Bioimpacts最新文献

{"title":"Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways.","authors":"Habib Tajalli, Masoud Maleki, Fatemeh Firouzi Amoudizaj, Zahra Akbarpour, Esmail Safavi, Reza Shahi, Alireza Sotoudeh, Ahmad Babazadeh Bedoustani","doi":"10.34172/bi.31018","DOIUrl":"https://doi.org/10.34172/bi.31018","url":null,"abstract":"<p><strong>Introduction: </strong>Infertility affects approximately 15% of couples worldwide, with male factors accounting for approximately half of the cases. Low-level laser therapy (LLLT) has been increasingly considered in modern medicine due to its high efficacy, ease of use, and lack of side effects. Evidence suggests that this method can prevent DNA damage in cells and activate key genes related to fertility. This study aimed to investigate the effects of LLLT on sperm production in azoospermic mice using in vitro and in vivo experimental models.</p><p><strong>Methods: </strong>Adult male NMRI mice (8-9 weeks old, 30-35 g) were divided into the negative control (healthy), positive control (azoospermia via intraperitoneal busulfan, 30 mg/kg), and experimental (azoospermia with 808 nm LLLT at 8 J/cm²) groups (8 mice per group) for in vivo experiments. For the in vitro part, spermatogonial stem cells were cultured from 6 azoospermic mice under control conditions or treated with laser (808 nm LLLT at 4 J/cm²). Morphological examination and real-time polymerase chain reaction were used to assess testicular structure and expression of several genes, such as deleted in azoospermia-like (<i>DAZL</i>), G protein-coupled receptor 125 (<i>GPR125</i>), synaptonemal complex protein 3 (<i>SYCP3</i>), DEAD-box helicase 4 (<i>VASA/DDX4</i>), protamine (<i>PRM</i>), acrosin (<i>ACR</i>), and tripartite motif containing 36 (<i>Haprin/TRIM36</i>).</p><p><strong>Results: </strong>In vivo, LLLT increased <i>VASA</i> expression, improved germ cell activity, and increased sperm production compared with untreated azoospermic control groups, although these changes were not statistically significant. In vitro, 4 J/cm² radiation modulated several genes related to spermatogenesis, supporting its role in germ cell differentiation.</p><p><strong>Conclusion: </strong>LLLT with a wavelength of 808 nm could improve spermatogenesis and sperm production in a mouse model of busulfan-induced azoospermia in vivo and in vitro. These results demonstrated its potential as a supportive treatment for male infertility.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"31018"},"PeriodicalIF":2.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional bioprinted hydrogels for the management of diabetic wounds: A review.","authors":"Piyali Khamkat, Bramhajit Chatterjee, Sourav Ghosh, Bhupendra Prajapati, Biswajit Basu, Sudarshan SIngh","doi":"10.34172/bi.32751","DOIUrl":"https://doi.org/10.34172/bi.32751","url":null,"abstract":"<p><p>Globally, the prevalence of diabetes mellitus (DM), a chronic metabolic disease, is at its peak. Type 2 diabetes (T2D) is more common worldwide, which raises the risk of ulcers and chronic healing, or non-healing wounds. Overall 15% to 20% of people with diabetes develop diabetic foot ulcers (DFUs), which is a significant consequence. Managing and treatment of wounds require an advancement of novel healing therapies with the use of biological dressings. The development of DFU wound dressings and the biomanufacturing of composite 3D skin substitutes are examples of 3D bioprinting technology for enhancing therapeutic approaches. These approaches and challenges of bioprinting technology in wound healing of chronic DFUs are covered in this review. Moreover, the review highlights the selection of biomaterials, integration of biomimetic approaches, and the ability of 3D bioprinting to replicate native skin architecture. Despite significant advances, the review identifies critical gaps including limited vascularization in printed constructs, standardization issues, and scalability challenges that impede clinical translation. Emerging biotechnological tools and novel biomaterial developments are also discussed, emphasizing their potential to overcome these limitations and improve DFU wound management.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32751"},"PeriodicalIF":2.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celastrol overcomes 5-fluorouracil resistance in osteosarcoma cells through p53-mediated apoptotic pathway modulation and P-glycoprotein inhibition: A comprehensive mechanistic study.","authors":"Mohammad Ebrahimnezhad, Amir Valizadeh, Bahman Yousefi, Dariush Shanehbandi","doi":"10.34172/bi.32819","DOIUrl":"https://doi.org/10.34172/bi.32819","url":null,"abstract":"<p><strong>Introduction: </strong>Osteosarcoma, a prevalent malignant bone tumor in children and adolescents, is hindered by chemoresistance, particularly to 5-fluorouracil (5-FU), driven by mechanisms such as P-glycoprotein (P-gp) overexpression and altered p53 signaling. Celastrol, a triterpenoid, exhibits anti-tumor properties, but its potential to overcome 5-FU resistance in osteosarcoma remains underexplored.</p><p><strong>Methods: </strong>We investigated the synergistic effects of celastrol and 5-FU in human osteosarcoma cell lines with varying p53 statuses (U-2OS, wild-type; SaOS-2, p53-null; HOS, mutant p53) using MTT assays for cytotoxicity, Chou-Talalay method for synergy, and Cell Death Detection ELISA for apoptosis. Gene expression (p53, Bax, Bcl-2, caspase-9) was quantified via qRT-PCR, P-gp levels by Western blot, and P-gp efflux activity by Rhodamine 123 assays. Non-malignant hFOB 1.19 cells served as controls.</p><p><strong>Results: </strong>Celastrol and 5-FU exhibited potent cytotoxicity, with combination therapy reducing IC₅₀ values 3.7- to 11.9-fold across cell lines, showing strong synergy. The combination significantly enhanced apoptosis and modulated p53-dependent (U-2OS) and -independent (SaOS-2, HOS) pathways, upregulating Bax and caspase-9 while downregulating Bcl-2. Celastrol reduced P-gp expression and increased intracellular drug accumulation, comparable to verapamil.</p><p><strong>Conclusion: </strong>Celastrol synergizes with 5-FU to overcome chemoresistance in osteosarcoma by enhancing p53-mediated and -independent apoptosis and inhibiting P-gp-mediated drug efflux. These findings suggest a promising low-toxicity therapeutic strategy, warranting further in vivo and clinical investigations.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32819"},"PeriodicalIF":2.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of phytochemical cocktail and aerobic exercise on mRNA and lncRNA networks modulating bone turnover in hypothyroid mice.","authors":"Malihe Bakhti, Farzaneh Taghian, Khosro Jalali Dehkordi, Rezvan Mirsafaei Rizi","doi":"10.34172/bi.30303","DOIUrl":"https://doi.org/10.34172/bi.30303","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic bone disease (MBD) is a multifactorial condition that leads to microarchitectural and bone mass disturbance. The association and mechanisms between MBD and hypothyroidism are not comprehensively elucidated. Moreover, long non-coding RNAs (lncRNAs), as critical regulators in biological processes, are one category of RNAs that could regulate gene expression through various mechanisms.</p><p><strong>Methods: </strong>Artificial intelligence indicated several mRNAs-lncRNAs involved in the bone tissue in hypothyroidism conditions. After in-silico and chemoinformatic analysis, 30 female C57BL/6 mice at six weeks old and an approximate weight of 24±2 g were divided into five subgroups (n=6 mice/groups), including 1) hypothyroidism in mice (HYPO), 2) hypothyroidism in mice treated with <i>Dorema aucheri</i> (DA) extract (0.4 mg/kg), 3) hypothyroidism in mice treated with aerobic exercise (AE), 4) hypothyroidism in mice treated DA extract bioactive compound along with AE, 5) Normal group (without any induction and treatments). Real-Time PCR detected the relative expression of <i>mRNA</i> and <i>lncRNAs</i>.</p><p><strong>Results: </strong>We indicated that the osteoblast and osteoclast markers are dysregulated in hypothyroidism. In addition, DA and AE modified the bone remodeling, bone resorption markers, and inhibitors of Wnt/beta-catenin. We revealed that <i>Adipoq</i>, <i>Dnmt1</i>, <i>Sirt-1, Ppar-ɑ</i>, <i>Ncor1</i>, and <i>Ctnnb1</i> networks are dysregulated in hypothyroidism conditions. DA and AE modulated this network in bone tissue. The relative expression of the four lncRNAs (TUG1, HOTAIR, H19, and MEG3) was altered in hypothyroidism. Notably, DA and AE significantly regulated the expression level of these lncRNAs.</p><p><strong>Conclusion: </strong>AE and DA complementary and alternative medicine ameliorated the metabolic bone disease induced by hypothyroidism in mice.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"30303"},"PeriodicalIF":2.2,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moroccan virgin olive oil triterpenes: HPLC-DAD-ELSD profiling and computational investigation of anti-diabetic potential.","authors":"Meryem Boutalaka, Noureddine Ouazzani, Mohamed Ouabane, Panagiotis Stathopoulos, Abdelkrim Guendouzi, Hamid Maghat, Alexios-Leandros Skaltsounis, Tahar Lakhlifi, Mohammed Bouachrine","doi":"10.34172/bi.31007","DOIUrl":"https://doi.org/10.34172/bi.31007","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or resistance. Conventional treatments like acarbose, miglitol, and voglibose inhibit carbohydrate-digesting enzymes but often cause adverse effects and have bioavailability limitations. This has led to interest in plant-derived bioactive compounds as safer alternatives. Oleanolic and maslinic acids in Moroccan virgin olive oil have shown potent inhibitory activity against α-glucosidase and α-amylase, enzymes regulating postprandial glucose levels.</p><p><strong>Methods: </strong>This study quantified the levels of oleanolic and maslinic acids in olive oils from various Moroccan regions, considering factors such as olive variety, maturity index, production method, and geographic origin. Pharmacokinetic properties were assessed using in silico ADME analysis. Molecular docking was performed to evaluate inhibitory interactions with α-amylase and α-glucosidase. Molecular dynamics (MD) simulations (1000 ns) assessed complex stability, and MM-PBSA calculations determined binding free energies.</p><p><strong>Results: </strong>The concentrations of oleanolic and maslinic acids varied across olive oil samples. The Moroccan Picholine variety had the highest levels (58.3 mg/kg for maslinic acid and 55.06 mg/kg for oleanolic acid). Olive oil from the two-phase milling method contained higher concentrations than the three-phase system, and lower maturity index olives showed greater concentrations. Pharmacokinetic analysis indicated favorable drug-likeness properties for these bioactive compounds. In silico docking suggested notable binding of maslinic acid to α-amylase (-41.42 kJ/mol) and oleanolic acid to α-glucosidase (-32.22 kJ/mol), with interactions involving key amino acid residues. Molecular dynamics simulations indicated stable ligand-enzyme interactions, and MM-PBSA analysis estimated binding energies of -39.05±16.78 kJ/mol for the maslinic acid-α-amylase complex and -13.97±7.08 kJ/mol for the oleanolic acid-α-glucosidase complex.</p><p><strong>Conclusion: </strong>Moroccan virgin olive oil, rich in oleanolic and maslinic acids, may serve as a natural alternative for diabetes management by modulating key enzymatic pathways involved in glucose metabolism.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"31007"},"PeriodicalIF":2.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exaggerating the risks of vaccination is a dangerous health threat.","authors":"Robert C Speth","doi":"10.34172/bi.33132","DOIUrl":"https://doi.org/10.34172/bi.33132","url":null,"abstract":"<p><p>Vaccine hesitancy and opposition lacking empirical support represent significant threats to public health, particularly when amplified by public health officials. This commentary provides evidence-based refutation of such anti-vaccine arguments, including (i) the robust epidemiological data demonstrating vaccine efficacy in reducing disease incidence, mortality, and transmission; (ii) the comprehensive safety surveillance systems (VAERS, VSD, CISA) that monitor adverse events and consistently demonstrate favorable risk-benefit profiles; (iii) the biological mechanisms underlying both vaccine-induced immunity and rare adverse events; and (iv) the distinction between temporal association and causation in adverse event reporting. Thus it can be deduced that flawed logic and falsifications have been used to misrepresent the risks of vaccination. This endangers the lives and well-being of people who are susceptible to the diseases that vaccines can effectively prevent.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33132"},"PeriodicalIF":2.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between non-coding RNAs and Wnt signaling pathway in leukemia: A narrative review.","authors":"Reza Biglari, Majid Farshdousti Hagh, Khadijeh Abbasi, Maghsood Shaaker, Amir Mehdizadeh","doi":"10.34172/bi.32564","DOIUrl":"https://doi.org/10.34172/bi.32564","url":null,"abstract":"<p><p>Leukemias are heterogeneous hematologic malignancies that involve dysregulated proliferation and impaired differentiation of hematopoietic cells. The Wnt signaling pathway, which regulates hematopoietic stem cell self-renewal and lineage commitment, is dysregulated across leukemia subtypes. Non-coding RNAs (ncRNAs), which include microRNAs, long non-coding RNAs (lncRNAs), and circular RNAs, have been identified as important post-transcriptional and epigenetic regulators of oncogenic signaling networks. There is growing evidence for a complex, bidirectional relationship between ncRNAs and the Wnt/β-catenin pathway, but this has not yet been summarized or integrated into the context of leukemia. This study examines how ncRNA manipulation of core Wnt components - β-catenin, Frizzled receptors, and Dvl (dishevelled) proteins - affect leukemic cell survival, proliferation, stemness, and treatment resistance. Furthermore, we discuss reciprocal regulation, in which Wnt stimulation affects ncRNA production, forming feed-forward loops that promote leukemogenesis. By synthesizing disparate findings from studies investigating ncRNA and Wnt signaling mechanisms across leukemia subtypes, we identify critical mechanistic gaps in the literature, as well as opportunities and controversies that could be that could be leveraged in evaluating ncRNA-Wnt interactions as diagnostic and therapeutic targets. This review presents a comprehensive study integrating ncRNA biology and Wnt-driven leukemic development in order to identify crucial insights into disease vulnerabilities and future research initiatives.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32564"},"PeriodicalIF":2.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes: Redefining intercellular communication and the future of translational medicine.","authors":"Khosro Adibkia, Adel Mahmoudi Gharehbaba","doi":"10.34172/bi.33099","DOIUrl":"https://doi.org/10.34172/bi.33099","url":null,"abstract":"<p><p>Exosomes are promising extracellular vesicles for diagnostics, drug delivery, and regenerative medicine. While we have made significant strides in understanding exosomes biogenesis and cargo variability, the translation of exosome-based methods into clinical applications remains limited by challenges in manufacturing, standardization, and regulatory requirements. This editorial attempts to summarize the diverse field of exosome research including advances in isolation technologies and methodologies, omics characterization, and emerging bioengineering strategies that are elevating profile of exosomes as biomaterials for biomedical applications. We propose that exosomes are not just by-products of biological processes, but active information carriers with exceptional therapeutic potential. Therefore, the advancement of exosome methodologies in practice will ultimately alter the ways clinicians will evaluate diagnostic and therapeutic measures. We anticipate that the coming decades will establish a new, integrated framework for exosome science, one that harmonizes innovation, ethics, and cross-disciplinary collaboration to translate the promise of exosomes into tangible clinical reality.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33099"},"PeriodicalIF":2.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emergence of advanced technologies in the pharmacy profession and the need for education: The case of point-of-care sensing systems and 3D printing of pharmaceuticals.","authors":"Jaleh Barar, Matthew Seamon, Yadollah Omidi","doi":"10.34172/bi.31081","DOIUrl":"https://doi.org/10.34172/bi.31081","url":null,"abstract":"<p><strong>Introduction: </strong>The pharmacy profession is undergoing significant transformation through the adoption of point-of-care testing (POCT) and three-dimensional (3D) printing of pharmaceuticals. These technologies offer enhanced diagnostic accuracy, faster therapeutic interventions, and the potential for personalized medication regimens. Accordingly, there lies a great need for proper education.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted to explore the impacts and current educational integration of POCT and 3D printing of pharmaceuticals in the pharmacy profession, and a qualitative analysis was performed.</p><p><strong>Results: </strong>Through the integration of POCT into community and clinical settings, pharmacists can promptly identify health conditions and provide timely referrals or interventions, ultimately improving patient outcomes. Additionally, 3D printing allows for the creation of highly customized dosage forms, supporting targeted drug delivery and better patient adherence. These innovations necessitate adjustments in pharmacy education to equip future professionals with the requisite clinical and technical skills to provide value to the healthcare system. Pharmacy educators must be current in their knowledge. Curricula must emphasize hands-on experiences, such as simulations and laboratory training, to foster proficiency in using diagnostic devices, interpreting results, and designing bespoke drug formulations. Interprofessional collaboration, policy development, advocacy, and ongoing faculty training are also crucial for ensuring that pharmacists remain at the forefront of technological advancements. This context underscores the importance of weaving these modern tools into educational strategies.</p><p><strong>Conclusion: </strong>By preparing pharmacists for expanded and more technical roles in healthcare, including diagnostics and medication customization, schools and colleges of pharmacy can propel the profession forward and elevate the standard of patient care in rapidly evolving healthcare environments and improve patient outcomes, thereby providing critical cost savings to the system.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"31081"},"PeriodicalIF":2.2,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Time dependency of morphological remodeling of endothelial cells in response to substrate stiffness.","authors":"Zahra Goli-Malekabadi, Mohammad Tafazzoli-Shadpour, Ali Tamayol, Ehsan Seyedjafari","doi":"10.34172/bi.32671","DOIUrl":"https://doi.org/10.34172/bi.32671","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.15171/bi.2017.06.].</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"32671"},"PeriodicalIF":2.2,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}