Journal of Hip Preservation Surgery最新文献

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What the papers say. 报纸怎么说。
IF 1.5 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-10-18 eCollection Date: 2023-07-01 DOI: 10.1093/jhps/hnad033
Ali Bajwa
{"title":"What the papers say.","authors":"Ali Bajwa","doi":"10.1093/jhps/hnad033","DOIUrl":"https://doi.org/10.1093/jhps/hnad033","url":null,"abstract":"","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"10 2","pages":"129-132"},"PeriodicalIF":1.5,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognosis and risk prediction of bone impaction grafting through femoral head–neck fenestration: a retrospective cohort study 股骨头颈开窗骨嵌塞移植术的预后及风险预测:一项回顾性队列研究
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-10-16 DOI: 10.1093/jhps/hnad035
Hao Chen, Shuai He, Hongzhong Xi, Peng Xue, Guangquan Sun, Bin Du, Xin Liu
{"title":"Prognosis and risk prediction of bone impaction grafting through femoral head–neck fenestration: a retrospective cohort study","authors":"Hao Chen, Shuai He, Hongzhong Xi, Peng Xue, Guangquan Sun, Bin Du, Xin Liu","doi":"10.1093/jhps/hnad035","DOIUrl":"https://doi.org/10.1093/jhps/hnad035","url":null,"abstract":"ABSTRACT The bone impaction grafting through femoral head–neck fenestration was a favorable hip preservation procedure but without prognosis estimation. This study retrospectively reviewed 79 patients’ clinical data (114 hips) with osteonecrosis of the femoral head (ONFH) who underwent this procedure from June 2009 to June 2019. By the end of June 2022, the median survival time of the hip was (74.13 ± 44.88) months, and the success rate of hip preservation was 68.42%. Lateral reserved angle (LPA) and combined reserved angle (CPA) had statistically significant differences (P < 0.001) both in univariate analysis and a multivariate logistic regression model. The multivariate logistic regression model of area under curve (AUC) area of the receiver operating characteristic (ROC) curve was 0.931(sensitivity = 95.00%, specificity = 88.40%, log-rank test: P < 0.01), and the calibration curve indicated good prediction accuracy. The ROC analysis and Cox proportional hazards regression model revealed that the cutoff point of LPA was 50.95° (sensitivity = 95.00%, specificity = 72.09%, log-rank test: P < 0.05) and the cutoff point of CPA was 90.51° (sensitivity = 90.00%, specificity = 90.70%, log-rank test: P < 0.05). A nomogram plot to predict the risk of failure (C-index = 0.873, 95% CI: 0.785 to 0.961) and nomograms for predicting the survival probability at 1, 2 or 3 years whose calibration curves showed excellent prediction accuracy were available for the clinician. Preserved angles (PAs) are valuable in the prediction of prognosis in surgical treatment. The bone impaction grafting through femoral head–neck fenestration can achieve better clinical efficacy, especially for patients with LPA >50.95° and CPA >90.51°.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136142828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovation in hip preservation surgery. 髋关节保留手术的创新。
IF 1.4 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-09-28 eCollection Date: 2023-07-01 DOI: 10.1093/jhps/hnad025
Richard E Field
{"title":"Innovation in hip preservation surgery.","authors":"Richard E Field","doi":"10.1093/jhps/hnad025","DOIUrl":"10.1093/jhps/hnad025","url":null,"abstract":"","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"10 2","pages":"61-62"},"PeriodicalIF":1.4,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing pinning in situ and capital realignment procedures for severe, stable slipped capital femoral epiphysis: a systematic review 比较原位钉钉和资本重组程序严重,稳定的股骨干骨骺滑动:系统回顾
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-09-28 DOI: 10.1093/jhps/hnad032
Grace E M Kennedy, Jack Pullan, Ahmed El-Bakoury
{"title":"Comparing pinning <i>in situ</i> and capital realignment procedures for severe, stable slipped capital femoral epiphysis: a systematic review","authors":"Grace E M Kennedy, Jack Pullan, Ahmed El-Bakoury","doi":"10.1093/jhps/hnad032","DOIUrl":"https://doi.org/10.1093/jhps/hnad032","url":null,"abstract":"ABSTRACT In severe, stable slipped capital femoral epiphysis, it is unclear whether pinning in situ (PIS) or capital realignment procedures (CRPs) are superior. Our primary aim was to compare patient-reported outcome measures (PROMs) following each strategy. Secondary aims were to compare rates of femoral head avascular necrosis (AVN) and complications. MEDLINE, Embase and Cochrane databases were searched according to an agreed strategy. Narrative review articles, case reports, letters to the editor and articles not written in English were excluded. The risk of bias was assessed using the Newcastle–Ottawa Scale. Of the 132 citations identified, 127 were excluded following de-duplication and application of the exclusion criteria. Three observational studies comparing PIS with CRP and two case series considering CRP alone were identified. One article was considered fair quality, and four articles were considered poor. In total, 198 hips from five studies were included (66 PIS, 132 CRP). PIS was associated with moderate-good functional outcomes, and CRP with good-high outcomes. Two comparative studies reported significantly better PROMs following CRP. AVN was reported in 1.5% following PIS and 10.6% following CRP. Regarding other complications, chondrolysis occurred in 3.0% following PIS and 2.4% following CRP. Femoroacetabular impingement rates were markedly higher following PIS (60.6% versus 2.3%). Reoperation rates were also greater following PIS (34.5% versus 13.3%). PIS tends to be associated with favourable AVN rates, but CRP with favourable PROMs and complication rates. However, comparisons were drawn from heterogeneous studies lacking long-term follow-up. Further high-quality research is required.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135425444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does pelvic tilt change with a peri-acetabular osteotomy? 髋臼周围截骨术会改变骨盆倾斜吗?
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-09-09 DOI: 10.1093/jhps/hnad029
Jeroen C F Verhaegen, Emin Süha Dedeoğulları, Isabel S Horton, Paul E Beaulé, George Grammatopoulos
{"title":"Does pelvic tilt change with a peri-acetabular osteotomy?","authors":"Jeroen C F Verhaegen, Emin Süha Dedeoğulları, Isabel S Horton, Paul E Beaulé, George Grammatopoulos","doi":"10.1093/jhps/hnad029","DOIUrl":"https://doi.org/10.1093/jhps/hnad029","url":null,"abstract":"ABSTRACT Change in pelvic tilt (PT) during and after peri-acetabular osteotomy (PAO) is important for surgical planning. The aims of this study were to (i) determine how PT varies throughout the course of treatment in patients undergoing PAO, (ii) test what factors influence the change in PT and (iii) assess whether changes in PT influenced achieved correction. This is an retrospective, single-centre, consecutive case series of 111 patients treated with PAO for global (n = 79), posterior (n = 49) or anterior dysplasia (n = 6) (mean age: 27.3 ± 7.7 years; 85% females). PT was determined on supine, anteroposterior pelvic radiographs pre-, intra-, 1 day, 6 weeks and 1 year post-operatively, using the sacro-femoral-pubic (SFP) angle, a validated, surrogate marker of PT. An optimal acetabular correction was based on the lateral centre-edge angle (25°–40°), acetabular index (−5° to 10°) and cross-over ratio (&amp;lt;20%). There was a significant difference across pre- (70.1° ± 4.8°), 1-day (71.7° ± 4.3°; P &amp;lt; 0.001) and early post-operative SFP (70.6° ± 4.7°; P = 0.004). The difference in SPF between pre-operative and 1-year post-operative was −0.5° ± 3.1° (P = 0.043), with 9% of cases having a difference of &amp;gt;5°. The difference in SFP did not correlate with age, sex, body mass index, type of dysplasia or achievement of optimal acetabular correction (P = 0.1–0.9). In the early post-operative period, PT is reduced, leading to a relative appearance of acetabular retroversion, which gradually corrects and is restored by annual follow-up. The degree of change in PT during PAO did not adversely affect fragment orientation. PT does not significantly change in most patients undergoing PAO and therefore does not appear to be a compensatory mechanism.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136107779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The revision hip arthroscopy complex: capsular deficiency, labral deficiency, femoral over-resection and adhesions can result in good survivorship with revision hip arthroscopy 髋关节翻修镜复合体:包膜缺损、唇部缺损、股骨过切除和粘连可导致髋关节翻修镜术后良好的生存率
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-09-09 DOI: 10.1093/jhps/hnad026
Heath P Melugin, Spencer M Comfort, Trevor S Shelton, Hannah K Day, Joseph J Ruzbarsky, Grant J Dornan, Marc J Philippon
{"title":"The revision hip arthroscopy complex: capsular deficiency, labral deficiency, femoral over-resection and adhesions can result in good survivorship with revision hip arthroscopy","authors":"Heath P Melugin, Spencer M Comfort, Trevor S Shelton, Hannah K Day, Joseph J Ruzbarsky, Grant J Dornan, Marc J Philippon","doi":"10.1093/jhps/hnad026","DOIUrl":"https://doi.org/10.1093/jhps/hnad026","url":null,"abstract":"ABSTRACT To evaluate the patient-reported outcomes (PROs) and survivorship of combined arthroscopic hip labral reconstruction/augmentation, capsular reconstruction, femoral neck remplissage and lysis of adhesions. Patients ≥18 years old who underwent this combination of procedures during revision hip arthroscopy and were eligible for minimum 2-year follow-up were identified. PRO scores including Hip Outcome Score (HOS)-Activities of Daily Living scale, HOS-Sports scale, modified Harris Hip Score, Short Form 12, and Western Ontario &amp; McMaster Universities Osteoarthritis Index, patient satisfaction and failure rates were analyzed. Seven patients (5 females and 2 males) with average age of 45.0 ± 5.2 (range: 40–54 years) met inclusion criteria. Patients had a median of 1 (range: 1–3) prior hip surgery at an outside institution. All patients had previously undergone femoral osteoplasty, and 85% (6/7) of patients had a labral repair performed. Four patients had no capsule closure performed in their prior procedures. Six patients were available for minimum 2-year follow-up. Two patients converted to total hip arthroplasty: one patient with four prior hip arthroscopies and the other had advanced osteoarthritis with outerbridge grade 3/4 defects requiring microfracture. Mean patient satisfaction was 7 (range: 2–9). At mean follow-up of 3 years, most patients who underwent the combination of labral reconstruction, capsular reconstruction, femoral neck remplissage and lysis of adhesions during revision hip arthroscopy demonstrated improved PROs. This salvage procedure has the potential to restore hip function in patients who have failed an initial hip arthroscopy procedure. In patients with these pathologies present and concomitant joint space narrowing, a total hip arthroplasty may be a more appropriate salvage option.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136191953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pelvic tilt after Bernese periacetabular osteotomy—a long-term follow-up study 伯尔尼髋臼周围截骨术后骨盆倾斜-一项长期随访研究
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-09-09 DOI: 10.1093/jhps/hnad030
Alexander F Heimann, Iris F Brouze, Guoyan Zheng, Angela M Moosmann, Joseph M Schwab, Moritz Tannast, Corinne A Zurmühle
{"title":"Pelvic tilt after Bernese periacetabular osteotomy—a long-term follow-up study","authors":"Alexander F Heimann, Iris F Brouze, Guoyan Zheng, Angela M Moosmann, Joseph M Schwab, Moritz Tannast, Corinne A Zurmühle","doi":"10.1093/jhps/hnad030","DOIUrl":"https://doi.org/10.1093/jhps/hnad030","url":null,"abstract":"ABSTRACT Patients with developmental dysplasia of the hip (DDH) are believed to present with increased anterior pelvic tilt to compensate for reduced anterior femoral head coverage. If true, pelvic tilt in dysplastic patients should be high preoperatively and decrease after correction with periacetabular osteotomy (PAO). To date, the evolution of pelvic tilt in long-term follow-up after PAO has not been reported. We therefore asked the following questions: (i) is there a difference in pelvic tilt between patients with DDH and an asymptomatic control group? (ii) How does pelvic tilt evolve during long-term follow-up after Bernese PAO compared with before surgery? This study is a therapeutic study with the level of evidence III. We retrospectively compared preoperative pelvic tilt in 64 dysplastic patients (71 hips) with an asymptomatic control group of 20 patients (20 hips). In addition, immediate postoperative and long-term follow-up (at 18 ± 8 [range 7–34 years) pelvic tilt was assessed and compared. Dysplastic patients had a significantly higher mean preoperative pelvic tilt than controls [2.3 ± 5.3° (−11.2° to 16.4°) versus 1.1 ± 3.0° (−4.9 to 5.9), P = 0.006]. Mean pelvic tilt postoperatively was 1.5 ± 5.3° (−11.2 to 17.0º, P = 0.221) and at long-term follow-up was 0.4 ± 5.7° (range −9.9° to 20.9°, P = 0.002). Dysplastic hips undergoing PAO show a statistically significant decrease in pelvic tilt during long-term follow-up. However, given the large interindividual variability in pelvic tilt, the observed differences may not achieve clinical significance.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136107780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative cotyloid fossa thickness and proximity to obturator neurovascular bundle: implications for arthroscopic ligamentum teres reconstruction 定量子叶窝厚度和接近闭孔神经血管束:关节镜下圆韧带重建的意义
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-08-28 DOI: 10.1093/jhps/hnad020
Jacek Mazek, Nader Helmy, Antonio Porthos Salas, Pawel Skowronek, Arkadiusz Madej, John M O´Donnell, Dimitris Dimitriou
{"title":"Quantitative cotyloid fossa thickness and proximity to obturator neurovascular bundle: implications for arthroscopic ligamentum teres reconstruction","authors":"Jacek Mazek, Nader Helmy, Antonio Porthos Salas, Pawel Skowronek, Arkadiusz Madej, John M O´Donnell, Dimitris Dimitriou","doi":"10.1093/jhps/hnad020","DOIUrl":"https://doi.org/10.1093/jhps/hnad020","url":null,"abstract":"ABSTRACT The aim of the present study was to report the in vivo thickness of the cotyloid fossa at the acetabular ligamentum teres (LT) attachment and investigate the clearance of the obturator neurovascular bundle. Fifty-five consecutive patients undergoing a total hip arthroplasty for hip osteoarthritis were included. The thickness of the cotyloid fossa was measured at the acetabular LT attachment using a standard depth gauge. The minimal distance (clearance) of the obturator neurovascular bundle to the center of the acetabular LT attachment was measured in 7 patients (14 hips) who also underwent a computed tomography angiography. The average thickness of the cotyloid fossa at the acetabular LT attachment was 4.1 ± 2.3 (range: 1–10) mm. The obturator vein was closest to the acetabular LT attachment, but the clearance was more than the defined safe zone of 15 mm in all cases. Based on the current findings, it can be assumed that bone anchors might not be suitable for fixation of the graft in LT reconstruction (LTR) and an alternative implant such as a cortical button should be considered. Acetabular fixation of the graft with a 12-mm cortical button is relatively safe concerning injury to obturator neurovascular structures. The results of the present study provide a better understanding of the cotyloid fossa anatomy and might be relevant for surgeons who perform arthroscopic LTR.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135088582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative weight-bearing restrictions and rehabilitation protocols after hip arthroscopy for femoroacetabular impingement: a systematic review 髋关节镜治疗股髋臼撞击术后负重限制和康复方案:一项系统综述
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-08-09 DOI: 10.1093/jhps/hnad023
Riley Hemstock, Drew Mulhall, Janine Didyk, Dan Ogborn, Devin Lemmex
{"title":"Postoperative weight-bearing restrictions and rehabilitation protocols after hip arthroscopy for femoroacetabular impingement: a systematic review","authors":"Riley Hemstock, Drew Mulhall, Janine Didyk, Dan Ogborn, Devin Lemmex","doi":"10.1093/jhps/hnad023","DOIUrl":"https://doi.org/10.1093/jhps/hnad023","url":null,"abstract":"ABSTRACT Despite recent increased interest in hip arthroscopy for the management of femoroacetabular impingement (FAI), there is little evidence to guide weight-bearing recommendations and rehabilitation postoperatively. The primary objective of this study was to determine if sufficient evidence exists to recommend specific weight-bearing restrictions postoperatively. This study was registered with PROSPERO (CRD42021247741). PubMed, MEDLINE and Embase were searched on 3 March 2023 for Level I–IV studies including patients over the age of 18 years, with a minimum 1-year follow-up and reporting of a weight-bearing status, a patient-reported outcome measure (PROM) and a clinical outcome. Meta-analysis was precluded due to heterogeneity in the included studies, and a descriptive analysis was undertaken. Methodological quality and risk of bias were assessed with the methodological index for non-randomized studies (MINORS). Twenty-four studies including 2231 patients who underwent hip arthroscopy for treatment of FAI were included (follow-up interval 33.2 ± 24.7 months). Most articles (62.5%) were case series. There were seven terms describing weight-bearing recommendations, with 83% being some variation of ‘partial weight-bearing’. Eight PROMs were reported, with 83% using the modified Harris Hip Score and 87.5% of studies reporting reoperation rates. Only 75% of studies reported rehabilitation protocols. The average MINORS score was 11.07 ± 1.10 out of 16 for non-comparative studies and 18.22 ± 1.48 out of 24 for comparative studies. The reporting of weight-bearing status, clinical outcomes, PROMs and rehabilitation parameters remains poor. At present, sufficient comparative evidence does not exist to make specific weight-bearing recommendation postoperatively.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135746209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The surgical destabilization of the abductor muscle leads to development of instability-associated hip osteoarthritis in mice 外展肌的手术失稳导致小鼠不稳定相关性髋关节骨关节炎的发展
4区 医学
Journal of Hip Preservation Surgery Pub Date : 2023-07-29 DOI: 10.1093/jhps/hnad015
Michael B Geary, Caitlin A Orner, Helen Shammas, John M Reuter, Alayna E Loiselle, Brian D Giordano, Chia-Lung Wu
{"title":"The surgical destabilization of the abductor muscle leads to development of instability-associated hip osteoarthritis in mice","authors":"Michael B Geary, Caitlin A Orner, Helen Shammas, John M Reuter, Alayna E Loiselle, Brian D Giordano, Chia-Lung Wu","doi":"10.1093/jhps/hnad015","DOIUrl":"https://doi.org/10.1093/jhps/hnad015","url":null,"abstract":"ABSTRACT Osteoarthritis (OA) of the hip is a common and debilitating painful joint disease. However, there is paucity of surgically induced hip OA models in small animals that allow scientists to study the onset and progression of the disease. A growing body of evidence indicates a positive association between periarticular myotendinous pathology and the development of hip OA. Thus, in the current study, we aimed to establish a novel mouse instability–associated hip OA model via selective injury of the abductor complex around the hip joint. C57BL6/J mice were randomized to sham surgery or abductor injury, in which the myotendinous insertion at the third trochanter and greater trochanter were surgically detached. Mice were allowed free active movement until they were sacrificed at either 3 weeks or 20 weeks post-injury. Histologic analyses and immunohistochemical staining of the femoral head articular cartilage were performed, along with microCT (µCT) analysis to assess subchondral bone remodeling. We observed that mice receiving abductor injury exhibited significantly increased instability-associated OA severity with loss of proteoglycan and type II collagen staining compared to sham control mice at 20 weeks post-surgery, while comparable matrix metalloproteinase 13 expression was observed between injury and sham groups. No significant differences in subchondral bone remodeling were found after 3 or 20 weeks following injury. Our study further supports the link between abductor dysfunction and the development of instability-associated hip OA. Importantly, this novel surgically induced hip OA mouse model may provide a valuable tool for future investigations into the pathogenesis and treatment of hip OA.","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135444755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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