Journal of Addictive Diseases最新文献

{"title":"Brief report: a retrospective chart review of benzodiazepine prescription patterns, discontinuation, and return-to-use over a decade in a community outpatient substance use treatment program.","authors":"Muhammet Celik, Ryan Harrington, Christopher Aloezos","doi":"10.1080/10550887.2025.2567902","DOIUrl":"https://doi.org/10.1080/10550887.2025.2567902","url":null,"abstract":"<p><strong>Background: </strong>Benzodiazepines are widely prescribed, yet their long-term use among patients with substance-use disorders (SUDs) remains poorly understood. This study examined benzodiazepines in a substance use treatment program.</p><p><strong>Objectives: </strong>This study aims to describe prescribing patterns, tapering and discontinuation characteristics, and return to use rates in SUD patients receiving benzodiazepines in a community-based outpatient substance use treatment program.</p><p><strong>Methods: </strong>In this single-site, retrospective chart review study, electronic health records of 51 patients, prescribed benzodiazepines between FY 2014-2024, in a community-based outpatient substance use treatment program were analyzed. Demographics, psychiatric and SUD diagnoses, benzodiazepine half-life, dose, taper duration, discontinuation status, and return to use were examined descriptively.</p><p><strong>Results: </strong>Intermediate-acting BZDs were the most commonly prescribed (68.6%), with limited attempts to switch to longer-acting agents. BZD prescriptions were discontinued in only 25.4% of cases, and 38.4% of those who discontinued returned to use. Patients who successfully tapered had longer down-titration durations compared to those who returned to use. (5.4 months vs. 2.2 months in return to use cases). Among patients with benzodiazepine use disorder, return to use occurred in 50.0% of those who discontinued. The patient population demonstrated notably high rates of psychiatric comorbidities and previous psychiatric hospitalizations.</p><p><strong>Conclusions: </strong>In patients with SUDs, benzodiazepine discontinuation is uncommon and frequently followed by return to use. Brief tapers show little benefit. Our data support that successful BZD tapering may require prolonged, structured tapering within integrated mental-health and substance use care to minimize return to use.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis exploring the recruitment hurdles and nonparticipation rate in noninvasive brain stimulation for addictive disorders.","authors":"Pinki Sevda, Priyanka Saha, Siddharth Sarkar, Rohit Verma, Naresh Nebhinani","doi":"10.1080/10550887.2025.2564446","DOIUrl":"https://doi.org/10.1080/10550887.2025.2564446","url":null,"abstract":"<p><strong>Background: </strong>Substance use disorders (SUDs) are a growing public health concern with high relapse rates. Noninvasive brain stimulation techniques are emerging as potential adjunctive therapies; however, recruitment challenges persist in related clinical trials. To use systematic review and meta-analysis to determine the rate and reasons for nonparticipation in randomized controlled trials (RCTs) involving noninvasive brain stimulation for substance-related and addictive disorders.</p><p><strong>Materials and methods: </strong>Major databases (PubMed, CENTRAL, and Google Scholar) were searched from inception to January 2025 for RCTs of noninvasive brain stimulation and SUD. Of 3589 abstracts searched, 55 RCTs met the inclusion criteria. Eligible studies were peer-reviewed, published in English and examined any form of noninvasive brain stimulation in individuals with substance-related or behavioral addictions. Studies were required to report the number of individuals screened and ultimately randomized. Non-randomized studies, those involving invasive brain stimulation, were excluded.Following PRISMA guidelines, data were extracted independently by two reviewers, with discrepancies resolved by a third. Risk of bias (RoB) was assessed using the Cochrane RoB tool. Random-effects model was used for meta-analysis.</p><p><strong>Results: </strong>A total of 55 randomized trials were included which involved diverse SUDs and behavioral addictions. The pooled nonparticipation rate was 55.9% (95% CI: 45.9-65.8%; <i>I</i>² = 99.56%, <i>p</i> < 0.001). Majority of the studies reported craving as an outcome measure. Key reasons included failure to meet inclusion criteria (reported in over 25 studies), refusal to participate due to anxiety or lack of motivation (≥15 studies), and logistical barriers such as travel or session frequency (≥10 studies).</p><p><strong>Conclusion: </strong>Nonparticipation in noninvasive brain stimulation trials for SUD are high, largely due to stringent eligibility criteria, procedural apprehension, and practical burdens faced by participants. Addressing these barriers through broader inclusion criteria, participant education, incentives, and flexible scheduling is essential to enhance recruitment, trial generalizability, and future clinical applicability of NIBS in addiction treatment.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-20"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological and therapeutic efficacy of somatic psychotherapies in addiction: primary behavioral focus with exploratory cross-addiction analyses.","authors":"Christopher Lomas","doi":"10.1080/10550887.2025.2560404","DOIUrl":"https://doi.org/10.1080/10550887.2025.2560404","url":null,"abstract":"<p><strong>Background: </strong>Behavioral addictions exhibit convergent dysregulation of meso-striatal reward, cortico-limbic stress, and executive-control circuits. Top-down interventions such as CBT demonstrate moderate, often transient effects, leaving autonomic dysregulation insufficiently targeted. Somatic and body-oriented psychotherapies (SBPs) may remediate these deficits <i>via</i> bottom-up interoceptive and autonomic mechanisms, but quantitative synthesis is lacking.</p><p><strong>Methods: </strong>Nine randomized controlled trials (RCTs) (total <i>N</i> = 573) of yoga, mindfulness, or somatic interventions for gambling, gaming, or compulsive sexual behavior were systematically reviewed. Hedges' g was pooled using random-effects meta-analysis (DerSimonian-Laird, Hartung-Knapp intervals). Risk-of-bias was evaluated with RoB-2; sensitivity analyses included leave-one-out models.</p><p><strong>Results: </strong>Pooled effect size indicated a large benefit (g = -2.62, 95% CI [-4.73, -0.51], <i>p</i> = .015), with heterogeneity substantial (<i>I</i>² = 95.6%). Directionality persisted under sensitivity analyses. No serious adverse events were reported.</p><p><strong>Conclusions: </strong>This review delivers the first quantitative synthesis of SBPs in behavioral addictions, delineating robust short-term symptom reduction alongside preliminary mechanistic signals implicating interoceptive-autonomic and fronto-striatal circuits. A novel phased, biomarker-guided treatment framework is proposed, situating SBPs as adjunctive modulators within integrative addiction care. Future trials should prioritize mechanistic endpoints, longer follow-up, and dismantling designs to isolate active components.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-21"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/10550887.2025.2557154","DOIUrl":"10.1080/10550887.2025.2557154","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"i"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of xylazine exposure in pregnancy: a narrative review.","authors":"Ilana Hull, Raagini Jawa, Margaret Shang, Corey Davis, Cambria King, Gary McMurtrie, Elizabeth Krans","doi":"10.1080/10550887.2024.2391156","DOIUrl":"10.1080/10550887.2024.2391156","url":null,"abstract":"<p><p>The rise in pregnancy-related overdose deaths has been driven by the use of high-potency illicitly-manufactured synthetic opioids including fentanyl. Xylazine, a veterinary sedative, is increasingly noted as a common adulterant in the United States illicit opioid supply. Exposure to the xylazine-fentanyl combination has been associated with severe harms including sedation, necrotic wounds, and symptoms of xylazine withdrawal. Due to limited data that directly addresses the risks of xylazine exposure during human pregnancy, we conducted a narrative review to summarize the available evidence about the clinical implications of xylazine exposure in pregnancy drawing from evidence from animal models, the general adult population, and the authors' clinical experiences. Because xylazine exposure presents unique risks to pregnant persons, management of xylazine exposure and related clinical sequelae in pregnant persons warrants nuanced clinical management. Further, additional research is critically needed to develop best practice guidelines related to the management of co-occurring xylazine-opioid exposure during pregnancy including harm reduction strategies to reduce exposure risk during pregnancy.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"394-401"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of artificial intelligence in addiction medicine.","authors":"R Gregory Lande","doi":"10.1080/10550887.2025.2546852","DOIUrl":"10.1080/10550887.2025.2546852","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"299-300"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient initiation of long-acting injectable buprenorphine at a community hospital: A retrospective case series.","authors":"Clarissa O'Conor, Shai Farhi, Ethan Cowan, Ruchi Fitzgerald","doi":"10.1080/10550887.2024.2391145","DOIUrl":"10.1080/10550887.2024.2391145","url":null,"abstract":"<p><strong>Objectives: </strong>Determine if long-acting injectable buprenorphine (LAIB) can be successfully and safely administered in the hospital with minimal sublingual buprenorphine lead-in and potentially improve follow-up engagement in care.</p><p><strong>Methods: </strong>We performed a retrospective case series of 46 patients who received LAIB while hospitalized at a safety-net community hospital. We abstracted demographic information, details about substance use disorder treatment history, in-hospital buprenorphine initiation methods and follow-up data from inpatient and outpatient electronic medical records.</p><p><strong>Results: </strong>In total, 46 hospitalized patients received LAIB during the study period. The majority of our patients were older Black adults with Medicaid who self-reported intranasal heroin use. A low-dose buprenorphine initiation protocol was used most commonly, either in sublingual or intravenous form, with only two cases of precipitated withdrawal occurring during the buprenorphine initiation process and no cases of precipitated withdrawal after the administration of LAIB. 87% (40) of the patients received LAIB after receiving either sublingual or IV buprenorphine for fewer than the recommended seven days. Of the 46 hospitalized patients who received LAIB, 23 (50%) attended a follow-up addiction medicine appointment within 30 days of discharge.</p><p><strong>Conclusions: </strong>Hospital administration of LAIB could play an important role in retention in care after hospital discharge.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"338-344"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pornography use on the sexual satisfaction: a systematic review and meta-analysis.","authors":"Fatemeh Abdi, Reza Pakzad, Farzaneh Alidost, Ehsan Aghapour, Vahid Mehrnoush, Mojdeh Banaei","doi":"10.1080/10550887.2024.2401680","DOIUrl":"10.1080/10550887.2024.2401680","url":null,"abstract":"<p><strong>Objective: </strong>Dissatisfaction with an inividual's sex life is underlying factor that can lead to pornography addiction. The current research aims to understand the relationship between pornography use and sexual satisfaction.</p><p><strong>Methods: </strong>The pooled correlation coefficient with 95% confidence interval was calculated using random effects. The meta-regression method was used to examine factors affecting heterogeneity between studies and Egger's test was used to evaluate of publication bias.</p><p><strong>Results: </strong>41 studies with a total sample size of 70541 participants were included in the meta-analysis. The pooled estimate for the correlation coefficient in total, in male and in female -0.06 (95% CI: -0.09 to -0.02), -0.07 (95% CI: -0.16 to 0.02) and -0.04 (95% CI: -0.08 to -0.01). The pooled estimate of correlation coefficient was -0.04 (95% CI: -0.07 to -0.02) in cross-sectional, -0.12 (95% CI: -0.19 to -0.05) in cohort, 0.00 (95% CI: -0.15 to 0.15) in studies that used self-report questionnaire and -0.06 (95% CI: -0.08 to -0.03) in studies that used online survey. Based on the results of the meta-regression, the publication year was found to have a significant effect on heterogeneity among studies (<i>B</i> = 0.013, <i>p</i> = 0.018). However, study design, age, data collection method, quality score and sample size did not have a significant effect.</p><p><strong>Conclusions: </strong>There was a significant negative correlation between pornography and sexual satisfaction and the disaggregation of results by gender also indicated this negative correlation among women. However, the relationship between pornography and sexual satisfaction was not significant in men.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"301-318"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High dose opioid agonist therapy for patients with opioid use disorder: a case series exploring this patient-centered approach.","authors":"Priya Nigam, Jennifer Marx, Omolara Olasimbo, Vikranth Induru, Ho-Man Yeung","doi":"10.1080/10550887.2024.2383804","DOIUrl":"10.1080/10550887.2024.2383804","url":null,"abstract":"<p><strong>Objectives: </strong>Management of opioid withdrawal in the inpatient setting can vary widely depending on the patient, the physician, and the institution. Although buprenorphine and methadone are first-line therapy for withdrawal management, some patients experience barriers to those medications. In this case series, we explore high dose opioid agonist therapy (HDOAT) as a novel and effective option to bridge to recovery in this particular setting.</p><p><strong>Methods: </strong>This retrospective case series includes- five patients with opioid use disorder (OUD) who were treated with HDOAT while hospitalized and reports on their outcomes.</p><p><strong>Results: </strong>All five patients completed lifesaving medical therapy, engaged with community health workers for resources, and successfully transitioned to medications for opioid use disorder (MOUD). More importantly, none of the patients had patient directed discharges (PDDs). Furthermore, there were no inpatient drug uses or overdoses requiring naloxone administration, even with very high doses of oxycodone. None of the five patients were readmitted within thirty days.</p><p><strong>Conclusions: </strong>Although more rigorous research is needed, HDOAT may be a viable strategy for OUD when patients continued to decline buprenorphine or methadone on admission. This case series demonstrated the successful use of this strategy toward preventing PDDs, promoting treatment completion, and allowing substance recovery and rehabilitation, in patients who elected to defer MOUD on arrival.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"386-393"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of tobacco products and associated factors among outpatient visitors of two healthcare facilities in Northern Cyprus: a descriptive cross-sectional study.","authors":"Ozen Asut, Songul Vaizoglu, Gulifeiya Abuduxike, Ebthal Khader, Nada Galal Ramadan, Sanda Cali","doi":"10.1080/10550887.2024.2386492","DOIUrl":"10.1080/10550887.2024.2386492","url":null,"abstract":"<p><strong>Background: </strong>Tobacco use is one of the leading causes of preventable mortality and morbidity. Although Cyprus is considered a developed country, the tobacco prevalence and related issues have not been explored sufficiently in the general population of North Cyprus.</p><p><strong>Objective: </strong>The objective of this study is to determine the rate of tobacco product consumption and related factors among the visitors of a community health center and a university hospital in Northern Cyprus.</p><p><strong>Methods: </strong>The study was designed as a cross-sectional study The data were collected using a questionnaire developed in compliance with WHO guidelines. The data were analyzed using IBM-SPSS18.0 with <i>p</i> < 0.05 evaluated as significant.</p><p><strong>Results: </strong>Out of a total of 635 individuals approached, 615 provided responses. The participation rate was 96%. The frequency of male smokers was 47.2%, while the frequency of female smokers was 34.0%, with a total smoking rate of 40.7%, much higher than world averages. The survey identified friendship influence as the primary reason for starting tobacco use, accounting for 42%, followed by being stressed at 34.6%. Male gender, being single, having no children, Turkish nationality were predictors of smoking, while financial status was not. The participants indicated a high frequency regarding exposure to passive smoke (51.1%). More than half of the respondents thought tobacco control in Northern Cyprus is not satisfactory.</p><p><strong>Conclusion: </strong>More research needs to be done to determine the exact overall prevalence of tobacco consumption in the population, which was found high in this study. Moreover, implementation of comprehensive tobacco control strategies is essential to control the prevalent tobacco dependence.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"329-337"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}