Laryngoscope Investigative Otolaryngology最新文献

{"title":"Healthcare Practitioners' Perceptions of Quality-of-Life Tools in Head and Neck Surgical Oncology: A Qualitative Descriptive Content Analysis.","authors":"Keshav Kumar Gupta, Jameel Muzaffar","doi":"10.1002/lio2.70531","DOIUrl":"https://doi.org/10.1002/lio2.70531","url":null,"abstract":"<p><strong>Objectives: </strong>Quality of life (QoL) outcomes are becoming increasingly important in the era of patient-centered medicine. This is especially true in head and neck surgical oncology due to the life-altering effects of major head and neck surgery. This study aimed to gain in-depth feedback surrounding the awareness, perceptions, and utilization of QoL tools in head and neck surgical oncology among the multidisciplinary team (MDT).</p><p><strong>Methods: </strong>A qualitative descriptive content analysis of semi-structured interviews from 10 members of the head and neck surgical oncology MDT.</p><p><strong>Results: </strong>The overarching categories from the interviews were of healthcare practitioners (HCPs) expressing that they thought the assessment of QoL to be important in this patient group and that this was important for clinical practice, patients, and in research. While most respondents assessed QoL, this was largely done on an informal basis, with very few regularly employing formal QoL tools. Various barriers to their use in terms of patient, clinician, and logistical factors were explored.</p><p><strong>Conclusions: </strong>Overall, this study adds to the literature by providing an important analysis of perceptions of QoL and formal tools in head and neck surgical oncology from the underexplored perspective of HCPs in this MDT. While clinicians across the MDT generally viewed QoL assessment positively, implementation of structured tools remained inconsistent and was influenced by structural barriers. These findings suggest that future efforts should focus on developing feasible, clinically embedded approaches to QoL integration within this context.</p><p><strong>Level of evidence: </strong>N/A.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70531"},"PeriodicalIF":1.9,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Care Engagement and Psychosocial Factors With Tracheostomy Decannulation.","authors":"Cyrus W Abrahamson, Abbey L Landini, Maya Frost, Jorge A Gutierrez, James A Burns, Andrew P Stein","doi":"10.1002/lio2.70543","DOIUrl":"10.1002/lio2.70543","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate associations between care engagement and psychosocial factors and decannulation success and timing among adults with laryngotracheal stenosis and tracheostomy dependence.</p><p><strong>Methods: </strong>This retrospective cohort study included 60 adults with tracheostomy dependence in the setting of laryngotracheal stenosis who underwent airway surgery between September 2021 and November 2025. Patient demographics, clinical history, psychiatric and substance use history, tracheostomy information, surgical information, and follow-up care were extracted from electronic medical records. Fisher's exact tests, chi-squared tests, and accelerated failure time models were used to assess associations with decannulation timing and success.</p><p><strong>Results: </strong>Forty-seven patients (78.3%) achieved decannulation. No significant differences in ability to decannulate were found based on age, sex, race, body mass index (BMI), comorbidities, reason for tracheostomy, or stenosis characteristics. Patients who were not decannulated had significantly higher rates of missed appointments (38.5% vs. 8.5% with ≥ 2 no-shows, <i>p</i> = 0.025) and were more frequently lost to follow-up (<i>p</i> < 0.001). Each missed appointment was associated with a 25% increase in time to decannulation (<i>p</i> = 0.004). Patients with psychiatric diagnoses had a longer time to decannulation, though this relationship was not statistically significant (<i>p</i> = 0.091). Substance use diagnosis, distance to hospital, social vulnerability index, emergency department visits, and complications were not significantly associated with outcomes.</p><p><strong>Conclusion: </strong>Care engagement patterns, including better appointment adherence, were significantly associated with improved decannulation rates in patients with laryngotracheal stenosis. Psychiatric comorbidities may delay decannulation. These findings suggest that interventions targeting consistent follow-up and mental health support may improve tracheostomy outcomes in this complex patient population.</p><p><strong>Level of evidence: </strong>4.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70543"},"PeriodicalIF":1.9,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Hypoglossal Nerve Stimulator Implant in Obstructive Sleep Apnea Patients With Various Health Statuses.","authors":"Ahmad Saeed, Adrienne Biskaduros, Nicholas Wilmerding, Ashutosh Kacker","doi":"10.1002/lio2.70541","DOIUrl":"10.1002/lio2.70541","url":null,"abstract":"<p><strong>Objectives: </strong>Hypoglossal nerve stimulation (HGNS) is increasingly used in the management of moderate-to-severe obstructive sleep apnea (OSA). In this study, we investigated whether common medical and psychiatric comorbidities are associated with apnea-hypopnea index (AHI) reduction and treatment success after HGNS implantation.</p><p><strong>Methods: </strong>Charts of patients who underwent HGNS implantation with pre-operative AHI of 65 or below were reviewed. ANOVA, linear mixed-effects model (LMM), and multivariate logistic regression analyses on AHI and demographics and medical comorbidities were performed on <i>RStudio</i>. Outcomes for logistic analysis pertained to whether they met the Sher20 criteria for treatment success.</p><p><strong>Results: </strong>A total of 204 patients were included, of whom 174 were male and 30 were female. At the nominal 0.05 threshold, obesity was associated with higher AHI across time in the ANOVA analysis (<i>F</i> = 7.539, <i>p</i> = 0.0066) and with lower odds of Sher20 treatment success at 6 months (OR = 0.31, 95% CI: 0.10-0.90). In the small CAD subgroup (<i>n</i> = 16), CAD was associated with a lower longitudinal percent reduction in AHI in the linear mixed-effects model (<i>β</i> = -31.88, <i>p</i> = 0.033). No other modeled covariates met the nominal significance threshold.</p><p><strong>Conclusion: </strong>Obesity and CAD emerged as potential, rather than established, predictors of less favorable HGNS response. These findings are exploratory and require validation, particularly the CAD association, which was based on only 16 patients and arose in the setting of multiple unadjusted comparisons.</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70541"},"PeriodicalIF":1.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish Hearing in Noise Test for Adults: Revisited and Updated Normative Data.","authors":"Şule Çekiç, Ecem Kartal Özcan, Gonca Sennaroğlu","doi":"10.1002/lio2.70540","DOIUrl":"https://doi.org/10.1002/lio2.70540","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to revisit and update the normative data for the Turkish HINT by presenting headphone and loudspeaker results, establishing reference values in a quiet, non-sound-treated room, and identifying common clinical application errors with recommendations for improving test accuracy and consistency.</p><p><strong>Methods: </strong>This was a prospective cross-sectional study. A total of 30 normal-hearing adults were participated. The measurements were performed in a quiet, non-sound-treated room in an ENT clinic. Each participant was tested with both headphones and loudspeakers under four listening conditions: Quiet, Noise Front (NF), Noise Right (NR), and Noise Left (NL). The Reception Threshold for Sentences (RTS) in quiet and the signal-to-noise ratio (SNR) in three conditions (NF, NR, and NL) were assessed.</p><p><strong>Results: </strong>The mean scores and standard deviations of the best two-score averages obtained with headphones and loudspeakers were presented. A significant multivariate effect of presentation mode (loudspeakers vs. headphones) was detected (<i>p</i> < 0.001). Performance varied significantly across front and side listening conditions, while no difference was found between the NR and NL conditions under either presentation mode (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Normative data for headphones and loudspeakers in a quiet room rather than a sound-treated booth were provided. Such data are important because many clinics either lack access to sound-treated booths or have booths that are too small to accommodate the loudspeakers. In addition, several issues encountered during test administration were discussed, and practical solutions were presented.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70540"},"PeriodicalIF":1.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota and Mycobiota Dysbiosis in Sinonasal Fungus Ball: A Paired Lesional and Contralateral Analysis.","authors":"Yen-Ting Lu, Cheng-Yang Lee, Shao-Hung Wang, Chung-Han Hsin, Yu-Xuan Li, Ying-Chou Lu, Shun-Fa Yang, Yih-Yuan Chen, Tzu-Hao Chang","doi":"10.1002/lio2.70534","DOIUrl":"https://doi.org/10.1002/lio2.70534","url":null,"abstract":"<p><strong>Objectives: </strong>Fungus ball (FB) is a unilateral form of fungal rhinosinusitis, but it remains unclear whether associated microbial dysbiosis is restricted to the lesional sinus or extends across the sinonasal cavity. This study aimed to determine whether bacterial and fungal dysbiosis in maxillary sinus FB is spatially localized by comparing paired lesional and contralateral-normal sites within the same individuals.</p><p><strong>Methods: </strong>This prospective paired-sample study enrolled 14 adults with surgically confirmed unilateral maxillary sinus FB at a tertiary referral center. Middle-meatal swabs were obtained from lesional and contralateral-normal sides during endoscopic sinus surgery. Bacterial and fungal communities were profiled using 16S rRNA gene and internal transcribed spacer (ITS) sequencing. Alpha and beta diversity, taxonomic composition, predicted functional pathways, and bacterial-fungal co-occurrence networks were analyzed.</p><p><strong>Results: </strong>Lesional sinuses showed significantly reduced bacterial alpha diversity compared with contralateral-normal sides (Wilcoxon <i>p</i> < 0.001) and distinct bacterial beta diversity (PERMANOVA <i>p</i> = 0.003). Fungal beta diversity also differed between sites (<i>p</i> = 0.001), whereas fungal alpha diversity was preserved. Lesional communities showed enrichment of anaerobic and pathobiont taxa, including <i>Haemophilus</i>, <i>Enterococcus</i>, and <i>Pseudomonas</i>, with reduced relative abundance of <i>Staphylococcus</i>. Although <i>Aspergillus</i> abundance was similar bilaterally, network analysis suggested altered <i>Aspergillus</i>-associated connectivity in lesional samples, consistent with a shift in inferred interaction topology rather than increased <i>Aspergillus</i> abundance. Predicted functional analysis further suggested pathway differences that may reflect altered local metabolic conditions.</p><p><strong>Conclusion: </strong>In this cohort, microbial dysbiosis in maxillary sinus FB appeared to be spatially localized, with patterns suggestive of anaerobe enrichment and ecological reorganization centered on <i>Aspergillus</i>. These findings are compatible with the standard surgical emphasis on fungal mass removal and restoration of sinus drainage/aeration, but the microbiome-based relevance of aeration requires confirmation in larger studies.</p><p><strong>Level of evidence: </strong>3.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70534"},"PeriodicalIF":1.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics in Pro-Inflammatory Cytokines in Response to Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea.","authors":"Ralph Pries, Yi Cai, Kirstin Plötze-Martin, Sanja Jelic, Jonas Fleckner, Karl-Ludwig Bruchhage, Armin Steffen","doi":"10.1002/lio2.70472","DOIUrl":"https://doi.org/10.1002/lio2.70472","url":null,"abstract":"<p><strong>Objective: </strong>Obstructive sleep apnea (OSA) is associated with chronic low-grade systemic inflammation. In cases of continuous positive airway pressure (PAP) failure, hypoglossal nerve stimulation (HNS) is a treatment option for OSA but its impact on systemic inflammation to date is unknown. Herein, we investigated changes in cytokines and endothelial markers before and after HNS.</p><p><strong>Methods: </strong>Eighteen adults with moderate or severe OSA underwent fasting blood sample collection before and 6-8 months after HNS implantation. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang2), C-reactive protein (CRP), and E-selectin were measured using ELISA. Clinical metrics, including apnea-hypopnea index (AHI) and Epworth Sleepiness Scale (ESS), were assessed.</p><p><strong>Results: </strong>HNS significantly reduced AHI (from 25.9 ± 13.4 to 14.2 ± 10.5) and ESS scores (from 12.6 ± 5.0 to 7.1 ± 4.0). There were significant decreases in VEGF (<i>p</i> = 0.033) and TNF-α (<i>p</i> = 0.0013) with HNS. CRP levels were elevated among OSA patients when compared with healthy donors and did not change after HNS. IL-6 levels did not change with HNS, but were low in both healthy and OSA patients. No significant overall changes were observed in Ang2 or E-selectin. Obese participants exhibited higher baseline inflammatory profiles compared with non-obese participants.</p><p><strong>Conclusions: </strong>In this small cohort, HNS improved OSA severity and was associated with decreases in VEGF and TNF-α while other inflammatory markers were unchanged. Larger, long-term studies are needed to understand the potential of HNS to confer cardiometabolic benefits through reduction of systemic inflammation in OSA.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70472"},"PeriodicalIF":1.9,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13476757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Anatomical Imaging Findings in Patients With Patulous Eustachian Tube.","authors":"Akshay R Prabhakar, Zain Mehdi, Justina R Varghese, Kayla Powell, Dominique Paderin, Aatin Dhanda, Sebastian Guadarrama-Sistos Vazquez, Kenny F Lin, Jeffrey T Vrabec","doi":"10.1002/lio2.70539","DOIUrl":"10.1002/lio2.70539","url":null,"abstract":"<p><strong>Objectives: </strong>The pathophysiology of patulous Eustachian tube (PET) remains poorly understood. This study characterizes nasopharyngeal anatomy to identify features that distinguish PET patients from controls and determine whether anatomical measurements predict symptom laterality.</p><p><strong>Methods: </strong>Head CT scans from patients with PET diagnosed by Japanese Otologic Society criteria were compared to scans from demographically matched controls. Anatomical features of the Eustachian tube (ET), turbinates, and nasopharynx were measured. PET patients were stratified into bilateral PET, unilateral affected sides, and unilateral unaffected sides.</p><p><strong>Results: </strong>Thirty PET patients (23 unilateral, 7 bilateral) were included. Compared with controls, PET patients demonstrated significantly larger ET orifice diameters (5.61 vs. 4.54 mm, mean difference 1.07 mm, <i>p</i> < 0.001), greater ET patent depth (6.51 vs. 4.76 mm, mean difference 1.74 mm, <i>p</i> < 0.001), larger lateral recess length (6.40 vs. 3.86 mm, mean difference 2.54 mm, <i>p</i> = 0.002), larger lateral recess width (4.37 vs. 2.51 mm, mean difference 1.86 mm, <i>p</i> < 0.001), and greater inferior turbinate-to-ET asymmetry (2.67 vs. 1.24 mm, mean difference 1.43 mm, <i>p</i> < 0.001). Nasopharyngeal dimensions did not differ between groups. No significant differences were identified across groups in the primary analysis. Sensitivity analyses accounting for within-patient correlation demonstrated greater ET patent depth and lateral recess width in symptomatic compared with asymptomatic unilateral PET ears.</p><p><strong>Conclusion: </strong>PET patients demonstrate distinct nasopharyngeal anatomy beyond simple ET patency, including enlarged lateral recesses and greater asymmetry in inferior turbinate positioning. However, anatomical measurements poorly predict symptom laterality, indicating that additional physiologic mechanisms not captured by static CT imaging likely contribute to symptom expression.</p><p><strong>Level of evidence: </strong>4.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70539"},"PeriodicalIF":1.9,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions for Unhealthy Eating Patterns of Resident Otolaryngologists on Call.","authors":"Hannah G Luk, Harold Pine","doi":"10.1002/lio2.70538","DOIUrl":"10.1002/lio2.70538","url":null,"abstract":"<p><strong>Objectives: </strong>Resident physicians commonly experience elevated stress levels and disrupted sleep while on call. Many also report intense cravings for comfort food, typically high in fat, sugar, and salt. The objective of this pilot study was to explore the physiological and psychological factors contributing to the desire for unhealthy food among US otolaryngology residents on call, and to present strategies for reducing these behaviors. The hypothesis was that the introduction of a simple behavioral intervention would be associated with reduced unhealthy food consumption.</p><p><strong>Methods: </strong>Twelve otolaryngology residents from a single academic institution were prospectively enrolled and followed over a 61-day study period consisting of a pre- and post-intervention phase. During the initial 31-day pre-intervention period, participants completed a brief survey following each call shift and reported total sleep duration and whether unhealthy food was consumed. During the subsequent 30-day intervention period, residents were instructed to complete box breathing and/or consume green tea, and reported intervention adherence, sleep duration, and whether unhealthy food was consumed.</p><p><strong>Results: </strong>Survey responses reporting unhealthy food consumption were associated with shorter sleep duration compared to responses reporting no unhealthy food consumption (mean difference = 1.73 h, CI 1.02-2.45, <i>p</i> < 0.0001). Participation in the intervention phase was associated with a reduction in unhealthy eating habits; however, the change was not significant (<i>p</i> = 0.066). Similarly, residents who performed the intervention of box breathing and/or drinking green tea demonstrated fewer episodes of unhealthy food consumption; however, the magnitude of change was not significant (<i>p</i> = 0.857).</p><p><strong>Conclusion: </strong>This pilot study evaluated practical behavioral strategies as potential approaches to reducing unhealthy food consumption during call. Although reductions in unhealthy eating episodes were observed, findings should be interpreted cautiously given the small sample size. Further research is needed to design, implement, and assess strategies that support healthier dietary practices among US resident physicians on call.</p><p><strong>Level of evidence: </strong>4.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70538"},"PeriodicalIF":1.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Sleep Endoscopy in Infants With Obstructive Sleep Apnea: Current Evidence and Knowledge Gaps.","authors":"Melissa Bouhraoua, Christophe Salois, Mathieu Bergeron","doi":"10.1002/lio2.70536","DOIUrl":"10.1002/lio2.70536","url":null,"abstract":"<p><strong>Objective: </strong>To map and synthesize the available evidence and evidence gaps on drug-induced sleep endoscopy (DISE) in infants with obstructive sleep apnea (OSA), focusing on reported sites of obstruction, DISE-associated management decisions, postoperative outcomes, safety, and limitations in current reporting.</p><p><strong>Data sources: </strong>PubMed/MEDLINE/Embase/Google Scholar was searched for studies published in English and French from January 1980 to September 2025.</p><p><strong>Review methods: </strong>This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Eligible studies included original reports describing infants under 12 months with OSA who underwent DISE. Two reviewers independently screened titles, abstracts, and full texts, extracted data with a standardized form, and synthesized results descriptively. Extracted variables included available polysomnography (PSG) parameters, DISE methodology, comparator airway evaluations when reported, DISE-directed interventions, postoperative outcomes, and complications.</p><p><strong>Results: </strong>Eight observational studies published between 2013 and 2024 met inclusion criteria, involving 151 infants. DISE often revealed multilevel obstruction, most commonly involving the supraglottis (epiglottis, aryepiglottic folds, arytenoids; including sleep-state laryngomalacia) and retrolingual airway. Contributors from the nasal and adenotonsillar regions were also reported. DISE findings were associated with variable interventions, most frequently supraglottoplasty and adenoidectomy/tonsillectomy, with selected cases requiring mandibular distraction, tongue-lip adhesion, or tracheostomy. When postoperative PSG was available, indices generally improved (mean apnea-hypopnea index [AHI] approximately 10.6 events/h preoperatively and 3 events/h postoperatively). No major DISE-related complications were consistently described.</p><p><strong>Conclusion: </strong>In infants with OSA, DISE appears feasible and may identify dynamic, often multilevel obstruction, particularly supraglottic and retrolingual collapse. However, current evidence remains limited by small retrospective series, inconsistent PSG reporting, variable DISE protocols, and limited objective postoperative outcomes. Prospective studies with standardized DISE methods, uniform PSG reporting, defined outcome measures, and comparator airway evaluations are needed.</p><p><strong>Level of evidence: </strong>2.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70536"},"PeriodicalIF":1.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, Factor Structure, and Preliminary Psychometric Evaluation of the Rhinitis Medicamentosa Questionnaire (RMQ) Among Topical Nasal Decongestant Users.","authors":"Lili Lakatos, Attila Velich, Zsolt Demetrovics, Andrea Czakó, Ildikó Danis, Szabolcs Szentpéteri, József Rácz","doi":"10.1002/lio2.70535","DOIUrl":"10.1002/lio2.70535","url":null,"abstract":"<p><strong>Background: </strong>Rhinitis medicamentosa (RM) is associated with prolonged topical nasal decongestant (TND) use and may involve dependency-like behavioral patterns extending beyond nasal obstruction alone. Existing sinonasal patient-reported outcome measures do not specifically assess these behavioral features. This study aimed to develop the Rhinitis Medicamentosa Questionnaire (RMQ) and perform a preliminary psychometric evaluation in individuals reporting TND use.</p><p><strong>Methods: </strong>Instrument development followed Waltz's four-stage framework and was informed by Griffiths' addiction model and DSM-5-TR substance use disorder criteria. An initial 50-item pool underwent face and content evaluation involving patients and a multidisciplinary expert panel, resulting in a 37-item version. A total of 390 Hungarian adults reporting TND use within the previous 12 months completed the online questionnaire. Exploratory factor analysis (EFA; <i>n</i> = 210) and confirmatory factor analysis (CFA; <i>n</i> = 180) were performed on non-overlapping subsamples. Internal consistency, preliminary test-retest reliability, and score distribution were assessed.</p><p><strong>Results: </strong>The final RMQ consisted of 16 items across four factors: Overuse, Salience, Tolerance, and Withdrawal. CFA demonstrated good model fit (CFI = 0.975, TLI = 0.970, RMSEA = 0.055). Internal consistency was high across all subscales (Cronbach's α = 0.872-0.944), and preliminary test-retest reliability was favorable (ICC = 0.92). Higher RMQ scores were associated with more frequent and prolonged self-reported TND use. An exploratory sample-derived threshold was identified for higher dependency-related burden within the study population.</p><p><strong>Conclusion: </strong>The RMQ is a newly developed multidimensional questionnaire designed to assess dependency-related behavioral patterns associated with prolonged TND use. This preliminary study supports its internal structure, reliability, and interpretability. Further validation in clinically confirmed RM populations and international settings is required.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 4","pages":"e70535"},"PeriodicalIF":1.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}