its prognostic significance in patients with renal cell carcinomas (RCCs).</div></div><div><h3>Materials and methods</h3><div>Patients with RCC who underwent nephrectomy and regional lymph node dissection between January 2010 and August 2023 were retrospectively included. Two senior radiologists scored lymph nodes in consensus using MRI-based Node-RADS. The performance of MRI-based Node-RADS for the diagnosis of RLNM was estimated using area under receiver operating characteristic (AUC) curves and compared against size criteria. Three additional readers scored all lesions to assess interobserver agreement. Progression-free survival and overall survival were estimated and compared between patients with low (1–3) and high (4–5) scores.</div></div><div><h3>Results</h3><div>Overall, 216 patients with RCC were enrolled, including 58 with RLNM. There were 157 men and 59 women with a median age of 54 years (range: 8–83 years). Node-RADS showed larger AUC (0.93 [95 % confidence interval (CI): 0.87–0.97]) and higher specificity (96.8 % [95 % CI: 92.8–99.0]) compared to size criteria (0.88 [95 % CI: 0.83–0.94] and 87.3 % [95 % CI: 81.1–92.1], respectively) for the diagnosis of RLNM (<em>P</em> = 0.039 and <em>P</em> < 0.001, respectively). Substantial interobserver agreement in Node-RADS scoring was obtained between the three readers (weighted κ, 0.75 [95 % CI: 0.69–0.80]). During a median follow-up of 56 months, patients with high Node-RADS score experienced poorer progression-free survival (<em>P</em> < 0.001) and overall survival (<em>P</em> < 0.001) than those with low Node-RADS score. At multivariable Cox regression analysis, Node-RADS was an independent variable associated with RCC prognosis after adjustment for confounders.</div></div><div><h3>Conclusions</h3><div>The MRI-based Node-RADS demonstrates notable performance in detecting RLNM and showed potential prognostic significance for RCCs.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"106 4","pages":"Pages 117-125"},"PeriodicalIF":4.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma Boubaker, Romain Gillet, Cécile Parietti-Winkler, Dominik Nickel, Francis Veillon, Michael Eliezer
{"title":"Breaking barriers in inner ear MRI: The changing role of deep learning reconstruction","authors":"Fatma Boubaker, Romain Gillet, Cécile Parietti-Winkler, Dominik Nickel, Francis Veillon, Michael Eliezer","doi":"10.1016/j.diii.2024.07.010","DOIUrl":"10.1016/j.diii.2024.07.010","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 10","pages":"Pages 409-411"},"PeriodicalIF":4.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous cryoablation of abdominal wall endometriosis: An analysis of 38 patients","authors":"","doi":"10.1016/j.diii.2024.02.010","DOIUrl":"10.1016/j.diii.2024.02.010","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to evaluate the efficacy of percutaneous cryoablation in the treatment of abdominal wall endometriosis (AWE) nodules.</p></div><div><h3>Materials and methods</h3><p>Thirty-eight women treated for symptomatic AWE nodules with percutaneous cryoablation under ultrasound and computed tomography (CT) guidance between May 2020 and July 2023 were retrospectively included. Pain was estimated using visual analog scale (VAS) and assessed at baseline, three months, six months, and 12 months after percutaneous cryoablation. Baseline VAS score, volume of AWE nodule and magnetic resonance imaging (MRI) features of AWE nodules were compared to those obtained after percutaneous cryoablation. Major complications, if any, were noted.</p></div><div><h3>Results</h3><p>Thirty-eight women with a median age of 35.5 years (interquartile range [IQR]: 32, 39; range: 24–48 years) and a total of 60 AWE nodules were treated. Percutaneous cryoablation was performed under local or regional anesthesia in 30 women (30/38; 79%). Significant decreases between initial median VAS score (7; IQR: 6, 8; range: 3–10) and median VAS score after treatment at three months (0; IQR: 0, 5; range; 0–8) (<em>P</em> < 0.001), six months (0; IQR: 0, 1; range; 0–10) (<em>P</em> < 0.001) and 12 months (0; IQR: 0, 2; range: 0–7) (<em>P</em> < 0.001) were observed. Percutaneous cryoablation resulted in effective pain relief in 31 out of 38 women (82%) at six months and 15 out of 18 women (83%) at 12 months. Contrast-enhanced MRI at six-month follow-up showed a significant decrease in the volume of AWE nodules and the absence of AWE nodule enhancement after treatment by comparison with baseline MRI (<em>P</em> < 0.001). No major complications were reported.</p></div><div><h3>Conclusion</h3><p>Percutaneous cryoablation is an effective, minimally invasive intervention for the treatment of AWE nodules that conveys minimal or no morbidity.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 9","pages":"Pages 319-325"},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of low-energy virtual monoenergetic images between photon-counting CT and energy-integrating detectors CT: A phantom study","authors":"","doi":"10.1016/j.diii.2024.02.009","DOIUrl":"10.1016/j.diii.2024.02.009","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to assess image quality and dose level using a photon-counting CT (PCCT) scanner by comparison with a dual-source CT (DSCT) scanner on virtual monoenergetic images (VMIs) at low energy levels.</p></div><div><h3>Materials and methods</h3><p>A phantom was scanned using a DSCT and a PCCT with a volume CT dose index of 11 mGy, and additionally at 6 mGy and 1.8 mGy for PCCT. Noise power spectrum and task-based transfer function were evaluated from 40 to 70 keV on VMIs to assess noise magnitude and noise texture (f<sub>av</sub>) and spatial resolution on two iodine inserts (f<sub>50</sub>), respectively. A detectability index (d’) was computed to assess the detection of two contrast-enhanced lesions according to the energy level used.</p></div><div><h3>Results</h3><p>For all energy levels, noise magnitude values were lower with PCCT than with DSCT at 11 and 6 mGy, but greater at 1.8 mGy. f<sub>av</sub> values were higher with PCCT than with DSCT at 11 mGy (8.6 ± 1.5 [standard deviation [SD]%), similar at 6 mGy (1.6 ± 1.5 [SD]%) and lower at 1.8 mGy (-17.8 ± 2.2 [SD]%). For both inserts, f<sub>50</sub> values were higher with PCCT than DSCT at 11- and 6 mGy for all keV levels, except at 6 mGy and 40 keV. d’ values were higher with PCCT than with DSCT at 11- and 6 mGy for all keV and both simulated lesions. Similar d' values to those of the DSCT at 11 mGy, were obtained at 2.25 mGy for iodine insert at 2 mg/mL and at 0.96 mGy for iodine insert at 4 mg/mL at 40 keV.</p></div><div><h3>Conclusion</h3><p>Compared to DSCT, PCCT reduces noise magnitude and improves noise texture, spatial resolution and detectability on VMIs for all low-keV levels.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 9","pages":"Pages 311-318"},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous image-guided cryoablation of abdominal wall endometriosis: Towards a novel standard of care?","authors":"","doi":"10.1016/j.diii.2024.03.004","DOIUrl":"10.1016/j.diii.2024.03.004","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 9","pages":"Pages 299-300"},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Side branch embolization before endovascular abdominal aortic aneurysm repair to prevent type II endoleak: A prospective multicenter study","authors":"","doi":"10.1016/j.diii.2024.03.003","DOIUrl":"10.1016/j.diii.2024.03.003","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of the study was to evaluate the efficacy and safety of pre-emptive transcatheter arterial embolization (P-TAE) of aortic side branches to prevent type II endoleak in patients with abdominal aortic aneurysm after endovascular abdominal aneurysm repair (EVAR).</p></div><div><h3>Materials and methods</h3><p>This multicenter, prospective, single-arm trial enrolled 100 patients with abdominal aortic aneurysm from nine hospitals between 2018 and 2021. There were 85 men and 15 women, with a mean age of 79.6 ± 6.0 (standard deviation) years (range: 65–97 years). P-TAE was attempted for patent aortic side branches, including the inferior mesenteric artery, lumbar arteries, and other branches. The primary endpoint was late type II endoleak incidence at 6 months post-repair. Secondary endpoints included changes in aneurysmal sac diameter at 6- and 12 months, complications, re-intervention, and aneurysm-related mortality. Aneurysm sac changes at 6- and 12 months was compared between the late and no-late type II endoleak groups.</p></div><div><h3>Results</h3><p>Coil embolization was successful in 80.9% (321/397) of patent aortic side branches, including 86.3% of the inferior mesenteric arteries, 80.3% of lumbar arteries, and 55.6% of other branches without severe adverse events. Late type II endoleak incidence at 6 months was 8.9% (8/90; 95% confidence interval: 3.9–16.8%). Aneurysm sac shrinkage > 5 mm was observed in 41.1% (37/90) and 55.3% (47/85) of the patients at 6- and 12-months post-EVAR, respectively. Patients with late type II endoleak had less aneurysm sac shrinkage than those without type II endoleak at 12 months (˗0.2 mm <em>vs.</em> ˗6.0 mm; <em>P</em> = 0.040). No patients required re-intervention for type II endoleak, and no aneurysm-related mortalities occurred.</p></div><div><h3>Conclusion</h3><p>P-TAE is safe and effective in preventing type II endoleak, leading to early sac shrinkage at 12 months following EVAR.</p></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"105 9","pages":"Pages 326-335"},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}