Laryngoscope Investigative Otolaryngology最新文献

{"title":"Prognostic Factors and Clinical Characteristics in Pediatric Sudden Sensorineural Hearing Loss: A Retrospective Analysis","authors":"Ranshi Zhao,&nbsp;Maoling Huang,&nbsp;Cheng Zhong","doi":"10.1002/lio2.70112","DOIUrl":"https://doi.org/10.1002/lio2.70112","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the clinical characteristics and prognostic factors influencing treatment outcomes in pediatric sudden sensorineural hearing loss (PSSNHL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on 63 children (64 ears) diagnosed with PSSNHL from January 2013 to December 2023. All patients received either systemic or intra-tympanic steroid therapy. Data on age, tinnitus presence, audiogram types, and initial hearing thresholds were analyzed using SPSS 25.0. Univariate and multivariate logistic regressions were performed to identify significant prognostic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age was 16 years (interquartile range:14–17 years). Median time from symptom onset to treatment was 7 days (interquartile range: 4–13 days). Tinnitus was present in 85.7% of cases. Post-treatment hearing thresholds improved from 84.52 ± 3.29 dB HL to 64.17 ± 4.48 dB HL (<i>p</i> &lt; 0.001). The overall therapeutic efficacy rate was 48.4%. Multivariate analysis identified time from onset to treatment (OR = 0.923; 95% CI: 0.789–0.997; <i>p</i> &lt; 0.01) and initial hearing threshold (OR = 0.939; 95% CI: 0.869–0.981; <i>p</i> &lt; 0.05) as independent prognostic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Early intervention and lower initial hearing thresholds are associated with a better prognosis in PSSNHL. Prompt treatment significantly improves outcomes, highlighting the importance of early diagnosis and intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level 4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage Laryngectomy in Clinically N0 Patients: Is Elective Neck Dissection Indicated?","authors":"Mazin Merdad,&nbsp;Nada Al Taylouni","doi":"10.1002/lio2.70076","DOIUrl":"https://doi.org/10.1002/lio2.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This systematic review and meta-analysis investigated the role of elective neck dissection (END) in the salvage management of clinically N0 necks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data Sources</h3>\u0000 \u0000 <p>PubMed/Medline, Google Scholar, and the Cochrane Library were systematically searched for relevant studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Both electronic and manual search strategies were conducted within the abovementioned databases and included articles and reviews to find the relevant studies. Rates of occult nodal metastasis, survival outcomes, and postoperative complications were analyzed in N0 patients undergoing salvage laryngectomy with END. Fixed and random effects models were used to calculate pooled estimates of overall survival metastasis rates with 95% confidence intervals, and heterogeneity was assessed using tau², <i>I</i>², and Cochran's <i>Q</i> test. Statistical analyses were performed in R software with <i>p</i> &lt; 0.05 as significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The included eight studies reported occult metastasis rates ranging from 4% to 10% in clinically N0 necks post-radiotherapy. Overall survival was approximately 52%, with mixed evidence on the survival advantage of END. Disease-free survival and recurrence-free survival rates ranged from 71.7% to 95.5% at 5 years. Complication rates associated with END were high, with up to 47.4% of patients experiencing postoperative morbidity. The metastasis rate was 10%–13% highlighting the ability of END to detect occult metastases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The survival benefits of END are not consistently supported by current evidence, while the significant morbidity associated with the procedure raises concerns about its routine use. A conservative approach may be more appropriate for clinically node-negative patients, particularly when weighed against the elevated risks of complications. END demonstrates moderate overall survival rates and an ability to detect occult metastases, but its role in improving long-term outcomes remains unclear. Larger prospective studies and randomized trials are needed to better define the indications and outcomes of END in the salvage management of clinically N0 necks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Authorship Representation in Otolaryngology Clinical Trials","authors":"Hong-Ho Yang,&nbsp;Jeffrey D. Huynh,&nbsp;Clare Moffatt,&nbsp;Rolvix H. Patterson,&nbsp;Mary Jue Xu,&nbsp;Maie St. John","doi":"10.1002/lio2.70092","DOIUrl":"https://doi.org/10.1002/lio2.70092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate global authorship representation in clinical trials published in major general otolaryngology journals over the past two decades.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a bibliometric analysis of clinical trials published in four major general otolaryngology journals between 2000 and 2020. The affiliated nationalities of authors in leading positions (first, senior, corresponding) were reviewed for each trial. Countries were classified by World Bank income group. The temporal trajectory of representation was estimated in multivariable logistic regression models, adjusting for publication environment and study design. The academic impact of trials across income groups was also compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 1432 trials, the leading authors for most were affiliated with non-USA nations (57%) and high-income countries (HIC) (87%). Trials led by authors from upper-middle income countries (UMIC), lower-middle income countries (LMIC), and low-income countries (LIC) were severely underrepresented (11%, 3%, 0%, respectively). Over time, non-USA representation increased (+0.5%, 95% CI [+0.13%, +0.92%] per year), HIC representation decreased (−0.45% [−0.77%, −0.12%]), UMIC representation remained stable (0.19% [−0.13%, 0.51%]), LMIC representation mildly increased (0.26% [0.16%, 0.35%]), and LIC representation remained absent (0%). UMIC author-led trials (aIRR 0.80 [0.68, 0.94]) received significantly fewer citations compared to HIC author-led trials regardless of study design and publication year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The clinical trial literature in the four most widely circulated OHNS journals is dominated by HIC authorship, with only marginal growth in LMIC contributions and no representation from LICs over the past two decades. This underrepresentation may impact the applicability of clinical guidelines in lower-income regions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an e-Health Software for Speech and Swallowing Rehabilitation Following Laryngectomy","authors":"M. Gugatschka,&nbsp;N. Egger,&nbsp;R. Rehb,&nbsp;C. Reiter,&nbsp;M. Rudes,&nbsp;R. Mischak,&nbsp;K. Haspl","doi":"10.1002/lio2.70136","DOIUrl":"https://doi.org/10.1002/lio2.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We present data from a feasibility study where patients following laryngectomy and/or hemi-laryngectomy received speech and swallowing rehabilitation via a newly designed e-health software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients were recruited during their stay at the hospital and were equipped with a tablet upon discharge. Alternatively, patients who already underwent training but did not improve significantly were included to receive a more intense training. The training protocol comprised asynchronous (e.g., self-assessment and pre-defining training protocols) and synchronous (e.g., video communication) therapies; participation lasted for 8 weeks. General demographic parameters, as well as specific parameters (quality of life, speech comprehensibility) were assessed pre- and post-interventional.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our cohort consisted of eight patients (mean age: 69 years.) Essential outcome parameters improved significantly (weight, comprehensibility for syllables).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our feasibility study showed that our software is safe and easy-to-use and can be easily integrated into patients' everyday lives. Key parameters such as weight and comprehensibility improved after just 8 weeks of training.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>NA</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Trends in Treatment of Acute Unilateral Vocal Fold Paralysis at Tertiary Care Voice Centers","authors":"Sydney Ring,&nbsp;Nicholas Colwell,&nbsp;Andrew J. Bowen,&nbsp;Natalia Arroyo,&nbsp;Koffi L. Lakpa,&nbsp;Jaime Faus,&nbsp;Miranda Rasmussen,&nbsp;Peter Nordby,&nbsp;Jiwei Zhao,&nbsp;David O. Francis,&nbsp;the CoPE Collaborative","doi":"10.1002/lio2.70135","DOIUrl":"https://doi.org/10.1002/lio2.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Acute unilateral vocal fold paralysis (UVFP) management differs across the United States. This study aims to characterize current trends in UVFP treatment at US tertiary care voice centers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data Sources</h3>\u0000 \u0000 <p>A survey was distributed to laryngologists at 51 tertiary care voice centers within the CoPE (Vocal <span>Co</span>rd <span>P</span>aralysis <span>E</span>xperience) Collaborative.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Review Methods</h3>\u0000 \u0000 <p>Participants provided information on voice center, laryngologist, and speech-language pathologist (SLP) characteristics, diagnostic practices, treatment decision-making, and therapies offered for acute UVFP (symptoms present for ≤ 6 months). National trends in diagnostic and treatment practices were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 51 CoPE centers, 48 completed the questionnaire (17% Northeast, 33% South, 35% Midwest, 15% West). Most centers (77%) had 1–2 laryngologists managing acute UVFP, with SLP availability varying widely (0–8+ per site). Diagnostic practices varied significantly: only 26% of centers routinely measured mean airflow during phonation, 47% recorded maximum phonation time (MPT), and 53% assessed GRBAS. Treatment commonly included vocal fold injection augmentation, alone or combined with voice therapy, with injections typically administered 3–4 weeks after diagnosis (83%). Hyaluronic acid (95%), PROLARYN GEL (60%), and calcium hydroxyapatite (56%) were the most frequently used materials. Injection procedures were performed “often” in clinic settings (90%) and “rarely” or “never” in the operating room (42%) and hospital bedside (56%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Significant variability exists in the diagnostic testing, evaluation, and treatment of acute UVFP across tertiary care centers. Future studies are warranted to explore the causes of these variations and assess the role of multidisciplinary approaches in optimizing UVFP care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Molecular Weight Heparin Dosing in Relation to Postoperative Bleeding After Tracheotomy in Patients Infected With SARS-CoV-2—A Descriptive Study","authors":"David Victorin,&nbsp;Henrik Bergquist,&nbsp;Louise Hafsten,&nbsp;Åsa Nihlén,&nbsp;Ellen Lindell","doi":"10.1002/lio2.70122","DOIUrl":"https://doi.org/10.1002/lio2.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to analyze whether patients with SARS-CoV-2 who received surgical tracheotomy had a lower incidence of postoperative bleeding if their LMWH was postponed or canceled on the day of surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with SARS-CoV-2 admitted to the intensive care units who underwent surgical tracheotomy were assessed retrospectively through their medical records. Data on comorbidity, LMWH dose, and timing were collected. Bleedings &lt; 72 h post surgery were noted as stomal or airway bleedings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All 101 patients included were on LMWH. Twenty-two patients had no change of dose of LMWH, 24 patients had their dose of LMWH postponed to post surgery, and 50 patients had their dose reduced to only the evening dose on the day of surgery. Twenty-six patients had a stomal bleeding, one patient had an airway bleeding, and four patients had both stomal and airway bleedings. No significant difference in the incidence of bleeding was identified between various groups of different LMWH doses or timing, reduced dose versus no change of dose, OR 1.29 (95% CI 0.42–3.92). Postponed dose versus no change of dose of LMWH, OR 1.03 (95% CI 0.28–3.75). Increasing age was correlated to a higher risk of bleeding post-surgery by an OR of 1.64 (95% CI 1.06–2.54, <i>p</i> = 0.026 for every 10 years added). No fatal bleeding related to surgical tracheotomy was observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Decreased doses of LMWH on the day of surgery were not associated with a risk reduction for post-surgical bleeding in patients with SARS-CoV-2 who received tracheotomy. Increasing age was a risk factor for post-surgical bleeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Retrospective, level 3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parent–Child Agreement on Fatigue in Pediatric Otolaryngology Patients","authors":"Amy E. Ensing,&nbsp;Amy L. Zhang,&nbsp;Rebecca Z. Lin,&nbsp;Emma K. Landes,&nbsp;Henok Getahun,&nbsp;Judith E. C. Lieu","doi":"10.1002/lio2.70128","DOIUrl":"https://doi.org/10.1002/lio2.70128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate parent–child agreement on fatigue reporting in pediatric otolaryngology patients and whether agreement might vary by diagnosis and other patient factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>Cross-sectional survey.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients ages 5–18 years old being evaluated for hearing loss (HL) or obstructive sleep apnea (OSA) were recruited from a pediatric otolaryngology clinic and sleep center. Children and parents completed the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL MFS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses of 42 patients with HL, 49 with OSA, 10 with sleep-disordered breathing (SDB), and 34 controls were analyzed. Parent and child PedsQL MFS scores were strongly correlated (Pearson <i>r</i> &gt; 0.7) across groups with few exceptions. Only the median child–parent score differences for general domain score in the SDB group (12.5; 95% CI 2.08 to 22.9), and total score (7.41; 95% CI −0.69 to 25.7) and general domain score (11.5; 95% CI 2.08 to 27.1) in the developmental delay group met clinical significance thresholds. Wide confidence intervals prevented definitive conclusions regarding clinical significance. A pattern of decreased parent–child score correlations was observed in children reported to have delays. Weak (±0.1 to ±0.4) to moderate (±0.4 to ±0.69) correlations were observed for total score, general domain score, and cognitive domain score for children with reported developmental/speech/language delay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, the parent-proxy PedsQL MFS demonstrates strong agreement with self-reports for pediatric otolaryngology patients being evaluated for HL and OSA. However, parent–child score discrepancies within specific patient groups, especially children whose parents reported speech/developmental/language delays, emphasize the importance of administering self-reports when possible.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The US-Mexico Border Wall Height Extension Is Associated With Increased Incidence and Severity of Facial Trauma","authors":"Alexander Tenorio,&nbsp;Gautam R. Produturi,&nbsp;Farhoud Faraji,&nbsp;Víctor de Cos,&nbsp;Carson P. McCann,&nbsp;Amanda A. Gosman,&nbsp;David B. Hom,&nbsp;Jay J. Doucet,&nbsp;Todd W. Costantini,&nbsp;Alexander A. Khalessi,&nbsp;Joseph D. Ciacci","doi":"10.1002/lio2.70129","DOIUrl":"https://doi.org/10.1002/lio2.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The recent United States (US)-Mexico border wall height extension has been associated with greater migrant neurological and musculoskeletal morbidity after falls. However, the impact on facial trauma has yet to be characterized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective cohort study, patients presenting to the UC San Diego Health Trauma Center for border wall fall-related injuries between 2016 and 2021 were included. Patients were compared based on the presence of facial fractures and whether their injuries were before the height extension (2016–2018) or after (2020–2021). Demographics, clinical characteristics, concurrent injuries, and hospital charges were compared. Due to low counts of facial fractures, temporal groups were compared with Zero-Inflated Poisson (ZIP) regressions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 383 patients met inclusion criteria, with 9 patients (78% male) sustaining facial fractures and 374 patients (76% male) who did not. Patients with facial fractures were younger (26 [IQR 22–27] vs. 30 years [IQR 24–39], <i>p</i> = 0.047), had a greater concurrence of traumatic brain injuries (22% vs. 3.2%, <i>p</i> = 0.039), and longer ICU length of stay (5 [IQR 2–4] vs. 3 days [IQR 4–14], <i>p</i> = 0.034). The post-height extension cohort had an increased rate of facial fractures (0.34 vs. 0.03 per month), multi-facial-unit fractures (50% vs. 0%), and facial injuries requiring operative intervention (38% vs. 0%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Facial fractures present with greater morbidity, and the recent border wall height extension is associated with an increased risk for facial trauma. In addition to the physical trauma, facial trauma is known to harbor enduring psychological repercussions. Altogether, these injury and resource burdens pose multifaceted concerns regarding international border infrastructure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Laryngeal Nerve Reinnervation and Pediatric Dysphagia Outcomes","authors":"Swapnika Alahari,&nbsp;Rishi Suresh,&nbsp;Neila Kline,&nbsp;Palmila Liu,&nbsp;Ashley F. Brown,&nbsp;Yann-Fuu Kou,&nbsp;Stephen R. Chorney,&nbsp;Romaine F. Johnson","doi":"10.1002/lio2.70126","DOIUrl":"https://doi.org/10.1002/lio2.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine the frequency of aspiration resolution after recurrent laryngeal nerve (RLN) reinnervation among children with dysphagia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>Case series with chart review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All pediatric RLN reinnervations between January 2013 and December 2022 at a tertiary aerodigestive program were included. Only children completing video fluoroscopic swallow studies (VFSS) prior to the RLN procedure were analyzed. Postoperative outcomes included swallowing function from VFSS, including thin liquid aspiration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four RLN reinnervations were reviewed, with six children obtaining both preoperative and postoperative VFSS. Following RLN reinnervation, no patients were noted to aspirate, and all patients had advancement in their diet consistencies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Resolution of dysphagia and advancement of the oral diet after RLN reinnervation is common among children with aspiration and unilateral vocal fold immobility. Long-term improvement of swallowing function in children with unilateral vocal cord paralysis corrected by RLN reinnervation must be examined further.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Consider Aspirin for the Treatment of Vestibular Schwannoma? A Brief Review and Randomized, Double-Blind, Placebo-Controlled Study Proposal","authors":"D. Bradley Welling,&nbsp;Brian A. Neff,&nbsp;Fred F. Telischi,&nbsp;Neil Patel,&nbsp;Konstantina M. Stankovic","doi":"10.1002/lio2.70121","DOIUrl":"https://doi.org/10.1002/lio2.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The primary objective of this study is to review the evidence for aspirin use to prevent the growth of vestibular schwannomas (VS) and to propose a prospective trial to determine the progression-free survival of VS patients after up to 42 months of treatment with aspirin. Secondary study objectives are to determine the effect of aspirin on VS growth, hearing function, serum biomarker levels, and the quality of life, as well as to determine the tolerability of aspirin treatment and whether serum biomarker and salicylate levels predict the response to aspirin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>Literature review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Six academic and private medical centers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Review of recent English literature regarding prophylactic aspirin use for VS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The retrospective reviews on the utility of aspirin to prevent VS growth are inconclusive. Eighty-four patients have been enrolled in a prospective double-blinded, placebo-controlled trial thus far to determine the effect of aspirin on VS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Completion of a robust study design is necessary. The current aspirin dose has been well tolerated, with minimal adverse events to date.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Review of retrospective studies: Level 4; Proposed randomized, placebo-controlled, double-blinded clinical trial: Level 2.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}