Laryngoscope Investigative Otolaryngology最新文献

{"title":"Validation of the NOSE-Perf Scale for Nasal Septal Perforation: A Cross-Cultural Study With a Nasal Obstruction Comparator","authors":"Kyung Won Kwon,&nbsp;Mi Hyeon Jin,&nbsp;Nak Gyeong Ko","doi":"10.1002/lio2.70218","DOIUrl":"https://doi.org/10.1002/lio2.70218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Nasal septal perforation (NSP) presents complex diagnostic and therapeutic challenges, particularly due to the absence of a validated, symptom-specific patient-reported outcome measure. The nasal obstruction symptom evaluation-perforation (NOSE-Perf) scale was recently developed to address this gap. This study aimed to cross-culturally validate the Korean version of the NOSE-Perf scale and evaluate its clinical utility in distinguishing NSP-related symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The 12-item NOSE-Perf scale, which includes five NOSE items and seven additional, non-obstruction-related questions, was translated into Korean. Thirty-six patients with NSP, 40 with nasal obstruction only, and 40 control patients with no rhinologic symptoms completed the questionnaire. The scale's internal consistency, test–retest reliability, and validity were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The most commonly reported symptoms on the NOSE-Perf scale among patients with NSP were nasal congestion and obstruction (32/36 for each), followed by nasal crusting and difficulty breathing through the nose. The scale demonstrated good internal consistency (Cronbach's <i>α</i> = 0.789) and high test–retest reliability (<i>p</i> &lt; 0.001). The mean NOSE-Perf scale scores differed significantly across the three groups (<i>p</i> &lt; 0.001), with the highest scores in patients with NSP, followed by those in the nasal obstruction and control groups (16.97 vs. 13.03 vs. 1.30, respectively). Conversely, the NOSE scale score was the highest in the nasal obstruction group, followed by those in the NSP and control groups (12.20 vs. 8.72 vs. 0.50, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Korean version of the NOSE-Perf scale is a valid and reliable assessment tool for NSP in Korean patients, facilitating more accurate diagnosis and treatment evaluation compared with the NOSE scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Not applicable.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ongoing Discrepancy Between Unilateral Meniere's Disease and Bilateral Endolymphatic Hydrops on Hydrops MRI","authors":"Ting-Hua Yang,&nbsp;Ling-Chen Meng,&nbsp;Yi-Ho Young","doi":"10.1002/lio2.70216","DOIUrl":"https://doi.org/10.1002/lio2.70216","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>In the era of Hydrops MRI, a clinical dilemma has emerged: while Meniere's disease (MD) is diagnosed unilaterally, Hydrops MRI demonstrates endolymphatic hydrops (EH) bilaterally. This study aims to clarify this ongoing discrepancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-six MD patients underwent an inner ear test battery followed by 3 T Hydrops MRI. Eight unilateral MD patients with EH on both ears were classified as Group A and subdivided into Groups A1 (symptomatic EH on the affected ear, <i>n</i> = 8 ears) and A2 (asymptomatic EH on the opposite unaffected ear, <i>n</i> = 8 ears). Another 48 unilateral MD patients with EH on one ear only were referred to Group B and were subdivided into Group B1 (present EH, <i>n</i> = 48 ears) and Group B2 (absent EH, <i>n</i> = 48 ears).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both Groups A1 and B1 showed a significantly declining sequence of abnormality rates running from audiometry, cervical, and ocular vestibular-evoked myogenic potential tests to caloric test. However, such a declining trend was not observed in Groups A2 and B2. Significant differences in the abnormality rates of audiometry were noted in Groups A1 (88%) versus A2 (0) and Groups B1 (94%) versus B2 (27%). Four (50%) out of eight ears in Group A2 progressed to MD after a mean interval of 4 ± 2 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>If Hydrops MRI identifies EH in both ears of a unilateral MD patient, monitoring cochlear symptoms, hearing thresholds, and imaging findings in the opposite (unaffected) ear may help predict the progression from unilateral MD to bilateral MD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Vocal Fold and Airway Injury Models: A Scoping Review","authors":"Rahul D. Patel,&nbsp;Nour Awad,&nbsp;Denzel Ryan D. Cruz,&nbsp;Aida M. Hasson,&nbsp;Cameron D. Cook,&nbsp;Danielle Hall,&nbsp;Gregory R. Dion","doi":"10.1002/lio2.70173","DOIUrl":"https://doi.org/10.1002/lio2.70173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Preclinical models are necessary to study the pathophysiology of laryngotracheal diseases and novel treatments. Currently, there is no consensus on species, injury mechanics, and study duration This review provides a contemporary overview of the studies of vocal fold and laryngotracheal injuries in preclinical models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A search was performed in PubMed and Web of Science involving various animal models undergoing vocal fold, trachea, and laryngotracheal injury and/or wound healing studies from 2013 to 2023. Articles were independently screened and selected by four reviewers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 1279 filtered studies, 197 studies were identified and categorized by species, study duration, and mechanism of injury (MOI): vocal fold stripping, intubation, lasers, microtools, scraping, and other MOIs. Within each MOI, studies were grouped by animal model, with subsections discussing tissue target, research aim, analysis method, and study duration. Leporine and rat models were the most employed animal models for both vocal fold wound healing and laryngotracheal models. Leporine studies had the broadest diversity in MOIs, with lasers, microtools, scraping, and other methods used. Comparatively, rat studies primarily utilized vocal fold stripping as a MOI, perhaps second to anatomic limitations. Larger species, specifically porcine models, were most prevalent in intubation injury studies. Ferret, mouse, and ovine models were less utilized. Study duration varied from 1 day to 3 months in vocal fold injury models and 30 min to 12 months in laryngotracheal injuries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review provides a foundational framework to collate and interpret available data on preclinical vocal fold and laryngotracheal injury models to guide future study design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Five scoping review/NA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen Matrix Combined With Hydroxyapatite and Nasoseptal Flap for Skull Base Reconstruction","authors":"Maithrea Suresh Narayanan,&nbsp;Sung Seok Ryu,&nbsp;Jang Wook Gwak,&nbsp;Young-Hoon Kim,&nbsp;Ji Heui Kim","doi":"10.1002/lio2.70192","DOIUrl":"https://doi.org/10.1002/lio2.70192","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Extended endoscopic endonasal transsphenoidal approaches (ExEETSA) commonly result in high-flow cerebrospinal fluid (CSF) leaks that demand robust reconstruction strategies. Although nasoseptal flap (NSF) is a standard reconstructive technique, high-flow grade 3 CSF leaks require additional rigid reconstruction. This study evaluated the long-term outcomes of collagen matrix-hydroxyapatite (HXA)-NSF for rigid skull base reconstruction without lumbar drain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective cohort study was conducted on 100 patients undergoing ExEETSA involved intraoperative high-flow grade 3 CSF leak that were managed using a collagen matrix for dural repair followed by HXA and NSF reconstruction without lumbar drainage between January 2016 and December 2023. The primary outcomes assessed were postoperative CSF leakage, meningitis, and HXA-related complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median skull base defect diameter was 22.9 mm. Tuberculum sellae meningioma represented the predominant pathology (39.0%), with the transplanum/transtuberculum region being the most commonly affected area (77.0%). Postoperative CSF leakage occurred in 4% of cases. HXA exposure accompanied by partial NSF necrosis was observed in eight patients (8.0%). Of these, complete re-mucosalization of the exposed HXA surface was achieved in five patients (62.5%), with a mean healing time of 23.6 months. There were no cases of meningitis or local infection requiring reoperation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of collagen matrix, HXA, and NSF without lumbar drainage represents a safe and effective reconstruction strategy for managing intraoperative high-flow Grade 3 CSF leaks in ExEETSA. This reconstructive technique yielded favorable outcomes, characterized by a low incidence of postoperative CSF leakage, manageable complications, and sustained long-term effectiveness.</p>\u0000 \u0000 <p><b>Level of Evidence</b>: IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Childhood Tonsillectomy on Adult Height—A Study of the UK Biobank","authors":"Wendan Gong,&nbsp;Ioannis Psychogios,&nbsp;Yihan Hu,&nbsp;Shangjun Li,&nbsp;Wenwen Chen,&nbsp;Jiaming Su,&nbsp;Huan Song,&nbsp;Xue Xiao,&nbsp;Zhe Zhang,&nbsp;Yi Huang,&nbsp;Fang Fang","doi":"10.1002/lio2.70213","DOIUrl":"https://doi.org/10.1002/lio2.70213","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Previous studies have suggested a postoperative “catch-up growth” in children undergoing tonsillectomy. Given the tonsils' crucial role in early immune development, examining long-term effects is imperative. This study aims to investigate the impact of tonsillectomy in early life on adult height and height disparity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the UK Biobank, we compared individuals with a childhood tonsillectomy to individuals without such an experience, after matching them individually by age and sex. We used standing height measured at recruitment to the UK Biobank as attained adult height, polygenic risk score (PRS) for height as a proxy for genetically determined height, and height deviation and height deficit as proxies for height disparity. We assessed the association of tonsillectomy with these outcomes, using a linear mixed-effect model or conditional logistic regression, after multivariable adjustment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Individuals with a childhood tonsillectomy had a slightly higher attained adult height (mean: 169.0 cm; standard deviation [SD] 9.23) compared to their age- and sex-matched comparators (mean: 168.5 cm; SD 9.30). After multivariable adjustment, childhood tonsillectomy was associated with a marginally higher attained adult height (<i>β</i>: 0.34; 95% confidence interval [CI]: 0.26–0.41), a positive height deviation (<i>β</i>: 1.7; 95% CI: 1.4–2.1), and lower odds of height deficit (odds ratio [OR]: 0.89; 95% CI: 0.87–0.92), but not PRS for height (<i>β</i>: −0.24; 95% CI: −0.50 to 0.03). The first three associations were more pronounced among individuals with a lower PRS for height, compared to those with a higher PRS for height. The magnitude of the associations for adult height and height deviation also appeared to decrease with increasing age at surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Individuals with childhood tonsillectomy did not demonstrate height disparity as adults, compared to individuals without such a procedure or relative to their genetically determined height.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks Associated With Extent of Surgical Management for Benign, Non-Toxic Goiter","authors":"Jacob S. Brady,&nbsp;Neeraja Konuthula,&nbsp;Austin Lam,&nbsp;Sean Massa,&nbsp;Zain H. Rizvi","doi":"10.1002/lio2.70214","DOIUrl":"https://doi.org/10.1002/lio2.70214","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Surgery for benign, non-toxic thyroid goiter remains the most common indication for thyroidectomy worldwide, yet the optimal surgical extent remains controversial. While total thyroidectomy is assumed to have greater risks than lobectomy, the difference in complications has not been quantified. The objectives of this study are to (1) compare the risk of surgical complications and (2) quantify the magnitude of this risk difference.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This is a retrospective analysis utilizing the National Surgical Quality Improvement Program (NSQIP) Thyroid-Specific Dataset harmonized with the general NSQIP dataset for the years 2016–2020. The study was designed to determine if total thyroidectomy is independently associated with postoperative complications when compared to thyroid lobectomy using multivariable analyses controlling for confounding factors. Exposure groups were lobectomy (CPT 60220) and total thyroidectomy (CPT 60240). Outcomes included overall complications, thyroidectomy-specific complications (hypocalcemia prior to discharge, hypocalcemia within 30 days of discharge, clinically severe hypocalcemia, recurrent laryngeal nerve dysfunction, neck hematoma), other surgical complications (infections, wound disruption, and blood transfusion), medical complications, unplanned readmission, reoperation, length of stay, and operative time.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eight thousand nine hundred twenty-nine thyroidectomies were included: 5052 lobectomies and 3877 total thyroidectomies. Total thyroidectomy was associated with significantly greater odds of any complication (OR = 1.8, CI = 1.5–2.2), any thyroidectomy-specific complication (OR = 1.9, CI = 1.6–2.3), increased odds of RLN dysfunction (OR = 1.5, CI = 1.2–1.9), hypocalcemia prior to discharge (OR = 3.8, CI = 2.2–6.7), hypocalcemia after discharge (OR = 4.6, CI = 3.1–6.8), and severe hypocalcemia (OR = 5.4, CI = 3.2–9.0). Rates of unplanned readmission (OR = 1.5, CI = 1.1–2.3), length of hospital stay (+ 0.33 days, CI = 0.1–0.5), and operative time (+ 26.1 min. CI = 23.7–28.6) were also increased in total thyroidectomy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this largest study to date, when controlling for comorbidity, extent of disease, and calcium repletion, total thyroidectomy patients had significantly greater rates of surgical and medical complications, as well as readmission. These data should inform shared decision making when determining extent of surgical intervention for this di","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Resolution Pharyngeal Manometry Assessment of Swallowing in Asymptomatic Myotonic Dystrophy","authors":"Rie Asayama,&nbsp;Kaori Tanaka-Nishikubo,&nbsp;Keiko Tanaka,&nbsp;Naohito Hato","doi":"10.1002/lio2.70209","DOIUrl":"https://doi.org/10.1002/lio2.70209","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Myotonic dystrophy (MyD) adversely affects swallowing function from an early stage. However, the swallowing characteristics of patients with MyD, who rarely seek medical attention owing to a lack of subjective symptoms, remain unclear. We aimed to analyze multifaceted swallowing function tests, including high-resolution manometry (HRM), in patients with asymptomatic MyD and evaluate the swallowing pathophysiology in these patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included patients who underwent HRM and swallowing function tests, including videofluoroscopic swallow study (VFSS), at our hospital. We analyzed the results along with the clinical and demographic profiles of the patients, comparing them to those in a non-MyD control group of patients with mild dysphagia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The MyD group demonstrated significantly decreased swallowing motility on VFSS and reduced pharyngeal contraction force at all stages from the pharynx to the upper esophageal sphincter (UES) on HRM. In the non-MyD control group, a weak negative correlation was observed between maximum pharyngeal contraction force and minimum UES pressure during swallowing. Conversely, in the MyD group, the minimum UES pressure remained consistently low, regardless of weak pharyngeal contraction force.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study confirmed that patients with MyD exhibited significant motor disorders of swallowing-related muscles even when unaware of their dysphagia. While constant UES relaxation may help maintain swallowing, particularly for liquids, it hinders patients' ability to recognize their swallowing problems and can lead to sudden choking episodes. Early risk management and intervention are, thus, necessary for patients with MyD, even those unaware of their dysphagia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologic Therapy Relieves Otologic Symptoms and Signs in Patients With Asthma and Chronic Rhinosinusitis With Nasal Polyps","authors":"Anna Suikkila,&nbsp;Annina Lyly,&nbsp;Riitta Saarinen,&nbsp;Marie Lundberg,&nbsp;Lena Hafrén","doi":"10.1002/lio2.70212","DOIUrl":"https://doi.org/10.1002/lio2.70212","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Multiple biologics are available for severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Otologic symptoms are common among these patients, and otitis media (OM) is considered part of the associated eosinophilic multimorbidity. However, few studies describe the effect of biologics on OM. This study aimed to explore whether type 2 anti-inflammatory biologics can also alleviate otologic symptoms and signs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrieved patients who were prescribed biologics for CRSwNP from the electronic patient records (EPRs) of a tertiary referral ear, nose, and throat center. We also included patients from two previous studies on otologic manifestations of NSAID-exacerbated respiratory disease (NERD), who were prescribed biologic medication at a skin and allergy center. Patients who were followed up for less than 12 months were excluded. Demographic information and the response to the biologic therapy were collected from EPRs. Regular appointments were at 0, 4–8, and 12 months, and included a physical examination by ear, nose, and throat (ENT) specialist and two validated patient-reported outcome measures (PROMs): the Sino-Nasal Outcome Test-22 (SNOT-22) and the otology-specific Ear Outcome Survey-16 (EOS-16).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All of the 40 patients included had CRSwNP, and 90% had asthma. A total of 17 (42.5%) had clinical otologic signs before starting biologic medication. The main indications for biologic therapy were CRSwNP (70%) and asthma (22.5%). Three patients (7.5%) had both CRSwNP and asthma, but their severe OM symptoms were the main indication for biologic therapy. The SNOT-22 scores were significantly lower at 12 months in all the ear/facial domain questions: ear fullness (<i>Z</i> = −3.434, <i>p</i> &lt; 0.001), dizziness (<i>Z</i> = −3.452, <i>p</i> &lt; 0.001), ear pain (<i>Z</i> = −3.097, <i>p</i> = 0.002), and facial pain/pressure (<i>Z</i> = −3.133, <i>p</i> = 0.002). Similarly, the EOS-16 yielded significantly lower scores (Z = −2.791, <i>p</i> = 0.005). Additionally, the clinical otologic signs improved (<i>Z</i> = −2.994, <i>p</i> = 0.003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The biologics prescribed for asthma and CRSwNP significantly reduced otologic symptoms and signs. Prospective studies are warranted to explore associated OM as a new target for biologic therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Oral Health Disparity Among Refugee Children: A Systematic Review","authors":"Nazineen Kandahari,&nbsp;Fareha Moulana Zada,&nbsp;Zainab Farzal","doi":"10.1002/lio2.70194","DOIUrl":"https://doi.org/10.1002/lio2.70194","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We sought to understand oral health problems among refugee children resettled in developed nations and determine best practices for addressing them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was performed and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search was performed using the PubMed, CINAHL, and Scopus databases from 1980 through 2024 using Medical Subject Heading terms: “children,” “refugee,” and “oral health,” and a separate search in which “oral health” was replaced with “dental caries.” Interventional, qualitative, and epidemiological studies about children resettled in developed nations were included. Critical study appraisal was done using the Critical Appraisal Skills Program (CASP) tool developed at Oxford University. Final data were synthesized in tables and graphs, depicting the study designs, locations, dates of data collection, sample sizes, sample characteristics, and major findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 30 studies, 25 analyzed oral health in refugee children directly, and six were qualitative studies interviewing parents/caregivers and key informants. Twelve cross-sectional studies included clinical exams, identifying as many as 78% of refugee children with dental caries. Eight studies comparing refugee children to age-and sex-matched children in respective developed countries showed refugee status conferred significantly worse oral health. Two interventional studies demonstrated that parental education improved knowledge but did not improve children's oral health, whereas oral screenings at dedicated refugee health clinics facilitated children receiving referrals and completing treatment. Review data was limited by the lack of standardized or comprehensive measures of oral health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The refugee pediatric population is at higher risk of oral disease than nonrefugee immigrant and native-born patient populations. Developed nations should address this disparity with community and healthcare partnerships and research, particularly prospective and interventional studies. Otolaryngologists care for the clinical consequences of poor oral health and hygiene and therefore share responsibility in facilitating preventive efforts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Surgical Intervention in Adults With Recurrent Acute Rhinosinusitis","authors":"Obadah Tolaymat,&nbsp;Ruifeng Cui,&nbsp;John Dewey,&nbsp;Hassan H. Ramadan,&nbsp;Chadi A. Makary","doi":"10.1002/lio2.70211","DOIUrl":"https://doi.org/10.1002/lio2.70211","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The need for surgical intervention in patients with recurrent acute rhinosinusitis (RARS) is not well defined. The goal of this study is to understand the different factors that predict receiving surgical intervention in patients with RARS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cohort study of adult patients presenting with RARS with at least one objective evidence of rhinosinusitis. Patient characteristics and comorbidities were reviewed. The 22-item sinonasal outcome test (SNOT-22) and endoscopy scores were collected at baseline. Surgical intervention consisted of functional endoscopic sinus surgery (FESS) with or without septoplasty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and eighteen patients were included, of which 53 patients underwent surgical intervention during a mean follow-up period of 5.4 (±5.3) months. Patients who underwent surgery were significantly younger (30.0 vs. 48.8, <i>p</i> &lt; 0.01), had higher BMI (43.1 vs. 31.9, <i>p</i>&lt; 0.01), higher CT LM scores (5.3 vs. 2.7, <i>p</i> &lt; 0.01), and were more likely to have nasal septal deviation (NSD) (64.2% vs. 41.5%, <i>p</i> = 0.01). Gender, endoscopy scores, SNOT-22 total and domain scores, and rates of other medical comorbidities did not significantly differ by cohort (<i>p</i> &gt; 0.05 for all). On multivariate analysis, age (OR = 0.89, 95% CI: 0.85, 0.94), BMI (1.05, 95% CI: 1.05, 1.18), CT scores (OR = 1.28, 95% CI: 1.10, 1.48), and NSD (3.52, 95% CI: 1.10, 11.28) remained significant predictors for surgical intervention in patients with RARS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RARS patients who proceed to surgical intervention are younger, have higher BMI, and have higher objective disease burden, including evidence of NSD and higher CT LM scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}