Laryngoscope Investigative Otolaryngology最新文献

{"title":"Recommendation for Standardized Exam for Nasal Obstruction","authors":"Jordan Kai Simmons,&nbsp;Wasiq Nadeem,&nbsp;Matthew K. Lee,&nbsp;Henry H. Chen","doi":"10.1002/lio2.70117","DOIUrl":"https://doi.org/10.1002/lio2.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Nasal septal deviation, inferior turbinate hypertrophy, and nasal valve compromise are among the most common etiologies of NAO seen by facial plastic surgeons and otolaryngologists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>While both validated and non-validated scales and grading systems exist, they are inconsistently used. Further, anecdotally useful tools such as the Cottle maneuver have been adapted for purposes outside of patient care, such as billing. Although these NAO assessment systems have great utility in the diagnosis of nasal pathology, in isolation, they are not robust enough to influence surgical decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this study, we summarize the existing literature surrounding the nasal exam in cases of obstruction and offer a standardized nasal exam protocol based on grading systems and physical exam maneuvers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>N/A.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces","authors":"Ryan Horne,&nbsp;Caleb Escudero,&nbsp;Morgan Ellerman,&nbsp;C. Allan Guymon,&nbsp;Marlan Hansen","doi":"10.1002/lio2.70118","DOIUrl":"https://doi.org/10.1002/lio2.70118","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non-zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten the time required for a mucus-plugged tube to unplug when exposed to saline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Zwitterionic and conventional hydrogel films on typical medical surfaces reduce resistance to mucus flow, increase mucus discharge, and may facilitate faster unplugging of dried mucus. These effects are the most pronounced on tubes of larger inner diameter (greater than 2.6 mm) and tend to dissipate for tubes of smaller diameter. These results may help guide future improvements to medical tubes intended to discharge mucus and ventilate, resulting in fewer complications for patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level 2, randomized individual trial.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutations in Anaplastic Thyroid Carcinoma: An Analysis of the Japanese National Genomic Database","authors":"Hiromi Nagano,&nbsp;Hayato Matsumoto,&nbsp;Yumi Ando,&nbsp;Masatoyo Nakajo,&nbsp;Masaru Yamashita","doi":"10.1002/lio2.70110","DOIUrl":"https://doi.org/10.1002/lio2.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The purpose of this study is to investigate the genetic mutational status of anaplastic thyroid carcinoma (ATC) and its prognostic implications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were analyzed for 129 consecutive patients with ATC registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and June 2024. Genetic alterations were determined by FoundationOne CDx or Liquid CDx next-generation sequencing. The survival of patients was determined by the log-rank test and a Cox proportional hazards model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The top 30 mutations in ATC were <i>TERT</i> (98/129), <i>TP53</i> (88/129), <i>BRAF</i> (72/129), <i>CDKN2A</i> (39/129), <i>CDKN2B</i> (29/129), <i>LTK</i> (26/129), <i>NRAS</i> (25/129), <i>KMT2D</i> (24/129), <i>PIK3CA</i> (26/129), <i>NOTCH3</i> (27/129), <i>NF2</i> (19/129), <i>MTAP</i> (17/129), <i>TET2</i> (16/129), <i>STK11</i> (15/129), <i>ATM</i> (14/129), <i>FANCA</i> (14/129), <i>NF1</i> (13/129), <i>DNMT3A</i> (13/129), <i>KIT</i> (13/129), <i>NOTCH1</i> (13/129), <i>EP300</i> (12/129), <i>BRCA2</i> (11/129), <i>CARD11</i> (11/129), <i>KEL</i> (11/129), <i>MSH3</i> (11/129), <i>PTEN</i> (11/129), <i>RICTOR</i> (11/129), <i>TSC1</i> (11/129), <i>ROS1</i> (10/129), and <i>KMT2A</i> (10/129) with 13.7 ± 0.5 (mean ± SEM) mutations/individual. Mutations in <i>BRAF</i> (<i>p</i> = 0.003), <i>PIK3CA</i> (<i>p</i> = 0.014), and <i>BRCA2</i> (<i>p</i> = 0.036) were associated with a significantly better prognosis, whereas mutations in <i>STK11</i> (<i>p</i> = 0.024) was associated with a significantly worse prognosis, as determined by log-rank tests. The hazard ratios for cases with these mutations were 0.248 (95% CI, 0.0973–0.633, <i>p</i> = 3.5 × 10⁻³) for <i>PIK3CA</i>, 2.410 (1.054–5.515, <i>p</i> = 0.037) for <i>STK11</i>, and 0.157 (0.0376–0.659, <i>p</i> = 0.011) for <i>BRCA2</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In ATC, <i>PIK3CA</i>, and <i>BRCA2</i> mutations were associated with a better prognosis, and <i>STK11</i> mutation was associated with a poorer prognosis in this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral Transorbital Approach for Lateral Sphenoid Defects: Anatomy, Surgery, Nasoseptal Flap Use, and a 4-Case Series","authors":"Darlene Lubbe,&nbsp;Lien Deschuytere,&nbsp;Kris S Moe","doi":"10.1002/lio2.70115","DOIUrl":"https://doi.org/10.1002/lio2.70115","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the effectiveness and anatomical advantages of the lateral transorbital approach for complex skull base repairs in the lateral recess of a pneumatized sphenoid sinus and compare it to standard transnasal methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Case series of four patients across two institutions (Otorhinolaryngology and Neurosurgery departments in Cape Town, South Africa, and Seattle, USA). Three patients with spontaneous cerebrospinal fluid (CSF) leaks underwent a pure lateral transorbital repair; one patient with skull base fractures from a gunshot wound received a combined transnasal and transorbital repair with a nasoseptal flap through the lateral transorbital corridor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The lateral transorbital approach effectively accessed the lateral sphenoid recess in all patients, allowing repair with standard zero-degree tools while avoiding nasal morbidity and hypesthesia associated with the transpterygoid access. When necessary, an ipsilateral nasoseptal flap can be utilized for complex defects, with placement under direct vision through the lateral transorbital route. The flap provides sufficient length to extend into the lateral corridor up to the temporalis muscle when required.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The lateral transorbital approach enhances visualization, reduces nerve injury risk, and lowers nasal morbidity, making it a valuable method for repairing pneumatized sphenoid sinus defects. The nasoseptal flap provides versatile and effective CSF leak prevention in transorbital procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization Trends of Transnasal Endoscopic Sphenopalatine Artery Ligation (TESPAL) in the Medicare Population","authors":"Jake G. Stenzel,&nbsp;Devyani Lal,&nbsp;Amar Miglani,&nbsp;Michael J. Marino","doi":"10.1002/lio2.70111","DOIUrl":"https://doi.org/10.1002/lio2.70111","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Transnasal endoscopic sphenopalatine artery ligation (TESPAL) has been proposed as a first-line therapy for intractable epistaxis before utilizing posterior nasal packing and embolization. A specific procedure code for TESPAL was newly introduced in 2018, adding to two prior codes for procedural control of epistaxis. This study compares all-time utilization of the TESPAL CPT code in Medicare beneficiaries with alternative procedural codes for epistaxis management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The publicly available data from the Centers for Medicare and Medicaid Services in the 2013–2022 period was analyzed for the reporting of TESPAL (31241), transcatheter permanent occlusion or embolization of noncentral nervous system, head, or neck (61626), and endoscopic control of epistaxis (31238) codes. Welch two sample <i>t</i>-test and linear regression were used to characterize CPT code utilization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 2018 to 2022, TESPAL CPT code reporting averaged 378 instances annually, with a stable utilization trend (<i>p</i> = 0.432). CPT codes 61626 and 31238 averaged 1429 and 3779 instances annually, respectively. CPT 31238 showed a significant decline (<i>p</i> &lt; 0.001), and CPT 61626 showed a stable trend (<i>p</i> = 0.082). There was a significant decline in CPT code 31238 use after 2018 (<i>p</i> &lt; 0.01). CPT 61626 showed a significant increase in usage post-2018 (<i>t</i> = 2.90, <i>p</i> = 0.044).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>After an initial increase in 2019, TESPAL reporting flattened, while CPT 61626 (which includes all embolization in head and neck vessels) significantly increased post-2018. As recent studies show significant advantages of TESPAL over embolization, these findings warrant further attention and study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Gel Application on the Transducer in Cartilage Conduction Hearing Aids: A Case Series Study","authors":"Tadashi Nishimura,&nbsp;Hiroshi Hosoi,&nbsp;Osamu Saito,&nbsp;Ryota Shimokura,&nbsp;Tadao Okayasu,&nbsp;Chihiro Morimoto,&nbsp;Tadashi Kitahara","doi":"10.1002/lio2.70108","DOIUrl":"https://doi.org/10.1002/lio2.70108","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In ultrasonography, gels are used as conduction media to improve sound transmission and to obtain high-quality images; however, gels are rarely used in hearing devices. The application of gel to couple the transducer to the ear could potentially improve the benefits of hearing aids, particularly cartilage conduction (CC) hearing aids, which deliver sound through vibrating the aural cartilage. This study aimed to investigate the effects of gel application on the performance of CC hearing aids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-three patients (30 ears) with aural atresia or severe canal stenosis were treated with CC hearing aids. The aided thresholds, maximum speech recognition scores (SRSs), and hearing levels at which the maximum SRS (dB [Max]) was observed were compared before and after gel application to the transducer of the CC hearing aids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thresholds &gt; 1 kHz significantly decreased (improved) when the gel was applied to the transducer (<i>p</i> &lt; 0.05). The threshold improvement at 1 kHz was significantly better than that at 0.5 kHz, and that at 4 kHz was significantly better than at 0.25 and 0.5 kHz. No significant differences were observed in the maximum SRS or dB (Max).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Gel application, which is considered to have minimum risk, showed statistically significant improvements in hearing levels at higher frequencies. Therefore, the application of gel can be considered a beneficial option to enhance the performance of CC hearing aids by improving the coupling conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Positional Obstructive Sleep Apnea in Children Undergoing Adenotonsillectomy for Obstructive Sleep Apnea","authors":"Seckin O. Ulualp,&nbsp;Romaine F. Johnson,&nbsp;Ron B. Mitchell","doi":"10.1002/lio2.70116","DOIUrl":"https://doi.org/10.1002/lio2.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the prevalence of positional obstructive sleep apnea (pOSA) in children undergoing adenotonsillectomy (AT) for OSA and to assess whether pOSA improves following AT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Children with OSA diagnosed by polysomnography (PSG) at a tertiary care children's hospital were included. Data was collected on demographics, PSG parameters, and surgical management. Statistical comparisons between groups for the prevalence of pOSA were performed with the χ2 test or Fisher's exact test, for PSG parameters prior to AT with Student's <i>t</i>-test or Mann–Whitney Rank Sum Test, and for PSG parameters before and after AT with paired t-test and Wilcoxon Signed Rank Test. <i>p</i> &lt; 0.05 was considered significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 1167 children (682 male, 485 female, median age = 5.7 years), 321 (28%) had pOSA. POSA children (median age = 7.4 years) were older than children with no pOSA (median = 5.2) (<i>p</i> ≤ 0.001). The prevalence of pOSA in the subgroups of gender and weight was not different. The prevalence of pOSA was significantly different amongst the race groups (<i>p</i> = 0.005). Compared with the Black/African American race, the white race had 1.4 times the odds of pOSA (95% CI, 1.07–1.98). The prevalence of pOSA was not significantly different between mild, moderate, and severe OSA groups (<i>p</i> = 0.7). Of the 66 POSA children who had PSG pre- and post-TA, 50 (76%) had resolution of pOSA. Children older than 6 years of age and children with obesity had a higher rate of persistent pOSA (<i>p</i> = 0.02 and <i>p</i> = 0.008, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>POSA occurred frequently in OSA children undergoing AT. POSA is resolved in the majority of children after AT. Persistent pOSA was more prevalent in older and obese children. AT is used as the first-line treatment for pOSA in children. Future studies are needed to determine the role of positional therapy and other OSA therapies in the management of persistent pOSA after AT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Profiles to Structure in Cochlear Nerve: A Clinical Study of Auditory Neuropathy","authors":"Danyang Li,&nbsp;Hongyang Wang,&nbsp;Mengtao Song,&nbsp;Lan Lan,&nbsp;Linyi Xie,&nbsp;Fen Xiong,&nbsp;Jin Li,&nbsp;Yiming Li,&nbsp;Rui Zhou,&nbsp;Xiaolong Zhang,&nbsp;Qiuju Wang","doi":"10.1002/lio2.70100","DOIUrl":"https://doi.org/10.1002/lio2.70100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the clinical and audiological features in auditory neuropathy (AN) patients with different image performance of cochlear nerve (CN) on MRI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>AN patients were selected from the Multicenter Study on Clinical Diagnosis and Intervention of AN (2003–2023). Subjects were divided into four groups by CN size on MRI: bilateral AN with CN normalization (BAN^cnn), bilateral CN deficiency (BAN^cnd), unilateral AN with CND (UAN^cnd), and CN normalization (UAN^cnn) groups. Clinical and audiological features were analyzed, alongside differential analysis using the Internal auditory meatus (IAM) grading system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Totally 132 cases were included. The rate of CND was 35.6% (47/132), with 32.7% (36/110) and 50.0% (11/22) in bilateral and unilateral AN patients. The proportion of IAM I to IV grades increased progressively. Clinical and audiological characteristics differed between bilateral and unilateral AN patients. For bilateral AN patients, the age of onset and diagnosis of BAN^cnd were older, which were 11.8 ± 7.2 years and 19.5 ± 11.1 years, respectively, compared to patients in BAN^cnn group. UAN^cnd patients exhibited more severe hearing loss at all frequencies compared to UAN^cnn. Prognostic analysis indicated that AN patients with CND had no lower intervention rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The detection rate of CND was 35.6%, predominantly in unilateral AN patients and IAM IV was the most common type. Some clinical and audiological indicators were associated with imaging features of CN but varied between bilateral and unilateral AN. Variation in image performance may not be related to prognosis in AN patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety, Depression and Cancer-Related Post-Traumatic Stress in Patients Undergoing Total Laryngectomy","authors":"Mai Yokoi,&nbsp;Naoki Nishio,&nbsp;Hiroyuki Kimura,&nbsp;Tatsuya Tokura,&nbsp;Shinichi Kishi,&nbsp;Hidenori Tsuzuki,&nbsp;Nobuaki Mukoyama,&nbsp;Sayaka Yokoi,&nbsp;Akihisa Wada,&nbsp;Mayu Shigeyama,&nbsp;Yasushi Fujimoto,&nbsp;Masashi Ikeda,&nbsp;Michihiko Sone","doi":"10.1002/lio2.70109","DOIUrl":"https://doi.org/10.1002/lio2.70109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aims to elucidate the incidence of cancer-related post-traumatic stress (PTS) and the fluctuations in anxiety and depression levels before and one year after laryngectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective longitudinal study was conducted on 97 consecutive patients scheduled to undergo laryngectomy (total laryngectomy or pharyngolaryngectomy) at a single university hospital between 2007 and 2022. To assess cancer-related PTS, anxiety, and depression, participants completed two brief self-reported questionnaires: the Impact of Event Scale-Revised (IES-R) and the Hospital Anxiety and Depression Scale (HADS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Prior to laryngectomy, 32 patients planning for the procedure were considered as cancer-related PTS based on IES-R. The prevalence of anxiety and depression before surgery was 56% and 76% in the 32 patients with PTS, respectively, compared to 8% and 20% in the 65 patients without PTS. Patients with PTS exhibited significantly worse HADS-anxiety and HADS-depression scores compared to those without PTS at baseline (<i>p</i> &lt; 0.001 for both). Although no significant difference was found in the HADS-anxiety score between the two groups (<i>p</i> = 0.15), patients with PTS exhibited a significantly worse HADS-depression score than those without PTS one year after surgery (<i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Early identification of possible depressive disorders and active psychiatric interventions are crucial for patients undergoing laryngectomy during the follow-up period. Preoperative assessment of cancer-related PTS may offer an opportunity to implement appropriate psychological interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoalbuminemia and Postoperative Outcomes Following Major Salivary Gland Resection","authors":"Praneet C. Kaki,&nbsp;Aman M. Patel,&nbsp;Jason A. Brant,&nbsp;Steven B. Cannady,&nbsp;Karthik Rajasekaran,&nbsp;Robert M. Brody,&nbsp;Ryan M. Carey","doi":"10.1002/lio2.70107","DOIUrl":"https://doi.org/10.1002/lio2.70107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Hypoalbuminemia (HA) is a proxy for malnutrition that has been associated with postoperative complications in several surgical subspecialties. This study investigates the association between pre-operative HA and complications following major salivary gland (MSG) resection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients undergoing outpatient, elective MSG resection were extracted from the 2005 to 2020 National Surgical Quality Improvement Program database. Demographics and comorbidities were compared between HA (preoperative serum albumin &lt; 3.5 g/dL) and non-HA cohorts. To determine associations between albumin status and postoperative complications, univariate and multivariable binary logistic regression analyses were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 5774 patients undergoing MSG resection were included, of which 321 (5.6%) had preoperative HA. HA was associated with older age on univariate analysis (65.2 vs. 60.2 years, <i>p</i> &lt; 0.001). Multivariable analysis found HA to be independently associated with any surgical complication (OR 2.03, 95% CI 1.09–3.56, <i>p</i> = 0.019) and length of stay (LOS) ≥ 90th percentile (OR 1.58, 95% CI 1.04–2.38, <i>p</i> = 0.032).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Preoperative HA may be a poor prognostic factor associated with an increased risk of surgical complications and prolonged LOS among patients undergoing MSG resection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>4.</p>\u0000 </section>\u0000 </div>","PeriodicalId":48529,"journal":{"name":"Laryngoscope Investigative Otolaryngology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lio2.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}