Laryngoscope Investigative Otolaryngology最新文献

{"title":"Low Skeletal Muscle Mass as a Key Predictor of Postoperative Diet Outcomes in Circumferential Hypopharyngeal Cancer Reconstruction.","authors":"Hiroki Kodama, Doruk Orgun, Haruyuki Hirayama, Keita Kishi, Samuel O Poore, Aaron M Wieland, Katsuhiro Ishida, Takeshi Miyawaki","doi":"10.1002/lio2.70373","DOIUrl":"https://doi.org/10.1002/lio2.70373","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between preoperative lumbar skeletal muscle index (LSMI) and postoperative dietary outcomes (regular diet versus texture-modified diet) in patients undergoing circumferential hypopharyngeal cancer resection with tubed anterolateral thigh flap reconstruction.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included 73 patients between 2009 and 2020. LSMI was calculated from lumbar skeletal muscle cross-sectional area at the C3 vertebral level on preoperative CT scans. The primary outcome was dietary restriction, defined as Functional Oral Intake Scale ≤ 6 at ≥ 12 months postoperatively. Candidate predictors (pre-, intra- and postoperative) with <i>p</i> < 0.20 in univariate screening underwent theory-driven confounder assessment based on directed acyclic graphs, prior literature, and clinical knowledge. Change-in-estimate criterion (Δ<i>β</i> ≥ 10%) supported selecting confounding. LSMI components (C3CSA, L3CSA, age, sex, weight, height, BMI) were excluded from adjustment to prevent overadjustment for mediators and multicollinearity. The final model analyzed LSMI as a continuous predictor with logistic regression.</p><p><strong>Results: </strong>Fifteen patients (20.5%) developed dietary restriction (FOIS < 7). Three confounders (Eichner A, Stage IV, hemoglobin) for LSMI were identified. Multivariable adjustment improved model fit (AIC: 65.8 → 63.4; Nagelkerke <i>R</i> ²: 0.237 → 0.383) while maintaining statistical significance. Each 1 cm²/m² increase in LSMI was associated with a 16.1% reduction in the odds of FOIS < 7 (adjusted OR: 0.839; <i>p</i> = 0.006). The optimal LSMI cut-off value was 42.82 cm²/m².</p><p><strong>Conclusion: </strong>Preoperative LSMI independently predicts long-term dietary outcomes after hypopharyngeal reconstruction. Restricting the cohort to uniform resection and reconstruction methods clarified the relationship between skeletal muscle mass and swallowing function, enabling precise risk stratification and supporting targeted prehabilitation interventions.</p><p><strong>Level of evidence: </strong>4.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 2","pages":"e70373"},"PeriodicalIF":1.7,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Numerical and Experimental Investigations on Endolaryngeal Mobilization.","authors":"Weibing Cai, Azure Wilson, Guofeng He, Elizabeth Hary, Ivan Tkac, Stephanie Misono, Lea Sayce, Zheng Li","doi":"10.1002/lio2.70419","DOIUrl":"https://doi.org/10.1002/lio2.70419","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate how subperichondrial mobilization affects implant-tissue mechanics, glottal configuration, and vibratory behavior in computational simulations of medialization laryngoplasty (ML).</p><p><strong>Methods: </strong>We used a finite-discrete element method (FDEM) framework to simulate subperichondrial tissue-cartilage separation and implant insertion in laryngeal models reconstructed from high-resolution magnetic resonance imaging. Four dissection conditions were evaluated, ranging from no mobilization to increasing dissection length distal to the thyroplasty window. Outcome measures included change in glottal area, vocal fold medial displacement, finite element fracturing along the tissue-cartilage interface, and estimated vibratory frequency.</p><p><strong>Results: </strong>Increasing dissection length produced increased medial displacement, progressive reductions in glottal area, fewer secondary extensions of the dissection plane during implantation, and higher estimated vibratory frequencies (range: 100.4-120.8 Hz). These findings indicate that subperichondrial tissue mobilization alters implant-induced force transmission and modifies boundary conditions relevant to vibration.</p><p><strong>Conclusion: </strong>In this first application of FDEM to simulate laryngeal biomechanics in ML, subperichondrial dissection length demonstrated direct effects on model predictions relevant to implant sizing, placement strategy, and anticipated phonatory outcomes. Incorporating tissue mobilization into computational frameworks as a mechanically meaningful variable improves physiological realism and supports future development of subject-specific surgical planning tools.</p><p><strong>Level of evidence: </strong>Level V. This study provides preclinical computational evidence using FDEM, supporting and extending clinical observations in ML.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70419"},"PeriodicalIF":1.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Intravenous Immunoglobulin Therapy With Healthcare Utilization in Immunodeficient Adults With Chronic Rhinosinusitis.","authors":"Mitchell Figueroa, Jaynelle Gao, Connie J Tian, Kevin Hur","doi":"10.1002/lio2.70424","DOIUrl":"https://doi.org/10.1002/lio2.70424","url":null,"abstract":"","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70424"},"PeriodicalIF":1.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss and Chronic Rhinosinusitis in the Obese Population: Associations With Disease Risk and Burden.","authors":"Zain Mehdi, Akshay R Prabhakar, Jagan M R Dwarampudi, Justina R Varghese, Heli Majeethia, Faizaan Khan, Roshan Dongre, Franklin M Wu, Aatin Dhanda, Sebastian Guadarrama-Sistos-Vazquez, Tania Banerjee, Renjie Hu, Amber U Luong, Dennis M Tang, Edward D McCoul, Mohammad Chaaban, Masayoshi Takashima, Omar G Ahmed","doi":"10.1002/lio2.70416","DOIUrl":"https://doi.org/10.1002/lio2.70416","url":null,"abstract":"<p><strong>Objective: </strong>Obesity is associated with increased risk and severity of chronic rhinosinusitis (CRS), yet the impact of weight loss (WL) on CRS development and burden is not well defined. This study investigates whether weight reduction influences the likelihood of developing CRS and improves clinical outcomes among obese adults.</p><p><strong>Methods: </strong>Retrospective cohort study using the NIH All of Us database. Obese adults (BMI ≥ 30) with complete demographics and follow-up were included. To assess CRS onset, patients were stratified into sequential WL cohorts and followed for 1 year. To assess CRS outcomes, patients who lost ≥ 5 BMI points were categorized into any WL (AWL), unsustained WL (UWL), or sustained WL (SWL; ≥ 1, 2, 3 years) and compared with no WL (NWL) controls matched on demographics and healthcare visit frequency. Time-to-event analyses used Kaplan-Meier and Cox models to evaluate CRS onset. Among CRS patients, follow-up visits, new nasal symptoms, and medication use were analyzed using odds ratios (ORs).</p><p><strong>Results: </strong>Among 3203 obese patients, a ≥ 5-BMI decrease was associated with reduced CRS risk versus NWL (HR 0.57, 95% CI 0.37-0.87). Of 2714 obese CRS patients, 537 lost weight. Two-year SWL was associated with fewer follow-up CRS visits versus NWL (10.4% vs. 20.1%; OR 0.46, 95% CI 0.24-0.90). Any SWL demonstrated lower odds of nasal symptoms, and 2-year SWL demonstrated reduced antibiotic usage (OR 0.43, 95% CI 0.21-0.88).</p><p><strong>Conclusion: </strong>Sustained WL may reduce both the risk of developing CRS and the burden of ongoing disease, supporting its relevance as a potential adjunctive management strategy.</p><p><strong>Level of evidence: </strong>Level III.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70416"},"PeriodicalIF":1.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swedish Translation and Psychometric Validation of the Paediatric Throat Disorders Outcome Test (T-14).","authors":"Hanna Gerhardsson, Anders Broström, Fredrik Alm, Sara Axelsson, Pia Nerfeldt, Erik Odhagen, Ola Sunnergren","doi":"10.1002/lio2.70413","DOIUrl":"https://doi.org/10.1002/lio2.70413","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to translate the T-14 questionnaire into Swedish and validate it in a Swedish pediatric population with tonsil-related disease.</p><p><strong>Methods: </strong>A prospective validation study was conducted across five Swedish otorhinolaryngology departments from October 2022 to June 2024. Translation followed a standardized forward-backward procedure. Caregivers of patients (< 16 years) scheduled for tonsil surgery completed the Swedish T-14 and EQ-5D-Y VAS (EuroQol five-Dimensional questionnaire for Youth, Visual Analog Scale [VAS]) at baseline, 2 weeks later, and 6 months postoperatively. A healthy control group was included for comparison. Psychometric evaluation included known-groups validity (Mann-Whitney <i>U</i>), construct validity (confirmatory factor analysis), convergent validity (Spearman's correlation), internal consistency (Cronbach's <i>α</i>), test-retest reliability (intraclass correlation coefficient), and responsiveness (Wilcoxon signed-rank, Cohen's <i>d</i>).</p><p><strong>Results: </strong>A total of 249 participants were included (case group 169, control group 80). Known-groups validity was confirmed, with significantly higher baseline T-14 scores in the case group (<i>p</i> < 0.001). Confirmatory factor analysis supported the predefined two-factor model (comparative fit index = 0.94, Tucker-Lewis index = 0.92, standardized root mean square residual = 0.061), although root mean square error of approximation (0.099) indicated some misfit. Convergent validity was demonstrated by a weak but significant negative correlation with EQ-5D-Y VAS (<i>r</i>s = -0.32; <i>p</i> < 0.001). Internal consistency was good (<i>α</i> = 0.83), and test-retest reliability showed good stability (ICC = 0.77). Responsiveness was strong, with a large reduction in T-14 scores 6 months after surgery (<i>p</i> < 0.001; Cohen's <i>d</i> = 1.89).</p><p><strong>Conclusion: </strong>T-14 demonstrated good validity, reliability, and responsiveness, effectively distinguishing patients from healthy controls. It is suitable for clinical use and enables comparisons with international studies.</p><p><strong>Level of evidence: </strong>Level III-non-randomized controlled cohort.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70413"},"PeriodicalIF":1.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-Graft for Single Stage Laryngotracheal Reconstruction: Revisiting a Previously Described Technique.","authors":"Miles J Klimara, Deepa Shivnani, J Scott McMurray, Matthew R Hoffman","doi":"10.1002/lio2.70426","DOIUrl":"https://doi.org/10.1002/lio2.70426","url":null,"abstract":"<p><strong>Objective: </strong>Use of costal cartilage grafts for longer segment anterior graft laryngotracheal reconstruction can pose a risk for the inferior aspect of the graft prolapsing into the airway lumen. This is particularly true when incorporating a tracheostoma into the reconstruction. Use of two costal cartilage grafts combined to form an inverted T-shape can be helpful in addressing this issue. This technique has been previously described in two reports but is not widely used. We review the technical aspects of this approach and outcomes in two patients.</p><p><strong>Methods: </strong>Two pediatric patients with subglottic/tracheal stenosis and tracheostomy underwent SS-LTR using inverted T-shaped costal cartilage grafts. The vertical limb was secured to expand the subglottic/proximal tracheal airway, while the horizontal segment provided wider coverage of the stomal defect and supported the inferior aspect of the vertical limb. The technical details and postoperative course are reviewed.</p><p><strong>Results: </strong>Both patients exhibited successful airway healing without evidence of graft prolapse or dehiscence. The T-graft supported the inferior aspect of the reconstruction effectively and closed the stomal defect without tension. Follow-up endoscopic evaluation confirmed a patent airway with stable graft integration. Serial excision of foci of granulation was required postoperatively.</p><p><strong>Conclusion: </strong>The previously described but infrequently reported inverted T-graft technique is a useful approach for longer segment stenosis. Larger series with longer follow-up are needed to clarify long-term outcomes.</p><p><strong>Level of evidence: </strong>4.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70426"},"PeriodicalIF":1.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into Retrograde Cricopharyngeus Dysfunction (R-CPD) Through Analysis of Internet Search Pattern.","authors":"Hardeep S Tiwana, Xiang Yu Gao, Kevin J Fujita-Howie, Benjamin A Lerner, Michael Z Lerner","doi":"10.1002/lio2.70425","DOIUrl":"https://doi.org/10.1002/lio2.70425","url":null,"abstract":"<p><strong>Objectives: </strong>To assess public awareness and interest in retrograde cricopharyngeus dysfunction (R-CPD) in the United States by analyzing trends in internet search behavior.</p><p><strong>Methods: </strong>Using Google Trends, data from Google Search queries from the United States related to R-CPD between January 2013 to May 2024 were obtained. The means of RSV from 2013 to 2018 were compared to RSV from 2019 (when R-CPD was officially defined) to the present. Comparisons of the RSV means between these two periods were performed using paired <i>t</i>-tests with <i>p</i> value < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Google Trends data from January 2013 through May 2024 were analyzed for 24 R-CPD-related search terms. Mean RSV values from 2013 to 2018 were compared with those from 2019 to 2024, corresponding to the period following formal description of R-CPD. The mean RSV for \"R-CPD\" increased by 116% (11.5 ± 3.9 vs. 24.6 ± 15.4; <i>p</i> < 0.002). Significant increases were also observed for related symptom-based queries, including \"why can't I burp\" (4.3 ± 4.8 vs. 17.6 ± 4.8; <i>p</i> < 0.002), \"can't burp\" (5.9 ± 1.2 vs. 9.3 ± 1.6; <i>p</i> < 0.002), \"need to burp\" (35.7 ± 10.0 vs. 61.7 ± 9.9; <i>p</i> < 0.002), and \"no burp\" (10.9 ± 4.0 vs. 18.4 ± 5.9; <i>p</i> < 0.002). Across all terms, metropolitan areas demonstrated consistently higher RSVs than broader regional areas.</p><p><strong>Conclusion: </strong>Search interest related to R-CPD has increased significantly since its formal description, suggesting rising public awareness and information-seeking behavior. Higher search volumes in metropolitan areas may reflect increased recognition, access to specialty care, or disease awareness in urban settings.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70425"},"PeriodicalIF":1.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Septoplasty With Sinonasal and Related Outcomes in Adults With Nasal Septal Deviation.","authors":"Mitchell Figueroa, Kevin Hur","doi":"10.1002/lio2.70414","DOIUrl":"https://doi.org/10.1002/lio2.70414","url":null,"abstract":"","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70414"},"PeriodicalIF":1.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gabapentinoids for Upper Airway Surgery Pain Management: Systematic Review and Meta-Analysis.","authors":"Andrew Stephen Franklin, Chad Alexander Nieri, Meghana Chowdhary Chanamolu, Alex Leonardo Jin, Lauren Reid, Jenessa McElfresh, M Boyd Gillespie","doi":"10.1002/lio2.70390","DOIUrl":"https://doi.org/10.1002/lio2.70390","url":null,"abstract":"<p><strong>Objectives: </strong>Assess the analgesic and potential adverse effects of gabapentinoids in patients undergoing upper airway surgery (UAS).</p><p><strong>Methods: </strong>A systematic review and meta-analysis was conducted following PRISMA guidelines. Data sources included Ovid Medline, Embase, Scopus, and Cochrane. All RCTs and cohort studies from June 2002 to August 2024 regarding treatment outcomes of gabapentinoids for UAS were extracted. Studies were subjected to a two-reviewer blinded screening, extraction, and appraisal process. Assessment of study quality was implemented via the NIH quality assessment tool for RCTs. Primary outcome was decreased postoperative pain. Secondary outcomes included adverse drug events and opiate needs postoperatively.</p><p><strong>Results: </strong>Out of 397 studies screened, 21 met inclusion criteria. There were 828 gabapentinoid patients and 684 controls. Twelve studies were adenotonsillectomies and tonsillectomies, six were septoplasties, one was septoplasty with and without turbinoplasty, one lateral pharyngoplasty and tonsillectomy, and one maxillomandibular advancement. Appraisal revealed studies were of low (18) and moderate (3) risk of bias. Meta-analyses with subgroupings as appropriate were performed for these categories: pain score at 0-2 and 16-24 h; opioid consumption post-surgery; minutes to first analgesia; postoperative dizziness, nausea, and vomiting. Gabapentinoids significantly lowered pain levels 0-2 and 16-24 h postoperatively, decreased opioid consumption, and increased time to first analgesia.</p><p><strong>Conclusion: </strong>This review of current scientific literature supports perioperative use of gabapentinoids for UAS to reduce postoperative pain and lower analgesic requirement. Future studies should include larger cohorts with standardized protocols regarding timing, dosing of medication, objective measurements, proper blinding procedures for study personnel, and robust statistical analysis.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 2","pages":"e70390"},"PeriodicalIF":1.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histology of Minor Salivary Glands in Tonsillar Diseases.","authors":"Nelli Vanhapiha, Johanna Wikstén, Enni Sanmark, Jaana Hagström, Karin Blomgren","doi":"10.1002/lio2.70420","DOIUrl":"https://doi.org/10.1002/lio2.70420","url":null,"abstract":"<p><strong>Objectives: </strong>To explore a possible difference in the histology of the minor salivary glands in the peritonsillar space between patients with peritonsillar abscess, acute tonsillitis, or tonsillar hypertrophy. To compare if there were remnants of possible changes in elevated serum amylase and its isoenzymes between these three groups to clarify the ambiguous etiology of peritonsillar abscess.</p><p><strong>Methods: </strong>This is a cross-sectional study, in which we analyzed 75 tonsil and blood samples collected from patients with peritonsillar abscess, acute tonsillitis, or tonsillar hypertrophy prior to tonsillectomy. Histological findings of minor salivary glands in peritonsillar space were examined. Serum C-reactive protein, serum amylase, and its isoenzymes (pancreatic type and the salivary type) were analyzed from blood samples collected in conjunction with tonsillectomy.</p><p><strong>Results: </strong>Minor salivary glands were present in 62 (82.7%) tonsil samples. Peritonsillar abscess group exhibited more periductal inflammation in the minor salivary glands (85.0%) than in the acute tonsillitis (70.6%) or hypertrophy group (28.0%) (<i>p</i> = 0.001). There was no difference in serum amylase (<i>p</i> = 0.864), pancreatic type amylase isoenzyme (<i>p</i> = 0.776), or salivary type amylase isoenzyme <i>(p</i> = 0.963) between the three groups.</p><p><strong>Conclusion: </strong>Peritonsillar abscess patients had more periductal inflammation in the minor salivary glands than acute tonsillitis or hypertrophy patients, suggesting that peritonsillar abscess may originate from an infection of the minor salivary glands. Blood samples for amylase isoenzymes should be collected during the acute phase of the disease to obtain additional information about the link between peritonsillar abscess and minor salivary gland activity.</p><p><strong>Level of evidence: </strong>3.</p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"11 ","pages":"e70420"},"PeriodicalIF":1.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}