Beni-Suef University Journal of Basic and Applied Sciences最新文献

{"title":"Phylogenetic and DNA barcoding study on Dehaasia pugerensis Koord. & Valeton, an endemic and critically endangered species from East Java, Indonesia","authors":"Aulia Hasan Widjaya,&nbsp;Andi Salamah,&nbsp;Tety Maryenti,&nbsp;Iyan Robiansyah,&nbsp;Irfan Martiansyah,&nbsp;Muhammad Rifqi Hariri,&nbsp;Weibang Sun","doi":"10.1186/s43088-025-00641-x","DOIUrl":"10.1186/s43088-025-00641-x","url":null,"abstract":"<div><h3>Background</h3><p><i>Dehaasia pugerensis</i> Koord. &amp; Valeton is an endemic plant species classified as critically endangered (CR) in Jember, Java. It thrives in arid, rocky forest regions, making it a significant genetic resource for plant conservation initiatives. This study aimed to analyze the genetics of <i>Dehaasia pugerensis</i> through a molecular approach utilizing DNA (deoxyribonucleic acid) barcoding technique. This experiment utilized three accessions from three populations in Puger Jember, East Java: Igir Pletes (IP), Watu Susu (WS), and Undak Sebanen (US), along with Klatakan (KT). Notably, samples from the WS accession were excluded from internal transcribed spacer (ITS) primers due to poor sequencing results and were substituted with samples from the US accession. A single sample from each population of <i>Dehaasia pugerensis</i> underwent DNA sequencing utilizing DNA barcoding markers from three chloroplast genes: ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (<i>rbc</i>L), maturase K (<i>mat</i>K), and the transfer RNA-histidine and the photosystem II protein D1 (<i>trn</i>H-<i>psb</i>A) intergenic spacer, as well as one nuclear ITS region. </p><h3>Results</h3><p>Sequence analysis demonstrated identical base composition in the plastid genes <i>rbc</i>L and <i>mat</i>K, minor variation in <i>trn</i>H-<i>psb</i>A intergenic spacer, and significant variation in the nuclear ITS region. This demonstrates that the evolutionary rate of the chloroplast genome is lower than that of the nuclear genome. The chloroplast and nuclear genomes exhibit significant differences in evolutionary rates, influenced by various internal and external factors such as inheritance mode, mutation rate, and evolutionary pressures. Phylogenetic analysis indicated that the three accessions clustered together within the same group, as determined by chloroplast genes and ITS region. The three accessions exhibit a close relationship with <i>Dehaasia hainanensis</i> and <i>Dehaasia incrassata</i>, as indicated by the genetic distance observed on the phylogenetic tree.</p><h3>Conclusions</h3><p>DNA barcoding with <i>rbc</i>L, <i>mat</i>K, <i>trn</i>H-<i>psb</i>A intergenic spacer, and ITS confirmed the identity of <i>Dehaasia pugerensis</i> and revealed key genetic diversity. Phylogenetic analysis grouped the three accessions (KT450, IP42, WS152) into a single clade, closely related to <i>Dehaasia hainanensis</i> and <i>Dehaasia incrassata</i>, indicating shared evolutionary traits. While <i>rbc</i>L and <i>mat</i>K were genetically stable, <i>trn</i>H-<i>psb</i>A intergenic spacer and ITS showed notable variability, particularly in ITS, which revealed important genetic differences. These findings highlight the value of molecular data in shaping conservation strategies for <i>Dehaasia pugerensis,</i> such as propagation, reintroduction, and seed banking.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00641-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of colchicine against osteoarthritis in rat induced by monosodium iodoacetate","authors":"Medhat Ibraheem,&nbsp;Ahmad Mostafa Mahmoud,&nbsp;Nahla Abd Elaal Ahmed,&nbsp;Hekmat O. Abdel Aziz,&nbsp;Suzan Elsayed Abo Elnasr","doi":"10.1186/s43088-025-00648-4","DOIUrl":"10.1186/s43088-025-00648-4","url":null,"abstract":"<div><h3>Background</h3><p>Knee osteoarthritis (OA) is a debilitating condition that can severely limit an individual's mobility and quality of life. This study evaluated the efficacy of colchicine therapy in promoting cartilage healing in a rat model with monosodium iodoacetate (MIA)-induced knee OA. Histological and biochemical changes as well as semiquantitative radiographic characteristics were used to evaluate this.</p><h3>Methods</h3><p>An experimental knee OA model was induced by MIA in rats. Subsequently, 40 Wistar albino female rats were randomly divided into four groups, each consisting of 10 rats: a negative control group, an osteoarthritic control group, an osteoarthritic reference group treated with meloxicam®, and an osteoarthritic group administered an intraperitoneal injection of colchicine. Body weight and knee diameter measurements were taken weekly. Semiquantitative radiographic imaging and enzyme-linked immunosorbent assay analysis were performed on serum samples to assess the levels of inflammatory cytokine interleukin-1 beta (IL-1β) and the anti-inflammatory cytokine interleukin-10 (IL-10) prior to the conclusion of the trial. Histological examination was conducted using hematoxylin and eosin staining.</p><h3>Results</h3><p>Colchicine significantly reduced the osteoarthritic conditions after six weeks of supplementation. We observed decreased joint diameters in response to treatment in OA animals. Colchicine significantly decreased the IL-1β (<i>p</i> = 0.000) and increased the IL-10 (<i>p</i> = 0.000) in the serum of osteoarthritic rats in response to treatment in OA rats compared to the OA group with no treatment. Colchicine reduced the osteoarthritic rats' radiographic scores and enhanced the knee joint's histological structure.</p><h3>Conclusion</h3><p>The results indicate that colchicine could be beneficial in the treatment of rats with MIA-induced knee osteoarthritis, as it appears to postpone cartilage deterioration and reduce the activity of inflammatory mediators.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00648-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of irisin in metabolic and cardiovascular disorders and its therapeutic potential","authors":"Rehab G. Khalil,&nbsp;Tarek Atia,&nbsp;Ahmed I. Yousef,&nbsp;Hader Ibrahim Sakr,&nbsp;Osama M. Ahmed","doi":"10.1186/s43088-025-00643-9","DOIUrl":"10.1186/s43088-025-00643-9","url":null,"abstract":"<div><p>Irisin, a myokine produced by cleaving fibronectin type III domain-containing protein 5 (FNDC5), is a key regulator of metabolic processes and cardiovascular health. Its discovery in 2012 sparked significant interest due to its potential to impact fat and glucose metabolism, convert white fat to brown, and reduce inflammation—crucial in managing metabolic syndrome, obesity, and diabetes. Found in various tissues, including the brain, liver, heart, kidneys, and skeletal muscle, irisin has been linked to improved metabolic dysregulation and increased energy expenditure. Moreover, it has the potential to enhance endothelial function, reduce oxidative stress, and possibly regulate blood pressure, all contributing to improved cardiovascular health. This review explores the promising potential of irisin as a treatment for cardiovascular diseases (CVDs), metabolic syndrome, and related conditions. While more research is needed to fully understand its pathways, the future of irisin-based therapies in clinical settings looks promising.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00643-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Internet of Things security in healthcare using a blockchain-driven lightweight hashing system","authors":"Bassam W. Aboshosha,&nbsp;M. Mokhtar Zayed,&nbsp;Hany S. khalifa,&nbsp;Rabie A. Ramadan","doi":"10.1186/s43088-025-00644-8","DOIUrl":"10.1186/s43088-025-00644-8","url":null,"abstract":"<div><h3>Background</h3><p>The rapid expansion of Internet of Things applications in healthcare has created new opportunities for improving patient care through real-time monitoring and data sharing. However, this growth also introduces significant challenges related to data security, privacy, and system efficiency, especially for devices with limited processing power and energy resources. To address these issues, this study introduces a blockchain-based lightweight hashing system specifically designed for healthcare environments with resource-constrained devices. The goal is to ensure secure, efficient, and scalable handling of sensitive medical data without overwhelming the capabilities of connected devices.</p><h3>Results</h3><p>The proposed system combines a collision-resistant, lightweight hash function with blockchain technology to enhance data integrity, authentication, and privacy. The hash function minimizes computational demands, making it ideal for wearable and embedded healthcare devices. Blockchain integration enables decentralized data management, preventing unauthorized access and tampering. The system generates unique, immutable patient identifiers and protects electronic health information from common security threats, including collision attacks, Sybil attacks, and cryptographic analysis. Simulation results show improved computational efficiency, lower latency, and effective handling of high transaction volumes with minimal resource usage.</p><h3>Conclusions</h3><p>This research presents a secure and efficient framework for managing medical data in healthcare Internet of Things applications. By leveraging lightweight cryptographic techniques and decentralized data structures, the system addresses key limitations in current solutions while supporting scalability and real-world deployment. Potential applications include secure patient monitoring, real-time sharing of health data, and decentralized management of medical records. The proposed approach provides a foundation for future advancements in digital healthcare systems, particularly in remote care, emergency response, and wearable health technologies.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00644-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression study of durum wheat hybrids under water deficit conditions","authors":"Ahmed Mohsen,&nbsp;Khaled Adly Khaled,&nbsp;Ayman Hamdi Mahdi,&nbsp;Aladdin Hamwieh,&nbsp;Sherif El-Areed","doi":"10.1186/s43088-025-00649-3","DOIUrl":"10.1186/s43088-025-00649-3","url":null,"abstract":"<div><h3>Background</h3><p>The present study was conducted at the CerealMed project farm during the 2021–2022 and 2022–2023 growing seasons using a strip plot design with two replications. The objective was to evaluate durum wheat hybrids and six durum wheat cultivars as parents under normal irrigation and water deficit stress. The study aimed to assess the tolerance of six durum wheat cultivars to water deficit stress, develop new tolerant durum wheat hybrids, and detect gene expressions to tolerance water deficit stress, using start codon-targeted (SCoT) markers. The traits studied included grain weight per plant, number of spikes per plant, number of kernels per spike, and 1000-kernel weight.</p><h3>Results</h3><p>The most tolerant parent genotypes to water deficit stress were BENI-SUEF 1 (56.98 g/plant), BENI-SUEF 6 (46.31 g/plant), BENI-SUEF 7 (45.54 g/plant), and SOHAG 5 (45.52 g/plant). The most tolerant hybrids were BENI-SUEF 1 × BENI-SUEF 6 (55.33 g/plant) and BENI-SUEF 7 × SOHAG 4 (50.16 g/plant), based on LSD at 5%. The SCoT analysis revealed variations in gene expression patterns among the different genotypes in response to water deficit stress.</p><h3>Conclusion</h3><p>This study highlighted the utility of SCoT markers in analyzing the genetic basis of drought tolerance in durum wheat. By identifying variations in gene expression patterns (like <b><i>TaBTF3</i></b> <b>gene for primer1)</b>, the study provided a deeper understanding of the complex mechanisms underlying plant responses to water deficit stress. The best durum wheat genotypes (BENI-SUEF 1, BENI-SUEF 6, BENI-SUEF 7, and SOHAG 5) are recommended for use in breeding programs targeting water deficit stress. Selection in segregating populations will be effective for the hybrids BENI-SUEF 1 × BENI-SUEF 6 and BENI-SUEF 7 × SOHAG 4.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00649-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients","authors":"Enas Ahmed Osman,&nbsp;Khaled Mabrouk,&nbsp;Ahmed Abdelsamie Mahmoud,&nbsp;Medhat Madbouly,&nbsp;Mohamed Moharam Mohamed Hussin,&nbsp;Osama Mosbah,&nbsp;Nevine Sherif,&nbsp;Mohammed Ghanem Gaber,&nbsp;Farida M. Khanany","doi":"10.1186/s43088-025-00645-7","DOIUrl":"10.1186/s43088-025-00645-7","url":null,"abstract":"<div><h3>Background</h3><p>One of the most prevalent non-communicable diseases in the world today is diabetes. Diabetic kidney disease (DKD) is the predominant etiology of chronic kidney disease (CKD) and a major side effect of diabetes. Diagnosis of DKD is challenging and imprecise; thus, new diagnostic modalities are necessary to address this problem. The aim of the present study is to assess the role of the combined diagnostic performance of serum levels of MBL and imaging techniques, Doppler ultrasonographic renal resistive index (RRI) and shear wave elastography as a diagnostic tool for diabetic nephropathy. This case–control study included 450 type 2 diabetes mellitus (T2DM) patients, 225 without nephropathy and 225 diagnosed with diabetic nephropathy. We evaluated serum mannose-binding lectin (MBL) by enzyme-linked immunosorbent assay (ELISA) as a marker of diabetes-related inflammation, Doppler ultrasonographic renal resistive index (RRI) as a tool for assessment of blood flow in the kidney and shear wave elastography (SWE) as an imaging technique for detection of kidney fibrosis.</p><h3>Result</h3><p>The average serum MBL levels, mean RI and SWE of both kidneys were significantly higher in DKD patients compared to T2DM patients without nephropathy. The integration of the aforementioned methodologies significantly enhanced diagnostic performance, achieving a sensitivity of 96.89% and a specificity of 95.11%.</p><h3>Conclusion</h3><p>Combined serum levels of MBL and imaging techniques, Doppler ultrasonographic renal RI and shear wave elastography are promising diagnostic tools of diabetic nephropathy.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00645-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric exploration of the state of the art on acrylamide and glycidamide in food safety","authors":"Yaman Ahmed Mohammed Naji,&nbsp;Mahboob Alam,&nbsp;Suhail Bashir,&nbsp;Nurul Huda Abd Kadir","doi":"10.1186/s43088-025-00639-5","DOIUrl":"10.1186/s43088-025-00639-5","url":null,"abstract":"<div><h3>Background</h3><p>Acrylamide (AA), a probable human carcinogen (Group 2A) classified by the International Agency for Research on Cancer (IARC), has emerged as a significant food safety concern worldwide. Its formation during high-temperature cooking processes, such as frying, baking, and roasting of starchy foods, has spurred extensive research efforts to understand its toxicity and develop effective mitigation strategies. This study aims to provide a comprehensive bibliometric analysis of scientific literature on AA and its metabolite, glycidamide (GA), published from 1965 to the end of 2024, focusing on the evolving trends and research emphasis related to their toxicity and mitigation in food.</p><h3>Results</h3><p>A comprehensive bibliometric analysis of 3729 Scopus articles was conducted using VOSviewer. The analysis revealed a general increase in the number of annual research publications on AA. Most studies focused on various types of toxicity associated with AA, such as neurotoxicity, cytotoxicity, and nephrotoxicity, utilizing different models. The findings indicate a growing emphasis on research to mitigate AA formation in foods as a response to its toxicity.</p><h3>Conclusions</h3><p>The study concludes that both the quality and quantity of research articles on AA have significantly improved over time, with an anticipated continued increase in the future research. This trend reflects the ongoing global concern about AA’s toxicity and the importance of developing strategies to reduce its presence in foods, which has significant implications for public health and food safety.</p><h3>Graphic abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00639-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of signaling transduction pathways of drug target molecules with recent advancements and future perspectives for successful therapy: a comprehensive and exploratory review","authors":"Sujana Kamepalli,&nbsp;Sambamoorthy Unnam,&nbsp;Satyabrata Bhanja,&nbsp;Krishna Reddy Yeduru,&nbsp;Pratap Kumar Patra,&nbsp;Nasreen Sulthana,&nbsp;Roja Pathakota,&nbsp;Renukadevi Thota,&nbsp;Arun Kumar Sanapala","doi":"10.1186/s43088-025-00640-y","DOIUrl":"10.1186/s43088-025-00640-y","url":null,"abstract":"<div><h3>Background</h3><p>With an emphasis on current developments and potential future perspectives in therapeutic applications, this comprehensive review delves into the molecular mechanisms of signaling transduction pathways associated with pharmacological target molecules. Since these pathways are essential to the cellular response to pharmacological drugs, understanding them is necessary for developing effective treatments. The notion of cellular signaling and the range of signaling pathways that control important cellular functions are first explained in this chapter. It highlights the intricate interactions between the essential elements of signaling pathways, such as effectors, ligands, receptors, and intercellular messengers. </p><h3>Main body</h3><p>It explores the activation and subsequent signaling events of several receptors, including intracellular nuclear, t-kinase, GPCR (G-protein-coupled receptors), and ionic receptors. We reviewed innovative methods that have sped up the discovery of new drug targets and clarified intricate signaling networks, like X-ray crystallography, advanced Cryo-EM (Cryo-Electron Microscopy), high-throughput screening, allosteric modulations, Artificial intelligence, and machine learning. This review attempts to explain the clear pathway of drug target molecules for novel, focused treatments that improve patient outcomes and further the field of drug development by combining existing knowledge and suggesting future research avenues. </p><h3>Conclusion</h3><p>Prospects for the future highlight the value of interdisciplinary teams in addressing these issues, encouraging advancements in combination therapies and tailored delivery systems that can get around current drawbacks in traditional therapy. In a rapidly changing biomedical landscape, this review seeks to shed light on pathways toward more effective, customized therapies that address the underlying molecular mechanisms of disease. Ultimately, it hopes to improve patient care and therapeutic outcomes by synthesizing current knowledge and suggesting strategic research directions.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00640-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An improved algorithm for prediction of vehicle trajectories using short-term goal-driven network","authors":"Abdalla Tawfik,&nbsp;Zaki Nossair,&nbsp;Roaa Mubarak","doi":"10.1186/s43088-025-00638-6","DOIUrl":"10.1186/s43088-025-00638-6","url":null,"abstract":"<div><h3>Background</h3><p>Prediction of vehicle trajectories is a crucial task for automated driving systems to accurately take movement actions according to the dynamic traffic environment, especially the future positions of the surrounding vehicles. Predicting how road users will behave in the future is one of the most critical and complex challenges in autonomous driving. Different data types must be combined to accomplish this task using deep learning, such as sensor readings and maps. After that, this data is used to predict a range of possible future outcomes. Existing goal-driven approaches predict the final goal and use it to complete the trajectory; this requires accurate goal prediction, which is challenging. Short-Term Goal Network (STG) addresses this challenge using multiple short-term goals instead of a single final goal.</p><h3>Results</h3><p>The proposed STG network is evaluated on the Argoverse motion forecasting dataset, and the results show significantly better performance than other goal-driven approaches. STG demonstrated a substantial improvement of over 6% in average displacement error and more than 8% in final displacement error.</p><h3>Conclusion</h3><p>This article presents an improved algorithm for predicting vehicle trajectories using short-term goals. The proposed STG algorithm is based on long short-term memory (LSTM) and attention mechanism for predicting trajectories. This work verifies that predicting more than one goal along the trajectory improves the accuracy of the predicted goal and the whole trajectory accordingly.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00638-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomedicine and green nanotechnology: enhancing glass ionomer cements for sustainable dental restorations: a comprehensive review","authors":"Dina Ezzat,&nbsp;Amr Azab,&nbsp;Ibrahim S. Kamel,&nbsp;Mohamed Abdelmonem,&nbsp;Mohamed Ahmed Ibrahim,&nbsp;Abdullah Ayad,&nbsp;Romesa Soomro,&nbsp;Mohamed Wagdy,&nbsp;Mohamed Eldebawy","doi":"10.1186/s43088-025-00633-x","DOIUrl":"10.1186/s43088-025-00633-x","url":null,"abstract":"<div><h3>Background</h3><p>Integrating phytomedicine with glass ionomer cements (GICs) offers a promising avenue for improving dental restoratives. This review comprehensively discusses the incorporation of plant extracts and derivatives into GICs to enhance their antimicrobial, mechanical, and aesthetic properties.</p><h3>Main text</h3><p>The addition of plant extracts, such as propolis, miswak, and grape seed, and the respective disinfecting derivatives of gallic acid, epigallocatechin-3-gallate, and curcumin improved both the antibacterial and mechanical properties of GICs. Furthermore, the incorporation of these derivatives is in line with current practices, which emphasize the use of natural products to minimize the use of synthetic preservatives in dental applications. In addition, this review discussed the role of these plant extracts in the green synthesis of nanoparticles (NPs), providing insights into how these sustainable approaches can fill existing gaps in dental material technology. This intersection of plant-based compounds and nanotechnology not only paves the way for innovative dental materials but also supports the broader movement toward sustainable practices in dentistry. This review revealed that the incorporation of plant extracts may significantly improve the antimicrobial properties of GICs and maintain or slightly improve their mechanical properties; however, the disparate methodologies and extraction concentrations used in these studies call for further standardized research.</p><h3>Conclusion</h3><p>This review highlights the potential of phytomedicine to optimize the performance of GICs in clinical settings and calls for further research to establish the most effective formulations.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bjbas.springeropen.com/counter/pdf/10.1186/s43088-025-00633-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}