Beni-Suef University Journal of Basic and Applied Sciences最新文献

{"title":"Metabolic engineering of terpene metabolism in lavender","authors":"Ojo Michael Oseni,&nbsp;Reza Sajaditabar,&nbsp;Soheil S. Mahmoud","doi":"10.1186/s43088-024-00524-7","DOIUrl":"10.1186/s43088-024-00524-7","url":null,"abstract":"<div><h3>Background</h3><p>Several members of the Lamiaceae family of plants produce large amounts of essential oil [EO] that find extensive applications in the food, cosmetics, personal hygiene, and alternative medicine industries. There is interest in enhancing EO metabolism in these plants.</p><h3>Main body</h3><p>Lavender produces a valuable EO that is highly enriched in monoterpenes, the C₁₀ class of the isoprenoids or terpenoids. In recent years, substantial effort has been made by researchers to study terpene metabolism and enhance lavender EO through plant biotechnology. This paper reviews recent advances related to the cloning of lavender monoterpene biosynthetic genes and metabolic engineering attempts aimed at improving the production of lavender monoterpenes in plants and microbes.</p><h3>Conclusion</h3><p>Metabolic engineering has led to the improvement of EO quality and yield in several plants, including lavender. Furthermore, several biologically active EO constituents have been produced in microorganisms.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00524-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of different diaphragm wall cracking scenarios on seepage and slope stability in Earth dams using experimental and numerical modeling approaches","authors":"Momen Atef Fawzy,&nbsp;Nagy Ali Ali Hassan,&nbsp;Neveen Yousif Saad,&nbsp;Doaa Anas El-Molla","doi":"10.1186/s43088-024-00523-8","DOIUrl":"10.1186/s43088-024-00523-8","url":null,"abstract":"<div><h3>Background</h3><p>Seepage control measures are essential in earth dams to enhance their safety against seepage and slope failures. A diaphragm is a thin impervious wall that is used in the core area of the dam to prevent the seepage of water. Any crack in the diaphragm can reduce its efficiency and threaten the safety and stability of the dam. Extensive evaluation of the influence of diaphragm fracturing on dam safety is required to establish a safe design and offer the appropriate measures. This study investigates the effect of diaphragm cracking on the safety of the dam for seepage and slope stability. A permeability tank is first used to validate the numerical model; then, different scenarios for cracked diaphragm walls are studied numerically. The crack’s height, width, direction, and number are all investigated. The effect of having a downstream horizontal blanket drain with cracked internal diaphragms is also evaluated.</p><h3>Results</h3><p>The results showed that the internal diaphragm enhances the safety of earth dams as it reduced the seepage discharge by 98% and increased the downstream slope safety by 34%. Considering the development of a crack in the internal diaphragm, the most critical location was at the base of the dam, wider cracks were more destructive, and the most critical direction was the horizontal crack. The fracturing of the diaphragm at multiple locations proved to be detrimental to the safety of the dam. Having three cracks caused the seepage discharge to reach 74% of its value for no diaphragm, the pore water pressure to raise drastically, and the downstream critical factor of safety to be higher than the case of no diaphragm by 8% only.</p><h3>Conclusions</h3><p>According to the findings, it is advised to continuously monitor the components of diaphragm-type earth dams and perform the necessary maintenance works whenever any sign of damage or water seepage appears. Furthermore, using a well-graded horizontal drain of sufficient length and high permeability with the internal diaphragm is highly recommended as a mitigation measure if diaphragm fracturing occurs. This helps to quickly release the seeping water and keep the phreatic line away from the downstream slope.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00523-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assessment of workability, mechanical and durability properties of high-strength concrete incorporating nano-silica and recycled E-waste materials","authors":"Pawan Hinge,&nbsp;Tushar Shende,&nbsp;Rahul Ralegaonkar,&nbsp;Bhupesh Nandurkar,&nbsp;Sanjay Raut,&nbsp;Muralidhar Kamath,&nbsp;Adithya Tantri,&nbsp;Sujay Raghavendra Naganna","doi":"10.1186/s43088-024-00521-w","DOIUrl":"10.1186/s43088-024-00521-w","url":null,"abstract":"<div><h3>Background</h3><p>Presently, the proper disposal of E-waste is a major challenge for all nations. Portland cement and aggregates continue to play a major role in the construction industry's operations. Meanwhile, natural resources like gravel (aggregates) are becoming scarce. Thus, E-waste is now offering the building industry a chance to replace traditional aggregates. The main goal of the current study is to determine the highest amount of E-waste that may be replaced with 10-mm coarse aggregates with a nano-silica associated ternary blend in M-60 grade high-strength concrete while still maintaining the designed concrete's mechanical, durability, microstructural and workability characteristics.</p><h3>Results</h3><p>When compared to normal concrete, concrete with 15% E-waste replacement maintained the design-required compressive, flexural and tensile strength properties. When the E-waste plastic component percentage is considerably high (15–30%), there is a significant decremental performance regarding the mechanical properties and the decremental rate is found to be in the range of 13–23%. Even the microstructure characteristics of concrete validate the mechanical performance of concrete. Nevertheless, the durability characteristics of E-waste incorporated concrete were found to be promising.</p><h3>Conclusions</h3><p>The overall outcome of the study recommends 15% as the optimal replacement percentage of E-waste for conventional concrete, and it is recommended to adopt for real-time practices.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00521-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141495496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nanocellulose-based anthraquinone from marine fungi Penicillium flavidorsum as an alternative therapy for skin wound healing: histopathological and immunohistochemical evidences from a rat model","authors":"Reham Reda,&nbsp;Doaa H. Assar,&nbsp;Ibrahim I. Al-Hawary,&nbsp;Ayman Atiba,&nbsp;Alaa Abdelatty,&nbsp;Norah Althobaiti,&nbsp;Zizy I. Elbialy","doi":"10.1186/s43088-024-00522-9","DOIUrl":"10.1186/s43088-024-00522-9","url":null,"abstract":"<div><h3>Background</h3><p>Wound healing represents a complex clinical challenge, necessitating the selection of appropriate wound dressings to facilitate an efficient healing process. This study aims to explore an effective approach to enhance wound healing by investigating the therapeutic potential of a nanocellulose-based anthraquinone derived from marine fungi.</p><p>Forty male Wistar rats were divided into five groups, including a control group and various four treatment groups. The wound healing process was assessed by measuring the wound area at different time points.</p><h3>Results</h3><p>The results showed promising outcomes in terms of wound healing progression. The group treated with anthraquinone and nanocellulose demonstrated the most favorable results, with normal epidermal architecture, marked hyperkeratosis, and minimal dermal edema. This study provides comprehensive evidence supporting the efficacy of this novel alternative therapy through histopathological and immunohistochemical analyses conducted on a rat model.</p><h3>Conclusion</h3><p>By addressing the limitations associated with conventional wound dressings, our research contributes to the development of innovative strategies for optimizing wound healing outcomes. The findings presented herein underscore the potential of nanocellulose-based anthraquinone as a promising therapeutic option for promoting skin wound healing. Further investigations are warranted to elucidate the underlying mechanisms and establish the clinical viability of this alternative therapy.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00522-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141495491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near open generalizations of rough sets and their applications","authors":"A. S. Salama,&nbsp;A. A. El Atik,&nbsp;A. M. Hussein,&nbsp;O. A. Embaby,&nbsp;M. S. Bondok","doi":"10.1186/s43088-024-00500-1","DOIUrl":"10.1186/s43088-024-00500-1","url":null,"abstract":"<div><h3>Background</h3><p>The concept of near open sets is a potent tool that empowers researchers to achieve a more encompassing approximation of rough sets, thereby enhancing the accuracy of measurements. The evolution of rough set theory into various generalized forms, based on topological structures, has emerged as a significant approach in the realm of knowledge discovery within databases.</p><h3>Results</h3><p>This paper’s primary contribution lies in the introduction of a novel category of generalized near open sets, termed “inverse simply open sets,” within the context of the <span>(text{j})</span>-neighborhood space. The paper proposes diverse methods for extending the Pawlak’s rough approximations leading to the definition of new approximations in the <span>(text{j})</span>-neighborhood space. By employing these newly introduced generalizations, we establish fresh connections between two pivotal theories, namely “general topology and rough set theory”. Through a comprehensive investigation, we conduct multiple comparisons between our methodology and classical approaches. Furthermore, we showcase practical applications of these techniques within real-life scenarios, demonstrating their utility in decision-making processes.</p><h3>Conclusions</h3><p>We reduced the data’s ambiguity while increasing its accuracy measure. As a result, we may conclude that the proposed approximations were more precise than earlier techniques and contributed to the elimination of data ambiguity in real-world scenarios requiring accurate decisions.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00500-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141495493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relief of double-J stent-related symptoms: a comparison between mirabegron, tamsulosin and solifenacin","authors":"Akrm A. Elmarakbi,&nbsp;Osama M. Elsayed,&nbsp;Tamer R. Mohamed,&nbsp;Amr M. Lotfy","doi":"10.1186/s43088-024-00508-7","DOIUrl":"10.1186/s43088-024-00508-7","url":null,"abstract":"<div><h3>Background</h3><p>Inserting ureteral stents is a routine intervention that often results in problems. The cornerstone for treating stent-related symptoms is pharmacological therapy. This study was conducted to evaluate and to compare the effectiveness of mirabegron, tamsulosin, solifenacin and control in reducing double-J stent-related symptoms.</p><h3>Results</h3><p>Patients were evaluated preoperatively, one week after stent insertion and two weeks after the start of medications by the Ureteral Stent Symptom Questionnaire (USSQ), International Prostate Symptom Score (IPSS), overactive bladder questionnaire (OAB-q) and visual analogue pain scale (VAPS). Solifenacin and mirabegron groups had significantly lower sexual scores after the 1st and 2nd weeks post-operatively (PO) when compared with the control group. Mirabegron group had significantly lower sexual scores after 1st and 2nd weeks PO when compared with patients in tamsulosin and solifenacin groups. Patients in mirabegron group had significantly fewer additional problems after the 1st and 2nd weeks PO when compared with patients in the control and tamsulosin groups.</p><h3>Conclusions</h3><p>To sum up, mirabegron was found to be superior to solifenacin in lowering urinary symptoms scores, sexual performance scores and work performance scores at both first and second weeks post-operatively. Mirabegron is a good alternative choice for SRSs when tamsulosin or solifenacin is ineffective or not tolerated.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00508-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141448065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new mathematical technique and its Python program to assess wind potential","authors":"Shafiq Ur Rehman,&nbsp;Naeem Sadiq,&nbsp;Iqbal Tariq,&nbsp;Mahwish Mobeen Khan,&nbsp;Muhammad Mustaqeem Zahid,&nbsp;Ahmed Ali Rajput,&nbsp;Zaheer Uddin","doi":"10.1186/s43088-024-00510-z","DOIUrl":"10.1186/s43088-024-00510-z","url":null,"abstract":"<div><h3>Background</h3><p>A new approach based on the Newton–Gauss method is used to find the Weibull parameters.</p><h3>Results</h3><p>A Python program was developed to employ the Newton–Gauss method. It is implemented to find Weibull parameters and wind potential of Pakistan’s eight cities (Hyderabad, Khuzdar, Multan, Quetta, Bahawalpur, Islamabad, Lahore, and Peshawar). Wind speed data recorded at an interval of ten minutes for 2016 is used to implement a Python program to calculate wind potential. To compare the values of the parameters, five known methods, the empirical method, method of moments, energy pattern factor method, maximum likelihood method, and modified maximum likelihood method, were also used to model and determine the wind potential. The root mean square error, mean absolute error, coefficient of determination, and Akaike information criterion were calculated to compare values of wind parameters and average wind speed. The correlation between recorded and modeled Weibull pdf was almost 99% for each city.</p><h3>Conclusions</h3><p>The new method only caters to those wind speeds that contribute to the wind potential; therefore, the average value of the wind speed is the least in the case of the new method. The maximum wind potential was observed for Hyderabad.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00510-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsponges: a promising frontier for prolonged release-current perspectives and patents","authors":"N. Srinatha,&nbsp;Sowjanya Battu,&nbsp;B. A. Vishwanath","doi":"10.1186/s43088-024-00519-4","DOIUrl":"10.1186/s43088-024-00519-4","url":null,"abstract":"<div><h3>Background</h3><p>Microsponges are one of the advanced drug delivery systems that facilitates precise and controlled release of active ingredients that are suitable for topical and oral use. These porous microspheres are typically sized between 5 and 300 μm, offer benefits including controlled release, stability, and minimized side effects. Manufacturing techniques like quasi-emulsion solvent diffusion and liquid–liquid suspension polymerization are usually employed to prepare microsponges, although various challenges arise from the use of potentially hazardous organic solvents.</p><h3>Main body</h3><p>Microsponges possess distinct traits such as extended drug release, formulation flexibility, and high drug loading capacity. Entrapment of drugs requires considerations of solubility, stability, and miscibility, while evaluation methods encompass production yield and particle size analysis. Their applications range from dermatological to biopharmaceutical delivery, with diverse products utilizing this technology. Ongoing innovations about microsponges are evident in patents concerning medical dressings and hyaluronic acid delivery systems.</p><h3>Conclusion</h3><p>Microsponges present a promising avenue in drug delivery, despite many challenges. Current review addresses on limitations and diverse products highlighting commercial viability. Patent activity signifies continued interest, suggesting significant potential for enhancing patient care.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00519-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141435575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anemia in relation to pinch strength and hand dexterity in preschool children: a cross-sectional study","authors":"Fatma Essam Amer,&nbsp;Khaled Ahmed Mamdouh,&nbsp;Tamer Hasan Moustafa Hassan,&nbsp;Walaa A. Abd-El-Nabie,&nbsp;Hoda Eltalawy","doi":"10.1186/s43088-024-00518-5","DOIUrl":"10.1186/s43088-024-00518-5","url":null,"abstract":"<div><h3>Background</h3><p>Iron deficiency anemia (IDA) constitutes a considerable nutritional problem in Egyptian preschool children. Moreover, IDA limits physical activity performance and interferes with children's development. Accordingly, we aim to investigate the correlation between IDA and hand dexterity and pinch grip strength in preschool children.</p><h3>Results</h3><p>This observational cross-sectional study encompassed the participation of 87 children, comprising both genders, with an age range of 5–6 years. The cohort was initially stratified into three distinct groups: Group A comprised 36 non-anemic children, group B included 25 children with mild iron-deficiency anemia (IDA), and group C consisted of 26 children with moderate IDA. After group delineation, comprehensive laboratory analyses were performed on all participants to assess for IDA, involving a thorough examination of their complete blood picture, hemoglobin (Hb) levels, serum iron levels, and serum ferritin levels. The evaluative metrics employed in this study encompassed the Bruininks-Oseretsky Test of Motor Proficiency-Second Edition (BOT-2) and the Baseline Mechanical Pinch Gauge. These instruments were utilized to assess manual dexterity and pinch strength, specifically tip-to-tip and tripod strength. This investigation revealed a positive correlation between Hb, serum iron, and serum ferritin levels with both manual dexterity and pinch strength across all three groups.</p><h3>Conclusion</h3><p>This study highlights that IDA negatively affects hand dexterity and pinch grip strength in preschool children. Managing IDA early is crucial for improving their physical performance and overall development.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00518-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized chitosan-G-poly caprolactone vaccine delivery system fabricated to display antigen–antibody immune complexes of Mycobacterium tuberculosis elicits immune response in Ex-vivo model","authors":"Sam Ebenezer Rajadas,&nbsp;Vignesh Sounderrajan,&nbsp;Rajendran Amarnath Prabhakaran,&nbsp;Ragini Agrawal,&nbsp;Lavanya Jeyadoss,&nbsp;Mariappan Rajan,&nbsp;Krupakar Parthasarathy,&nbsp;Shakila Harshavardhan","doi":"10.1186/s43088-024-00520-x","DOIUrl":"10.1186/s43088-024-00520-x","url":null,"abstract":"<div><h3>Background</h3><p>Vaccine development against tuberculosis remains a global health imperative, necessitating robust immunogenicity and safety profiles. Nanoparticle-based delivery systems offer promising avenues to enhance vaccine efficacy while ensuring tolerability. This study explores the utilization of chitosan micelles as a delivery platform for immune complex vaccination against tuberculosis. Leveraging two key antigens of <i>Mycobacterium tuberculosis</i>, namely HspX and Mpt51, known for their relevance in latent tuberculosis and its co-infection with the human immunodeficiency virus, immune complexes were synthesized <i>in vitro</i> using antibodies raised against these antigens. The immune complexes were then conjugated onto chitosan micelles, characterized for their physicochemical properties, and evaluated for their biocompatibility and immunogenicity.</p><h3>Results</h3><p>Chitosan nanoparticles conjugated with either antigen or its immune complexes were synthesized as micelles and physicochemical characterizations confirm the formation of micelles without altering the polymer composition. These immune complex-conjugated chitosan micelles were found to be safe, exhibiting no significant hemolytic and cytotoxic activity even at a higher concentration of 400 µg/ml. Peripheral blood mononuclear cells upon stimulation with immune complex-conjugated chitosan micelles showed enhanced cellular uptake and one to two-fold increased expression of key immune markers—interferon gamma and CD-86.</p><h3>Conclusions</h3><p>These findings underscore the potential of chitosan nanoparticles as a versatile delivery platform for immune complex vaccination against tuberculosis. While limitations exist, such as including only two markers of immune modulation, this study lays a foundation for future investigations into immune complex vaccine potential in animal models. In conclusion, chitosan micelles carrying immune complexes of HspX and Mpt51 tuberculosis antigens exhibit promising immunogenicity, highlighting their potential as a platform for multi-antigenic vaccine components warranting further <i>in vivo</i> studies.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-024-00520-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}