Laryngoscope Investigative Otolaryngology最新文献

{"title":"A Novel Hybrid Solution for Hearing Impairments","authors":"Hassan Alshehri,&nbsp;Medhat Yousef,&nbsp;Anas Ibrahim,&nbsp;Yassin Abdelsamad,&nbsp;Farid Alzhrani","doi":"10.1002/lio2.70089","DOIUrl":"https://doi.org/10.1002/lio2.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Conventional hearing aids (HAs) and bone conduction devices have limitations in providing clear and audible sound in some cases and situations. The clinicians' primary purpose is to enhance audibility and intelligibility in hearing, offering a solution for users dissatisfied with current hearing technologies. This study proposes a novel hybrid system and investigates its performance compared to HAs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This pilot study compares the performance of a novel hybrid system with traditional HAs. Ten HA users underwent a prospective intra-subject study at a tertiary hearing center. Audiological tests measured unaided and aided thresholds across specific frequencies in two conditions (HAs and Hybrid system). Furthermore, subjective outcomes were assessed via a questionnaire on the perceptual consequences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The patient's mean age was 36 years. The mean PTA4 values were 63.75, 40.74-, and 37.88-dB HL in the unaided, HA-aided, and Hybrid-aided groups, respectively. The speech reception thresholds varied significantly between the unaided and (i) aided using HA (<i>p</i> = 0.0009) and (ii) aided using the Hybrid solution (<i>p</i> = 0.0001). There is no significant variation between HA and Hybrid solutions (<i>p</i> &lt; 0.4195). The mean SDS at 65 dB using the HA and Hybrid solution was 87% and 90%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The proposed Hybrid system, combining conventional air-conduction HAs with bone-conduction devices, offers promising improvements in sound quality and user satisfaction. Further studies are essential to fully understand the Hybrid system's capabilities and evaluate its ability to avoid the dissatisfaction that could result from HA in some instances.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Prospective cohort study (Level 3).</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Effect of Allium tuncelianum Extract: Topical Application Improves Wound Healing in a Nasal Septal Perforation Rat Model","authors":"Doğan Çakan,&nbsp;Zeliha Kübra Çakan,&nbsp;Gülderen Yılmaz,&nbsp;David Yeung,&nbsp;Gülnur Ekşi Bona","doi":"10.1002/lio2.70095","DOIUrl":"https://doi.org/10.1002/lio2.70095","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of the current study was to investigate the influence of <i>Allium tuncelianum</i> (AT) extract on wound healing in a nasal septum perforation (NSP) model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-two healthy male Sprague–Dawley rats were included in this study and separated into two groups. A standardized NSP was created in each subject. A 0.09% saline (control group) and the 25% AT solution (study group) were delivered intranasally daily for 14 days. At the end of the experiment, the subjects were sacrificed and the septa were excised for histopathological investigation. The macroscopic closure rate of NSP, intranasal pH, counts of acute inflammatory cells, eosinophil, fibroblast, and giant cell, epithelial regeneration and degeneration, vascularization, granulation formation, collagen density, cartilage regeneration, and degeneration were examined. The obtained data were analyzed statistically.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The macroscopic closure rate (<i>p</i> = 0.006), the fibroblast number (<i>p</i> = 0.003), vascularization (<i>p</i> = 0.003), collagen density (<i>p</i> = 0.044), and granulation tissue amount (<i>p</i> = 0.022) were found to be significantly higher in AT group. However, the acute inflammatory cells count was significantly lower in AT group (<i>p</i> = 0.031) (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The topically delivered AT extract may improve wound healing in an experimental NSP model. Consequently, the local application of AT might be promising to prevent the formation of NSP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No-Shows in a Tertiary Care Pediatric Otolaryngology Clinic: Predictors and Impact on Provider Productivity","authors":"Yukta Sunkara,&nbsp;Seckin O. Ulualp,&nbsp;Kimberly Robinson,&nbsp;Felicity Lenes-Voit,&nbsp;Christopher C. Liu,&nbsp;Ron B. Mitchell","doi":"10.1002/lio2.70097","DOIUrl":"https://doi.org/10.1002/lio2.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>No-show appointments (NS) lead to a mismatch between supply and expected demand, operational inefficiency, decreased access to care, and economic deficit. We evaluated the predictors and impact of NS on provider productivity in a tertiary pediatric otolaryngology clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who had a pediatric otolaryngology clinic appointment were identified. Demographics, type of appointment and clinic visit, provider, insurance, appointment lead time, time of the appointment, caregiver income, distance to the clinic, and season of the year were analyzed. Predictors of NS and loss of providers' work-RVUs and revenue were assessed. NS and non-NS populations were compared using <i>χ</i>² test for categorical variables and Mann–Whitney test for continuous variables. Multivariable analysis was performed with a binary logistics regression model for the prediction of NS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 24,593 appointments, 10,392 (42%) were female, (age median = 5 years) and of the 4627 NS 2016 (44%) were female, (age median = 5 years). Logistic regression identified male (OR: 0.093, 95% CI [0.88–0.99], <i>p</i> = 0.04), Black/African American race (OR: 1.97, 95% CI [1.72–2.26], <i>p</i> &lt; 0.001), spring (OR: 0.88, 95% CI [0.80–0.97], <i>p</i> = 0.007), summer (OR: 0.90, 95% CI [0.83–0.99], <i>p</i> = 0.04), clinic focus-general clinic (OR: 1.32, 95% CI [1.20–1.45], <i>p</i> &lt; 0.001), and appointment lead times of 0–7 days (OR: 0.36, 95% CI [0.29–0.46], <i>p</i> &lt; 0.001), 8–14 days (OR: 0.49, 95% CI [0.39–0.63], <i>p</i> &lt; 0.001), 15–30 days (OR: 0.60, 95% CI [0.47–0.76], <i>p</i> &lt; 0.001) were predictive of NS. The estimated loss of work-RVU ranged from 3852 to 14,820, and the estimated loss of revenue ranged from $276,831 to $959,908 per year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>No-show appointments led to a substantial loss of provider productivity and revenue. Of the multiple demographic and clinic visit determinants associated with high NS rates, appointment lead time can be tested in future studies of strategies to reduce NS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory-Swallow Coordination of Uncued Swallows in Dysphagic and Tracheotomized Patients","authors":"Martin Gerbert,&nbsp;Veronika Segler,&nbsp;Julia Adam,&nbsp;Arneborg Ernst,&nbsp;Benjamin Riebold,&nbsp;Philipp Mittmann,&nbsp;Rainer Seidl","doi":"10.1002/lio2.70098","DOIUrl":"https://doi.org/10.1002/lio2.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the respiratory-swallow coordination (RSC) in healthy, dysphagic, and subjects with blocked, unblocked or without tracheostomy cannula (TC) over 2 h with focus on unintended deglutition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a single center (cross-sectional) observational study, a total of 65 subjects were included. Swallowing processes were recorded using RehaIngest (Hasomed GmbH, Magdeburg, Germany), combining electromyography (EMG) and bioimpedance (BI) inputs. Group differences were calculated using non-parametric tests, the influences of age and gender were evaluated using regression analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Respiratory patterns from 3761 swallows were evaluated. Nineteen healthy and 46 dysphagic subjects, including 15 without TC, 15 with blocked TC and 16 with unblocked TC, were recorded. In the dysphagia cohort unblocked and without TC demonstrated increased post-deglutitive expiration (<i>p</i> = 0.012, <i>p</i> = 0.001) and a decrease in post-deglutitive inspiration (<i>p</i> = 0.028, <i>p</i> = 0.013) compared with healthy probands. In addition, a higher proportion of subjects demonstrating post-deglutitive expiration was recorded amongst probands with unblocked TC compared to blocked TC (<i>p</i> = 0.012). Neither age nor gender significantly impacted the aforementioned outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our novel cross-sectional study shows that the RSC adapts in a compensatory fashion in the acquired dysphagia cohort. The adaptation depends on the occurrence of dysphagia and the type of TC. If the TC cuff is blocked, patients likely have an inadequate adaptation of the RSC, mainly because of the absence of a transglottic air flow. These findings indicate that RSC and TC care should be closely incorporated into clinical routine to improve dysphagia therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>1</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analysis of MRI-related Cochlear implant adverse events reported by FDA's manufacturer and user facility device experience database","authors":"Amy Lin BS,&nbsp;Arjun K. Menta BSA, BBA,&nbsp;Syed Ameen Ahmad BS,&nbsp;Aileen Zhang BA,&nbsp;Dianela Perdomo BS,&nbsp;Ashwin Reddy BS,&nbsp;Bryan K. Ward MD","doi":"10.1002/lio2.70073","DOIUrl":"https://doi.org/10.1002/lio2.70073","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Identify MRI-related cochlear implant (CI) adverse events from the Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database and determine whether devices with diametric magnets are associated with reduced adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on MRI-related adverse events were collected from the MAUDE database for reports filed between 01/01/2013 and 01/29/2023. Outcomes and interventions were manually extracted. Device problems, electrode designs, and correlated patient problems were grouped and analyzed using R.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All CI complications were derived from three manufacturers: Cochlear Limited, Advanced Bionics, and MED-EL. MRI-related CI complications occurred in 668 of 32,446 reports (2.1%). MRI-related CI complications increased from 32 reports (4.8%) in 2013 to a peak of 142 reports (21.3%) in 2019 and decreased to 56 reports (8.4%) in 2022. The most common MRI-related device problems were dislodgment/dislocation (39.9%, <i>n</i> = 266) or migration/expulsion (33.4%, <i>n</i> = 223). The most frequently identified patient problems identified were pain (31.6%, <i>n</i> = 211), hearing impairment (4.9%, <i>n</i> = 33), unspecified medical problems (3.7%, <i>n</i> = 25), implant failure (3.0%, <i>n</i> = 20), and injury (1.5%, <i>n</i> = 10). Of these, 358 reports (53.6%) contained the date of device manufacture. The median MDR per year decreased from 11 in the 3 years before each manufacturer released their MRI-conditional CI to 0 in the 3 years following the release (<i>p</i> = 0.014).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The introduction of MRI-conditional CIs has successfully reduced MRI-associated adverse events. There have been no reported cases of MRI-related CI complications for devices containing the new MRI-conditional magnets for each of the three major US manufacturers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of evidence</h3>\u0000 \u0000 <p>N/A</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Clinical Prediction Model to Predict Malignant Transformation of Sinonasal Inverted Papilloma Based on Hematological Indices and Clinical Features","authors":"Kai Sun,&nbsp;Ce Wu,&nbsp;Zengxiao Zhang,&nbsp;Jiahong Chen,&nbsp;Xudong Yan,&nbsp;Shunke Li,&nbsp;Lin Wang,&nbsp;Longgang Yu,&nbsp;Yan Jiang","doi":"10.1002/lio2.70075","DOIUrl":"https://doi.org/10.1002/lio2.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Sinonasal inverted papilloma (SNIP) has a risk of malignant transformation into SNIP with squamous cell carcinoma (SNIP-SCC). Early detection of SNIP-SCC is crucial for patient outcomes. This study aimed to evaluate the utility of tumor-related hematological indices in the early diagnosis of SNIP-SCC and to develop a nomogram incorporating imaging and clinical features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 159 patients with SNIP with (<i>n</i> = 34) or without (<i>n</i> = 125) SCC. Univariate and multivariate logistic regression analyses were employed to identify independent risk factors and develop nomogram. The diagnostic model was evaluated using receiver operating characteristics (ROC), standard, clinical decision, and clinical impact curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Elevated serum cytokeratin fragment antigen 21-1 (CYFRA 21-1), the loss of convoluted cerebriform pattern, bone destruction, headache/facial pain, and epistaxis/blood-tinged mucus were identified as independent risk factors for SNIP-SCC. The optimal cut-off value for serum CYFRA 21-1 was 3.51 ng/mL, with the nomogram area under the ROC curve of 0.966 based on the above indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that CYFRA 21-1 is a promising diagnostic marker for SNIP-SCC. The nomogram incorporating serum CYFRA 21-1, imaging features, and clinical factors demonstrates strong clinical utility and can be a reference tool for clinical decision-making.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Mutations—A Genetic Marker for Extracapsular Spread in Human Papillomavirus/p16-Positive Oropharyngeal Carcinoma","authors":"Raphaela Graessle,&nbsp;Iris Piwonski,&nbsp;Cora Husemann,&nbsp;Karsten Kleo,&nbsp;Deema Sabtan,&nbsp;Achim Franzen,&nbsp;Heidi Olze,&nbsp;Ulrike Erben,&nbsp;Michael Hummel,&nbsp;Annekatrin Coordes","doi":"10.1002/lio2.70094","DOIUrl":"https://doi.org/10.1002/lio2.70094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In the 8th edition of the TNM classification, extracapsular spread (ECS) became a factor in classifying the UICC stage of oropharyngeal carcinomas (OPSCC). We aimed to find genetic markers for ECS and to identify differences between HPV/p16-positive and HPV/p16-negative cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed targeted next-generation sequencing on 99 samples of operable OPSCC and a retrospective analysis of clinical data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 55 HPV/p16-positive and 44 HPV/p16-negative patients. We found a significant difference between both groups, particularly in TP53 mutation (<i>p</i> &lt; 0.001). Among other things, a small primary tumor (<i>p</i> &lt; 0.001), no ECS (<i>p</i> = 0.026) were identified as predictors for survival. Multiple mutations were associated with an increased incidence of ECS, especially in HPV+/p16+ cases (<i>p</i> = 0.017). A mutation in PIK3CA occurred more frequently in nonsmokers, especially in HPV−/p16− patients (<i>p</i> = 0.027). A PTEN mutation—which only occurred in HPV+/p16+ tissues—reduced disease-free survival (DFS, <i>p</i> = 0.026).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The presence of multiple mutations in HPV+/p16+ OPSCC was associated with a higher risk of ECS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Case of Tracheobronchopathia Osteochondroplastica in an 82-Year-Old Patient From Saudi Arabia","authors":"Mohammed Hady Albitar,&nbsp;Nida Mariyam,&nbsp;Seba Albitar,&nbsp;Reem Warrar,&nbsp;Anas Sultan,&nbsp;Sarmad Chaudhry,&nbsp;Abdullah AlMahmoud","doi":"10.1002/lio2.70093","DOIUrl":"https://doi.org/10.1002/lio2.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tracheobronchopathia osteochondroplastica (TPO) is a benign tracheobronchial disorder characterized by the presence of osseous or cartilaginous nodules, typically affecting the proximal large airways while sparing the posterior membranous trachea. Around 600 cases has been documented worldwide for this rare disorder. While most cases are asymptomatic, some patients may exhibit symptoms such as dyspnea and chronic cough. These symptoms could be attributed to either the ulceration of the nodules or the onset of an acute infection. As it is a vague and rare disease, TPO goes undiagnosed in most cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Description</h3>\u0000 \u0000 <p>This case represents an 82-year-old male with ischemic cardiomyopathy and a history of colon cancer who presented with a six-month history of mild hemoptysis, occasional cough, and wheezing. Laboratory tests were normal except for a positive PPD test. Imaging showed tracheal thickening with nodularity and calcification, and bronchoscopy confirmed the diagnosis. The patient was managed with symptomatic treatment and close follow-up. Over 2 years, he remained stable, experiencing only two self-limiting hemoptysis episodes with resolution of other symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This is the first case of TPO reported in Saudi Arabia. Given its nonspecific presentation, clinicians consider TPO as a differential diagnosis for patients with recurrent respiratory symptoms that do not respond to standard medical treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional cone beam computed tomography analysis of craniofacial phenotype in nonobese apneic young adults","authors":"Mathilde Jadoul DDS,&nbsp;Adelin Albert PhD,&nbsp;Nathalie Maes MSc,&nbsp;Robert Poirrier MD, PhD,&nbsp;Anne-Lise Poirrier MD, PhD,&nbsp;Annick Bruwier DDS, PhD","doi":"10.1002/lio2.70061","DOIUrl":"10.1002/lio2.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The obstructive sleep apnea (OSA) syndrome with its various phenotypes, as assessed by the apnea-hypopnea index (AHI), has become a major public health issue. While physicians are regularly faced with a variety of patients with OSA complaints, they may not be aware that OSA in nonobese young adults remains a largely underinvestigated topic. It is hypothesized that, in these subjects, facial bone volumes are smaller than in healthy adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional, nonrandomized, controlled study was designed to compare the 3D cephalometric analysis of bone and craniofacial soft tissues in a group of 23 nonobese apneic (AHI ≥ 15), young (18–35 years) adults and in a control group of 23 nonapneic (AHI &lt; 15) healthy subjects by using cone beam computed tomography (CBCT). All subjects were Caucasian and underwent a sleep examination in the Sleep Clinic of the University Hospital of Liege.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The two groups were comparable except for age and medications. The maxillary bone volume (23.2 ± 4.6 cm³ vs. 24.8 ± 2.9 cm³) and the mandibular bone volume (44.0 ± 6.4 cm³ vs. 46.9 ± 5.2 cm³) adjusted for demographic and biometric characteristics were significantly smaller in OSA subjects than in controls. OSA subjects had also a smaller angle of the maxillary diagonals (95.3 ± 13.9° vs. 106 ± 15.9°) and, at the mandible, a narrower width (90.8 ± 8.0 mm vs. 95.1 ± 5.3 mm), a wider gonial angle (119.9 ± 5.5° vs. 116.5 ± 4.4°), a longer ramus (51.2 ± 6.6 mm vs. 47.3 ± 5.0 mm), and a shorter corpus (74.1 ± 10.3 mm vs. 78.9 ± 5.8 mm) than controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Craniofacial structures that most discerned apneic subjects from controls were the maxillary and mandible bone volumes. An overly narrow maxilla and a postero-rotating mandible were also associated with OSA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>III.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Registration</h3>\u0000 \u0000 <p>NCT06022679.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Anti-Fatigue Floor Mat on Surgical Staff Comfort Levels in Head and Neck Surgery Cases","authors":"B. S. Jacey Elliott,&nbsp;Pawan Acharya,&nbsp;Lurdes Queimado,&nbsp;Daniel Zhao,&nbsp;Wesley Greene,&nbsp;Greg Krempl,&nbsp;Rachad Mhawej","doi":"10.1002/lio2.70083","DOIUrl":"10.1002/lio2.70083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Musculoskeletal symptoms are common among surgical staff and can have long-term implications on health and wellbeing. The purpose of this study is to evaluate the impact of anti-fatigue floor mat on the comfort level of surgical teams during head and neck surgeries lasting ≥ 3 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Over 4 months, we prospectively randomized 34 major (≥ 3 h) head and neck procedures to the use or not of an anti-fatigue floor mat. Anonymous questionnaires measured the comfort levels in different subjects including the surgeons, assistant surgeons, and surgical scrub technicians (<i>n</i> = 57). Subjects completed questionnaires before, immediately after, and one day after surgery. Variables collected included demographics, overall discomfort level, overall energy level, discomfort level in different body parts, number of breaks taken during the case, time since last physical exercise, and frequency of physical exercise. The analysis of variance (ANOVA) technique was used for data analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The group that used anti-fatigue floor mats reported lower increases in discomfort from pre-op to immediately post-op and 24 h post-op compared to the group that did not (<i>p</i> = 0.009 and <i>p</i> &lt; 0.001). Participants who used the mats reported significant lower levels of pain in the ankles and feet, knees, and shoulders immediately post-op compared to participants who did not. Participants who used the mats reported lower increases in discomfort in their back, hips, knees, neck, and shoulders from pre-op to post-op.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Using anti-fatigue floor mats during surgery is an effective and low-cost intervention to decrease the musculoskeletal symptoms experienced by the surgical team.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>2.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}