Beni-Suef University Journal of Basic and Applied Sciences最新文献

{"title":"Morphological, pathological and molecular investigation of equine filariasis in Assiut Governorate, Egypt","authors":"Basem R. Nageib,&nbsp;Gehan M. Sayed,&nbsp;Mohsen I. Arafa,&nbsp;Abeer H. M. El Hendy,&nbsp;Wafaa G. Mahmoud","doi":"10.1186/s43088-026-00771-w","DOIUrl":"10.1186/s43088-026-00771-w","url":null,"abstract":"<div><h3>Background</h3><p>Filariasis poses a major global problem, affecting the overall health of equine. This study aimed to determine the occurrence of equine filariasis, studying the seasonal behavior of the infection, and perform morphological and molecular identification of the recovered adult and microfilariae.</p><h3>Methods</h3><p>A total of 120 equine blood samples collected from Assiut Governorate were subjected to microscopic examination, as well as histopathological sections were performed. Polymerase Chain Reaction amplification of the targeted regions (12S rRNA and 18S rRNA) and phylogenetic analysis were conducted from adult worms and infected tissues.</p><h3>Results</h3><p>The microscopy revealed that, <i>Setaria</i> spp. microfilariae in 10 donkeys and 3 horses (10.83%). Additionally, <i>Onchocerca</i> spp. microfilariae were detected in 2 donkeys (1.66%), however, none of the examined horses showed microfilariae of both species. Mixed infection with <i>Setaria</i> spp., and <i>Onchocerca</i> spp. microfilariae were observed in only 2 donkeys (1.66%). Post-mortem examination of 34 equine showed the presence of adult <i>Onchocerca</i> spp. and <i>S. equina</i> with infection rates of 17.64% and 26.47%, respectively. Parasitological examination of skin snips at the umbilical region from these animals revealed <i>Onchocerca</i> microfilariae in five donkeys (14.7%); however, no microfilariae were detected in horses. The peak of occurrence of <i>Setaria</i> spp. microfilariae was recorded in the summer season (17.5%), while the peak of the intensity of <i>Onchocerca</i> spp. infection was detected during the summer and autumn (5%). Films stained with Giemsa and Harris hematoxylin stains displayed enhanced details of microfilarial structures compared to Leishman’s stain. To date, no information available regarding the genetic diversity and phylogeny of <i>Onchocerca cervicalis</i> in Egypt. In the present study, phylogenetic analysis based on the nematode-specific 12S rRNA region was performed to determine the genetic diversity of <i>Setaria</i> spp. The BLAST results of the sequences of two samples were 100% identical with the reference sequences of <i>S. digitata</i> and one sample was 100% identical to <i>S. equina.</i> Likewise, phylogenetic analysis based on the nematode-specific 18S rRNA, revealed five samples were showing 99.8% identity to <i>O. cervicalis</i> reference sequence.</p><h3>Conclusions</h3><p>This study represents the first phylogenetic analysis of <i>O. cervicalis</i> in Egypt. Higher infection rates need urgent attention and control strategies, including vector control and suitable management practices. Giemsa and Harris hematoxylin stains are the staining methods of choice for microfilarial examination.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00771-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148173641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the molecular landscape and functional spectrum of Polygonatum sibiricum: a review of active components and processing-induced innovations","authors":"Zhang Mengqin,&nbsp;Tao Xie","doi":"10.1186/s43088-026-00772-9","DOIUrl":"10.1186/s43088-026-00772-9","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;&lt;i&gt;Polygonatum sibiricum&lt;/i&gt;, a highly esteemed traditional tonic in China, is a typical dual-purpose food-medicine resource with deep roots in culinary traditions. It is widely recognized for its efficacy in tonifying qi, nourishing yin, bolstering the spleen, moistening the lungs, and benefiting the kidneys—properties attributed to its rich array of bioactive constituents, primarily polysaccharides, saponins, and flavonoids. These bioactive molecules exhibit significant biological activities, including antioxidant, immune-modulating, and metabolic-regulating effects, which are exerted through interactions with diverse molecular targets and the regulation of intricate signaling pathways. This context lays the foundation for exploring the scientific basis of &lt;i&gt;Polygonatum sibiricum’s&lt;/i&gt; traditional and potential functional applications.&lt;/p&gt;&lt;h3&gt;Main body&lt;/h3&gt;&lt;p&gt;This review conducts a systematic and in-depth investigation into recent advancements related to the key bioactive components (primarily polysaccharides, saponins, and flavonoids) of &lt;i&gt;Polygonatum sibiricum&lt;/i&gt;, covering cutting-edge techniques and progress in their extraction, separation, and structural characterization—critical steps for deciphering their biological functions; at the same time, it places special emphasis on how processing methodologies (including traditional and modern preparation methods) alter the qualitative and quantitative profiles of these bioactive compounds and directly influence their resultant biological activities, addressing the key gap between traditional processing practices and modern scientific validation. Furthermore, the review meticulously dissects the distinct functional mechanisms of each major bioactive component: polysaccharides are focused on for their immune-regulatory functions, such as modulating immune cell activity, cytokine secretion, and immune signaling pathways; saponins are highlighted for their metabolic-regulating prowess, including their effects on glucose and lipid metabolism and potential in addressing metabolic disorders; and flavonoids are emphasized for their potent antioxidant properties, such as scavenging free radicals, inhibiting oxidative stress-related enzymes, and protecting cells from oxidative damage.&lt;/p&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;By synthesizing the latest research findings and highlighting emerging insights into &lt;i&gt;Polygonatum sibiricum’s&lt;/i&gt; bioactive components, this review aims to establish a robust scientific foundation and provide strategic references for two key objectives—one being advancing innovative research on &lt;i&gt;Polygonatum sibiricum&lt;/i&gt;, particularly in clarifying the links between its chemical composition, processing, and biological activity, and the other being facilitating the development of &lt;i&gt;Polygonatum sibiricum&lt;/i&gt; as a high-value functional food ingredient, which ultimately unlocks its full molecular potential for applications in nutrition, health promotion, and related ind","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00772-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148009695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Buoyant tablets loaded with Nanosponges containing entrapped Cefditoren pivoxil","authors":"Naga Raju Kandukoori,&nbsp;Gundegani Saikumar,&nbsp;Deepika B.,&nbsp;N. Saritha Devi,&nbsp;Kiran Thadkala","doi":"10.1186/s43088-026-00781-8","DOIUrl":"10.1186/s43088-026-00781-8","url":null,"abstract":"<div><h3>Background</h3><p>The main objective of this research was to develop a novel gastroretentive formulation for Cefditoren pivoxil, an insoluble and poorly permeable drug. Floating and drug release characteristics of tablets formulated with pure Cefditoren pivoxil were compared with the same of formulations loaded with nanosponges (NS) form of drug.</p><h3>Results</h3><p>Test results related to physicochemical properties of all prepared tablets were observed to be in compliance with standards. More floating lag time (6 to 12 minutes) and less log time (less than 12 hours) have been resulted from the formulations with pure form of drug (F1 to F4), whereas, vice-versa (93 to 6 minutes lag time &amp; more than 12 hours log time) was found with NS based dosage forms (F5 to F8). An evaluation test for in-vitro drug release was performed for all the dosage units and more controlled release pattern with diffusion mechanism was seen from tablets loaded with NS. F7 with a combination of NS form of drug and Guar gum in 1:1 ratio has shown best buoyancy (2.1±0.22 minutes lag-time and &gt;12 hours log-time) and more controlled drug release (99.77±1.13%) among all 8 tablet compositions.</p><h3>Conclusions</h3><p>The importance and need for entrapment of an insoluble, less permeable drug to obtain the fruitful buoyant and drug release properties from Gastroretentive tablet dosage forms has been witnessed by all the observed results.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00781-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148009183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends on the anticancer potential of Ficus spp.: a bibliometric analysis","authors":"Justin Dave Manantan,&nbsp;Helen Jenina Sto. Domingo,&nbsp;Imelda Corpuz,&nbsp;Jan Karlo Ecalne,&nbsp;Mylene Andal,&nbsp;Mark Angelo Balendres","doi":"10.1186/s43088-026-00787-2","DOIUrl":"10.1186/s43088-026-00787-2","url":null,"abstract":"<div><p>Although numerous studies have isolated anticancer compounds from <i>Ficus</i> spp., there are still key gaps that hinder clinical translation. This study aimed to provide a quantitative overview of compounds derived from <i>Ficus</i> spp., identify leading contributors, evaluate collaboration networks, and highlight research gaps and future directions. A bibliometric analysis was conducted using the Scopus® database (from inception to mid-2025). Data on publication and citation trends, as well as leading countries, institutions, authors, and journals, were analyzed. Socioeconomic indicators were obtained from the IMF and World Bank databases. Statistical analysis was performed using Microsoft® Excel, and bibliometric networks were visualized using VOSviewer (v1.6.20). A total of 316 original and review articles were included, showing a slow increase in publications from the 2010s onward. Most studies originated from India, China, and Saudi Arabia, while leading authors were affiliated with institutions in Indonesia, Italy, and Belgium. Frequently used keywords included “human”, “article”, and “plant extract”. Highly cited articles indicate a gradual shift toward applied and commercial research interests. Overall, the findings demonstrate growing global interest in the anticancer potential of <i>Ficus</i> spp., alongside persistent translational limitations. Research remains largely focused on crude extract screening and in vitro assays, with limited progression to in vivo and clinical studies. Future work should emphasize standardized extraction protocols, isolation and characterization of bioactive compounds, mechanistic and toxicity studies, and translational pharmacological validation to support the development of clinically relevant <i>Ficus</i>-derived anticancer agents.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00787-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148009539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational screening of seaweed metabolites as potential antifungal agents against Candida auris","authors":"Md. Al-Amin,&nbsp;Afsana Mustak Mim,&nbsp;Salman Reja,&nbsp;Samia Sadaf,&nbsp;Md. Younus Shekh,&nbsp;Sabiha Akter,&nbsp;Ive Sithi Chambugong,&nbsp;Shanjida Akter Joyoti,&nbsp;Md. Ifteker Hossain,&nbsp;Noimul Hasan Siddiquee","doi":"10.1186/s43088-026-00784-5","DOIUrl":"10.1186/s43088-026-00784-5","url":null,"abstract":"<div><h3>Background</h3><p><i>Candida auris (C. auris)</i> has emerged as a serious global health threat due to its resistance to antifungal treatments and its persistence in healthcare environments. Effective therapeutic intervention is essential to reduce mortality and transmission. This computational study identifies potential inhibitors of dihydrofolate reductase (DHFR), a crucial enzyme for the survival and replication of <i>C. auris</i>.</p><h3>Result</h3><p>A total of 1,191 seaweed metabolites were screened using molecular docking, and the top 20 candidates were selected based on binding affinity. Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiling further refined the selection to three lead compounds, CIDs 145,937, 11,672,129, and 159,086, based on their favorable drug-likeness and toxicity profiles. These compounds commonly interacted with active site residues such as GLU_32, THR_57, ALA_11, ILE_9, ILE_19, LEU_25, MET_33, PHE_36, TYR_126, and VAL_10, indicating a shared binding pocket. Post-docking Molecular Mechanics/Generalized Born Surface Area (MM-GBSA) analysis revealed strong protein-ligand interactions, with binding free energies of −40.43, −54.74, and −54.70 kcal/mol, for CIDs 145,937, 11,672,129, and 159,086, respectively. Highest Occupied Molecular Orbital and Lowest Unoccupied Molecular Orbital (HOMO-LUMO) gap analysis indicated excellent electronic stability, while Prediction of Activity Spectra for Substances (PASS) prediction suggested potential biological activity. Molecular Dynamics Simulation (MD simulation) confirmed the stability of the complex; Principal Component Analysis (PCA) and Dynamic Cross-Correlation Matrix (DCCM) showed consistent dynamics. Post-simulation MM-GBSA binding free energies and PCA3 values were −49.88, −48.64, −70.83 kcal/mol, and 4.85%, 6.69%, 8.25% for CIDs 145,937, 159,086, and 11,672,129, respectively.</p><h3>Conclusion</h3><p>In brief, though all leads showed potential against <i>C. auris</i>, CID 145,937, derived from <i>Ecklonia stolonifera</i>, forms the strongest and most stable complex with the target protein, making it a promising antifungal candidate for further in vitro and in vivo validation.</p><h3>Clinical trial number</h3><p>Not applicable.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00784-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148009599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoid-enriched fractions of Pimpinella anisum and Coriandrum sativum: antioxidant, hepatoprotective, and antimutagenic activities supported by in vivo and dynamics simulation studies","authors":"Salma El Sawi,&nbsp;Amal M. El-Feky,&nbsp;Eman A. Younis,&nbsp;Ayman A. Farghaly,&nbsp;Entesar E. Hassan,&nbsp;Ahmed F. El-Sayed","doi":"10.1186/s43088-026-00760-z","DOIUrl":"10.1186/s43088-026-00760-z","url":null,"abstract":"<div><h3>Background</h3><p><i>Pimpinella anisum</i> and <i>Coriandrum sativum</i>, members of the Apiaceae family, have long been used in traditional medicine, yet comprehensive phytochemical and pharmacological profiling of their aerial parts remains scarce. This study aimed to investigate the flavonoid composition, hepatoprotective, antimutagenic, and antioxidant potentials of their flavonoid-enriched fractions, supported by in vivo assessments and molecular docking studies.</p><h3>Results</h3><p>LC–ESI–MS analysis revealed that <i>P. anisum</i> contained 11 phenolic acids and 29 flavonoids, while <i>C. sativum</i> comprised 13 phenolic acids and 28 flavonoids. The flavonoid-rich extracts demonstrated significant antioxidant activities, with <i>P. anisum</i> showing strong DPPH inhibition (83.72–86.22%) and <i>C. sativum</i> exhibiting comparable effects (86.43–88.18%) to ascorbic acid. In vivo studies confirmed the hepatoprotective effect of both extracts in thioacetamide-induced hepatic fibrosis in rats, as evidenced by reduced serum transaminases, nitric oxide (NO), and tumor necrosis factor-alpha (TNF-α), along with enhanced total antioxidant capacity (TAC) and MMP-9 levels. Histological examinations supported the biochemical findings. Antimutagenic studies further revealed a reduction in chromosomal aberrations, DNA damage, and sperm abnormalities. Molecular docking identified six flavonoid compounds—apigenin 6-<i>C</i>-glucoside, apigenin 7-<i>O</i>-glucoside, myricetin 3-<i>O</i>-β-D-glucopyranoside, luteolin, kaempferol, and chrysin—as potent ligands for TNF-α, MMP-9, SOD, and GPx. ADMET predictions indicated high oral bioavailability, drug-likeness, and minimal toxicity. Additionally, Molecular dynamics simulations were used to evaluate the binding energetics and stability of GPx1, MMP-9, and TNF complexes with specific flavonoids. Trajectory analyses demonstrated that GPx1 and MMP-9 rapidly form structurally compact, highly stable, and tightly anchored interactions.</p><h3>Conclusions</h3><p>The flavonoid-enriched fractions of <i>P. anisum</i> and <i>C. sativum</i> exhibit potent antioxidant, hepatoprotective, and antimutagenic activities, likely mediated through modulation of oxidative stress and inflammatory pathways. The identified flavonoids represent promising candidates for the development of multi-target hepatoprotective therapeutics with favorable safety and pharmacokinetic profiles.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00760-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From waste to color: IR-assisted extraction of functional colorants from pomegranate peel for dyeing eco-friendly antimicrobial fabrics","authors":"Safia A. Mahmoud,&nbsp;Heba M. El-Hennawi,&nbsp;Hanan Shaban","doi":"10.1186/s43088-026-00764-9","DOIUrl":"10.1186/s43088-026-00764-9","url":null,"abstract":"<div><h3>Background</h3><p>Infrared (IR) heating offers rapid, intense heat delivery and serves as a lower-cost alternative to conventional heating methods. Pomegranate peels represent a sustainable source of natural dyes and antibacterial polyphenols. This study explores the use of IR technology to extract these bioactive compounds for textile applications.</p><h3>Methods</h3><p>Extraction parameters were optimized using IR heating, followed by dyeing of cotton and wool fabrics at 80 °C for 60 min to preserve the bioactivity of the compounds and achieve uniform coloration. Dyed fabrics were evaluated for color strength, color fastness properties, and antibacterial efficacy.</p><h3>Results</h3><p>IR heating significantly increased the yield of bioactive compounds from pomegranate peels compared to conventional heating. Dyed wool fabrics exhibited superior color strength and enhanced antimicrobial activity, specifically against <i>S. aureus</i>.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00764-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147937873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data-driven optimization of friction stir welding parameters of AA7075 aluminium alloy using ANN surrogates and genetic algorithms","authors":"Omnia Abouhabaga,&nbsp;Eman El Shrief","doi":"10.1186/s43088-026-00755-w","DOIUrl":"10.1186/s43088-026-00755-w","url":null,"abstract":"<div><h3>Background</h3><p>This study proposes a data-driven hybrid framework for optimizing the process parameters of friction stir welding (FSW) of AA7075 aluminium alloy by integrating artificial neural network (ANN) surrogate models with genetic algorithm (GA) optimization<b>.</b></p><h3>Methods</h3><p>A Design of Experiments (DoE) approach comprising 27 systematically designed trials was employed to investigate the combined influence of rotational speed, welding speed, plunge depth, and shoulder-to-pin diameter ratio on the ultimate tensile strength (UTS) and microhardness of FSW joints. The experimental data were used to train and validate ANN surrogate models capable of capturing the nonlinear and interdependent relationships between the process variables and mechanical responses.</p><h3>Results</h3><p>The developed ANN models demonstrated high predictive accuracy, with R2 values exceeding 0.94 and 0.96 for ultimate tensile strength (UTS) and hardness, respectively, accompanied by low root mean square error (RMSE) and mean absolute error (MAE) values. Experimental validation confirmed the robustness of the models, yielding prediction errors ranging from 0.18% to 11%, with an average deviation of 3.6%. Coupling the trained ANN surrogate with a GA-based optimizer enabled the identification of parameter combinations that simultaneously maximize UTS and hardness. The optimal UTS of 345.76 MPa was obtained at a rotational speed of 814.13 rpm, welding speed of 51.53 mm/min, plunge depth of 0.213 mm, and a shoulder-to-pin ratio of 3.6, whereas the maximum hardness of 143.41 HV was achieved at lower rotational and welding speeds, combined with a higher plunge depth and shoulder-to-pin ratio.</p><h3>Conclusion</h3><p>The findings demonstrate that the ANN–GA hybrid approach provides a robust, accurate, and computationally efficient tool for predictive modelling and process optimization in FSW. This framework offers valuable potential for Industry 4.0 and intelligent manufacturing applications, particularly in the design of lightweight, high-performance aluminium structures.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00755-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remediation of poultry wastewater contaminated with multi-drug-resistant Pseudomonas aeruginosa using Triazole-modified MIL-53(Fe)","authors":"Sahar A. Abdel Aziz,&nbsp;Maha B. Abd Elhaleem,&nbsp;Safaa M. Abbas,&nbsp;Sawsan Abd Elkhalik,&nbsp;Fatma M. Elantabli","doi":"10.1186/s43088-026-00745-y","DOIUrl":"10.1186/s43088-026-00745-y","url":null,"abstract":"<div><h3>Background</h3><p>Multi-drug-resistant spectrum of <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is frequently issue in wastewater of poultry industry, posing a major public hazard. Also, the incorporation of promising nano-scale materials, notably metal organic frameworks (MOFs), is an auspicious tool for enhancing the biological quality of wastewater.</p><h3>Methods</h3><p>A total of wastewater samples (<i>n</i> = 50) were collected to from randomly chosen poultry shops in Beni-Suef Governorate, Egypt, to isolate <i>P. aeruginosa</i>, the antibiotic profile of the most frequently used antibiotics in the poultry farming sector was investigated, as well as the dissemination of antibiotic coding genes (<i>blaTEM</i> and <i>blaKPC</i> genes) through the molecular techniques was done, and finally, antimicrobial evaluation of the synthesized 3-amino-1,2,4-triazole, MOF, and T@MOFs composite is carried out against strains of <i>P. aeruginosa</i> exhibiting MRD.</p><h3>Results</h3><p><i>P. aeruginosa</i> identified in 68.0% of wastewater samples, showing multi-drug resistance to most of antibiotics including nalidixic acid, ciprofloxacin, amikacin cefoxitin, clindamycin, lincomycin, and gentamicin, with a Multiple Antibiotic Resistance (MAR) index extending from 0.5 to 0.83. Additionally, T@MOFs composite demonstrated a significant bactericidal potency indicated by a minimum bactericidal concentration of 83.33 ± 2.83 μg/mL, a minimum inhibitory concentration of 41.63 ± 10.43 μg/mL as well as a prominent inhibition zone diameter that measured 20.00 ± 2.31 mm.</p><h3>Conclusion</h3><p>The study reveals that wastewater in the examined areas poses noteworthy reservoir for the spread of MDR <i>P. aeruginosa</i> and their encoding genes. Also, T@MOFs composite displays exceptional antimicrobial efficacy against <i>P. aeruginosa</i> isolates, with a promising issue for critical wastewater bioremediation, addressing worldwide water scarcity challenges.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00745-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring new solutions for the stochastic Gardner equation forced by advection Brownian motion used in nonlinear wave propagation","authors":"Sofian T. Obeidat,&nbsp;Hamdy Ahmed,&nbsp;Mohamed S. Algolam,&nbsp;Hijyah M. Alshammary,&nbsp;Wael W. Mohammed","doi":"10.1186/s43088-026-00761-y","DOIUrl":"10.1186/s43088-026-00761-y","url":null,"abstract":"<div><h3>Background</h3><p>The stochastic Gardner equation with Itô-type advection Brownian motion provides an effective mathematical framework for modeling the propagation of nonlinear waves in random environments. It plays a key role in understanding the transition from coherent wave structures to irregular dynamics by elucidating the interplay among randomness, nonlinearity, and dispersion in complex physical systems. Consequently, obtaining exact analytical solutions of the stochastic Gardner equation is of significant theoretical and practical importance.</p><h3>Methods</h3><p>By employing appropriate transformation techniques together with Itô calculus, the stochastic Gardner equation is decomposed into two coupled components: a deterministic Gardner equation with an additional diffusion term and a stochastic ordinary differential equation. The extended tanh-function method is applied to derive exact traveling wave solutions of the deterministic Gardner equation. These solutions are then combined with the analytical solution of the stochastic ordinary differential equation to construct exact solutions of the original stochastic Gardner equation. The effectiveness of the proposed framework can be demonstrated by deriving various stochastic wave solutions and graphing them, thus proving its ability to investigate nonlinear wave propagation in the presence of stochastic effects.</p><h3>Results</h3><p>A variety of exact analytical solutions for the stochastic Gardner equation are successfully obtained, including solitary wave structures influenced by stochastic effects. The impact of advection Brownian motion on the wave dynamics is systematically investigated. Three-dimensional graphical simulations, generated using MATLAB, illustrate how stochastic advection modifies the shape, amplitude, and evolution of the solutions compared to their deterministic counterparts. Additionally, these findings shed light on how stochastic perturbations affect the amplitude and propagation characteristics of nonlinear waves in the Gardner model.</p><h3>Conclusion</h3><p>The proposed analytical framework provides explicit exact solutions for the stochastic Gardner equation and reveals the significant role of advection Brownian motion in altering nonlinear wave behavior. These results enhance the understanding of stochastic nonlinear wave propagation and may be useful for modeling realistic physical systems subject to random perturbations.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00761-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}