Beni-Suef University Journal of Basic and Applied Sciences最新文献

{"title":"Analyzing fractional glucose-insulin dynamics using Laplace residual power series methods via the Caputo operator: stability and chaotic behavior","authors":"Sayed Saber,&nbsp;Safa M. Mirgani","doi":"10.1186/s43088-025-00608-y","DOIUrl":"10.1186/s43088-025-00608-y","url":null,"abstract":"<div><h3>\u0000 <b>Background</b>\u0000 </h3><p>The dynamics of glucose-insulin regulation are inherently complex, influenced by delayed responses, feedback mechanisms, and long-term memory effects. Traditional integer-order models often fail to capture these nuances, leading to the adoption of fractional-order models using Caputo derivatives. This study applies the Laplace residual power series method (LRPSM) to explore the glucose-insulin regulatory system’s stability, oscillatory behaviors, and chaotic transitions.</p><h3>\u0000 <b>Results</b>\u0000 </h3><p>Morphologically, the fractional-order glucose-insulin regulatory system revealed transitions between stability, oscillations, and chaos. Key system behaviors were characterized using Lyapunov exponents, bifurcation diagrams, and phase portraits. Numerical simulations validated the effectiveness of LRPSM in capturing essential dynamics, including sensitivity to parameters such as insulin sensitivity and glucose uptake rates. The chaotic behaviors observed emphasize the system’s sensitivity to initial conditions and fractional order.</p><h3>\u0000 <b>Conclusion</b>\u0000 </h3><p>This study highlights the utility of LRPSM in modeling fractional-order biological systems, offering significant advancements in understanding diabetes pathophysiology. The findings pave the way for designing glycemic control strategies and exploring optimized interventions for diabetes management. Future research could integrate additional physiological parameters and explore real-time applications to enhance glycemic control.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00608-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency assisted delivery of broccoli, cabbage and kale conjugated activated carbon nanoparticles for radio-photodynamic colorectal cancer vitro and vivo treatment","authors":"Samir Ali Abd El-Kaream,&nbsp;Yara Ahmed Mohamed Elsaid Mohamed Ahmed,&nbsp;Hagar Mohamed Mohamed,&nbsp;Amal Saleh Mohamed Soliman,&nbsp;Nabila Gaber Ali Hussein,&nbsp;Sohier Mahmoud El Kholey","doi":"10.1186/s43088-025-00615-z","DOIUrl":"10.1186/s43088-025-00615-z","url":null,"abstract":"<div><h3>Background</h3><p>There is no doubt that one of the most considerable researcher dilemmas is cancer. Radiofrequency-photodynamic therapy (RFPDT) offers novel approaches to cancer treatment by combining radiofrequency-dynamic therapy and photodynamic therapy with sensitizers. While novel sensitizers for RFPDT have been synthesized successfully, their effective application is still limited. Their limited ability to transfer sensitizer's deeper intratumorally, low tumor-targeting selectivity, and failing tumor microenvironment all restrict their anti-tumor activity. The goal of the current work was to examine the most recent advancement in activated cancer treatment using radiofrequency assisted drug delivery of conjugated activated carbon nanoparticles of broccoli, cabbage, and kale (BCK-ACNP) to treat colorectal cancer (CRCA) using both in vivo and in vitro RFPDT.</p><h3>Materials and methods</h3><p>The current study included human CRCA cells (SW-620) and Swiss albino induce CRCA mice [treated with 1,2-dimethylhydrazine (DMH) and dextran sulphate sodium (DSS) only] were used in the in vitro and in vivo study. The study treatment protocol started only after CRCA induction, and involved daily administration of BCK-ACNP as RFPDT sensitizer whether or not to be exposed to laser (IRL) or radiofrequency (RF) or a combination of them for 3 min for a period of 2 weeks.</p><h3>Results</h3><p>Demonstrated that ACNP is a useful BCK delivery mechanism that targets CRCA cells directly. Furthermore, BCK-ACNP is a promising RFPS that, when used in conjunction with RFPDT, can be very effective in in vitro treating CRCA-SW-620 (in a dose-dependent manner cell viability declined, an increase in the population of cells during the S and G2/M phases indicates that the cell cycle was arrested, and an increase in the Pre-G cell population, autophagic cell death, as well as early and late apoptosis and necrosis, indicate that cell death was induced) and DMH/DSS-CRCA-induced mice in vivo (induced antiproliferative genes, p53, Bax, TNFalpha, caspase 3,9, repressed antiangiogenic and antiapoptotic genes, VEGF and Bcl2 respectively), successfully slowing the growth of tumors and even killing cancer cells, as well as lowering oxidative stress (MDA), improving the functions of the kidneys (urea, creatinine), liver (ALT, AST), and antioxidants (GPx, GR, GST, GSH, CAT, SOD, TAC). RFPDT, the photochemical or radiofrequency BCK activation mechanism, and the antioxidant capacity of non-activated BCK can all be linked to this process.</p><h3>Conclusion</h3><p>Based on the findings, BCK-ACNP shows a great promise as a cutting-edge, efficient selective delivery system for localized RFPDT-activated colorectal cancer treatment.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00615-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the import of mechatronics engineering in medicine: a review","authors":"Oluwaseun O. Martins,&nbsp;Christiaan C. Oosthuizen,&nbsp;Dawood A. Desai","doi":"10.1186/s43088-025-00618-w","DOIUrl":"10.1186/s43088-025-00618-w","url":null,"abstract":"<div><h3>Background</h3><p>The interdisciplinary nature of mechatronics has spurred huge progress in medicine to facilitate the creation of robotic surgery, wearable health monitoring, and bio-inspired robots. All these technologies enhance the precision of surgery, boost diagnostic capability, and enable real-time patient monitoring. For example, robotic-assisted surgeries have recorded a 50% cut in complications and a 40% reduction in healing times, while wearable health technology has enhanced early anomaly detection by 80%, saving emergency hospitalisation.</p><h3>Main body</h3><p>This review critically examines the evolution and interdisciplinary applications of mechatronics in medicine focusing on problems including financial burdens, confidentiality of data, and compliance with regulation. Emphasis is placed heavily on the regulatory approval processes required by organisations such as the US Food and Drug Administration (FDA) and the International Organisation for Standardisation (ISO) that typically delay the use of life-saving equipment by 3–5 years. In addition, the expensive price of robotic surgery systems (~$2 million per unit) and extensive training (20–40 procedures to be proficient) are inhibiting factors. New trends such as bio-inspired robots and nanomedicine are also considered here, which have exhibited fantastic potential in minimally invasive therapy, and nanorobot-based cancer therapies have exhibited tumour growth inhibition by 50% while limiting systemic side effects.</p><h3>Conclusions</h3><p>To propel the ethical and sustainable adoption of mechatronics in healthcare, this review proposed the development of interdisciplinary partnerships among engineers, clinicians, and policymakers, simplifies regulatory clearance processes, and designs low-cost, scalable products. Through these avenues, mechatronics can proceed to revolutionise healthcare, enhancing patient outcomes and expanding the accessibility of cutting-edge medical technology.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00618-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracts of Carica papaya L. and Capsicum annuum L. showed comparable efficacy to piperazine citrate and levamisole hydrochloride in treatment of poultry helminths","authors":"Gerald Zirintunda,&nbsp;John Kateregga,&nbsp;Sarah Nalule,&nbsp;Savino Biryomumaisho,&nbsp;Francis Omujal,&nbsp;James Okwee-Acai,&nbsp;Patrick Vudriko","doi":"10.1186/s43088-025-00607-z","DOIUrl":"10.1186/s43088-025-00607-z","url":null,"abstract":"<div><h3>Background</h3><p>In rural smallholder poultry production systems, synthetic anthelmintic drugs are considered expensive and in some instances ineffective because of anthelmintic resistance. We report on the phytochemical properties and efficacy of crude extracts of <i>Carica papaya</i> L. and <i>Capsicum annuum</i> L. against helminth infections of chickens. The experiments that compared the extract action to piperazine and levamisole were carried out in Soroti District, Eastern Uganda.</p><h3>Method</h3><p>An experiment was set to evaluate efficacy of crude extracts of <i>C. papaya</i> and <i>C. annuum</i> against natural poultry helminths infections. Commercially available formulations of levamisole and piperazine were used to make a comparative efficacy study. Faecal egg count reduction (FECR) tests were used to measure efficacy of the treatments.</p><h3>Results</h3><p>On gas chromatograph mass spectrometry (GC–MS) analysis of CPLa showed, vitamin C (42%), sterols (13%) and Triterpenoids (6%). CPLe contained lipids (45.04%), pyranones (20.3%), diterpenoids (4.9%), triterpenoids (3.5%), phenolics (3.1%), glycosides (2.2%) and steroids (1.4%). GC–MS analysis of CAFa gave lipids (45.04%), alkanes (27.7%) and alkaloids (8.2%). CAFe showed lipids (50.16%), alkaloids (22.73%), glycosides (3.61%) and pyranones (3.55%). In the in vitro assays, 0.08 g/ml of each of the extracts caused motility inhibition of more than 50% of adult <i>A. galli</i> after 5 h. The ranking of the in vivo average FECR was levamisole hydrochloride &gt; CPLa &gt; CAFa &gt; CAFe &gt; CPLe &gt; piperazine citrate with the percentage reductions of 98.67 ± 2.309, 97.67 ± 2.517, 79.67 ± 1.528, 76.33 ± 1.528, 54.00 ± 2.00, 35.67 ± 2.082, respectively.</p><h3>Conclusion</h3><p>The GC–MS analysis of the analysed plants shows presence of terpenoids, phenolics and alkaloids which are known for anthelmintic action. All the extracts caused higher FECR than piperazine. The presence of vitamin C in CPLa made it the best extract. Combinations of anthelmintics with vitamin C are recommended and toxicological studies of extracts.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00607-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of calcium and vitamin A in patients with metabolic-associated fatty liver diseases","authors":"Reem M. Makbol,&nbsp;Zeinab Mahmoud Kadry,&nbsp;Mohamed Mamdouh Noaman,&nbsp;Shimaa Abd El-Kareem Mohammed,&nbsp;Ahmed Othman","doi":"10.1186/s43088-025-00612-2","DOIUrl":"10.1186/s43088-025-00612-2","url":null,"abstract":"<div><h3>Background</h3><p>Non-alcoholic fatty liver disease (NAFLD) is a condition where there is an excessive accumulation of fat in the liver. Non-alcoholic steatohepatitis is a chronic liver injury that may result from benign steatosis, which is a common form of NAFLD. Chronic liver diseases such as NAFLD tend to be related to vitamin A deficiency.</p><p>The study aimed to investigate the role of vitamin A and calcium and their relation in the occurrence of fibrosis or steatosis in NAFLD patients, as well as the incidence of liver steatosis in NAFLD.</p><h3>Results</h3><p>The study was cross-sectional and involved 110 subjects. A detailed history, clinical examination, laboratory investigations, serum calcium and vitamin A assessments, abdominal ultrasonography, and fibroscan examination were performed. The study included 110 individuals aged 18–70. Based on imaging, the participants were classified into the NAFLD group (70 patients) and the control group (40 persons). According to the study results indicate of patients with NAFLD were classified as 37.3% as S1, 19% as S2, and 7.3% as S3. Regarding the degree of fibrosis, 30% of NAFLD patients were F1, 17.3% were F2, and 16.4% were F3. The study found that the NAFLD group had lower levels of vitamin A than the control group but higher calcium levels.</p><h3>Conclusion</h3><p>Individuals with non-alcoholic fatty liver disease may exhibit varying degrees of steatosis based on their serum retinol levels. The findings suggest that vitamin A and calcium may play a role in the development and progression of NAFLD.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00612-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cockroach activities of biosynthesized silver nanoparticles using Petiveria alliacea extracts","authors":"Oladele Abiodun Olaniran,&nbsp;Joseph Adetunji Elegbede,&nbsp;Agbaje Lateef,&nbsp;Timothy Abiodun Adebayo,&nbsp;Evariste Bosco Gueguim-Kana,&nbsp;Lorika Selomi Beukes,&nbsp;Ntombozuko Matyumza,&nbsp;Fatai Olaitan Alao","doi":"10.1186/s43088-025-00614-0","DOIUrl":"10.1186/s43088-025-00614-0","url":null,"abstract":"<div><h3>Background</h3><p>This study was conducted with a view to biosynthesize silver nanoparticles (AgNPs) using the root (PaR) and leaf (PaL) extracts of <i>Petiveria alliacea</i> and evaluation of their activities against cockroaches, which is a major household insect pest.</p><h3>Methods</h3><p>The biosynthesized AgNPs were characterized by UV–Vis spectrophotometry, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), and energy-dispersive X-ray (EDX). PaR-AgNPs and PaL-AgNPs were tested at three different concentrations (1, 5, 10% v/v) using two modes of applications (fumigant and contact toxicity) at different hours of exposure.</p><h3>Results</h3><p>The peak absorbance of the AgNPs occurred at the wavelengths of 426 and 442 nm for PaL-AgNPs and PaR-AgNPs, respectively, with the brownish colloidal solutions. FITR peaks indicated the presence of alkenes (= C–H), esters (= O), amides (= N–H), and aliphatic amines (= C–N) in the samples, while the TEM and EDX analyses showed the presence of silver in the AgNPs colloidal solution, with the spherical nanoparticles ranging from 5.95 to 76.19 nm in size. Both AgNPs demonstrated insecticidal action against adult cockroaches, with the fumigant application causing more rapid death than the contact application. The fumigant application resulted in 80–90% cockroach mortality, while the contact application caused 40–50% mortality after three hours of exposure at 10% v/v. These results demonstrate that the effectiveness of the bio-fabricated AgNP formulations depends on the concentrations, hours of exposure, and mode of application.</p><h3>Conclusion</h3><p>Therefore, the pest management program for household pests, particularly cockroaches, can incorporate silver nanoparticle-based insecticides.</p><h3>Article Highlights</h3><ul>\u0000 <li>\u0000 <p>TEM and EDX analyses indicate the presence of silver in the nano-insecticide products</p>\u0000 </li>\u0000 <li>\u0000 <p>Biosynthesized AgNPs exhibited insecticidal action against adult cockroach</p>\u0000 </li>\u0000 <li>\u0000 <p>Toxicity effect of nano-insecticides depends on mode of application</p>\u0000 </li>\u0000 <li>\u0000 <p>Nano-insecticides applied through fumigant killed faster than when applied through contact</p>\u0000 </li>\u0000 <li>\u0000 <p>Effectiveness of biosynthesized AgNPs was dose-dependent</p>\u0000 </li>\u0000 </ul></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00614-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of CYP1B1 in the treatment and prognosis of breast cancer","authors":"Maria Carolina Stipp,&nbsp;Jeanine Marie Nardin,&nbsp;José Claudio Casali-da-Rocha,&nbsp;Sérgio Ioshii,&nbsp;Alexandra Acco","doi":"10.1186/s43088-025-00609-x","DOIUrl":"10.1186/s43088-025-00609-x","url":null,"abstract":"<div><h3>Background</h3><p>Cytochrome P450 1B1 (CYP1B1) enzyme plays an important metabolic role, especially in the metabolism of xenobiotics, endogenous substances, and procarcinogens. It may be involved in tumor initiation and progression. High levels of CYP1B1 have been identified in aggressive breast cancer cell lineages. The aim of the present study was to identify the expression and role of this enzyme in progression, prognosis, and clinical features of breast cancer patients.</p><h3>Methods</h3><p>Microarray paraffin-embedded tumor samples from 166 women with breast cancer were analyzed by immunohistochemical for CYP1B1. Statistical analyses were performed to correlate CYP1B1 expression with various clinical parameters among breast cancer patients. Bioinformatic tools were used to determine differential CYP1B1 mRNA and protein expression from patients in databases compared with our cohort.</p><h3>Results</h3><p>The CYP1B1 enzyme was overexpressed in 75% of breast cancer tissues. This result remained consistent regardless of the treatment regimen. Furthermore, although it was not negatively associated with overall survival, its expression was notably higher in patients who died and in patients with ER- (estrogen receptor negative) and PR- (progesterone receptor negative) tumors and p53 (protein 53) mutation carriers. These findings align with the consulted databases, which indicated a relationship between CYP1B1 expression, tumor progression, and malignancy, suggesting its potential role as a biomarker for tumor aggressiveness.</p><h3>Conclusions</h3><p>In conclusion, CYP1B1 showed a positive correlation with breast cancer malignancy, tumor progression, and toxicity effects in breast cancer patients. These findings emphasize the importance of CYP1B1 as a potential treatment target and its significance in the clinical management of breast cancer.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00609-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity assessment of collagen from Decapterus macarellus: a zebrafish model study","authors":"Nipuna Deelaka Wimalagunarathna,&nbsp;Varuni Karunika Gunathilake","doi":"10.1186/s43088-025-00613-1","DOIUrl":"10.1186/s43088-025-00613-1","url":null,"abstract":"<div><h3>Background</h3><p>Collagen, derived from various biological sources, is crucial in supporting a range of physiological processes and developmental pathways. However, concerns have been raised regarding the potential teratogenic effects of collagen. The zebrafish (<i>Danio rerio</i>) model has emerged as a premier vertebrate model for investigating the impact of biomaterials on vertebrate development, both under normal and pathological conditions. The present study sought to assess the acute toxicity, developmental toxicity, cardiotoxicity, and teratogenic toxicity of fish collagen extracted from <i>Decapterus macarellus</i> fish species on various developmental parameters. Acid-solubilized collagen was extracted from <i>D. macarellus</i>, and zebrafish embryos (&lt; 96 h) were subsequently exposed to varying collagen concentrations of 62.5 parts per million (ppm), 125 ppm, 250 ppm, 500 ppm, and 1000 ppm. Key developmental parameters, including survival rate, hatching rate, heart rate, and deviations in four apical points: embryo coagulation, lack of somite formation, non-detachment of the tail, and lack of heartbeat observations were recorded over a period of 0–96 h post-fertilization (hpf). Positive and negative controls were parallelly carried out analysing the results statistically with pairwise Kruskal–Wallis test followed by a Dunn pairwise test.</p><h3>Results</h3><p>The results indicated that the survival rate of zebrafish embryos ranged from 96.97 ± 5.25 to 82.28 ± 9.80% at 96 hpf across all tested collagen concentrations. No significant differences were observed (<i>P</i> &gt; 0.05) compared to the negative control group or between the various treated concentrations. The hatching rate at 48 hpf and heart rates at 72 hpf and 96 hpf in the treated groups showed no significant variations compared to the negative control (<i>P</i> &gt; 0.05). Furthermore, no abnormal changes were recorded in the four apical points; embryo coagulation, lack of somite formation, non-detachment of the tail, and lack of heartbeat in embryos, treated with collagen. All the observed results cumulatively indicated the nontoxic effect of collagen from <i>D. macarellus</i> on zebrafish embryo development.</p><h3>Conclusions</h3><p>The results confirm the extracted from <i>D. macarellus</i> is nontoxic and causes no teratogenic effects in zebrafish embryo development. It further validates the potential of using collagen as a biocompatible material, where non-toxicity and developmental safety are paramount.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00613-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced structural, dielectric, and antibacterial properties of Sr(1−x)CuxO2 nanoparticles synthesized via sol–gel method","authors":"Ahmed S. Atlam,&nbsp;Abeer T. Talha,&nbsp;Talaat M. Meaz,&nbsp;Mohamed S. Hasanin,&nbsp;Amany M. El Nahrawy","doi":"10.1186/s43088-025-00611-3","DOIUrl":"10.1186/s43088-025-00611-3","url":null,"abstract":"<div><p>In this study, we investigated the preparation, characterization, and antibacterial properties of strontium oxide (SrO) nanoparticles doped with different ratios of copper oxide (CuO) (1, 2, 3, and 4 mol.%). The SrO@CuO nanoparticles were synthesized using the sol–gel method, which is known for producing highly homogeneous and pure nanoparticles in a versatile and cost-effective manner. The study investigates the impact of CuO on the growth of the nanoparticles and their antibacterial and dielectric properties. Several techniques including X-ray diffraction, transmission electron microscopy, FTIR, and dielectric spectroscopy were used to analyze the morphological, crystallographic, and electric properties of the SrO@CuO nanoparticles. The dielectric properties of the nanoparticles were performed to study the polarization at the interface, energy loss (tan ε), and conductivity from 0.1 Hz to 20 MHz. Koop's two-layer model was suggested to explain the changes in impedance with frequency. The model suggests that the samples contain well-directing grains detached by some insulating grain boundary. As the frequency increases, the impedance decreases, and the interfacial polarization goes down. This happens when the dielectric dipoles stop following the applied reciprocating electric field. The antibacterial effects of CuO nanoparticles on Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis were also observed. The samples showed antibacterial efficacy. The study found that the concentration of CuO significantly affects the structure, spectroscopic properties, and antibacterial efficacy of the CuO nanoparticles. The results indicate that SrO@CuO nanoparticles are appropriate for energy storage, recording media, microwaves, and antimicrobial agents.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00611-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel synergistic antibacterial activity of meloxicam-curcumin and diclofenac-curcumin combinations against methicillin-sensitive S. aureus and E. faecium","authors":"Asem M. Karajeh,&nbsp;Rawan N. Alkaraki,&nbsp;Yasser Gaber","doi":"10.1186/s43088-025-00606-0","DOIUrl":"10.1186/s43088-025-00606-0","url":null,"abstract":"<div><h3>Background</h3><p>Some nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to have antibacterial activities in different experimental settings. In the current study, the antibacterial activities of meloxicam and diclofenac were evaluated when combined with curcumin, a polyphenolic compound, against clinically relevant bacteria. The aim was to determine whether these combinations could provide a novel, synergistic approach to combat pathogenic bacteria.</p><h3>Results</h3><p>The minimum inhibitory concentration (MIC) values of curcumin (CCM), meloxicam (MXM), and diclofenac (DC), alone or in combination, were determined using the microdilution broth method. The CCM/MXM combination exhibited synergistic activity against a methicillin-sensitive <i>Staphylococcus aureus</i> (MSSA) strain which is resistant to chloramphenicol and clindamycin. It reduced MICs up to 32-fold and achieved a fractional inhibitory concentration index (FICI) of 0.28 (FICI &lt; 0.5 indicates synergy). Synergy was also observed against a levofloxacin-resistant <i>Enterococcus faecium</i> (FICI = 0.5). Growth kinetics experiments confirmed these findings, with significant reductions in MSSA and <i>E. faecium</i> growth rates (<i>P</i> &lt; 0.001 and <i>P</i> &lt; 0.01, respectively). Additionally, the biofilm inhibition activity was evaluated.</p><h3>Conclusion</h3><p>These findings suggest that curcumin combined with meloxicam could offer a good antibacterial combination specifically for Gram-positive bacteria. This is a promising approach for topical antibacterial preparations, where high local concentrations can be achieved to combat clinical pathogenic bacteria. Further research on these combinations may support their potential as adjunct therapies for managing bacterial infections or cases of topical infection with concurrent inflammatory disorders.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00606-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}