Journal of Hip Preservation Surgery最新文献

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Innovative modified light bulb technique with custom offset curettes for treating precollapsed femoral head osteonecrosis. 创新改良灯泡技术与定制偏移曲管治疗股骨头坏死前塌陷。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-06-12 eCollection Date: 2026-01-01 DOI: 10.1093/jhps/hnaf021
Ali Parsa, Morteza Behjat, Neda Mirzaei, Mohammad Ghorbani, Elham Rahmanipour
{"title":"Innovative modified light bulb technique with custom offset curettes for treating precollapsed femoral head osteonecrosis.","authors":"Ali Parsa, Morteza Behjat, Neda Mirzaei, Mohammad Ghorbani, Elham Rahmanipour","doi":"10.1093/jhps/hnaf021","DOIUrl":"10.1093/jhps/hnaf021","url":null,"abstract":"<p><p>Osteonecrosis of the femoral head is a devastating disease that accounts for 10-15% of all hip arthroplasty cases in the USA, eventually leading to femoral head collapse and joint destruction. Even the current forms of treatment only slightly slow down the progression of the disease itself. This article describes a modified lightbulb technique, which perfects the method, the instrument, and the flap used in order to ensure hip musculature preservation and improved outcomes. With the direct anterior approach, there is no need to perform surgical dislocation, so the time of the surgery is reduced, as well as the risk of vascular injury. The necrotic bone can be precisely removed using custom-made offset curettes, and a bone graft substitute and autograft can be placed under C-arm guidance. This technique may be beneficial in treating early osteonecrosis of the femoral head by reducing operative time and reducing the risk of complications related to surgical dislocation.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"13 1","pages":"56-59"},"PeriodicalIF":1.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating a semiquantitative magnetic resonance imaging-based scoring system to predict hip preservation or arthroplasty in patients with an intact preoperative joint space. 评估一种基于半定量磁共振成像的评分系统,用于预测术前关节间隙完整的患者髋关节保留或关节置换术。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-05-30 eCollection Date: 2025-12-01 DOI: 10.1093/jhps/hnaf027
Benjamin D Kuhns, Ady H Kahana-Rojkind, Roger Quesada-Jimenez, Tyler R McCarroll, Yasemin E Kingham, Matthew J Strok, Veer Shah, Benjamin G Domb
{"title":"Evaluating a semiquantitative magnetic resonance imaging-based scoring system to predict hip preservation or arthroplasty in patients with an intact preoperative joint space.","authors":"Benjamin D Kuhns, Ady H Kahana-Rojkind, Roger Quesada-Jimenez, Tyler R McCarroll, Yasemin E Kingham, Matthew J Strok, Veer Shah, Benjamin G Domb","doi":"10.1093/jhps/hnaf027","DOIUrl":"10.1093/jhps/hnaf027","url":null,"abstract":"<p><p>Subjective interpretation of magnetic resonance imaging (MRI) findings in the setting of early hip osteoarthritis can be challenging with little agreement between surgeons. While arthroplasty is rarely indicated for patients with preserved joint space, it may be the preferred surgical option when advanced imaging reveals severe intra-articular pathology. The purpose of this study was to evaluate a semiquantitative MRI-based scoring system in patients undergoing surgery for hip pain without advanced radiographic joint space loss. Consecutive patients with hip pain refractory to conservative measures and without severe radiographic hip osteoarthritis [Tönnis grade 0-1, Joint Space Width (JSW)> 3 mm] who received primary total hip arthroplasty with a preoperative MRI were included. This cohort was propensity-matched by Tönnis grade and JSW, as well as age, gender, and BMI, to patients undergoing hip preservation surgery. Preoperative MRIs were evaluated according to the Scoring Hip Osteoarthritis with MRI (SHOMRI) grading system. SHOMRI scores were compared between the arthroplasty and hip preservation cohorts with threshold values calculated to evaluate associations with treatment pathways. Patients undergoing arthroplasty had significantly greater SHOMRI total scores as well as cartilage component scores. Threshold values for the cartilage component SHOMRI score were significantly associated with the designated surgical treatments between the two groups (<i>P</i> < .001). Subjects in each treatment group had significant postoperative improvement to the 2-year time point with high postoperative satisfaction, indicating appropriate treatment designation. Application of SHOMRI scoring thresholds may decrease subjectivity in surgeon decision making when using advanced imaging in patients without significant radiographic osteoarthritis.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 4","pages":"256-264"},"PeriodicalIF":1.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12712967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normal range of femoral version for different measurement methods on CT or MRI-scoping review of normal femoral version. 正常范围的股骨版本不同的测量方法在CT或mri范围内审查正常的股骨版本。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-05-21 eCollection Date: 2025-08-01 DOI: 10.1093/jhps/hnaf003
Till D Lerch, Thierry Leimbacher, Malin K Meier, Adam Boschung, Emanuel F Liechti, Moritz Tannast, Simon D Steppacher, Florian Schmaranzer
{"title":"Normal range of femoral version for different measurement methods on CT or MRI-scoping review of normal femoral version.","authors":"Till D Lerch, Thierry Leimbacher, Malin K Meier, Adam Boschung, Emanuel F Liechti, Moritz Tannast, Simon D Steppacher, Florian Schmaranzer","doi":"10.1093/jhps/hnaf003","DOIUrl":"10.1093/jhps/hnaf003","url":null,"abstract":"<p><p>Correct quantification of femoral version (FV) is crucial for femoroacetabular impingement (FAI) patients for diagnosis and for surgical planning. However, different measurement methods for FV and different normal values are confusing. The study aimed to investigate differences in FV measurement methods and to review normal FV. This retrospective comparative study investigated a total of 84 hips for FV measurement: 48 hips (asymptomatic patients) and 36 hips (asymptomatic volunteers) without hip pain. The 48 patients underwent computed tomography (CT) for another reason (mean age 63 ± 11 years) and most (39 hips, 81%) were male patients. The 36 hips reported no hip pain at the time of magnetic resonance imaging (MRI) (mean age 27 ± 7 years, 20 female patients, 56%). FV was measured on CT or MRI included pelvis and knee) and with the Murphy method. Mean FV for 48 hips was 22° (range 5-34°), and for 36 hips, it was 24° (7-44°). No significant differences were found between the two groups. For 39 male patients with CT scans, the mean FV was 21° (6-34°) and was significantly (<i>P</i> = 0.041) decreased compared to female patients (FV of 26°). For the review, 18 studies were compared that evaluated normal FV (total of 2275 hips) in the literature. Increasing values for normal FV were found for measurement methods with a more distal definition of the femoral neck axis: Normal values were reported for the Lee method (most proximal definition; 8-11°), Reikeras method (9-20°), Oblique/Jarrett method (9-15°), Tomczak method (22-24°), and Murphy method (most distal: 18-23°). Reported normal range of FV differs between measurement methods. This is important for patients with FAI/hip dysplasia undergoing hip preservation surgery (hip arthroscopy/femoral derotation osteotomy).</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 3","pages":"157-163"},"PeriodicalIF":1.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of quality and readability of information provided by ChatGPT in relation to developmental dysplasia of the hip and periacetabular osteotomy. 评估ChatGPT提供的与髋关节发育不良和髋臼周围截骨有关的信息的质量和可读性。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-05-08 eCollection Date: 2025-12-01 DOI: 10.1093/jhps/hnaf025
Vincent J Leopold, Stephen Fahy, Carsten Perka, Jens Goronzy, George Grammatopoulos, Paul E Beaulé, Sebastian Hardt
{"title":"Assessment of quality and readability of information provided by ChatGPT in relation to developmental dysplasia of the hip and periacetabular osteotomy.","authors":"Vincent J Leopold, Stephen Fahy, Carsten Perka, Jens Goronzy, George Grammatopoulos, Paul E Beaulé, Sebastian Hardt","doi":"10.1093/jhps/hnaf025","DOIUrl":"10.1093/jhps/hnaf025","url":null,"abstract":"<p><p>This study evaluates the quality and readability of responses given by ChatGPT 4 relating to common patient queries on Developmental Dysplasia of the Hip (DDH) and Periacetabular Osteotomy (PAO). Frequently asked questions on DDH and PAO were selected from online Patient Education Materials and posed to ChatGPT 4. The responses were evaluated by four high-volume PAO surgeons using a well-established evidence-based rating system, categorizing responses from 'excellent response not requiring clarification' to 'unsatisfactory requiring substantial clarification'. Readability assessments were subsequently conducted to determine the required literacy level to understand the content provided. Responses from ChatGPT 4 varied significantly between preoperative and postoperative queries. In the postoperative category, 50% of responses were rated as 'excellent', showing no need for further clarification, while the preoperative responses frequently required minimal to moderate clarification. The overall median response rating was 'satisfactory requiring minimal clarification'. Readability tests showed that the average Reading Grade Level was 13.44, considerably higher than the recommended sixth-grade level for patient education materials, indicating a substantial barrier to comprehension for the general public. While ChatGPT delivers generally reliable information, the complexity of its language is a major barrier to widespread utilization as a tool for patient education. Future iterations of ChatGPT should aim to utilize more simplistic language, as such enhancing accessibility without compromising content quality.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 4","pages":"242-247"},"PeriodicalIF":1.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12712974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A centroid iterative method for fitting the femoral neck axis in rotational osteotomy: a finite element analysis and biomechanical investigation. 旋转截骨术中拟合股骨颈轴的质心迭代法:有限元分析和生物力学研究。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-05-08 eCollection Date: 2025-12-01 DOI: 10.1093/jhps/hnaf026
Liang Chen, Zexin Hong, Zhentao Ding, Jingyang Chen, Zhuohua Liu, Chenglin Chen, Yufeng Wu, Jianhai Chen, Dawei Gao
{"title":"A centroid iterative method for fitting the femoral neck axis in rotational osteotomy: a finite element analysis and biomechanical investigation.","authors":"Liang Chen, Zexin Hong, Zhentao Ding, Jingyang Chen, Zhuohua Liu, Chenglin Chen, Yufeng Wu, Jianhai Chen, Dawei Gao","doi":"10.1093/jhps/hnaf026","DOIUrl":"10.1093/jhps/hnaf026","url":null,"abstract":"<p><p>The femoral neck axis (FNA) is an important reference in femoral neck rotational osteotomy, which is a hip preservation procedure. The purpose of this study was to propose a method for determining the FNA with high accuracy and reliability and to evaluate the effect of FNA determination accuracy on the stress and strain distribution in the proximal femur. Femoral computed tomography data from 50 patients were reconstructed, and the FNA was fitted by the centroid iterative method. The fitting accuracy was evaluated in terms of the distance between the femoral head centre and the FNA. The reliability was assessed by intraclass correlation coefficient (ICC). Stress-strain distributions of the native femur model and rotational osteotomy models with accurate FNA and deviated FNA were simulated by finite element analysis and digital image correlation methods. The distance between the femoral head centre and the FNA was 1.24 ± 0.35 mm. The intra- and interobserver reliability was high, with ICC values of 0.960 and 0.924, respectively. The maximum von Mises stress was 25.76 MPa, 50.82 MPa, and 93.24 MPa for the native femur model, accurate FNA model, and deviated FNA model, respectively. The finite element strain distributions were linearly correlated with digital image correlation results. The centroid iterative method for FNA fitting has high accuracy and reliability. Accurate determination of the FNA reduces stress concentration in the proximal femur and decreases the risk of subsequent fracture and non-union of the osteotomy surface.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 4","pages":"248-255"},"PeriodicalIF":1.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12712969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What the papers say. 报纸上说的。
IF 1.4 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.1093/jhps/hnaf022
Ali Bajwa
{"title":"What the papers say.","authors":"Ali Bajwa","doi":"10.1093/jhps/hnaf022","DOIUrl":"https://doi.org/10.1093/jhps/hnaf022","url":null,"abstract":"<p><p>The <i>Journal of Hip Preservation Surgery</i> (<i>JHPS</i>) is not the only place where work in the field of hip preservation can be published. Although our aim is to offer the best of the best, we are continually fascinated by work, which finds its way into journals other than our own. There is much to learn from it, and so <i>JHPS</i> has selected six recent and topical subjects for those who seek a summary of what is taking place in our ever-fascinating world of hip preservation. What you see here are the mildly edited abstracts of the original articles, to give them what <i>JHPS</i> hopes is a more readable feel. If you are pushed for time, what follows should take you no more than 10 min to read. So here goes.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 1","pages":"81-83"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disruptors. 干扰物。
IF 1.6 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.1093/jhps/hnaf015
Richard E Field
{"title":"Disruptors.","authors":"Richard E Field","doi":"10.1093/jhps/hnaf015","DOIUrl":"10.1093/jhps/hnaf015","url":null,"abstract":"","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 1","pages":"1-2"},"PeriodicalIF":1.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of early bone union between anterior and posterior approach in periacetabular osteotomy: spherical periacetabular osteotomy and rotational acetabular osteotomy. 髋臼周围截骨前后入路早期骨愈合的比较:球形髋臼周围截骨与旋转髋臼截骨。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-04-26 eCollection Date: 2025-12-01 DOI: 10.1093/jhps/hnaf024
Hironori Kitajima, Eiji Takahashi, Makoto Fukui, Yusuke Sanji, Daisuke Soma, Toru Ichiseki, Ayumi Kaneuji
{"title":"Comparison of early bone union between anterior and posterior approach in periacetabular osteotomy: spherical periacetabular osteotomy and rotational acetabular osteotomy.","authors":"Hironori Kitajima, Eiji Takahashi, Makoto Fukui, Yusuke Sanji, Daisuke Soma, Toru Ichiseki, Ayumi Kaneuji","doi":"10.1093/jhps/hnaf024","DOIUrl":"10.1093/jhps/hnaf024","url":null,"abstract":"<p><p>Spherical Periacetabular Osteotomy (SPO) is a novel procedure using an osteotomy line similar to that for Rotational Acetabular Osteotomy (RAO). The major difference between these procedures is that an anterior approach is used for SPO and an anterior and posterior approach for RAO. This study compared early bone union between these procedures. We enrolled 12 patients (12 hips) post-RAO and 15 patients (15 hips) post-SPO who consented to undergo computed tomography (CT) imaging about 5 weeks after surgery. Results showed no significant differences in lateral centre-edge angle or acetabular roof obliquity between these groups, both before and after surgery. Partial bone union was observed in 7 of 12 cases (58.3%) in the RAO group and 14 of 15 cases (93.3%) in the SPO group, with the SPO group showing a significantly higher incidence of bone union (<i>P</i> = .03). X-ray images taken simultaneously with CT scans did not reveal any bone union in either group. Functional outcomes measured by the Japanese Orthopaedic Association score revealed no significant differences between groups at 6 months and 1 year postoperatively. Both procedures preserved the quadrilateral surface, avoided cutting the pubic bone, and achieved good stability of the pelvic ring as well as wide contact area on the cut bone. Through CT imaging, this study highlighted the potential of SPO to achieve superior early bone union, likely due to its preservation of blood flow and minimally invasive approach. This study suggests the potential utility of CT imaging in evaluating early bone union after osteotomy.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 4","pages":"237-241"},"PeriodicalIF":1.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12712962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A finite element analysis model to support ligamentum teres function. 支持韧带圆肌功能的有限元分析模型。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-04-18 eCollection Date: 2025-08-01 DOI: 10.1093/jhps/hnaf017
Yongni Zhang, Jianing Wang, Linxia Gu, Hal David Martin, RobRoy L Martin
{"title":"A finite element analysis model to support ligamentum teres function.","authors":"Yongni Zhang, Jianing Wang, Linxia Gu, Hal David Martin, RobRoy L Martin","doi":"10.1093/jhps/hnaf017","DOIUrl":"10.1093/jhps/hnaf017","url":null,"abstract":"<p><p>The function of the ligamentum teres (LT) remains debated, particularly its role in limiting motion. The aim of this study was to use finite element analysis to assess LT stress during hip movements, which included external rotation with flexion. A 3D model of the hip joint, including the femoral head and LT, was constructed from magnetic resonance imaging data using 3D Slicer. The models were imported into Ansys SpaceClaim 2022R1 for refinement and assembly. The von Mises stress in the LT was extracted during six hip movements: external rotation, internal rotation, abduction, adduction, flexion, and extension. LT stress response was also extracted during external rotation at hip flexion angles of 0°, 30°, 60°, and 90°. The results found there was a sharper increase in LT stress during movements involving hip external rotation, internal rotation, abduction, and adduction when compared to movements in flexion and extension. External rotation in larger hip flexion angles resulted in greater LT stress, with the highest stress observed at 90° flexion. These findings help to support the LT's role as a rotational stabilizer in the frontal and transverse planes wrapping around the femoral head to act as a sling. Additionally, the increased stress during external rotation at greater degrees of hip flexion suggests an enhanced role for the LT in hip stability as flexion increases. These results add as a proof of concept in that the LT is under stress during hip movements and has a potential role in stabilizing the hip joint.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 3","pages":"181-185"},"PeriodicalIF":1.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping review. 髋关节形态异常的遗传学及其对骨关节炎的影响:范围综述。
IF 1.1 4区 医学
Journal of Hip Preservation Surgery Pub Date : 2025-04-18 eCollection Date: 2025-08-01 DOI: 10.1093/jhps/hnaf020
Lainey G Bukowiec, Elizabeth S Kaji, John A Koch, Sami Saniei, Miguel M Girod-Hoffmann, Jason P Sinnwell, Cody C Wyles
{"title":"Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping review.","authors":"Lainey G Bukowiec, Elizabeth S Kaji, John A Koch, Sami Saniei, Miguel M Girod-Hoffmann, Jason P Sinnwell, Cody C Wyles","doi":"10.1093/jhps/hnaf020","DOIUrl":"10.1093/jhps/hnaf020","url":null,"abstract":"<p><p>Morphological hip abnormalities (MHAs) significantly influence lifelong prognosis of the hip, contributing to early-onset osteoarthritis and impaired functionality. Developmental dysplasia of the hip (DDH) and femoroacetabular impingement (FAI) represent key pathologies, resulting from insufficient or excessive femoral head coverage, respectively. These abnormalities alter hip biomechanics, leading to structural damage, pain, and accelerated joint degeneration. Advances in genetic research have illuminated the interplay between genetics and mechanical loading in shaping hip morphology. Genes associated with osteoarthritis, DDH, and FAI include <i>COL1A1, MMP13</i>, and <i>IL-6</i>. Genes associated with FAI and osteoarthritis include <i>ADAMTS4</i>. Genes associated with DDH and osteoarthritis include <i>FRZB, CX3CR1, ASPN, DKK1, PDRG1, GDF5</i>, <i>UQCC1</i>, and <i>TGF-β1</i>. The mechanisms linking morphological derangements to symptomatic osteoarthritis remain incompletely understood. Multimodal approaches integrating imaging, biomechanics, and genetics may uncover distinct disease subtypes, enabling personalized interventions. Early detection of MHAs is critical in preventing early-onset osteoarthritis. Incorporating advanced imaging techniques, such as statistical shape modelling, can enhance the understanding of complex 3D hip morphologies and their progression to osteoarthritis. Future research should explore the genetic underpinnings of other morphologic hip conditions, including Slipped Capital Femoral Epiphysis and Legg-Calvé-Perthes disease, to refine preventive and therapeutic strategies. A comprehensive approach combining genetics, imaging, and clinical insights holds promise for mitigating the lifelong impact of MHAs.</p>","PeriodicalId":48583,"journal":{"name":"Journal of Hip Preservation Surgery","volume":"12 3","pages":"202-216"},"PeriodicalIF":1.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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