IF 4.3 2区医学

Geohealth Pub Date : 2025-06-22 DOI: 10.1029/2025GH001386

Jingyi Xin, Zhaobin Sun, Juan He, Xiaoyi Hang, Yuxin Zhao, Shuwen Zhang, Yu Hao

{"title":"Extreme Drought Events (1585–1590) and Spatiotemporal Patterns of Infectious Diseases Outbreaks in Ming Dynasty China","authors":"Jingyi Xin, Zhaobin Sun, Juan He, Xiaoyi Hang, Yuxin Zhao, Shuwen Zhang, Yu Hao","doi":"10.1029/2025GH001386","DOIUrl":"https://doi.org/10.1029/2025GH001386","url":null,"abstract":"Droughts, historically recognized as drivers of societal transformation, have been implicated in the emergence of infectious diseases. While existing research has concentrated on the impact of climate change on infectious diseases outbreaks in modern, industrialized, and urban settings, there is a dearth of epidemiological evidence regarding the historical interplay between drought and disease. Here, we analyze the 1585–1590 extreme drought in Ming Dynasty China to investigate the concurrent development of drought and infectious diseases, as well as the temporal and spatial effects of drought on disease outbreaks. The findings reveal a positive correlation between drought and infectious diseases in both temporal and spatial dimensions, with famine identified as a critical intermediate factor. Drought's influence on famine and disease is both immediate and delayed, with the most significant effects occurring within the same year. Additionally, a north-to-south pattern in the occurrence of drought and infectious diseases is observed, with northern droughts more likely to precipitate disease outbreaks. These insights offer valuable perspectives for future strategies.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme Weather Events Interact With Local Contexts to Alter the Frequency of Firearm Violence and Child Maltreatment in Wayne County, Michigan 极端天气事件与当地环境的相互作用改变了密歇根州韦恩县枪支暴力和儿童虐待的频率

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-21 DOI: 10.1029/2025GH001406

Rebeccah Sokol, Cynthia Gerlein-Safdi, Michelle Degli Esposti, Mildred Wallace

{"title":"Extreme Weather Events Interact With Local Contexts to Alter the Frequency of Firearm Violence and Child Maltreatment in Wayne County, Michigan","authors":"Rebeccah Sokol, Cynthia Gerlein-Safdi, Michelle Degli Esposti, Mildred Wallace","doi":"10.1029/2025GH001406","DOIUrl":"https://doi.org/10.1029/2025GH001406","url":null,"abstract":"Climate change is creating more frequent extreme weather events, but impacts on violence are not well understood. We explored associations of extreme weather with firearm violence and child maltreatment in Wayne County, Michigan. To understand contextual influences, we estimated models using data from before (2018–2019), during (March 2020–March 2021), and after (2022–2023) the onset of the COVID-19 pandemic. In both 2018–2019 and 2022–2023, firearm violence was lower in the first couple days after extreme weather compared to no prior extreme weather (relative risks [RR]: 0.44–0.54; 95% confidence intervals [CI]: 0.21–0.37, 0.79–0.90), with the influence waning over the following week. We did not observe any reduction, however, during the first year of the COVID-19 pandemic. Associations differed for child maltreatment. In 2018–2019, we observed no change in maltreatment in the days following extreme weather. Yet, during the first year of the COVID-19 pandemic, child maltreatment was higher over the 10 days following extreme weather (RR: 1.24; 95% CI: 0.97, 1.58). In 2022–2023, child maltreatment was lower following extreme weather events, but this finding is likely an artifact of reduced reporting after extreme weather during this period. In Wayne County, extreme weather immediately reduced firearm violence, with effects waning as people likely resumed regular activities. The first year of the COVID-19 pandemic suspended this influence, as extreme weather may not have changed daily activities beyond pandemic-related disruptions. For child maltreatment, however, extreme weather created accumulating risk over several days when it disrupted an already stressed environment.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial and Ethnic Inequities to Cumulative Environmental and Occupational Impacts in Michigan 种族和民族不平等对密歇根州环境和职业的累积影响

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-20 DOI: 10.1029/2025GH001482

Abas Shkembi, Sung Kyun Park, Jon Zelner, Richard Neitzel

{"title":"Racial and Ethnic Inequities to Cumulative Environmental and Occupational Impacts in Michigan","authors":"Abas Shkembi, Sung Kyun Park, Jon Zelner, Richard Neitzel","doi":"10.1029/2025GH001482","DOIUrl":"https://doi.org/10.1029/2025GH001482","url":null,"abstract":"The contribution of occupational exposures to the extent of cumulative environmental impacts, and their implications for environmental justice (EJ), have not been investigated. We (a) characterized communities with cumulatively high occupational and environmental exposures, (b) examined whether marginalized, historically redlined neighborhoods were disproportionately affected by these exposures, and (c) evaluated the implications of failing to consider workplace exposures in EJ screening tools in Michigan. At the census tract-level, we combined occupational exposure estimates of six common workplace hazards, environmental exposures from EJScreen and the National Transportation Noise Map, demographic information from the American Community Survey, and redlining information from the 1930s Home Owners' Loan Corporation maps to test the first two objectives using supervised and unsupervised statistical methods. The last objective incorporated the occupational indicators into the Michigan-specific EJ screening tool (MiEJScreen) to test the third objective. Among 2,772 Michigan census tracts, 738 (27%) had cumulatively high occupational and environmental exposures, primarily in urban areas. Tracts with >90% (compared to <10%) of racial and ethnic minority individuals had 2.31 (95% CI: 1.78–3.03) times higher odds of cumulatively high exposures. A simultaneous increase to the 90th percentile (relative to the 50th) in all 13 occupational and environmental exposures was associated with 2.47 (95% CI: 1.20–5.36) times higher odds of a tract having been historically redlined. Not incorporating occupational exposures into the MiEJScreen would overlook 90 census tracts with cumulatively high environmental and occupational impacts, affecting around 255,000 individuals. Ignoring occupational exposures in cumulative environmental impact assessments may overlook important EJ hotspots.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time of Emergence and Future Projections of Extremes of Malaria Infections in Africa 非洲疟疾极端感染的出现时间和未来预测

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-19 DOI: 10.1029/2025GH001356

Christian L. E. Franzke, Ruchi Singh Parihar

{"title":"Time of Emergence and Future Projections of Extremes of Malaria Infections in Africa","authors":"Christian L. E. Franzke, Ruchi Singh Parihar","doi":"10.1029/2025GH001356","DOIUrl":"https://doi.org/10.1029/2025GH001356","url":null,"abstract":"The spread of malaria is a major health burden, which affects many people in Africa, depends on climate but also socio-economic conditions. Thus, it is important to gauge the impact of anthropogenic global warming on malaria and attribute anthropogenic causes. Here we compute the Time Of Emergence of vector density and of the entomological inoculation rate (EIR) in the SSP3-7.0 scenario using 50 bias-corrected members of Community Earth System Model version 2 Large Ensemble simulations. This reveals that vector density, which depends on climate conditions, and EIR, which depends on both climate and population density, will rise significantly and permanently above the pre-industrial background variability due to anthropogenic causes in Africa. Both the vector density and EIR have areas, mainly in central Africa, where anthropogenic causes have already significantly changed, and many more areas will experience anthropogenic caused changes in the period 2030–2050 and toward the end of this century. Our simulations also show clear evidence that extremes of vector density and EIR increase in the future by almost 100%, suggesting that major malaria epidemic outbreaks will become much more likely. We also perform simulations with constant population and with no global warming which partly reveal underlying malaria dynamics. Our results highlight the need to prepare for an expansion and intensification of the malaria burden if no health interventions are being taken.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Performance and Utility of Global Gridded Precipitation Products for Health Applications and Impact Assessments in South America 评估全球网格降水产品在南美洲的健康应用和影响评估的性能和效用

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-18 DOI: 10.1029/2024GH001260

Sally Jahn, Katy A. M. Gaythorpe, Caroline M. Wainwright, Neil M. Ferguson

{"title":"Evaluation of the Performance and Utility of Global Gridded Precipitation Products for Health Applications and Impact Assessments in South America","authors":"Sally Jahn, Katy A. M. Gaythorpe, Caroline M. Wainwright, Neil M. Ferguson","doi":"10.1029/2024GH001260","DOIUrl":"https://doi.org/10.1029/2024GH001260","url":null,"abstract":"Globally gridded precipitation products (GGPPs) are commonly used in impact assessments as substitutes for weather station data, each with unique strengths and limitations. Reanalysis products are among the most widely used for driving impact models, evaluating climate models, or bias-correcting and downscaling model outputs to generate climate change projections. However, they are often outperformed in accuracy by other GGPPs, particularly in tropical regions, including areas of the Global South. Therefore, we assessed the utility and suitability of GGPPs for climate and health research by examining how differences and uncertainties in these products affect area-level precipitation estimates, often used in health studies when epidemiological data are linked to administrative units. We compared reanalysis (ERA5/-Land) with satellite-based (CHIRPS, PERSIANN-CDR) and interpolated gauge-based products (CRUTS, GPCC), each a viable candidate to serve as reference climatology in climate change impact assessments. We focused on seasonal patterns, disease-related bioclimatic variables, and climate change-relevant indices, such as the number of wet or dry periods. Our findings revealed substantial variation in the accuracy of local precipitation estimates across GGPPs, with differences in maximum pixel precipitation values exceeding 75% between ERA5-Land and CHIRPS. These differences in GGPPs translated into area-level precipitation and, consequently, in vector carrying capacity estimates, demonstrating their impact on health assessments. Our analysis focused on Brazil and Colombia, two diverse countries differing for example, in orography, climate, and size. Each product was evaluated against national station data. Our results indicate that estimating tropical precipitation is particularly challenging for reanalysis, while CHIRPS demonstrated the best overall performance.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Systemic Barriers Can Impact Health Inequities When Facing Climate Change Stressors: A Scoping Review of Global Differences 面对气候变化压力时，系统障碍如何影响卫生不公平：全球差异的范围审查

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-18 DOI: 10.1029/2024GH001272

Ainslee Wong, Tuyet-Mai H. Hoang, Victoria Ferrara, Thanh H. Nguyen

{"title":"How Systemic Barriers Can Impact Health Inequities When Facing Climate Change Stressors: A Scoping Review of Global Differences","authors":"Ainslee Wong, Tuyet-Mai H. Hoang, Victoria Ferrara, Thanh H. Nguyen","doi":"10.1029/2024GH001272","DOIUrl":"https://doi.org/10.1029/2024GH001272","url":null,"abstract":"The objective of this scoping review is to explore the systemic barriers that impact health inequities among vulnerable populations (e.g., racial/ethnic and gender groups, people with disabilities, refugees, immigrants, elders, young children, agricultural and fishery workers, and low-income individuals) when facing climate change stressors. We conducted an extensive review using nine search engines, which yielded 21 publications that focused on the health outcomes and barriers on the topic of climate change among vulnerable populations. Our findings indicated that poverty is the largest challenge preventing people from adequate health access and achieving positive outcomes, particularly for vulnerable populations globally. In addition, institutional and systemic barriers also differ based on regional differences, which suggests that health inequities are context dependent. Our scoping review has implications for (a) enhancing the effectiveness of climate change mitigation strategies and (b) addressing the healthcare barriers of vulnerable populations based on country-specific challenges.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global Pattern and Disease Heterogeneity Drivers in Aging Populations 老龄化人口的全球模式和疾病异质性驱动因素

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-16 DOI: 10.1029/2025GH001335

Chengcheng Jin, Jialian Chen, Jinqiong Fang, Kaiyu Hua, Zherui Fu, Xingxing Chen, Hao Wu, Ying Hua

{"title":"Global Pattern and Disease Heterogeneity Drivers in Aging Populations","authors":"Chengcheng Jin, Jialian Chen, Jinqiong Fang, Kaiyu Hua, Zherui Fu, Xingxing Chen, Hao Wu, Ying Hua","doi":"10.1029/2025GH001335","DOIUrl":"https://doi.org/10.1029/2025GH001335","url":null,"abstract":"The unprecedented demographic shifts toward an aging population pose significant challenges to global healthcare systems. Understanding the heterogeneity in disease prevalence among the elderly is crucial for effective public health strategies. Using prevalence data of 85 types of age-related diseases, we calculated the global heterogeneity of disease distribution by the Shannon Diversity Index (SHDI). We observed significant geographic variations in disease heterogeneity, with higher SHDI values in high-income Western countries such as the United States of America and Sweden and lower in South Asia and Oceania (p < 0.05). In 2021, SHDI values in elderly populations (age ≥60 years) for Europe and North America countries were an average of 1.12 times higher than in Oceania. While SHDI increases toward higher ages (for instance, in 2021, SHDI for adults above 95 years is 1.06 times higher than for ages between 60 and 64 years), the global SHDI tends to decrease nonlinearly over time. From 1990 to 2021, global age-standardized SHDI (age ≥60 years) averagely decreased by 1.2% for both men and women. Our analysis further revealed that socio-economic factors (e.g., socio-demographic indices, governance) strongly impacted global SHDI changes, while climatic and environmental factors (e.g., extreme climate and air pollution) showed significant differences across genders. Our study highlights the need for implementing comprehensive healthcare strategies, focusing on reducing health disparities and addressing environmental and socio-economic determinants to address inequalities in age-related diseases effectively.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecological and Health Risks of Polycyclic Aromatic Hydrocarbons in Particulate Matter in Chinese Cities 中国城市大气颗粒物中多环芳烃的生态与健康风险

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-06 DOI: 10.1029/2024GH001126

Yongfu Wu, Yuan Meng, Han Zhang, Lianglu Hao, Tao Zeng, Yan Shi, Yunhe Chen, Ni Qiao, Yibin Ren

{"title":"Ecological and Health Risks of Polycyclic Aromatic Hydrocarbons in Particulate Matter in Chinese Cities","authors":"Yongfu Wu, Yuan Meng, Han Zhang, Lianglu Hao, Tao Zeng, Yan Shi, Yunhe Chen, Ni Qiao, Yibin Ren","doi":"10.1029/2024GH001126","DOIUrl":"https://doi.org/10.1029/2024GH001126","url":null,"abstract":"During the first two decades of the 21st century, the level of polycyclic aromatic hydrocarbon (PAH) pollution in urban atmospheric particulate matter (PM) in China significantly increased. By combining data from more than 6,695 individual samples covering 89 typical cities (population > 0.5 million people) across China, this study focuses on evaluating the health risks to urban residents and the ecological risks to the surrounding environment from PAHs in PM using the methods of the United States Environmental Protection Agency and sediment quality standards. The PAH contents and contamination levels in Central China (CC) were lower than those in South China (SC) and North China (NC). NC exhibited the most severe PAH pollution and greatest ecological risk, while CC had the highest population density and gross domestic product. The incremental lifetime cancer risk and hazard index values for people in NC were greater than those for people in CC and SC, and the health risk increased with increasing latitude. Based on ecological risk criteria and standard assessment methods, PAHs in PM in China pose a potential ecological risk, and the risk of harmful biological effects follows the order of NC > CC > SC. Given the significant risks of PAHs to people, animals and plants at both the national and global scales, under the guidance of the One Health concept of the World Health Organization, it is necessary to comprehensively manage PAHs in PM and reduce their threats to humans and ecosystems.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint Effects of Wildfire Smoke and Extreme Heat on Hospitalizations in California, 2011–2020 2011-2020年加州野火烟雾和极端高温对住院治疗的共同影响

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-06 DOI: 10.1029/2024GH001237

Caitlin G. Jones-Ngo, Rebecca J. Schmidt, Erwan Monier, Sara Ludwick, Mohammad Z. Al-Hamdan, Jason Vargo, Kathryn C. Conlon

{"title":"Joint Effects of Wildfire Smoke and Extreme Heat on Hospitalizations in California, 2011–2020","authors":"Caitlin G. Jones-Ngo, Rebecca J. Schmidt, Erwan Monier, Sara Ludwick, Mohammad Z. Al-Hamdan, Jason Vargo, Kathryn C. Conlon","doi":"10.1029/2024GH001237","DOIUrl":"https://doi.org/10.1029/2024GH001237","url":null,"abstract":"Wildfire smoke and extreme heat events are worsening in California, but their combined health effects are not well understood. This study estimates joint effects of extreme heat and wildfire smoke on hospitalizations in California, 2011–2020. We used a case crossover design with time-stratified controls and conditional logistic regression to estimate these effects at multiplicative and additive scales. Exposures were assessed for 16 combinations of exposure lags (0–3 days) for extreme heat and wildfire influenced fine particulate matter. Among over 28 million cases of all-natural cause morbidity, the majority were adults aged 65 and older (41.4%), English speakers (85.1%), and White, non-Hispanic (49.7%), mostly residing in urban areas (97.2%). The study found roughly 8% of respiratory morbidities (95% CI, 2.4%–13.8%) were attributable to the interaction of wildfire smoke and extreme heat. Significant joint effects were also observed for cardiovascular (5.5%) and renal morbidities (6.2%). Subgroup analyses revealed stronger effects: Respiratory (19.2%, 95% CI 6.5%–32.1%) and cerebrovascular morbidities (15.7%, 95% CI 4%–27.4%) were most pronounced in Black individuals; older adults (50–64 years) showed strong effects for renal morbidities (15.4%, 95% CI −1.6%−32.6%); and cardiovascular effects were highest among females (9.8%, 95% CI 2.9%–16.7%). Effects on all-natural cause morbidity were generally null. The interaction of wildfire smoke and extreme heat within a short exposure window (4 days) increases hospitalizations; highlighting the need for joint heat and wildfire smoke interventions that target populations at greater risk.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Death and Proliferation Variability Caused by Different Dust Clay Minerals Using the Single-Cell Method 用单细胞法研究不同粉尘黏土矿物引起的细胞死亡和增殖变异

IF 4.3 2区医学

Geohealth Pub Date : 2025-06-05 DOI: 10.1029/2024GH001280

Z. Ramirez-Diaz, A. Deonarine, M. Plantier, N. Shaghaghi, K. Ardon-Dryer

{"title":"Cell Death and Proliferation Variability Caused by Different Dust Clay Minerals Using the Single-Cell Method","authors":"Z. Ramirez-Diaz, A. Deonarine, M. Plantier, N. Shaghaghi, K. Ardon-Dryer","doi":"10.1029/2024GH001280","DOIUrl":"https://doi.org/10.1029/2024GH001280","url":null,"abstract":"Dust storms are recurring atmospheric phenomena in arid and semiarid regions that decrease air quality and pose significant health risks. However, there is still no consensus on why some dust storms are more toxic than others. To understand the influence of dust on particle size and composition, in vitro experiments were performed evaluating the impact of five different clay minerals: montmorillonites (montmorillonite, Na-rich montmorillonite, and Ca-rich montmorillonite), illite, and kaolinite on human epithelial alveolar cells (A549) utilizing the Single-Cell Analysis. Unlike other population techniques, this analysis monitors each cell individually by coupling fluorescent microscopy with an incubation system to continuously image the cells every 15 min for 48-hr. This live-cell imaging analysis was used to calculate the exact time of death, division rate, and type of death (apoptosis and necrosis). Ca-rich Montmorillonite and Kaolinite were the most and least toxic clays, respectively. Although Ca-rich Montmorillonite caused a significant increase in cell death and a decrease in cell proliferation compared to Kaolinite, both clays had a similar impact on the type of death (necrosis replaced apoptosis as the primary mechanism for cell death). Observations on the exact time of death show a significant increase in the rate of death between 34- and 48-hr post-exposure indicating a possible delay in health impact.","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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