Beni-Suef University Journal of Basic and Applied Sciences最新文献

{"title":"Chitosan nanoparticles, camel milk exosomes and/or Sorafenib induce apoptosis, inhibit tumor cells migration and angiogenesis and ameliorate the associated liver damage in Ehrlich ascites carcinoma-bearing mice","authors":"Amr A. Tawfic,&nbsp;Hany M. Ibrahim,&nbsp;Khaled Mohammed-Geba,&nbsp;Mohammed A. El-Magd","doi":"10.1186/s43088-024-00535-4","DOIUrl":"10.1186/s43088-024-00535-4","url":null,"abstract":"<div><h3>Background</h3><p>It is crucial to improve cancer patients' quality of life by developing medications that can treat cancer with minimum adverse effects. This study aimed to evaluate the therapeutic effect of chitosan nanoparticles (CNPs) and camel milk exosomes (CMEs) alone or in combination with Sorafenib (SOR) on Ehrlich ascites carcinoma (EAC)-bearing mice and to assess whether EAC-associated liver injury would be ameliorated due to this combination. Liver function and oxidant/antioxidant status were determined spectrophotometrically, while the levels of inflammatory cytokines were estimated by enzyme-linked immunosorbent assay. Gene expression was detected using real-time polymerase chain reaction.</p><h3>Results</h3><p>The tumor burden in EAC-bearing mice was reduced after treatment with CNPs ± CMEs ± SOR as indicated by (1) reduced ascetic fluid volume and tumor-cell viability; (2) induction of apoptosis [high p53, BCL2 associated X<i> (Bax</i>)<i>,</i> caspase 3, low B-cell leukemia/lymphoma 2 protein (<i>Bcl2</i>)]; (3) increased intracellular reactive oxygen species; (4) decreased migration [high matrix metalloproteinase 9 (<i>MMP9</i>) and low TIMP metallopeptidase inhibitor 1 (<i>TIMP1</i>)]; (5) declined angiogenesis [low vascular endothelial growth factor (<i>VEGF</i>). These treatments also reduced liver injury induced by EAC as noticed by (1) restored liver function indices [alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and albumin]; (2) restored redox balance [low malondialdehyde (MDA) levels and high superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities]; (3) increased antioxidant gene expression [high nuclear factor erythroid 2-related factor 2 (<i>Nrf2</i>) and heme oxygenase-1 (<i>HO-1</i>)]; (4) declined inflammation [low interleukin-1β (IL1β) and tumor necrosis factor alpha<b> (</b>TNFα) levels), and (5) enhanced structure of liver. SOR + CNPs-treated mice showed the most improvement, followed by SOR + CMEs-treated animals.</p><h3>Conclusions</h3><p>Based on these findings, we determined that CNPs and CMEs enhanced SOR's anticancer efficacy and had an ameliorative role against EAC-induced liver injuries.</p><h3>Graphic abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00535-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141880850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-step kinetic model for fisetin dye diffusion into fibroin fibre","authors":"Yusif Shukurlu,&nbsp;Zarintaj Shukurova","doi":"10.1186/s43088-024-00530-9","DOIUrl":"10.1186/s43088-024-00530-9","url":null,"abstract":"<div><h3>Background</h3><p>The study’s relevance is determined by the current desire to reduce the negative environmental impact of the textile industry. The study aims to develop and optimise dyeing processes using natural dyes in the textile industry.</p><h3>Results</h3><p>The process of dye transfer from solution to <i>Bombyx mori</i> natural silk fibre can be divided into three successive kinetic stages. The first stage involves the adsorption of dye molecules on the active surface of the fibre, the second, their diffusion deep into the fibre towards its centre, and the third, the uniform distribution of dye molecules along the fibre starting from its centre. It is noticed that diffusion at the third stage slows down significantly, and the third stage lasts much longer than the first and second stages. The analysis of experimental data on dye concentration over time on dyed materials and their comparison with hypothetical data will make it possible to establish time intervals for each stage of the process and diffusion coefficients for each of them.</p><h3>Conclusion</h3><p>This study has practical implications as it may contribute to more efficient and sustainable dyeing of textile materials using natural dyes, helping to reduce the negative environmental impact of the textile industry, and contributing to our knowledge of diffusion and dyeing processes.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00530-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of host antimicrobial peptides with type II diabetes mellitus complications: a systematic review","authors":"Hawraa Ibrahim Abdul Kareem,&nbsp;Suhad Hadi Mohammed","doi":"10.1186/s43088-024-00527-4","DOIUrl":"10.1186/s43088-024-00527-4","url":null,"abstract":"<div><h3>Background</h3><p>This systematic review aims to review and assess the importance and relationship between host defence antimicrobial peptides with type 2 diabetes mellitus (T2DM) complications and the correlation of their expression with hyperglycaemic status.</p><h3>Main body</h3><p>The systematic search included three electronic databases (PMC, PubMed, and Google Scholar) that were searched from July to November 2023. After identifying and screening the research articles, eleven studies fulfilled the selection criteria and were included (six case–control and five cross-sectional studies). The Newcastle Ottawa Scale assessed the selected studies’ quality. Most studies indicated a correlation between certain types of AMPs and diabetic complications.</p><h3>Conclusion</h3><p>Hyperglycaemia in type 2 diabetes mellitus (T2DM) affects the expression of certain types of antimicrobial peptides (AMPs) which have a dual function (antibacterial and modulation of immune response) that may enhance inflammation which may correlate with the development of long-term complications, increased susceptibility to bacterial infection, and impaired wound healing.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00527-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired algorithm integrated with sequential quadratic programming to analyze the dynamics of hepatitis B virus","authors":"Muhammad Shoaib,&nbsp;Rafia Tabassum,&nbsp;Muhammad Asif Zahoor Raja,&nbsp;Kottakkaran Sooppy Nisar","doi":"10.1186/s43088-024-00525-6","DOIUrl":"10.1186/s43088-024-00525-6","url":null,"abstract":"<div><h3>Background</h3><p>There are a variety of lethal infectious diseases that are seriously affecting people's lives worldwide, particularly in developing countries. Hepatitis B, a fatal liver disease, is a contagious disease spreading globally. In this paper, a new hybrid approach of feed forward neural networks is considered to investigate aspects of the SEACTR (susceptible, exposed, acutely infected, chronically infected, treated, and recovered) transmission model of hepatitis B virus disease (HBVD). The combination of genetic algorithms and sequential quadratic programming, namely CGASQP, is applied, where genetic algorithm (GA) is used as the main optimization algorithm and sequential quadratic programming (SQP) is used as a fast-searching algorithm to fine-tune the outcomes obtained by GA. Considering the nature of HBVD, the whole population is divided into six compartments. An activation function based on mean square errors (MSEs) is constructed for the best performance of CGASQP using proposed model.</p><h3>Results</h3><p>The solution's confidence is boosted through comparative analysis with reference to the Adam numerical approach. The results revealed that approximated results of CGASQP overlapped the reference approach up to 3–9 decimal places. The convergence, resilience, and stability characteristics are explored through mean absolute deviation (MAD), Theil’s coefficient (TIC), and root mean square error (RMSE), as well as minimum, semi-interquartile range, and median values with respect to time for the nonlinear proposed model. Most of these values lie around 10⁻¹⁰–10⁻⁴ for all classes of the model.</p><h3>Conclusion</h3><p>The results are extremely encouraging and indicate that the CGASQP framework is very effective and highly feasible for implementation. In addition to excellent reliability and level of precision, the developed CGASQP technique also stands out for its simplicity, wider applicability, and flexibility.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00525-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel single nucleotide polymorphism G216A of hormone-sensitive lipase gene associated with Awassi sheep reproduction","authors":"Suroor H. Mohammed,&nbsp;Tahreer M. Al-Thuwaini","doi":"10.1186/s43088-024-00533-6","DOIUrl":"10.1186/s43088-024-00533-6","url":null,"abstract":"<div><h3>Background</h3><p>Litter size plays a crucial role in determining profitability in the sheep industry. Breeding sheep with high litter sizes could be enhanced by selecting candidate genes. One gene affecting sheep's reproductive performance is the hormone-sensitive lipase (<i>HSL</i>) gene. As a result, this study investigated whether the <i>HSL</i> gene variation influenced the fertility of Awassi ewes. The genomic DNA was extracted from 52 singleton ewes and 48 twin ewes. The <i>HSL</i> gene exon 9 (278 bp) was amplified using polymerase chain reaction (PCR).</p><h3>Results</h3><p>Study results revealed two genotypes identified in the 278-bp amplicons: GG and GA. Molecular sequence analysis identified a novel mutation in the GA genotype 216G &gt; A. The statistical analysis revealed a significant association between the single nucleotide polymorphism (SNP) 216A &gt; G and reproductive performance. Ewes with the SNP 216G &gt; A genotype exhibited significantly increased litter sizes, twinning rates, lambing rates, and fewer days to lambing compared to ewes with GG genotypes (<i>P</i> ≤ 0.05). The logistic regression analysis results provided strong evidence that the 216G &gt; A mutation significantly increased litter sizes.</p><h3>Conclusions</h3><p>This study concluded that variant 216G &gt; A SNP positively impacts Awassi sheep reproduction. There is a higher litter size and more prolificacy in ewes with the 216G &gt; A SNP than in those without the SNP.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00533-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing nanotechnology for enhanced delivery of erlotinib: a dynamic duo in cancer treatment","authors":"Rakesh Pahwa,&nbsp;Swati Saini,&nbsp;Jatin Chhabra,&nbsp;Rajat Goyal,&nbsp;Shobhit Kumar,&nbsp;Rajendra Awasthi,&nbsp;Harish Dureja","doi":"10.1186/s43088-024-00528-3","DOIUrl":"10.1186/s43088-024-00528-3","url":null,"abstract":"<div><p>Erlotinib is a reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that acts by inhibiting signaling pathways, resulting in the disruption of cancerous cell proliferation. Erlotinib is a promising anticancer agent mainly utilized in the mitigation of non-small cell lung cancer cells (NSCLC) and pancreatic tumor. Apart from NSCLC and pancreatic tumor, erlotinib has also been employed in different malignancies, including metastatic colorectal cancer, malignant glioma, breast cancer, gastrointestinal cancers, etc. Despite erlotinib’s distinctive qualities as a targeted drug, its applications are still limited by poor solubility, variable oral bioavailability, a high daily dose requirement, large protein binding, and primitive or acquired therapeutic resistance. Nanotechnology is a favorable approach to increase therapeutic effectiveness of erlotinib. It is one of the newest scientific field directed toward the diagnosis and targeted treatment of cancer. This technology aids in the distinction between normal and malignant cells, which overlays the strategy for targeted delivery. This manuscript discussed the advances of erlotinib nanoformulations in the management of different cancers. Moreover, the manuscript also comprises various research outcomes of erlotinib nanoformulations with other therapeutic agents as combinational therapy. Erlotinib can be delivered to a precise target in the body utilizing different polymers, lipids, and metals.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00528-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring flexural performance and abrasion resistance in recycled brick powder-based engineered geopolymer composites","authors":"Junaid K. Ahmed,&nbsp;Nihat Atmaca,&nbsp;Ganjeena J. Khoshnaw","doi":"10.1186/s43088-024-00532-7","DOIUrl":"10.1186/s43088-024-00532-7","url":null,"abstract":"<div><h3>Background</h3><p>Due to growing global concerns regarding the management of construction waste, this study investigates the feasibility of creating engineered geopolymer composites by replacing traditional industrial by-products (slag) with construction waste, specifically recycled brick waste powder.</p><h3>Results</h3><p>Polyvinyl alcohol fibers were incorporated into the engineered geopolymer composite mixtures. The substitution of slag with recycled brick waste powder was carried out at varying percentages: 0, 20, 40, 60, 80, and 100%, resulting in six different engineered geopolymer composite mixtures. The study evaluated the flexural strength, sorptivity, water absorption, and abrasion resistance of the engineered geopolymer composites, and also, microstructural characterization was conducted using scanning electron microscopy. The findings demonstrated that incorporating recycled brick waste powder into the engineered geopolymer composite mixes resulted in a decrease in flexural strength by 35.59% and a notable increase in midspan deflection by 339% when slag was replaced. Concurrently, there was a significant rise in water absorption and sorptivity by approximately 304 and 214%, respectively, when slag was entirely substituted with recycled brick waste powder. Conversely, abrasion resistance decreased, with the inclusion of recycled brick waste powder resulting in an 84% increase in volume change. The scanning electron microscopy (SEM) analysis showed active geopolymerization of recycled brick waste powder within the engineered geopolymer composite mixtures.</p><h3>Conclusions</h3><p>The results of this investigation demonstrate that it is feasible to produce engineered geopolymer composites using recycled brick waste powder instead of slag. The greater ductility and increased midspan deflection point to areas that require further optimization, even in spite of the observed decreases in flexural strength and abrasion resistance. The SEM examination reveals an active geopolymerization, highlighting the potential of recycled brick waste powder to produce environmentally friendly and sustainable construction materials. These results offer a good starting point for further studies that try to maximize the durability and performance of these composites.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00532-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic engineering of terpene metabolism in lavender","authors":"Ojo Michael Oseni,&nbsp;Reza Sajaditabar,&nbsp;Soheil S. Mahmoud","doi":"10.1186/s43088-024-00524-7","DOIUrl":"10.1186/s43088-024-00524-7","url":null,"abstract":"<div><h3>Background</h3><p>Several members of the Lamiaceae family of plants produce large amounts of essential oil [EO] that find extensive applications in the food, cosmetics, personal hygiene, and alternative medicine industries. There is interest in enhancing EO metabolism in these plants.</p><h3>Main body</h3><p>Lavender produces a valuable EO that is highly enriched in monoterpenes, the C₁₀ class of the isoprenoids or terpenoids. In recent years, substantial effort has been made by researchers to study terpene metabolism and enhance lavender EO through plant biotechnology. This paper reviews recent advances related to the cloning of lavender monoterpene biosynthetic genes and metabolic engineering attempts aimed at improving the production of lavender monoterpenes in plants and microbes.</p><h3>Conclusion</h3><p>Metabolic engineering has led to the improvement of EO quality and yield in several plants, including lavender. Furthermore, several biologically active EO constituents have been produced in microorganisms.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00524-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of different diaphragm wall cracking scenarios on seepage and slope stability in Earth dams using experimental and numerical modeling approaches","authors":"Momen Atef Fawzy,&nbsp;Nagy Ali Ali Hassan,&nbsp;Neveen Yousif Saad,&nbsp;Doaa Anas El-Molla","doi":"10.1186/s43088-024-00523-8","DOIUrl":"10.1186/s43088-024-00523-8","url":null,"abstract":"<div><h3>Background</h3><p>Seepage control measures are essential in earth dams to enhance their safety against seepage and slope failures. A diaphragm is a thin impervious wall that is used in the core area of the dam to prevent the seepage of water. Any crack in the diaphragm can reduce its efficiency and threaten the safety and stability of the dam. Extensive evaluation of the influence of diaphragm fracturing on dam safety is required to establish a safe design and offer the appropriate measures. This study investigates the effect of diaphragm cracking on the safety of the dam for seepage and slope stability. A permeability tank is first used to validate the numerical model; then, different scenarios for cracked diaphragm walls are studied numerically. The crack’s height, width, direction, and number are all investigated. The effect of having a downstream horizontal blanket drain with cracked internal diaphragms is also evaluated.</p><h3>Results</h3><p>The results showed that the internal diaphragm enhances the safety of earth dams as it reduced the seepage discharge by 98% and increased the downstream slope safety by 34%. Considering the development of a crack in the internal diaphragm, the most critical location was at the base of the dam, wider cracks were more destructive, and the most critical direction was the horizontal crack. The fracturing of the diaphragm at multiple locations proved to be detrimental to the safety of the dam. Having three cracks caused the seepage discharge to reach 74% of its value for no diaphragm, the pore water pressure to raise drastically, and the downstream critical factor of safety to be higher than the case of no diaphragm by 8% only.</p><h3>Conclusions</h3><p>According to the findings, it is advised to continuously monitor the components of diaphragm-type earth dams and perform the necessary maintenance works whenever any sign of damage or water seepage appears. Furthermore, using a well-graded horizontal drain of sufficient length and high permeability with the internal diaphragm is highly recommended as a mitigation measure if diaphragm fracturing occurs. This helps to quickly release the seeping water and keep the phreatic line away from the downstream slope.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00523-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assessment of workability, mechanical and durability properties of high-strength concrete incorporating nano-silica and recycled E-waste materials","authors":"Pawan Hinge,&nbsp;Tushar Shende,&nbsp;Rahul Ralegaonkar,&nbsp;Bhupesh Nandurkar,&nbsp;Sanjay Raut,&nbsp;Muralidhar Kamath,&nbsp;Adithya Tantri,&nbsp;Sujay Raghavendra Naganna","doi":"10.1186/s43088-024-00521-w","DOIUrl":"10.1186/s43088-024-00521-w","url":null,"abstract":"<div><h3>Background</h3><p>Presently, the proper disposal of E-waste is a major challenge for all nations. Portland cement and aggregates continue to play a major role in the construction industry's operations. Meanwhile, natural resources like gravel (aggregates) are becoming scarce. Thus, E-waste is now offering the building industry a chance to replace traditional aggregates. The main goal of the current study is to determine the highest amount of E-waste that may be replaced with 10-mm coarse aggregates with a nano-silica associated ternary blend in M-60 grade high-strength concrete while still maintaining the designed concrete's mechanical, durability, microstructural and workability characteristics.</p><h3>Results</h3><p>When compared to normal concrete, concrete with 15% E-waste replacement maintained the design-required compressive, flexural and tensile strength properties. When the E-waste plastic component percentage is considerably high (15–30%), there is a significant decremental performance regarding the mechanical properties and the decremental rate is found to be in the range of 13–23%. Even the microstructure characteristics of concrete validate the mechanical performance of concrete. Nevertheless, the durability characteristics of E-waste incorporated concrete were found to be promising.</p><h3>Conclusions</h3><p>The overall outcome of the study recommends 15% as the optimal replacement percentage of E-waste for conventional concrete, and it is recommended to adopt for real-time practices.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00521-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141495496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}