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Regional Difference in the Association Between Long-Term PM and Cardiovascular Disease Incidence and Potential Determinants of the Difference
IF 4.3 2区 医学
Geohealth Pub Date : 2025-03-19 DOI: 10.1029/2024GH001245
Ok-Jin Kim, Sun-Young Kim
{"title":"Regional Difference in the Association Between Long-Term PM and Cardiovascular Disease Incidence and Potential Determinants of the Difference","authors":"Ok-Jin Kim,&nbsp;Sun-Young Kim","doi":"10.1029/2024GH001245","DOIUrl":"https://doi.org/10.1029/2024GH001245","url":null,"abstract":"<p>While short-term studies of the adverse effects of air pollution have found regional differences, there has been insufficient evidence from long-term studies. This study investigated the spatial variation of the association between long-term exposure to particulate matter (PM) air pollution and cardiovascular disease (CVD) incidence and their relevant regional characteristics. We selected 155,017 adults who have lived over 13 years in each of the 16 regions of South Korea from the National Health Insurance Service-National Sample Cohort. We assessed the individual long-term exposure as a 5-year average concentration at district-level residential addresses estimated by previously validated exposure prediction models. We applied time-dependent Cox-proportional hazard models to explore the spatial variation of long-term PM exposure's association with CVD incidence. After adjusting for individual-level characteristics, we estimated the region-specific hazard ratios (HRs) of incident CVD per 10 μg/m<sup>3</sup> increase in PM<sub>10</sub> and PM<sub>2.5</sub>. Then, we calculated the correlation coefficients between region-specific HRs and 80 regional attributes in 13 categories across 16 regions to identify the related regional characteristics. Region-specific HRs of CVD incidence for PM showed considerable variation in magnitude and direction across 16 regions. HRs of PM<sub>10</sub> and PM<sub>2.5</sub> were higher in major urban areas and lower in rural areas. Urbanicity and emission sources exhibited significant correlations with HRs of overall CVD. Our findings offer an opportunity to explore regional characteristics that derive the difference in air pollution-associated health effects and help us provide guidance to target specific characteristics to avoid the adverse health effects of air pollution.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thank You to Our GeoHealth 2024 Reviewers
IF 4.3 2区 医学
Geohealth Pub Date : 2025-03-18 DOI: 10.1029/2025GH001412
Thanh H. Nguyen
{"title":"Thank You to Our GeoHealth 2024 Reviewers","authors":"Thanh H. Nguyen","doi":"10.1029/2025GH001412","DOIUrl":"https://doi.org/10.1029/2025GH001412","url":null,"abstract":"<p>Peer-review is the foundation and the safeguard of scientific research. Without the dedication of our reviewers, the journal would not have been successful. In 2024, 231 reviewers completed the review for 238 manuscripts submitted to GeoHealth. Our reviewers are from all continents except Antarctica. Besides reviewers from North America, China, Europe, and China, we started to have reviewers from India, Latin America, and Africa. GeoHealth editorial board is committed to expanding the readership, authorship, and reviewership to other countries. If you have already reviewed for us, no matter where or who you are, we hope you and your colleagues will consider GeoHeatlh a home for your work. Below is the list of reviewers who completed more than two reviews (<i>noted in italics</i>) or have outstanding quality reviews. Two of our reviewers have been nominated for AGU Best Reviewers awards (*noted with an asterisk).</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions of Environmental and Health Effects of Quarry Activities at Klefe in the Ho Municipality of the Volta Region
IF 4.3 2区 医学
Geohealth Pub Date : 2025-03-06 DOI: 10.1029/2024GH001168
Selase Kofi Adanu, Maxwell Kwame Boakye, Shine Francis Gbedemah, Mexoese Nyatuame
{"title":"Perceptions of Environmental and Health Effects of Quarry Activities at Klefe in the Ho Municipality of the Volta Region","authors":"Selase Kofi Adanu,&nbsp;Maxwell Kwame Boakye,&nbsp;Shine Francis Gbedemah,&nbsp;Mexoese Nyatuame","doi":"10.1029/2024GH001168","DOIUrl":"https://doi.org/10.1029/2024GH001168","url":null,"abstract":"<p>Expansion of residential and commercial facilities have contributed to rapid urbanization of Ho municipality. As a result, quarry activities have intensified in Klefe a major stone quarry source for construction. The increased demand for quarry stones has created jobs for many but has also led to the perception of health and environment challenges negatively affecting the people and the natural environment. In view of the extensive quarry activities in the area, the aim of the study was to assess perceptions of effects of quarrying activities on human health and the environment. Stratified random sampling method was used to select respondents to answer questions on a questionnaire and application of a relative importance index to examine what the study community perceive as the most important environmental and health effects of quarrying. Exploratory factor analysis was used to determine relationships existing among environmental hazards and their perceived health effects. Sedimentation, land degradation and injury from quarrying were the main perceived effects of quarrying. Efforts to address any perceived effects of quarrying should focus on sedimentation, land degradation and injury from quarrying.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Times Matter, the Impact of Convective Dust Events on Air Quality in the Greater Phoenix Area, Arizona
IF 4.3 2区 医学
Geohealth Pub Date : 2025-03-04 DOI: 10.1029/2024GH001209
K. Ardon-Dryer, T. Aziz
{"title":"Times Matter, the Impact of Convective Dust Events on Air Quality in the Greater Phoenix Area, Arizona","authors":"K. Ardon-Dryer,&nbsp;T. Aziz","doi":"10.1029/2024GH001209","DOIUrl":"https://doi.org/10.1029/2024GH001209","url":null,"abstract":"<p>Convective dust events are common in the greater Phoenix area over the summer. These short-duration dust events degrade the air quality and pose a potential health threat to millions. In this study, 93 convective dust events that occurred in July and August 2015 to 2021 were examined to determine their impact on air quality. Seven PM<sub>10</sub> stations were used to evaluate the changes in PM<sub>10</sub> concentrations over different time intervals (10-min, hourly, and daily). Out of these 93 dust events, only 15.1% had a daily average above the EPA PM<sub>10</sub> daily threshold, however, these daily concentrations were 12.8 and 28 times lower compared to hourly and 10-min concentrations (respectively) at the peak of the dust. 10-minute PM<sub>10</sub> concentrations were on average 2.2 ± 0.8 times higher than the hourly concentrations. The findings of this study demonstrated that the traditional methods that use daily or hourly averages underestimate the atmospheric PM<sub>10</sub> concentrations during short convective dust events and therefore lower the estimated exposure. There is a need to consider shorter time intervals to capture the PM concentrations accurately and highlight the importance of real-time monitoring and accurate characterization of short-duration events to assess their impacts on air quality and human health.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Impacts of Global Solid Biofuel Emissions on Ambient Air Quality and Human Health for 2000–2019
IF 4.3 2区 医学
Geohealth Pub Date : 2025-02-27 DOI: 10.1029/2024GH001130
Debatosh B. Partha, Ying Xiong, Noah Prime, Steven J. Smith, Yaoxian Huang
{"title":"Long-Term Impacts of Global Solid Biofuel Emissions on Ambient Air Quality and Human Health for 2000–2019","authors":"Debatosh B. Partha,&nbsp;Ying Xiong,&nbsp;Noah Prime,&nbsp;Steven J. Smith,&nbsp;Yaoxian Huang","doi":"10.1029/2024GH001130","DOIUrl":"https://doi.org/10.1029/2024GH001130","url":null,"abstract":"<p>Globally, solid biofuels (SB) have been widely used for household cooking and energy production for decades due to electricity shortages and socio-economic barriers to adopting renewable energy alternatives. This has detrimental effects on air quality, human health, and climate through trace gas and aerosol emissions. Despite numerous studies, the long-term consequences of SB emissions remain poorly understood. Here, we use the Community Earth System Model and the Community Emissions Data System emission inventory to investigate the SB emission impacts on air quality and human health for 2000–2019. Global SB emission increased the ambient PM<sub>2.5</sub> (particulate matter with aerodynamic diameters <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>≤</mo>\u0000 </mrow>\u0000 <annotation> $mathit{le }$</annotation>\u0000 </semantics></math>2.5 μm) and ozone (O<sub>3</sub>) concentrations up to 23.61 <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mi>μ</mi>\u0000 <mi>g</mi>\u0000 </mrow>\u0000 <annotation> ${upmu }mathrm{g}$</annotation>\u0000 </semantics></math>/m<sup>3</sup> and 13.69 ppbv, with significant effects found in India, China, and the Rest of Asia (ROA). Our study estimates total annual premature deaths (APDs) associated with global SB-attributable PM<sub>2.5</sub> and O<sub>3</sub> exposure as 1.11 million [95% confidence interval (95% CI): 1.00–1.22 million] in 2000 up to 1.43 million (95% CI: 1.30–1.56 million) in 2019. China's SB emissions and associated APDs have reduced substantially, whereas India and ROA had a major leap in both estimates in 2019 compared to 2000. China's progress in cutting residential SB emissions accounts for its improvements. Our study urges the reduction of SB usage and emissions to potentially improve overall air quality and human health conditions, especially in highly populated, low- and middle-income countries, where the poor air quality and associated health burden attributable to SB emissions are estimated to be higher.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
IF 4.3 2区 医学
Geohealth Pub Date : 2025-02-18 DOI: 10.1029/2024GH001234
Siqi Zhang, Lingzhi Chu, Yuan Lu, Jing Wei, Robert Dubrow, Sarwat I. Chaudhry, Erica Spatz, Harlan Krumholz, Kai Chen
{"title":"Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study","authors":"Siqi Zhang,&nbsp;Lingzhi Chu,&nbsp;Yuan Lu,&nbsp;Jing Wei,&nbsp;Robert Dubrow,&nbsp;Sarwat I. Chaudhry,&nbsp;Erica Spatz,&nbsp;Harlan Krumholz,&nbsp;Kai Chen","doi":"10.1029/2024GH001234","DOIUrl":"https://doi.org/10.1029/2024GH001234","url":null,"abstract":"<p>The association between ambient ozone (O<sub>3</sub>) and acute myocardial infarction (AMI) onset is unclear, particularly for younger patients and AMI subtypes. This study examined the short-term association of O<sub>3</sub> with AMI onset in patients aged 18–55 years and explored differences by AMI subtypes and patient characteristics. We analyzed 2,322 AMI patients admitted to 103 US hospitals (2008–2012). Daily maximum 8-hr O<sub>3</sub> concentrations estimated using a spatiotemporal deep learning approach were assigned to participants' home addresses. We used a time-stratified case-crossover design with conditional logistic regression to assess the association between O<sub>3</sub> and AMI, adjusting for fine particulate matter, air temperature, and relative humidity. We conducted stratified analyses to examine associations for AMI subtypes and effect modification by sociodemographic status, lifestyle factors, and medical history. An interquartile range (16.6 ppb) increase in O<sub>3</sub> concentrations was associated with an increased AMI risk at lag 4 days (odds ratio [OR] = 1.21, 95% confidence interval [CI]: 1.08–1.34) and lag 5 days (OR = 1.11, 95% CI: 1.00–1.24). The association was more pronounced for non-ST-segment elevation AMI and type 2 AMI compared with ST-segment elevation AMI and type 1 AMI, respectively. Stronger O<sub>3</sub>-AMI associations were observed in non-Hispanic Blacks than in non-Hispanic Whites. Our study provides evidence that short-term O<sub>3</sub> exposure is associated with increased AMI risk in younger patients, with varying associations across AMI subtypes. The effect modification by race/ethnicity highlights the need for population-specific intervention strategies.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises
IF 4.3 2区 医学
Geohealth Pub Date : 2025-02-14 DOI: 10.1029/2024GH001254
Lars Ratjen, Emily Goddard, Elise B. Gilcher, Breanna K. Nguyen, Mariana Kelley, Hannah S. Feldman, Kelechi Akalaonu, Kate Nyhan, Andreas Backhaus, Miren López Lascurain, Nora E. Wyrtzen, Sara Smiley Smith, Maya Prabhu, Sarah R. Lowe, Kai Chen, Julie B. Zimmerman, Paul T. Anastas
{"title":"EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises","authors":"Lars Ratjen,&nbsp;Emily Goddard,&nbsp;Elise B. Gilcher,&nbsp;Breanna K. Nguyen,&nbsp;Mariana Kelley,&nbsp;Hannah S. Feldman,&nbsp;Kelechi Akalaonu,&nbsp;Kate Nyhan,&nbsp;Andreas Backhaus,&nbsp;Miren López Lascurain,&nbsp;Nora E. Wyrtzen,&nbsp;Sara Smiley Smith,&nbsp;Maya Prabhu,&nbsp;Sarah R. Lowe,&nbsp;Kai Chen,&nbsp;Julie B. Zimmerman,&nbsp;Paul T. Anastas","doi":"10.1029/2024GH001254","DOIUrl":"https://doi.org/10.1029/2024GH001254","url":null,"abstract":"<p>Understanding how the environment shapes our mental and cognitive health is imperative to support efforts that promote healthy and sustainable living conditions. The etiology of mental health conditions remains often unclear, and social factors have received more scrutiny than natural or built environments. We present a conceptual framework illustrating the emerging intersection between the environment and neuropsychological health, intended to structure and guide research and funding, as well as public health and environmental initiatives. We conducted a scoping review of reviews of existing evidence on the impacts of the environment on mental and cognitive health. We found that an extensive body of work was focused on chemical hazards and the built environment and their associations with neurological and mental health, including attention-deficit/hyperactivity disorder (ADHD), autism, dementia, and mood. We identified emerging areas of research intersecting environmental factors such as air, water, light, and green space with schizophrenia and behavioral health. Our analysis of the intersections between the environment and mental and cognitive health allows for the identification of knowledge clusters and gaps, contextualizing needs and opportunities for future research and funding strategies. These significant connections showcase the importance of understanding the relationships between the environment and mental and cognitive health. With this work, we assert that the protection of the environment and its integration into healthcare can bring cascading benefits and synergies to mental and cognitive health and well-being and address the social and economic burden of the mental health crises.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Health Impacts, Treatments, and Countermeasures of Martian Dust on Future Human Space Exploration
IF 4.3 2区 医学
Geohealth Pub Date : 2025-02-12 DOI: 10.1029/2024GH001213
Justin L. Wang, Jeremy J. Rosenbaum, Ajay N. Prasad, Robert R. Raad, Esther J. Putman, Andrea D. Harrington, Haig Aintablian, Brian M. Hynek
{"title":"Potential Health Impacts, Treatments, and Countermeasures of Martian Dust on Future Human Space Exploration","authors":"Justin L. Wang,&nbsp;Jeremy J. Rosenbaum,&nbsp;Ajay N. Prasad,&nbsp;Robert R. Raad,&nbsp;Esther J. Putman,&nbsp;Andrea D. Harrington,&nbsp;Haig Aintablian,&nbsp;Brian M. Hynek","doi":"10.1029/2024GH001213","DOIUrl":"https://doi.org/10.1029/2024GH001213","url":null,"abstract":"<p>The challenges of human space exploration produce some of humanity's greatest technological and scientific advances, not excluding innovations in medicine. The microgravity environment causes a host of physiological changes, and exposure to dust on the Moon caused considerable pulmonary distress to astronauts during the Apollo missions. As the National Aeronautics and Space Administration and other organizations prepare for long-duration exploration missions to Mars, the hazards and consequences of the Martian surface need to be accounted for. This review investigates how substances analogous to hazardous components of Martian dust have caused disease in people on Earth. Because of its small grain size, dust on Mars is more likely to cause lung irritation, absorb into the bloodstream, and lead to diseases in astronauts. Toxic components of martian dust include perchlorates, silica, nanophase iron oxides, and gypsum in addition to trace amounts of toxic metals whose abundances are debated: chromium, beryllium, arsenic, and cadmium. Predicted effects of dust exposure ranges from asymptomatic to life-threatening, with many substances being carcinogenic and most damage impacting the pulmonary system. The longer transit time for astronauts to return home makes the operations of performing emergency medical treatment more difficult and increases both the likelihood and consequences of developing chronic disease. Exposure mitigation needs to be prioritized; however, supplements may be taken to prevent disease from breakthrough exposures, and treatment regimens could lessen morbidity and mortality. Treatments and equipment need to be carefully considered and transported with the astronauts to be prepared for all possible scenarios.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geospatial Analysis of Food Insecurity and Adverse Human Health Outcomes in the United States 美国粮食不安全和人类健康不良后果的地理空间分析
IF 4.3 2区 医学
Geohealth Pub Date : 2025-02-12 DOI: 10.1029/2024GH001198
Naveen Joseph
{"title":"Geospatial Analysis of Food Insecurity and Adverse Human Health Outcomes in the United States","authors":"Naveen Joseph","doi":"10.1029/2024GH001198","DOIUrl":"https://doi.org/10.1029/2024GH001198","url":null,"abstract":"<p>Previous studies have reported that around 33 million people in the United States are food insecure, potentially leading to several health outcomes. This study aimed to evaluate the geospatial variation of food insecurity and its association with adverse human health outcomes at the state resolution in the United States. The adverse human health outcomes include diabetes and cardiovascular diseases. Data sets on diabetes and cardiovascular diseases were compiled from the Centers for Disease Control and Prevention Wonder database on chronic conditions. The food insecurity data was accessed from the USDA, which compiles the responses to household surveys from the Census Bureau. Mixed-effects regression models were used in this study to analyze the relationships between food insecurity and diabetes, and food insecurity and cardiovascular diseases. The incidence rate ratio was also estimated with 95% confidence intervals for both diabetes and cardiovascular diseases, comparing high food insecurity profiles to low food insecurity profiles. Food insecurity, diabetes, and cardiovascular diseases showed significantly higher rates in the southern part of the United States relative to other regions. Food insecurity showed significant associations with diabetes and cardiovascular diseases at a <i>p</i>-value &lt; 0.001. The 95% confidence interval of the incidence rate ratio was estimated as [1.198 1.234] for diabetes incidence and [1.033 1.091] for cardiovascular diseases, indicating a significant increase in both health outcomes while moving from a low food insecurity to a high food insecurity profile.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Joint Association Between Agrichemical Mixtures and Pediatric Cancer 探索农业化学混合物与小儿癌症之间的共同联系
IF 4.3 2区 医学
Geohealth Pub Date : 2025-02-12 DOI: 10.1029/2024GH001236
Jabeen Taiba, Cheryl Beseler, Muhammad Zahid, Shannon Bartelt-Hunt, Alan Kolok, Eleanor Rogan
{"title":"Exploring the Joint Association Between Agrichemical Mixtures and Pediatric Cancer","authors":"Jabeen Taiba,&nbsp;Cheryl Beseler,&nbsp;Muhammad Zahid,&nbsp;Shannon Bartelt-Hunt,&nbsp;Alan Kolok,&nbsp;Eleanor Rogan","doi":"10.1029/2024GH001236","DOIUrl":"https://doi.org/10.1029/2024GH001236","url":null,"abstract":"<p>Nebraska's age-adjusted incidence rates for childhood cancers are among the highest in the US. Previous studies indicated associations between agrichemical exposures (atrazine and nitrates) and pediatric cancer rate, assuming single pollutant exposure. We evaluated the joint association between the agricultural mixture and pediatric cancer. Agrichemical exposures at a county scale were quantified using the USGS Pesticide National Synthesis Project for frequently applied pesticides from 1992 to 2014 in 93 Nebraska counties. Outcomes were quantified using pediatric cancer diagnosed among children &lt;20 years of age (1992–2014) from the Nebraska cancer registry. We adjusted for social vulnerability factors such as race, income, employment, and access to care. The associations between 32 agrichemicals and cancer subtypes were assessed using the Generalized Weighted Quantile Sum Regression (gWQS) model. The model was fit assuming a Poisson distribution and using the pediatric population as an offset-term and social vulnerability factors as covariates. We observed a statistically significant positive association between the 32 agrichemicals and overall pediatric cancer and subtypes. The strength of associations was slightly stronger among brain and CNS cancers (<i>β</i> = 0.36, CI = 0.14, 0.57) compared to overall cancer (<i>β</i> = 0.30, CI = 0.16, 0.44) and leukemia (<i>β</i> = 0.23, CI = 0.09, 0.38). Dicamba, glyphosate, paraquat, quizalofop, triasulfuron, and tefluthrin largely contributed to the joint association. These findings may explain the joint associations of the agrichemical mixture on childhood cancer. Alternative biomarker-based approaches to measuring human exposure are worth investigating for chemicals of concern, particularly in counties with high agrichemical and cancer rates.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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