Monitoring and management of injection site reactions in patients receiving subcutaneous buprenorphine (Sublocade): two case reports and literature review.

IF 1.1 4区 医学 Q3 SUBSTANCE ABUSE
Hina Fawad, Jennifer Casarella, Yi-Lang Tang
{"title":"Monitoring and management of injection site reactions in patients receiving subcutaneous buprenorphine (Sublocade): two case reports and literature review.","authors":"Hina Fawad, Jennifer Casarella, Yi-Lang Tang","doi":"10.1080/10550887.2025.2555636","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Injectable extended-release buprenorphine is an effective treatment for opioid use disorder (OUD), but injection site reactions (ISRs) are common treatment-emergent adverse events that may impact patient comfort, adherence, and outcome. This report examines the clinical presentation, prevalence, and management of Sublocade-related ISRs through two case studies and a review of existing literature.</p><p><strong>Case presentation: </strong>We present two cases of ISRs in patients receiving extended-release buprenorphine, Sublocade. The first involves a 65-year-old male who experienced localized pain, swelling, and erythema after the injection. The second case features a 58-year-old male with injection site swelling, tenderness, and presumed cellulitis. We also examine ISR prevalence and severity from clinical trials and real-world data.</p><p><strong>Management & outcomes: </strong>Both patients received timely care and responded well to appropriate interventions. The first case was managed conservatively with cold compresses, topical hydrocortisone, and ibuprofen, resulting in symptom resolution. The second case required oral antibiotics after ultrasound imaging revealed a subcutaneous fluid collection; the cellulitis resolved without systemic complications.</p><p><strong>Conclusion: </strong>While ISRs associated with Sublocade are common, most are manageable with conservative interventions. Emphasizing patient education, proper injection techniques, and site rotation is essential to prevent ISRs, minimize their severity, and enhance treatment outcomes in patients with OUD.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Addictive Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10550887.2025.2555636","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Injectable extended-release buprenorphine is an effective treatment for opioid use disorder (OUD), but injection site reactions (ISRs) are common treatment-emergent adverse events that may impact patient comfort, adherence, and outcome. This report examines the clinical presentation, prevalence, and management of Sublocade-related ISRs through two case studies and a review of existing literature.

Case presentation: We present two cases of ISRs in patients receiving extended-release buprenorphine, Sublocade. The first involves a 65-year-old male who experienced localized pain, swelling, and erythema after the injection. The second case features a 58-year-old male with injection site swelling, tenderness, and presumed cellulitis. We also examine ISR prevalence and severity from clinical trials and real-world data.

Management & outcomes: Both patients received timely care and responded well to appropriate interventions. The first case was managed conservatively with cold compresses, topical hydrocortisone, and ibuprofen, resulting in symptom resolution. The second case required oral antibiotics after ultrasound imaging revealed a subcutaneous fluid collection; the cellulitis resolved without systemic complications.

Conclusion: While ISRs associated with Sublocade are common, most are manageable with conservative interventions. Emphasizing patient education, proper injection techniques, and site rotation is essential to prevent ISRs, minimize their severity, and enhance treatment outcomes in patients with OUD.

丁丙诺啡皮下注射部位反应的监测和管理:2例报告和文献复习。
可注射缓释丁丙诺啡是治疗阿片类药物使用障碍(OUD)的有效方法,但注射部位反应(ISRs)是常见的治疗不良事件,可能会影响患者的舒适度、依从性和结果。本报告通过两个病例研究和对现有文献的回顾,探讨了与亚位点相关的isr的临床表现、患病率和管理。病例介绍:我们报告了两例接受亚locade丁丙诺啡缓释患者的isr。第一例患者为65岁男性,注射后出现局部疼痛、肿胀和红斑。第二例患者为58岁男性,注射部位肿胀、压痛,疑似蜂窝织炎。我们还从临床试验和真实世界的数据中检查了ISR的患病率和严重程度。管理和结果:两名患者均得到及时的护理,并对适当的干预措施反应良好。第一例患者采用冷敷、外用氢化可的松和布洛芬进行保守治疗,症状得到缓解。第二个病例在超声成像显示皮下积液后需要口服抗生素;蜂窝织炎痊愈,无全身并发症。结论:虽然与亚locade相关的isr很常见,但大多数可以通过保守干预来控制。强调患者教育、适当的注射技术和部位轮换对于预防isr、降低其严重程度和提高OUD患者的治疗效果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.30
自引率
4.30%
发文量
69
期刊介绍: The Journal of Addictive Diseases is an essential, comprehensive resource covering the full range of addictions for today"s addiction professional. This in-depth, practical journal helps you stay on top of the vital issues and the clinical skills necessary to ensure effective practice. The latest research, treatments, and public policy issues in addiction medicine are presented in a fully integrated, multi-specialty perspective. Top researchers and respected leaders in addiction issues share their knowledge and insights to keep you up-to-date on the most important research and practical applications.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信