Laryngoscope Investigative Otolaryngology最新文献

{"title":"Comprehensive Genetic Analysis of NF2 in Sporadic Vestibular Schwannoma","authors":"Takeshi Wakabayashi,&nbsp;Koichiro Wasano,&nbsp;Kohei Nakamura,&nbsp;Makoto Hosoya,&nbsp;Ryutaro Kawano,&nbsp;Reika Takamatsu,&nbsp;Masafumi Ueno,&nbsp;Marie N. Shimanuki,&nbsp;Nobuyoshi Tsuzuki,&nbsp;Takanori Nishiyama,&nbsp;Takenori Akiyama,&nbsp;Masahiro Toda,&nbsp;Hiroshi Nishihara,&nbsp;Hiroyuki Ozawa,&nbsp;Naoki Oishi","doi":"10.1002/lio2.70265","DOIUrl":"https://doi.org/10.1002/lio2.70265","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To elucidate the genetic etiology of sporadic vestibular schwannomas (VSs) and investigate the correlation between <i>NF2</i> inactivation mechanisms and preoperative clinical characteristics, including hearing function and tumor growth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nineteen patients who underwent VS resection at our otorhinolaryngology or neurosurgery department between June 2020 and March 2022 were included in this study. Whole-exome sequencing (WES) was performed to detect somatic changes in <i>NF2</i>. Additionally, <i>NF2</i> promoter methylation status and copy number changes were evaluated using methylation analysis and multiple ligation-dependent probe amplification (MLPA). Preoperative clinical data, including pure tone audiometry, speech discrimination scores, and tumor growth rates, were collected and analyzed for correlations with genetic findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>WES identified somatic alterations in both <i>NF2</i> alleles in 16 cases (84.2%). The addition of methylation analysis and MLPA confirmed biallelic <i>NF2</i> inactivation in all cases. <i>NF2</i> promoter methylation was suggested to be associated with hearing loss and tumor progression. A weak correlation between <i>NF2</i> expression levels and tumor growth rate was observed (<i>r</i> = 0.21), while no significant correlation was found between <i>NF2</i> expression and pure tone audiometry or speech discrimination scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Comprehensive genetic analyses, including WES, methylation analysis, and MLPA, are essential for identifying <i>NF2</i> inactivation mechanisms in sporadic VSs. The findings suggest that <i>NF2</i> methylation may contribute to variations in clinical presentation. Further studies with larger cohorts are necessary to clarify the role of epigenetic modifications in disease progression and their potential impact on patient management strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sound Progress? Asian Representation in Otolaryngology Residency Programs: A 5-Year Update","authors":"Amy Wang,&nbsp;Yuki Yoshiyasu,&nbsp;Brian McKinnon,&nbsp;Tyler Janz","doi":"10.1002/lio2.70252","DOIUrl":"https://doi.org/10.1002/lio2.70252","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Gains in Asian representation have been reported across otolaryngology residency programs over the previous decade. We provide an update on otolaryngology resident demographics from 2018 to 2024 to determine how Asian representation has changed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Demographic data from annual reports by the Journal of the American Medical Association (JAMA) and Association of American Medical Colleges (AAMC). Otolaryngology resident reports were compared to other medical specialties. Asian representation was assessed and compared to that of other reported races/ethnicities. Trends were compared between 2018 and 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2018 and 2024, Asian representation in Otolaryngology remained stable, showing a small decline from 2018 to 2023 that was followed by rebound growth in 2023–2024 observed across multiple specialties. The total proportion of Asian, Black, and Hispanic residents rose significantly (<i>p</i> &lt; 0.05), while the percent of White residents declined. At 24.48%, Asian otolaryngology resident levels for the period were only 0.34% higher than the Asian medical student graduate level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>From 2018 to 2024, Asian representation in Otolaryngology remained stable, with limited but insignificant growth overall. Sustained increases in the proportion of Asian otolaryngology residents have yet to be seen, but there remain promising levels of Asian resident representation, especially compared to other minority groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>5</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Hairy Polyp of the Naso-Oropharynx: A Case Report and Systematic Literature Review","authors":"Diana Hallak,&nbsp;Logan F. McColl,&nbsp;Meredith M. Lind,&nbsp;Kris R. Jatana","doi":"10.1002/lio2.70262","DOIUrl":"10.1002/lio2.70262","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Hairy polyps (HPs), also known as bigerminal choristoma, are rare tumors most often occurring within the nasopharynx and oropharynx, linked to the development of the first and second pharyngeal arches. Commonly, HPs present in female neonates and are left-sided. This case report and systematic literature review provide a comprehensive overview of HPs' presentation, management, and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Description</h3>\u0000 \u0000 <p>A female neonate demonstrated persistent rightward head positioning and gagging at 1 day of life. Oral examination revealed a protuberant tubular soft-tissue mass appearing to originate from the posterior pharynx or nasopharynx. Neck MRI with and without contrast revealed a lobular, exophytic, and pedunculated soft-tissue mass arising from the left soft palate and extending to the oropharynx with minimal post-contrast enhancement. At 3 days of life, she underwent transoral mass resection. Final operative findings revealed a 6-cm mass based on the posterior aspect of the left soft palate near the superior left tonsillar pillar. Histopathological evaluation revealed skin-like epidermis with hair follicles and adnexa surrounding a cartilage core, muscle bundles, fat, and vascular channels consistent with bigerminal choristoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Literature Review</h3>\u0000 \u0000 <p>Systematic review, conducted according to PRISMA guidelines using PubMed database, yielded 106 published reports with 147 HP cases with a female and childhood-onset predominance. Respiratory distress, feeding difficulties, or a combination of both was the most commonly reported presenting symptoms occurring in 63.9% of cases. Surgical excision is the standard treatment across published reports.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>HPs commonly present with respiratory symptoms and a visible mass. Timely diagnosis and surgical intervention are critical to avoid significant complications to the airway and aerodigestive function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice Patterns in Management of Low- to Intermediate-Grade Salivary Gland Carcinoma: A Multi-Institutional Study","authors":"Mirabelle Sajisevi,&nbsp;Kenny Nguyen,&nbsp;Peter Callas,&nbsp;Andrew J. Holcomb,&nbsp;Emre Vural,&nbsp;Kyle P. Davis,&nbsp;Carissa M. Thomas,&nbsp;John S. Stein,&nbsp;Ameya Asarkar,&nbsp;Ricardo Aulet,&nbsp;Rebecca K. Bell,&nbsp;Michael A. Blasco,&nbsp;Vanessa B. Bowmaster,&nbsp;Clayton P. Burruss,&nbsp;Jeffson Chung,&nbsp;Kimberly Chan,&nbsp;Brent A. Chang,&nbsp;Charles S. Coffey,&nbsp;David M. Cognetti,&nbsp;Dylan J. Cooper,&nbsp;Joehassin Cordero,&nbsp;John Donovan,&nbsp;Yue Jennifer Du,&nbsp;Yusuf Dundar,&nbsp;Rogerio Dedivitis,&nbsp;Heather Edwards,&nbsp;Boban M. Erovic,&nbsp;Antoine Eskander,&nbsp;Philip A. Feinberg,&nbsp;Emily A. Garvey,&nbsp;David Goldstein,&nbsp;Joseph F. Goodman,&nbsp;Rafael N. Goulart,&nbsp;Neerav Goyal,&nbsp;Stefan Grasl,&nbsp;Jonathan Giurintano,&nbsp;Nikita Gupta,&nbsp;Andy Habib,&nbsp;Trevor Hackman,&nbsp;Jared H. Hara,&nbsp;Christina Henson,&nbsp;Michael L. Hinni,&nbsp;Nadia Hua,&nbsp;Stephanie Johnson-Obaseki,&nbsp;Aditya Juloori,&nbsp;Noah S. Kalman,&nbsp;Alexandra Kejner,&nbsp;Sobia F. Khaja,&nbsp;Jamie A. Ku,&nbsp;Arnaud Lambert,&nbsp;Bao K. Luu,&nbsp;Kelly R. Magliocca,&nbsp;Luiz R. Medina dos Santos,&nbsp;Cara Michael,&nbsp;Brett Miles,&nbsp;Giulianno Molina de Melo,&nbsp;Michael G. Moore,&nbsp;Gregoire B. Morand,&nbsp;Kauê Moura,&nbsp;Hesameddin Noroozi,&nbsp;Rusha Patel,&nbsp;Joseph Paydarfar,&nbsp;Karolina A. Plonowska-Hirschfeld,&nbsp;Nader Sadeghi,&nbsp;Fabrice Savaria,&nbsp;Nicole C. Schmitt,&nbsp;Justin Shapiro,&nbsp;Timothy B. Shaver,&nbsp;Sandro J. Stoeckli,&nbsp;William Alvo Stokes,&nbsp;Anita Sulibhavi,&nbsp;Jason Tasoulas,&nbsp;Varun Vendra,&nbsp;Daniel B. Vinh,&nbsp;Celina G. Virgen,&nbsp;Neil M. Woody,&nbsp;Geoffrey D. Young,&nbsp;Kiran Kakarala,&nbsp;Danny J. Enepekides,&nbsp;Michael P. Hier,&nbsp;Louise Davies,&nbsp;William R. Ryan","doi":"10.1002/lio2.70246","DOIUrl":"10.1002/lio2.70246","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To characterize practice patterns and outcomes in the management of low- and intermediate-grade salivary gland carcinoma prior to the existence of treatment guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Analysis of a registry of patients who underwent parotid and submandibular gland resections for low-and intermediate-grade carcinomas between 2010 and 2019.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of all 786 patients included in the study, 726 (92%) had preoperative imaging and 653 (83%) had preoperative biopsy. Of the 729 patients with parotid gland cancer, the majority underwent superficial (<i>n</i> = 384, 53%) or total (<i>n</i> = 254, 35%) parotidectomy. In patients with facial nerve preservation, total parotidectomy was associated with a significant increase in transient facial weakness (72/177 (41%) vs. 82/311 (26%), RR 0.65, 95% CI 0.50–0.84, <i>p</i> &lt; 0.05) and permanent facial nerve weakness (23/176 (13%) vs. 16/301 (5%), RR 0.41, 95% CI 0.22–0.75, <i>p</i> &lt; 0.05) compared to superficial parotidectomy. Adjuvant radiation therapy (RT) was delivered to 285 (36%) patients. The proportion of patients receiving adjuvant RT declined significantly over the time period from 2015 to 2019 compared to 2010 to 2014 at 162/504 (32%) and 123/282 (44%), respectively (RR 0.74, 95% CI 0.61–0.89, <i>p</i> &lt; 0.05). When comparing the time periods from 2015 to 2019 and 2010 to 2014, there was no significant difference in local control rates (RR 0.52, 95% CI 0.26–1.04, <i>p</i> = 0.06) or regional control rates (RR 0.75, 95% CI 0.26–2.13, <i>p</i> = 0.58).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Management of low- and intermediate-grade salivary cancer from 2010 to 2019 was variable, which is expected given the rarity and heterogeneity of the disease and the lack of treatment guidelines prior to 2021. Most patients with parotid malignancies underwent superficial or total parotidectomy. The extent of parotidectomy had an impact on facial nerve function outcomes. Delivery of adjuvant radiation trended down with time. The data presented here will support dissemination of the guidelines and provide data that could inform future trials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>2b.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CMS Exclusion of Global Period Visits From E/M Payment Reform: Estimated Payment Loss for Pediatric Otolaryngologists","authors":"Ashley L. Miller,&nbsp;Vinay K. Rathi,&nbsp;Molly O. Meeker,&nbsp;Lauren E. Miller,&nbsp;Jason Pedicini,&nbsp;Charles E. Elmaraghy","doi":"10.1002/lio2.70254","DOIUrl":"https://doi.org/10.1002/lio2.70254","url":null,"abstract":"<p>In an effort enhance reimbursement for cognitive specialties, the Centers for Medicare and Medicaid Services (CMS) increased the payment for outpatient and inpatient E&amp;M services in 2021 and 2023, respectively. Notably, visits during the postoperative global period were excluded from this increase. It is well-established that pediatric subspecialties, including pediatric otolaryngology, are less well-compensated than their adult counterparts. In this study, we estimated the potential annual revenue increase per academic pediatric otolaryngologist had CMS included global period visits in its revaluation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Other Than Complete Response in Oropharyngeal Carcinoma: Patient and Tumor-Related Factors","authors":"Francesco Mattioli,&nbsp;Matteo Miglio,&nbsp;Edoardo Serafini,&nbsp;Roberto Tonelli,&nbsp;Edoardo Meneguzzi,&nbsp;Elisa D'Angelo,&nbsp;Roberta Depenni,&nbsp;Martina Napolitano,&nbsp;Massimo Dominici,&nbsp;Daniele Marchioni,&nbsp;Federica Bertolini","doi":"10.1002/lio2.70258","DOIUrl":"10.1002/lio2.70258","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Oropharyngeal carcinoma represents a tumor with an increased concern in human health and treatment strategy. This study aims to identify any tumor or patient-related characteristics capable of predicting response to non-surgical curative treatment in a cohort of oropharyngeal squamous cell carcinoma and define oncological outcomes of overall survival and progression-free survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A monocentric retrospective cohort study was performed, including 223 patients with non-metastatic oropharyngeal squamous cell carcinoma treated with curative intent with a non-surgical strategy. Patients were treated at the University Hospital of Modena (Italy) after a multidisciplinary evaluation between January 2010 and December 2021. The treatment response was assessed by using the RECIST 1.1 Criteria on imaging performed 3 months after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Tonsil subsite and stage I were independently associated with a complete treatment response (OR = 0.53, <i>p</i> = 0.05, and OR = 0.32, <i>p</i> = 0.01, respectively). The association between smoking and p16− status resulted in a higher probability of a not-complete response (OR = 1.72, <i>p</i> = 0.05). Similar results were found for soft palate subsite, cT4, N2 in the p16+ group, and stage IVb in the p16− group. Conversely, cT1 was associated with a higher probability of complete response. Age and the extension to nearby structures did not influence the response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This retrospective study shows a possible stratification of patients with oropharyngeal squamous cell carcinoma based on factors that influence treatment response rate. The identification of a phenotype of a non-responding tumor could better define therapeutic and follow-up programs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Arabic Version of Anterior Skull Base Questionnaire 35 (AVQ-35) in Endoscopic Endonasal Resection","authors":"Ahlam Alamri,&nbsp;Abdulmajeed Alharbi,&nbsp;Hussain Albaharna,&nbsp;Ahmad Alsayed,&nbsp;Abdulrazag Ajlan,&nbsp;Ashwag Alqurashi,&nbsp;Basem Noor Elahi,&nbsp;Abdulaziz Alrasheed,&nbsp;Saud Alromaih,&nbsp;Saad Alsaleh,&nbsp;Ahmad Alroqi","doi":"10.1002/lio2.70263","DOIUrl":"10.1002/lio2.70263","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Quality of life (QoL) is a critical outcome measure in patients undergoing endoscopic endonasal resection of anterior skull base lesions. This study aimed to validate the Arabic version of the Anterior Skull Base Questionnaire 35 for endoscopic endonasal resections (AVQ35).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included patients who underwent endoscopic endonasal resection of anterior skull base lesions between January 2022 and December 2022 at King Saud University Medical City in Riyadh. QoL assessments were performed using standardized questionnaires at baseline and during the postoperative follow-up visits. Statistical analyses, including paired <i>t</i>-tests and regression analysis, were used to assess changes in QoL and to identify associated factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All individual components or items within the AVQ-35 questionnaire were valuable and relevant when assessing a patient's QoL. The findings demonstrated a significant improvement in QoL scores following endoscopic endonasal resection of the anterior skull base lesions (<i>p</i> &lt; 0.05). The AVQ-35's validity was established by evaluating its internal consistency, test–retest reliability, capacity, and ability to detect clinical changes before and after surgery at two different time points. The internal consistency of the AVQ-35 was excellent, with a Cronbach's alpha &gt; 0.95 (0.980) across all time points for all domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study successfully validated the AVQ-35 for use in patients undergoing endoscopic endonasal resection of anterior skull base lesions. The AVQ-35 demonstrated excellent internal consistency (Cronbach's alpha &gt; 0.95) and responsiveness to clinical changes, as evidenced by significant improvements in QoL scores postoperatively. These findings establish the AVQ-35 as a robust and culturally appropriate instrument for assessing QoL in Arabic-speaking populations, filling a critical gap in patient-reported outcome measures for anterior skull base surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charlson–Deyo Index Impact on Overall Survival After Surgery for Sinonasal Squamous Cell Carcinoma","authors":"David Herz,&nbsp;Aman M. Patel,&nbsp;George S. Bebawy,&nbsp;Anthony M. Saad,&nbsp;Ghayoour S. Mir,&nbsp;Andrey Filimonov","doi":"10.1002/lio2.70259","DOIUrl":"10.1002/lio2.70259","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Objective preoperative risk assessment tools inform physician and patient decision making. Our study examines the relationship between the Charlson–Deyo comorbidity index (CCI) and overall survival (OS) following surgery for sinonasal squamous cell carcinoma (SNSCC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a retrospective cohort study, the 2004–2016 National Cancer Database was used to extract adult patients with pT1-4N0-3 M0 SNSCC undergoing surgery. Kaplan–Meier survival analysis and Cox-proportional hazards modeling were used to analyze the impact of CCI on OS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 3307 patients satisfying inclusion criteria, 2613 (79.0%) were CCI = 0, 533 (16.1%) were CCI = 1, and 161 (4.9%) were CCI = 2+. On univariate analysis, CCI groups differed by age (42.8% were ≥ 65 years old in CCI = 0 vs. 53.3% and 64.0% in CCI groups 1 and 2+, respectively, <i>p</i> &lt; 0.001) and race (<i>p</i> &lt; 0.001). There was no significant difference between CCI groups in sex, T-stage, N-stage, margin status, primary site, radiation therapy, or systemic therapy. On Kaplan–Meier analysis, 5-year OS for CCI = 0, CCI = 1, and CCI = 2+ was 58.6%, 48.0%, and 42.9%, respectively (<i>p</i> &lt; 0.001). CCI = 1 (HR 1.20, 95% CI 0.99–1.45, <i>p</i> = 0.069) was not associated with worse OS than CCI = 0. CCI = 2+ (HR 1.43, 95% CI 1.05–1.96, <i>p</i> = 0.025) was associated with worse OS than CCI = 0.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In a cohort of adult patients with SNSCC undergoing surgery, higher CCI was independently associated with worse OS. These findings support the use of CCI as a predictor of postoperative outcomes in SNSCC patients. Future studies should explore how comorbidity burden interacts with frailty and other prognostic factors to refine risk stratification tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Anxiety, Depression, and Patient Tolerance in Patients With no Prior History of Mental Disorders Undergoing Office-Based Laser Surgery: A Case Study","authors":"Abdul-Latif Hamdan,&nbsp;Lana Ghzayel,&nbsp;Zeina Maria Semaan,&nbsp;Omar Aboul Hosn,&nbsp;Anne Marie Daou,&nbsp;Jonathan Abou Chaar,&nbsp;Nader Nawfal,&nbsp;Randa Barazi","doi":"10.1002/lio2.70256","DOIUrl":"10.1002/lio2.70256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate tolerance to office-based laser surgery (OBLS) in patients with no prior history of mental illnesses, and to analyze the correlation between patient tolerance, anxiety, and depression using validated questionnaires.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients aged 18–65 with no prior history of mental disorders undergoing OBLS from May 2024 to September 2024 were included in this study. All patients completed the Generalized Anxiety Disorder scale-7 (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9). After surgery, tolerance was assessed using the IOWA satisfaction with anesthesia scale and a Visual Analog Scale for discomfort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 25 patients were enrolled. Eighteen patients had moderate–severe anxiety and six patients had moderate–severe depression. The mean GAD-7 was 12.32 ± 4.09, and the PHQ-9 score was 6.60 ± 5.43. The mean IOWA score was 1.78 ± 1.07, and the mean VAS for discomfort was 4.60 ± 3.31. There was a moderate negative correlation between IOWA score and GAD-7 score (<i>r</i> = −0.489) and a mild positive correlation between the GAD-7 score and the VAS score for discomfort (<i>r</i> = 0.372). A mild negative correlation was found between IOWA scores and PHQ-9 scores (<i>r</i> = −0.357) and a weak positive correlation between the PHQ-9 score and the VAS score (<i>r</i> = 0.204). It is important to note that although this study group had a high risk for anxiety and depression, the results indicated that OBLS was a well-tolerated procedure. This could be ascribed to the non-invasiveness of OBLS and proper application of topical anesthesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study revealed a high tolerance level despite a high risk for anxiety and depression in a large percentage of our study group. Moreover, there was a mild to moderate negative correlation between anxiety, depression, and patient tolerance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>2.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Vestibular Evoked Myogenic Potentials in Different Dynamic Equilibrium Conditions","authors":"Nihal Evran,&nbsp;Gulcin Hancer Arslan,&nbsp;Murat Arslan,&nbsp;Selis Gulseven Guven,&nbsp;Ahmet Koder,&nbsp;Erdogan Bulut","doi":"10.1002/lio2.70253","DOIUrl":"10.1002/lio2.70253","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to investigate balance system modifications under different conditions using cervical Vestibular Evoked Myogenic Potentials (c-VEMP) testing. Specifically, we examined vestibular compensation mechanisms in various dynamic balance positions through evoked potential analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study conducted c-VEMP test repetitions on 45 healthy subjects under different conditions. Participants underwent comprehensive otoscopic examination and hearing and balance assessments, with only those demonstrating normal hearing included in the analysis. c-VEMP testing was performed under three distinct conditions: condition 1 (standing on a flat surface with eyes open), condition 2 (standing on a flat surface with eyes closed), and condition 3 (standing on a FoamPad with eyes open). The analysis evaluated P1-N1 latencies and amplitudes in c-VEMP responses, with subsequent statistical analysis of the collected data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis revealed statistically significant differences in P1-N1 amplitudes and latencies in left ears when comparing conditions 1 and 2 (<i>p</i> &lt; 0.01). Right ears demonstrated significant differences only in amplitudes between conditions 1 and 2 (<i>p</i> &lt; 0.01). Comparison of conditions 2 and 3 yielded statistically significant differences in P1-N1 amplitudes and latencies for left ears (<i>p</i> &lt; 0.01), while right ears showed significant differences in amplitudes and N1 latency only (<i>p</i> &lt; 0.01). No significant differences were observed in either ear when comparing conditions 1 and 3 (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings suggest that while the vestibular system is fundamental, visual input plays a more substantial role in balance maintenance compared to proprioceptive input.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}