Journal of Addictive Diseases最新文献

{"title":"Emergency department-initiated buprenorphine vs brief intervention for opioid use disorder: a systematic review and meta-analysis of clinical trials.","authors":"Ahmad Bavali-Gazik, Seyyedeh Negar Hosseini, Sajjad Salehian, Majid Kadkhoda, Ahmad Salari, Ayda Akhavan-Abdollahian","doi":"10.1080/10550887.2025.2605451","DOIUrl":"10.1080/10550887.2025.2605451","url":null,"abstract":"<p><strong>Introduction: </strong>Emergency departments (EDs) are critical points of contact for individuals at high risk, as opioid use disorder (OUD) remains a major public health crisis. While Screening, Brief Intervention, and Referral to Treatment (SBIRT) andother brief intervention (BI) models have been promoted as pragmatic approaches in acute care, their efficacy for OUD is uncertain. In contrast, ED-initiated buprenorphine (BUP) has shown promise for improving outcomes, but comparative trial data require synthesis.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines, we reviewed randomized and nonrandomized clinical trials comparing ED-initiated BUP with BI, referral, or usual care. Primary outcomes were treatment engagement and retention; secondary outcomes included opioid use, overdose risk behaviors, and healthcare utilization. Searches were conducted in PubMed, Scopus, Google Scholar, Web of Science, and trial registries through January 29, 2025. Risk of bias was assessed using ROB-2, and data were pooled <i>via</i> random-effects models.</p><p><strong>Findings: </strong>Nine trials (<i>n</i> = 1,172), primarily from North America, met inclusion criteria. Compared with BI (52%), BUP initiation yielded higher adherence (61%) and lower opioid use prevalence (17% vs. 28%). Multiple RCTs consistently favored BUP for short-term engagement, whereas BI showed minimal effects on treatment utilization, overdose risk, or substance use outcomes. Considerable heterogeneity (I² ≈ 99%) and potential publication bias were observed.</p><p><strong>Conclusion: </strong>ED-initiated BUP is superior to BI for short-term treatment engagement and reducing opioid use, reinforcing its role as a frontline intervention in acute care. Nevertheless, high heterogeneity, short follow-up, and limited geographic scope constrain the evidence base, highlighting the need for broader and longer-term studies.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"487-500"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological and therapeutic efficacy of somatic psychotherapies in addiction: primary behavioral focus with exploratory cross-addiction analyses.","authors":"Christopher Lomas","doi":"10.1080/10550887.2025.2560404","DOIUrl":"10.1080/10550887.2025.2560404","url":null,"abstract":"<p><strong>Background: </strong>Behavioral addictions exhibit convergent dysregulation of meso-striatal reward, cortico-limbic stress, and executive-control circuits. Top-down interventions such as CBT demonstrate moderate, often transient effects, leaving autonomic dysregulation insufficiently targeted. Somatic and body-oriented psychotherapies (SBPs) may remediate these deficits <i>via</i> bottom-up interoceptive and autonomic mechanisms, but quantitative synthesis is lacking.</p><p><strong>Methods: </strong>Nine randomized controlled trials (RCTs) (total <i>N</i> = 573) of yoga, mindfulness, or somatic interventions for gambling, gaming, or compulsive sexual behavior were systematically reviewed. Hedges' g was pooled using random-effects meta-analysis (DerSimonian-Laird, Hartung-Knapp intervals). Risk-of-bias was evaluated with RoB-2; sensitivity analyses included leave-one-out models.</p><p><strong>Results: </strong>Pooled effect size indicated a large benefit (g = -2.62, 95% CI [-4.73, -0.51], <i>p</i> = .015), with heterogeneity substantial (<i>I</i>² = 95.6%). Directionality persisted under sensitivity analyses. No serious adverse events were reported.</p><p><strong>Conclusions: </strong>This review delivers the first quantitative synthesis of SBPs in behavioral addictions, delineating robust short-term symptom reduction alongside preliminary mechanistic signals implicating interoceptive-autonomic and fronto-striatal circuits. A novel phased, biomarker-guided treatment framework is proposed, situating SBPs as adjunctive modulators within integrative addiction care. Future trials should prioritize mechanistic endpoints, longer follow-up, and dismantling designs to isolate active components.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"518-538"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building clinical fluency in artificial intelligence: basic knowledge for addiction medicine practitioners and researchers.","authors":"R Gregory Lande","doi":"10.1080/10550887.2026.2728793","DOIUrl":"https://doi.org/10.1080/10550887.2026.2728793","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":"44 4","pages":"377-379"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching the next generation of physicians: Evaluating addiction medicine curriculum interventions across two U.S. Medical schools.","authors":"Madison Walsh, Ilana Simon Greenberg, Jo Marie Reilly, Cara Poland","doi":"10.1080/10550887.2025.2597858","DOIUrl":"10.1080/10550887.2025.2597858","url":null,"abstract":"<p><strong>Background: </strong>Over 48 million Americans were diagnosed with a substance use disorder in 2023. However, only 4.5% of individuals with addiction received treatment. To effectively treat people with substance use disorders, comprehensive addiction medicine education should be required in all medical schools.</p><p><strong>Objectives: </strong>This study evaluated the effectiveness of an addiction medicine curriculum intervention across two universities.</p><p><strong>Methods: </strong>Students at Michigan State University (College of Human Medicine and College of Osteopathic Medicine) (MSU) and Keck School of Medicine (KSOM) of University of Southern California (USC), were surveyed before and after taking two- and four- week addiction medicine electives. The ten-question Likert scale survey assessed attitudes toward addiction and addiction treatment. In both MSU AND USC cohorts, pre and post scores were matched for analysis. The paired t-test and sign rank tests were used to compare pre- <i>vs.</i> post-test scores within schools and combined. The Wilcoxon rank sum test was employed to compare pre-post change in scores between universities. Significance was determined at <i>p</i> < 0.05.</p><p><strong>Results: </strong>There were 251 respondents. Significant within-group improvements were observed in seven of the ten questions. MSU showed significant change in seven questions, while USC showed significant change in four questions. Between-group comparisons showed that MSU and USC significantly differed on both pretest responses and post-test responses.</p><p><strong>Conclusions: </strong>These findings suggest that the addiction medicine curriculum did have an impact at both schools, but the differences need to be further studied.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"511-517"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"President's message.","authors":"Darrin Mangiacarne","doi":"10.1080/10550887.2026.2728791","DOIUrl":"10.1080/10550887.2026.2728791","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"444-445"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid use disorder and concurrent benzodiazepine use: clinical risks and management strategies.","authors":"Adam Fakhri, Alexis Ritvo, Jennifer Casarella, Yi-Lang Tang","doi":"10.1080/10550887.2025.2593244","DOIUrl":"10.1080/10550887.2025.2593244","url":null,"abstract":"<p><p>Concurrent use of benzodiazepines (BZDs) and opioids in patients with opioid use disorder (OUD) is prevalent and poses significant clinical challenges, including increased risks of overdose, ER visits, and treatment discontinuation. This article synthesizes current evidence on the prevalence, risks, and management of BZD co-use in OUD, focusing on patients receiving medications for OUD (MOUD) such as buprenorphine and methadone. Data indicate that approximately 16-21% of patients on buprenorphine and up to 40-47% of those on methadone use BZDs, with nonmedical use linked to a significant increase in overdose-related emergency visits and overdose mortality (95% CI: 7.8-13.2). We propose an evidence-informed framework for managing co-use, prioritizing OUD stabilization, close monitoring and harm reduction, gradual BZD tapering, and integrated psychosocial interventions. This approach balances safety and efficacy, ensuring patient-centered care while mitigating risks.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"479-486"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored psychotherapy and AI-enhanced contingency management for co-occurring disorders in cannabis use disorder: a systematic review.","authors":"Sidharth Mishra, Sayali Mishra, Sibanarayan Rath","doi":"10.1080/10550887.2026.2616726","DOIUrl":"10.1080/10550887.2026.2616726","url":null,"abstract":"<p><strong>Background: </strong>Cannabis use disorder (CUD) commonly co-occurs with depression, post-traumatic stress disorder (PTSD), anxiety, and attention-deficit/hyperactivity disorder (ADHD), resulting in poorer outcomes and underscoring the need for tailored interventions. Contingency management (CM) is one of the most effective behavioral treatments for substance use disorders, and emerging applications of artificial intelligence (AI) may enhance CM by predicting relapse risk and personalizing incentives. This review evaluates evidence on integrated interventions for CUD with co-occurring disorders and the developing role of AI-enhanced CM.</p><p><strong>Methods: </strong>A systematic search of PubMed, PsycINFO, Embase, and Web of Science (through October 2025) identified clinical studies and systematic reviews on tailored interventions for CUD with depression, PTSD, anxiety, or ADHD, as well as research on AI-driven CM. Data were extracted on study design, interventions, and outcomes.</p><p><strong>Results: </strong>Thirty-eight studies met inclusion criteria. Integrated cognitive-behavioral therapies improved psychiatric symptoms and reduced cannabis use, particularly in depression and PTSD. Pharmacotherapies showed inconsistent benefits, while ADHD-focused behavioral and stimulant-based approaches demonstrated promising reductions in cannabis use. AI applications such as machine-learning prediction of relapse using smartphone/sensor data, remote CM delivery, and reinforcement-learning-based incentive optimization-improved attendance, abstinence verification, and reward efficiency.</p><p><strong>Conclusion: </strong>Integrated psychosocial approaches and AI-augmented CM offer complementary pathways for improving outcomes in individuals with CUD and co-occurring disorders. Combining personalized psychotherapy with adaptive, technology-assisted reinforcement may strengthen treatment efficacy.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"399-412"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of high-definition transcranial direct current stimulation on craving in substance use disorders: a systematic review and meta-analysis.","authors":"Priyanka Saha, Jadeer K Muhammed, Pinki Sevda, Rohit Verma, Siddharth Sarkar","doi":"10.1080/10550887.2026.2658662","DOIUrl":"10.1080/10550887.2026.2658662","url":null,"abstract":"<p><p>Substance use disorder is a chronic, relapsing illness, and craving plays an important factor in relapse. High-definition transcranial direct current stimulation is a novel noninvasive brain stimulation technique which employs focal stimulation of the brain and has minimal adverse effects. However, its efficacy across substance use disorders remains underexplored. This systematic review and meta-analysis aimed to assess the efficacy of HD-tDCS on craving in substance use disorders. Five databases, including PubMed, CENTRAL, EMBASE, Scopus and Google Scholar, were searched from inception to April 2025. Review included randomized controlled trials comparing HD-tDCS vs sham intervention, which reported craving as an outcome. Pooled effect size was measured by random-effect model, and heterogeneity was estimated by I². Risk of bias was assessed by the revised Cochrane risk-of-bias tool (RoB 2.0). Out of 3155 records, three RCTs (<i>n</i> = 138) met the inclusion criteria. Substances studied included opioid, cannabis and methamphetamine use disorders. HD-tDCS protocols were almost similar across the studies. Pooled analysis demonstrated a moderate reduction in craving compared to sham stimulation (g = -0.596; 95% CI: -1.039 to -0.152; <i>p</i> = 0.008) across all the studies, with minimal heterogeneity (I² = 0%). Risk of bias ranged from low to moderate. HD-tDCS intervention produced a moderate, statistically significant reduction in craving across substance use disorder, with favorable tolerability. However, the small number of studies and smaller sample size of trials limits its generalizability. Larger and more substance-specific randomized trials are warranted to confirm the efficacy and optimize stimulation parameters.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"501-510"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory indices as biomarkers in adolescents with methamphetamine use disorder: a case-control study.","authors":"Mustafa Tolga Tunagur, Elif Merve Kurt Tunagur","doi":"10.1080/10550887.2025.2595156","DOIUrl":"10.1080/10550887.2025.2595156","url":null,"abstract":"<p><strong>Background: </strong>Despite the rising prevalence of methamphetamine use disorder (MUD) among adolescents and its severe consequences, data on hematological inflammatory indices in this population remain limited.</p><p><strong>Objectives: </strong>This study aimed to evaluate systemic inflammatory markers in adolescents with MUD and their associations with addiction severity.</p><p><strong>Methods: </strong>The retrospective case-control study included 44 adolescents with MUD and 44 age- and gender-matched healthy controls. Hematological indices were calculated from complete blood count data, including neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), Basophil-to-lymphocyte ratio (BLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). Group comparisons, receiver operating characteristic (ROC) analyses, and partial correlations were performed.</p><p><strong>Results: </strong>The MUD group included 30 females (68.2%) and 14 males (31.8%); the control group included 25 females (56.8%) and 19 males (43.2%). Adolescents with MUD showed significantly higher neutrophil and platelet counts, NLR, dNLR, PLR, MLR, SII, SIRI, and AISI, alongside reduced lymphocyte counts, compared with controls (all <i>p</i> < .05). ROC analyses revealed good discriminative ability for SII (AUC = 0.79), AISI (AUC = 0.73), and SIRI (AUC = 0.69). Several indices, including NLR, PLR, and SII, correlated negatively with treatment motivation, while PLR and MLR correlated positively with diagnostic severity.</p><p><strong>Conclusions: </strong>Adolescents with MUD demonstrate marked systemic inflammatory alterations detectable through routine hematological indices. These markers may serve as low-cost, clinically accessible biomarkers for identifying high-risk individuals and monitoring disease severity, with implications for early intervention and personalized treatment.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"539-548"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harm reduction vending machines in the digital sphere: Social media discourse, misinformation, and health promotion implications.","authors":"Aysha Jawed","doi":"10.1080/10550887.2026.2658657","DOIUrl":"10.1080/10550887.2026.2658657","url":null,"abstract":"<p><p>Harm reduction vending machines (HRVMs) are increasingly implemented across the United States and Canada as low‑barrier, 24‑hour distribution mechanisms for life‑saving supplies such as naloxone, drug‑checking tools, sterile equipment, and hygiene items. As these machines have become more visible within public health infrastructure, social media platforms have emerged as key arenas where HRVMs are framed, debated, and politicized. This commentary examines dominant themes in social media coverage of harm reduction vending machines, including narratives emphasizing overdose prevention and accessibility, as well as stigmatizing claims that portray machines as enabling substance use or social disorder. Drawing on program reports, implementation reviews, and media monitoring analyses, the paper situates online discourse within the existing evidence base and public health guidance. Social media discussions frequently amplify misinformation, yet they also function as channels for disseminating evidence‑based education, utilization data, and digital toolkits produced by public health agencies and advocacy organizations. Viral controversies surrounding HRVMs have demonstrated tangible consequences, including policy reviews and service disruptions, underscoring the influence of digital narratives on real‑world access to harm reduction resources. For clinicians and public health practitioners, understanding and engaging with social media representations of HRVMs is essential for effective patient counseling, community engagement, and program sustainability. Strategic, evidence‑based digital communication offers an opportunity to counter stigma, align public narratives with clinical guidance, and reinforce harm reduction vending machines as a routine and equitable component of overdose prevention and public health practice.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"579-584"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}