Molecular mechanisms of signaling transduction pathways of drug target molecules with recent advancements and future perspectives for successful therapy: a comprehensive and exploratory review

Abstract

Background

With an emphasis on current developments and potential future perspectives in therapeutic applications, this comprehensive review delves into the molecular mechanisms of signaling transduction pathways associated with pharmacological target molecules. Since these pathways are essential to the cellular response to pharmacological drugs, understanding them is necessary for developing effective treatments. The notion of cellular signaling and the range of signaling pathways that control important cellular functions are first explained in this chapter. It highlights the intricate interactions between the essential elements of signaling pathways, such as effectors, ligands, receptors, and intercellular messengers.

Main body

It explores the activation and subsequent signaling events of several receptors, including intracellular nuclear, t-kinase, GPCR (G-protein-coupled receptors), and ionic receptors. We reviewed innovative methods that have sped up the discovery of new drug targets and clarified intricate signaling networks, like X-ray crystallography, advanced Cryo-EM (Cryo-Electron Microscopy), high-throughput screening, allosteric modulations, Artificial intelligence, and machine learning. This review attempts to explain the clear pathway of drug target molecules for novel, focused treatments that improve patient outcomes and further the field of drug development by combining existing knowledge and suggesting future research avenues.

Conclusion

Prospects for the future highlight the value of interdisciplinary teams in addressing these issues, encouraging advancements in combination therapies and tailored delivery systems that can get around current drawbacks in traditional therapy. In a rapidly changing biomedical landscape, this review seeks to shed light on pathways toward more effective, customized therapies that address the underlying molecular mechanisms of disease. Ultimately, it hopes to improve patient care and therapeutic outcomes by synthesizing current knowledge and suggesting strategic research directions.

Graphical abstract