Bioimpacts最新文献

{"title":"Classification of recurrent implantation failure patients using peripheral blood immunological and metabolic markers.","authors":"Sina Baharaghdam, Özkan Yildirim, Mohammadbagher Pirouzpanah, Danial Abbas Kabiri, Shima Karimi, Mohammad Esfini Farahani, Amirhossein Aghapour, Ali Hassanzadeh, Amin Kamrani, Reza Mousavi Ardehaie, Amir Mehdizadeh, Parvin Hakimi, Javad Ahmadian Heris, Leili Aghebati-Maleki, Mehdi Yousefi","doi":"10.34172/bi.33372","DOIUrl":"10.34172/bi.33372","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent implantation failure (RIF) is a complex condition that makes it one of the most challenging cases in the field of infertility. The diagnosis of this condition with the immunological etiology may be aided by determining the endometrial immune profile for the classification of these patients. Current diagnostic approaches are based on invasive endometrial biopsies to classify patients into balanced, low, or over-immune activation profiles, which have limitations for routine use and serial monitoring. This study aimed to develop and validate a minimally invasive peripheral blood-based classification system using immunological and metabolic markers to mirror endometrial immune profiles in RIF patients.</p><p><strong>Methods: </strong>Endometrial tissue and peripheral blood samples were collected during the mid-luteal phase from 163 RIF patients and 28 fertile controls. Endometrial immune profiles were determined via RT-qPCR for IL-18, IL-15, TWEAK, Fn-14, and CD56, classifying RIF into balanced, low, and over-immune activation subgroups, with sample sizes of 32, 47, and 84 women, respectively. Peripheral blood was analyzed by flow cytometry to determine the Th1/Th2 ratio and NK cell percentage; by ELISA to measure nuclear antibodies (ANA, anti-dsDNA), phospholipid-related antibodies (anticardiolipin, anti-β2-glycoprotein I, antiphospholipid antibodies), thyroid-related antibodies (anti-TPO, anti-TG), anti-tissue transglutaminase (anti-TTG), and metabolites (S1P, adiponectin, leptin, PGE2, phosphatidylserine, IGF-1); and by spectrophotometry to quantify total phospholipids.</p><p><strong>Results: </strong>The over-immune activation group showed significantly elevated Th1/Th2 ratios, NK-cell percentages, and autoantibodies (ANA, anti-phospholipid, anti-β2-glycoprotein I, anti-TG, anti-TPO) compared to balanced and low-immune activation groups. Metabolic profiles revealed higher leptin, and total phospholipids but lower adiponectin, S1P, and PGE2 in over-immune activation group. The low-activation group exhibited lower Th1/Th2 ratios, reduced leptin, but elevated adiponectin, S1P, and PGE2 versus balanced and over-immune activation groups. No significant differences were found in phosphatidylserine or IGF-1 across groups.</p><p><strong>Conclusion: </strong>Our results demonstrate that peripheral blood immunological and metabolic markers can effectively distinguish RIF immune endotypes, offering a non-invasive alternative to endometrial biopsy for personalized assisted reproductive technology (ART) management and potentially improving implantation success through targeted therapies.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33372"},"PeriodicalIF":2.5,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured implants for enhanced integration and localized therapy.","authors":"Aditya Singh, Shubhrat Maheshwari, Anvi Patel, Bhupendra G Prajapati, Ankush Mehta, Kiran Dudhat","doi":"10.34172/bi.33489","DOIUrl":"10.34172/bi.33489","url":null,"abstract":"<p><p>Nanoparticles have emerged as a promising strategy in dental implantology to enhance implant integration and therapeutic functionality. Nanostructured surface modifications enable precise control over implant topography and chemistry, leading to increased surface area, improved protein adsorption, and enhanced cellular adhesion, key factors for successful osseointegration. Various nanoparticle systems, including titanium dioxide (TiO₂), hydroxyapatite, and bioactive glass, have been extensively explored for surface modification and functional enhancement of dental implants. In addition to structural benefits, nanoparticles facilitate localized and controlled drug delivery, reducing infection risk, minimizing systemic side effects, and accelerating tissue healing. Despite these advancements, challenges such as long-term stability, biocompatibility, optimization of drug release kinetics, and potential toxicity remain critical barriers to clinical translation. Therefore, further research is required to ensure safe and effective application of nanoparticle-based dental implants in clinical practice.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33489"},"PeriodicalIF":2.5,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The promising applications of 3D printing technology for diagnosis and therapy of cancer: Recent advances and challenges.","authors":"Mohsen Farrokhpour, Safa Samadzadeh Etehadi, Pejman Hassanpoor, Tola Abdulsattar Faraj, Ayad H Hasan, Vesal Abbasian, Sargol Aminnezhad, Mohammadreza Azimi, Soheila Kashanian, Mehran Alavi","doi":"10.34172/bi.32895","DOIUrl":"10.34172/bi.32895","url":null,"abstract":"<p><p>Using structured materials and special molecules, scientists can create synthetic materials that can change their properties in a controlled and efficient way, resulting in useful functions. These characteristics remind us of the most popular designs found in nature. Specifically, they can produce strong structures when needed, store information, cause movement, and hold and release therapeutic agents. These macromolecular systems can be created using three-dimensional (3D) printing technology that can respond to human physiological conditions. In this review, the reasons for this progress are explained, and the potential future developments for macromolecules with specific functions are discussed. This review delves into the advancements in 3D printing technology and polymeric nanomaterials, particularly in the diagnosis and therapy of cancer. In addition, it highlights the versatility of these materials in creating intricate scaffolds with enhanced therapeutic properties, leveraging nanotechnology to improve cell interactions.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32895"},"PeriodicalIF":2.5,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levosimendan in burn wound ischemia: Mechanistic rationale and therapeutic potential.","authors":"Zahra Nazari Taloki","doi":"10.34172/bi.33590","DOIUrl":"10.34172/bi.33590","url":null,"abstract":"","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33590"},"PeriodicalIF":2.5,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The involvement of circular RNAs in breast cancer metastasis: Insight into EMT-related signaling pathways.","authors":"Mehran Molavand, Maryam Majidinia, Bahman Yousefi","doi":"10.34172/bi.32903","DOIUrl":"10.34172/bi.32903","url":null,"abstract":"<p><p>Breast cancer, a complex and heterogeneous disease marked by uncontrolled cell growth in breast tissue, presents a significant global health challenge due to its high mortality rate. Metastasis, a major driver of cancer progression and mortality, poses a significant challenge in clinical oncology. This complex process involves profound changes in cytoskeletal dynamics and interactions with the extracellular matrix, including integrin-mediated adhesion and the activity of matrix metalloproteinases (MMPs). Circular RNAs (circRNAs) are a type of endogenous non-coding RNA with a covalently closed-loop structure. They serve as critical regulators of gene expression and modulate essential cellular processes, including proliferation, cell cycle control, and invasion. Through intricate interactions with key signaling pathways, including Wnt/β-catenin, PI3K/AKT, TGF-β/SMAD, and the MEK-MAPK pathway, circRNAs modulate these processes, particularly epithelial-to-mesenchymal transition (EMT), which is crucial in breast cancer metastasis. Mechanistically, circRNAs activate transcription factors associated with EMT, such as Slug, Snail, Twist, and Zeb. Moreover, circRNAs have emerged as promising clinical biomarkers in breast cancer, offering new opportunities for early diagnosis, prognostic assessment, and the development of targeted therapeutic strategies. In this article, the role of circRNAs in modulating EMT-regulating signaling pathways in the context of breast cancer metastasis will be reviewed.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32903"},"PeriodicalIF":2.5,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a novel therapeutic candidate vaccine for HPV16 using immunoinformatics approach: Targeting E6 and E7 epitopes with TLR4 agonist integration.","authors":"Zahra Samadi Moghaddam, Maryam Mashhadi Abolghasem Shirazi, Rosa Jahangiri, Babak Negahdari, Nasser Hashemi Goradel","doi":"10.34172/bi.30943","DOIUrl":"10.34172/bi.30943","url":null,"abstract":"<p><strong>Introduction: </strong>Although prophylactic vaccinations for human papillomaviruses (HPVs) have been approved, these vaccines lack therapeutic efficacy and cannot eradicate pre-existing infections. Although epitope-based vaccines represent a promising therapeutic vaccine platform, their anti-tumor efficacy has been limited due to low immunogenicity. This study aimed to apply bioinformatics tools to design a built-in adjuvant therapeutic candidate vaccine targeting HPV16 infections and associated cancers.</p><p><strong>Methods: </strong>The designed vaccine consists of HPV16 E6 and E7 epitopes conjugated to the domain 4 of pneumolysin (Ply4) from <i>Streptococcus pneumonia</i>, which serves as a potential toll-like receptor 4 (TLR4) agonist. <i>In silico</i> analyses were performed to evaluate the vaccine's physicochemical properties, antigenicity, immunogenicity, and binding interactions with the TLR4 receptor. The designed vaccine was expressed in <i>E. coli</i> and its expression was confirmed by SDS-PAGE and Western blot analysis.</p><p><strong>Results: </strong><i>In silico</i> analysis predicted that the designed vaccine could have desirable qualities, including non-toxicity, non-allergenicity, antigenicity, immunogenicity, hydrophilicity, and stability. Docking analysis between the vaccine and the TLR4 proteins predicted a high binding capacity and efficient binding. Furthermore, immunoinformatics tools showed that the vaccine could induce robust immune responses, specifically helper and cytotoxic T-cell responses, and promote the production of IFN-γ. The vaccine was successfully expressed in the <i>E. coli</i> system after being cloned into the pET28a vector. SDS-PAGE and Western blotting assays confirmed the purification of the target protein.</p><p><strong>Conclusion: </strong>The novel built-in adjuvant therapeutic candidate vaccine is a rationally designed construct for eradicating pre-existing HPV infections and HPV-induced cervical cancers that warrants further preclinical evaluation.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"30943"},"PeriodicalIF":2.5,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dutasteride-loaded nanostructured lipid carrier for androgenic alopecia treatment - An <i>in vivo</i> study.","authors":"Saman Heydari, Mohammad Barzegar Jalali, Maryam Kouhsoltani, Afsaneh Radmehr, Ana Cláudia Paiva-Santos, Siamak Barghi, Hamed Hamishehkar","doi":"10.34172/bi.30245","DOIUrl":"10.34172/bi.30245","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenic alopecia (AGA) is the most common type of hair loss that occurs due to androgens, specially, dihydrotestosterone (DHT), and the 5-alpha reductase is the key enzyme to control AGA, as it is responsible for the conversion of testosterone to DHT, the more potent form of testosterone involved in the pathogenesis of AGA. Blockers of this enzyme suppress the conversion of androgens to DHT. Dutasteride is one of the 5-alpha reductase inhibitors and is frequently used as an anti-hair loss treatment. Gamma-oryzanol (GO) is an anti-oxidant and anti-5-alpha reductase, which has been introduced as an anti-hair loss treatment by some studies.</p><p><strong>Methods: </strong>The nanostructured lipid carriers (NLCs) were developed for targeting the dutasteride and GO in hair follicles. The NLCs were prepared from herbal oils pumpkin seed oil (PSO) and saw palmetto (SP), which also have a 5-alpha reductase inhibitory effect, contributing to the therapeutic effect. NLCs in follicular targeting enable to accumulation of the drugs in the target area (hair follicle cells), reduce the absorption of dutasteride in other organs and tissues, and reduce the side effects. NLCs were prepared by adopting a hot homogenization method and were characterized by particle size analyzer, scanning electron microscope, and X-ray diffraction. An in-vivo study was conducted using C57BL/6 mice to assess NLCs ability in drug delivery and accumulation in hair follicles.</p><p><strong>Results: </strong>NLCs had great potentials for reducing the dutasteride daily dose. Moreover, the accumulation of NLCs was confirmed by histopathological images even after two weeks of the discontinued treatment.</p><p><strong>Conclusion: </strong>NLCs may have facilitated the follicular delivery of the anti-hair loss drugs. Since the NLCs have potential for accumulation in the hair follicles, the interval of formulation usage may have been increased to more than once a week which was of great interest to the practitioners aiming at developing more efficient formulations for androgenetic alopecia.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"30245"},"PeriodicalIF":2.5,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current advancements and future prospects in the biorefinery and hyper-production of astaxanthin from <i>Haematococcus pluvialis</i>.","authors":"Jafar Aghajani, Morteza Mirzaei, Ali Choopani, Hosna Abbasi, Fatemeh Shakeri, Ali Mohammad Latifi","doi":"10.34172/bi.32651","DOIUrl":"10.34172/bi.32651","url":null,"abstract":"<p><p>Astaxanthin (AXT) is a valuable xanthophyll carotenoid extensively utilized across the nutraceutical, pharmaceutical, cosmetic, and aquaculture industries. While this high-demand compound is produced both synthetically and biologically, natural AXT derived from the microalga <i>Haematococcus lacustris</i> (formerly called <i>Haematococcus pluvialis</i>) offers superior bioavailability and safety profiles, dominating the high-value market segment. However, the current industrial reality is hampered by low yields under standard cultivation, significantly restricting commercial viability. This comprehensive review systematically summarizes the latest advancements (2020-2025) in achieving cost-effective and sustainable hyper-production of natural AXT from <i>H. pluvialis</i>. We critically evaluate both established methodologies (e.g., two-phase cultivation, stress induction) and emerging strategies, including CRISPR-Cas9 editing, electrogenetics, and the application of nano-based stressors. Recent studies highlight significant yield enhancements, with reports of 20-35% increases via gene knock-ins and mild electric stimulation, achieving concentrations up to 200 mg L⁻¹. Crucially, this work provides an integrative comparison of advanced genetic engineering tools, nano-based induction protocols, and hybrid cultivation systems, distinguishing it from previous reviews focused predominantly on environmental factor optimization. The analysis offers actionable, evidence-based insights for accelerating the transition from lab-scale innovation to scalable industrial bioprocesses, thereby reducing production costs and enhancing the overall sustainability of natural AXT supply.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32651"},"PeriodicalIF":2.5,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrin-linked kinase (ILK) in hematologic malignancies: Bridging molecular mechanisms to therapeutic innovation.","authors":"Omer Qutaiba B Allela, Abdulkareem Shareef, Ashishkumar Kyada, H Malathi, Laxmidhar Maharana, Dinesh Puri, Harshit Gupta, Djamila Polatova, Hayder Naji Sameer, Ahmed Yaseen, Zainab H Athab, Mohaned Adil","doi":"10.34172/bi.32638","DOIUrl":"10.34172/bi.32638","url":null,"abstract":"<p><p>Therapy resistance remains a formidable challenge in hematologic malignancies despite significant advances in targeted therapies. This comprehensive review examines integrin-linked kinase (ILK) as a critical molecular hub at the nexus of cell adhesion, signal transduction, and therapy resistance across leukemias, lymphomas, and multiple myeloma. Unlike in solid tumors, where ILK primarily drives invasion and metastasis, in hematologic malignancies it uniquely mediates microenvironmental protection and therapy resistance through distinct signaling networks. ILK functions as a central mediator connecting microenvironmental signals to intracellular survival pathways, with expression levels 5-20-fold higher in malignant cells compared to normal counterparts. Through systematic analysis of structural properties, expression patterns, downstream signaling, and microenvironmental interactions, we present compelling evidence for ILK as a promising therapeutic target capable of overcoming resistance mechanisms. Current data demonstrate that ILK inhibition simultaneously disrupts multiple survival pathways, sensitizes resistant cells to established therapies, and selectively targets therapy-resistant leukemic stem cells while sparing normal progenitors. This review provides a comprehensive framework for translating ILK-targeted approaches into innovative therapeutic strategies with significant potential to improve outcomes in treatment-refractory hematologic malignancies.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32638"},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging advancements and expanding technological scope of education and practices in pharmacy and pharmaceutical sciences.","authors":"Jaleh Barar, Karen Fiano, Matthew Seamon, Benedict Albensi, Nile Khanfar, Yadollah Omidi","doi":"10.34172/bi.33047","DOIUrl":"10.34172/bi.33047","url":null,"abstract":"<p><strong>Introduction: </strong>The pharmacy profession stands at a pivotal moment, as emerging scientific advancements and evolving healthcare demands require adept pharmacy practitioners and scientists. The integration of precision medicine, cellular and acellular regeneration, nano and bioengineering (e.g., 3D/4D bioprinting), digital therapeutics, artificial intelligence (AI)-point-of-care testing, and treating is starting to reshape pharmacy education, practice, and patient care. Pharmacy education needs to embrace these innovations to prepare graduates for the future of practice, to optimize therapeutic outcomes, and contribute meaningfully to translational medicine.</p><p><strong>Methods: </strong>This review elaborates on the historical evolution toward the incoming wave of the pharmacy profession and considers the necessary educational models that might be associated with its practice.</p><p><strong>Results: </strong>Expanded patient care roles are essential in this new era, with clinical pharmacists increasingly working alongside physicians under collaborative practice agreements. Additionally, prescriptive authority for pharmacists is gaining traction, enhancing healthcare accessibility and medication management. The integration of digital health technologies (e.g., telepharmacy, automation, wearable medical devices, and AI-driven decision support systems) further empowers pharmacists to deliver efficient, patient-centered care. Certain prospective concentrations (e.g., precision/personalized medicine, industrial pharmacy, drug discovery and development, drug compounding and formulation, and advanced drug delivery systems and devices) can further empower pharmacy education towards healthcare needs.</p><p><strong>Conclusion: </strong>By embracing technological and scientific advancements, pharmacists can solidify their roles as integral healthcare providers, ensuring that the profession remains dynamic, relevant, and impactful in an evolving healthcare landscape.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33047"},"PeriodicalIF":2.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}