Clinical study of Wnt inhibitory factor-1 expression and its association with disease severity in non-segmental vitiligo

IF 2.5 Q2 MULTIDISCIPLINARY SCIENCES

Beni-Suef University Journal of Basic and Applied Sciences Pub Date : 2024-09-12 DOI:10.1186/s43088-024-00549-y

Yasser Mostafa Gohary, Ebtehal Gamal Abdelhady, Aya Nagy Sayed, Laila Ahmed Rashed, Hanan Abd El Razik Kamel

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引用次数: 0

Abstract

Background

Vitiligo is classified as an acquired chronic depigmentation disorder that includes the destruction of epidermal melanocytes. It affects 0.5–1% of the population all over the world. Wnt signaling pathway is vital in melanocytes differentiation and development. WIF-1 is an antagonist of the Wnt signaling pathway; it hinders Wnt from binding its receptors. The present study aims to detect WIF-1 expression in vitiligo skin and if it relates to the disease's severity.

Results

This case–control study included 70 subjects: 35 vitiligo patients and 35 healthy controls. Skin WIF-1 expression was estimated using quantitative real-time PCR. Assessment of the vitiligo disease activity score and vitiligo area severity index score was determined. WIF-1 expression showed significant elevation in the skin of vitiligo patients compared to the healthy control group.

Conclusion

Overexpression of WIF-1 may participate in the pathogenesis of vitiligo; hence, it should be a future therapeutic target.

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非节段型白癜风患者 Wnt 抑制因子-1 表达及其与疾病严重程度关系的临床研究

背景白癜风是一种获得性慢性色素脱失症，包括表皮黑色素细胞的破坏。全世界有 0.5-1% 的人患有此病。Wnt 信号通路对黑色素细胞的分化和发育至关重要。WIF-1 是 Wnt 信号通路的拮抗剂，它阻碍 Wnt 与其受体结合。本研究旨在检测 WIF-1 在白癜风皮肤中的表达，以及它是否与疾病的严重程度有关：本病例对照研究包括 70 名受试者：35 名白癜风患者和 35 名健康对照者。使用定量实时 PCR 对皮肤 WIF-1 的表达进行了估计。对白癜风疾病活动性评分和白癜风面积严重性指数评分进行了评估。与健康对照组相比，WIF-1在白癜风患者皮肤中的表达明显升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beni-Suef University Journal of Basic and Applied Sciences MULTIDISCIPLINARY SCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Beni-Suef University Journal of Basic and Applied Sciences (BJBAS) is a peer-reviewed, open-access journal. This journal welcomes submissions of original research, literature reviews, and editorials in its respected fields of fundamental science, applied science (with a particular focus on the fields of applied nanotechnology and biotechnology), medical sciences, pharmaceutical sciences, and engineering. The multidisciplinary aspects of the journal encourage global collaboration between researchers in multiple fields and provide cross-disciplinary dissemination of findings.