Association of Ambient Temperature and Relative Humidity With Respiratory Syncytial Virus Infections Among Hospitalized Children in Suzhou, Eastern China: A Time-Series Analysis

IF 4.3 2区 医学 Q2 ENVIRONMENTAL SCIENCES
Geohealth Pub Date : 2025-05-21 DOI:10.1029/2025GH001353
Yingfeng Lu, Shaolong Ren, Xuejun Shao, Jianmei Tian, Feifei Hu, Fang Yao, Tao Zhang, Genming Zhao
{"title":"Association of Ambient Temperature and Relative Humidity With Respiratory Syncytial Virus Infections Among Hospitalized Children in Suzhou, Eastern China: A Time-Series Analysis","authors":"Yingfeng Lu,&nbsp;Shaolong Ren,&nbsp;Xuejun Shao,&nbsp;Jianmei Tian,&nbsp;Feifei Hu,&nbsp;Fang Yao,&nbsp;Tao Zhang,&nbsp;Genming Zhao","doi":"10.1029/2025GH001353","DOIUrl":null,"url":null,"abstract":"<p>Respiratory syncytial virus (RSV) is the leading cause of clinical pneumonia in children. We aimed to investigate the associations between ambient temperature, relative humidity, and pediatric RSV infections, and to assess the disease burden attributable to cold or humid conditions. Daily data on RSV hospitalizations among children aged ≤5 years, mean temperature, and relative humidity in Suzhou, China, from January 2016 to December 2019 were collected. A distributed lag nonlinear model with quasi-Poisson regression was employed to assess the exposure-lag-response associations. Attributable risks were calculated to quantify the disease burden due to climatic factors. We found an inverted U-shaped relationship between temperature and RSV infections, with the cumulative risk of RSV peaking at 7.5°C (RR = 4.30, 95% CI: 3.08–6.02). The exposure-response curves for relative humidity exhibited a generally positive trend, peaking at 100.0% (RR = 3.14, 95% CI: 1.84–5.34). Using median values as references, the highest risk effects of extremely low (RR = 1.14, 95% CI: 1.04–1.25) and low (RR = 1.22, 95% CI: 1.12–1.32) temperatures, as well as high (RR = 1.09, 95% CI: 1.04–1.13) and extremely high (RR = 1.16, 95% CI: 1.07–1.27) relative humidity, occurred on the day of exposure and persisted for extended periods. The attributable fraction of RSV infections associated with cold or humid conditions was 55.23% (95% CI: 50.01%–64.03%) and 12.02% (95% CI: 9.36%–20.24%), respectively. The risk effect of high relative humidity was stronger in children aged 1–5 years. Our findings suggest nonlinear, lagged associations between climatic factors and pediatric RSV infections, which may inform future healthcare planning and RSV immunization strategies.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"9 5","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2025GH001353","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Geohealth","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1029/2025GH001353","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Respiratory syncytial virus (RSV) is the leading cause of clinical pneumonia in children. We aimed to investigate the associations between ambient temperature, relative humidity, and pediatric RSV infections, and to assess the disease burden attributable to cold or humid conditions. Daily data on RSV hospitalizations among children aged ≤5 years, mean temperature, and relative humidity in Suzhou, China, from January 2016 to December 2019 were collected. A distributed lag nonlinear model with quasi-Poisson regression was employed to assess the exposure-lag-response associations. Attributable risks were calculated to quantify the disease burden due to climatic factors. We found an inverted U-shaped relationship between temperature and RSV infections, with the cumulative risk of RSV peaking at 7.5°C (RR = 4.30, 95% CI: 3.08–6.02). The exposure-response curves for relative humidity exhibited a generally positive trend, peaking at 100.0% (RR = 3.14, 95% CI: 1.84–5.34). Using median values as references, the highest risk effects of extremely low (RR = 1.14, 95% CI: 1.04–1.25) and low (RR = 1.22, 95% CI: 1.12–1.32) temperatures, as well as high (RR = 1.09, 95% CI: 1.04–1.13) and extremely high (RR = 1.16, 95% CI: 1.07–1.27) relative humidity, occurred on the day of exposure and persisted for extended periods. The attributable fraction of RSV infections associated with cold or humid conditions was 55.23% (95% CI: 50.01%–64.03%) and 12.02% (95% CI: 9.36%–20.24%), respectively. The risk effect of high relative humidity was stronger in children aged 1–5 years. Our findings suggest nonlinear, lagged associations between climatic factors and pediatric RSV infections, which may inform future healthcare planning and RSV immunization strategies.

苏州地区住院儿童环境温度和相对湿度与呼吸道合胞体病毒感染的关系:时间序列分析
呼吸道合胞病毒(RSV)是儿童临床肺炎的主要原因。我们的目的是调查环境温度、相对湿度和儿童呼吸道合气道病毒感染之间的关系,并评估由寒冷或潮湿条件引起的疾病负担。收集2016年1月至2019年12月中国苏州≤5岁儿童RSV住院、平均温度和相对湿度的每日数据。采用拟泊松回归的分布滞后非线性模型来评估暴露-滞后-反应关系。计算归因风险以量化气候因素造成的疾病负担。我们发现温度与RSV感染之间呈倒u型关系,RSV的累积风险在7.5°C时达到峰值(RR = 4.30, 95% CI: 3.08-6.02)。相对湿度的暴露响应曲线总体呈正相关,在100.0%处达到峰值(RR = 3.14, 95% CI: 1.84 ~ 5.34)。使用中位数作为参考,极低(RR = 1.14, 95% CI: 1.04-1.25)和低(RR = 1.22, 95% CI: 1.12-1.32)温度以及高(RR = 1.09, 95% CI: 1.04-1.13)和极高(RR = 1.16, 95% CI: 1.07-1.27)相对湿度的最高风险效应发生在暴露当天并持续较长时间。RSV感染与寒冷或潮湿环境相关的归因比例分别为55.23% (95% CI: 50.01%-64.03%)和12.02% (95% CI: 9.36%-20.24%)。高相对湿度对1 ~ 5岁儿童的危险效应更强。我们的研究结果表明,气候因素与儿童RSV感染之间存在非线性滞后关联,这可能为未来的医疗保健计划和RSV免疫策略提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Geohealth
Geohealth Environmental Science-Pollution
CiteScore
6.80
自引率
6.20%
发文量
124
审稿时长
19 weeks
期刊介绍: GeoHealth will publish original research, reviews, policy discussions, and commentaries that cover the growing science on the interface among the Earth, atmospheric, oceans and environmental sciences, ecology, and the agricultural and health sciences. The journal will cover a wide variety of global and local issues including the impacts of climate change on human, agricultural, and ecosystem health, air and water pollution, environmental persistence of herbicides and pesticides, radiation and health, geomedicine, and the health effects of disasters. Many of these topics and others are of critical importance in the developing world and all require bringing together leading research across multiple disciplines.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信