The effect of calcium and vitamin A in patients with metabolic-associated fatty liver diseases

IF 2.5 Q2 MULTIDISCIPLINARY SCIENCES

Beni-Suef University Journal of Basic and Applied Sciences Pub Date : 2025-03-10 DOI:10.1186/s43088-025-00612-2

Reem M. Makbol, Zeinab Mahmoud Kadry, Mohamed Mamdouh Noaman, Shimaa Abd El-Kareem Mohammed, Ahmed Othman

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引用次数: 0

Abstract

Background

Non-alcoholic fatty liver disease (NAFLD) is a condition where there is an excessive accumulation of fat in the liver. Non-alcoholic steatohepatitis is a chronic liver injury that may result from benign steatosis, which is a common form of NAFLD. Chronic liver diseases such as NAFLD tend to be related to vitamin A deficiency.

The study aimed to investigate the role of vitamin A and calcium and their relation in the occurrence of fibrosis or steatosis in NAFLD patients, as well as the incidence of liver steatosis in NAFLD.

Results

The study was cross-sectional and involved 110 subjects. A detailed history, clinical examination, laboratory investigations, serum calcium and vitamin A assessments, abdominal ultrasonography, and fibroscan examination were performed. The study included 110 individuals aged 18–70. Based on imaging, the participants were classified into the NAFLD group (70 patients) and the control group (40 persons). According to the study results indicate of patients with NAFLD were classified as 37.3% as S1, 19% as S2, and 7.3% as S3. Regarding the degree of fibrosis, 30% of NAFLD patients were F1, 17.3% were F2, and 16.4% were F3. The study found that the NAFLD group had lower levels of vitamin A than the control group but higher calcium levels.

Conclusion

Individuals with non-alcoholic fatty liver disease may exhibit varying degrees of steatosis based on their serum retinol levels. The findings suggest that vitamin A and calcium may play a role in the development and progression of NAFLD.

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钙和维生素A在代谢性脂肪肝患者中的作用

背景：非酒精性脂肪性肝病（NAFLD）是肝脏中脂肪过度积累的一种疾病。非酒精性脂肪性肝炎是一种慢性肝损伤，可能由良性脂肪变性引起，这是NAFLD的一种常见形式。慢性肝病如NAFLD往往与维生素A缺乏有关。本研究旨在探讨维生素A和钙在NAFLD患者纤维化或脂肪变性发生中的作用及其关系，以及NAFLD患者肝脏脂肪变性的发生率。结果本研究为横断面研究，涉及110名受试者。详细的病史、临床检查、实验室检查、血清钙和维生素A评估、腹部超声检查和纤维扫描检查。该研究包括110名年龄在18-70岁之间的人。根据影像学检查，将参与者分为NAFLD组（70例）和对照组（40例）。根据研究结果显示，NAFLD患者分为S1的占37.3%，S2的占19%，S3的占7.3%。在纤维化程度方面，30%的NAFLD患者为F1级，17.3%为F2级，16.4%为F3级。研究发现，NAFLD组的维生素A含量低于对照组，但钙含量较高。结论非酒精性脂肪性肝病患者可根据其血清视黄醇水平表现出不同程度的脂肪变性。研究结果表明，维生素A和钙可能在NAFLD的发生和发展中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beni-Suef University Journal of Basic and Applied Sciences MULTIDISCIPLINARY SCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Beni-Suef University Journal of Basic and Applied Sciences (BJBAS) is a peer-reviewed, open-access journal. This journal welcomes submissions of original research, literature reviews, and editorials in its respected fields of fundamental science, applied science (with a particular focus on the fields of applied nanotechnology and biotechnology), medical sciences, pharmaceutical sciences, and engineering. The multidisciplinary aspects of the journal encourage global collaboration between researchers in multiple fields and provide cross-disciplinary dissemination of findings.