Journal of Addictive Diseases最新文献

{"title":"Epidemiology of Hepatitis C infection in pregnancy: Patterns and trends in West Virginia using statewide surveillance data.","authors":"Amna Umer, Candice Lefeber, Christa Lilly, Jana Garrow, Janine Breyel, Timothy Lefeber, Collin John","doi":"10.1080/10550887.2024.2372484","DOIUrl":"10.1080/10550887.2024.2372484","url":null,"abstract":"<p><strong>Background: </strong>The increasing rate of Hepatitis C virus (HCV) infection has been attributed to the substance use epidemic. There is limited data on the current rates of the paralleling HCV epidemic.</p><p><strong>Objectives: </strong>To estimate the prevalence of maternal HCV infection in West Virginia (WV) and identify contributing factors.</p><p><strong>Methods: </strong>Population-based retrospective cohort study of all pregnant individual(s) who gave birth in WV between 01/01/2020 to 01/30/2024 (<i>N</i> = 69,925). Multiple log-binomial regression models were used to estimate the adjusted risk ratio (ARR) and the 95% confidence intervals (CI).</p><p><strong>Results: </strong>The rate of maternal HCV infection was 38 per 1,000 deliveries. The mean age of pregnant individual(s) with HCV was 29.99 (SD 4.95). The risk of HCV was significantly higher in White vs. minority racial groups [ARR 1.93 (1.50, 2.49)], those with less than [ARR 1.57 (1.37, 1.79)] or at least high school [ARR 1.31 (1.17, 1.47)] vs. more than high school education, those on Medicaid [ARR 2.32 (1.99, 2.71)] vs. private health insurance, those residing in small-metro [ARR 1.32 (1.17, 1.48)] and medium-metro [ARR 1.41 (1.24, 1.61)], vs. rural areas, and those who smoked [ARR 3.51 (3.10, 3.97)]. HCV risk was highest for those using opioids [ARR 4.43 (3.95, 4.96)]; followed by stimulant use [ARR = 1.79 (1.57, 2.04)].</p><p><strong>Conclusions: </strong>Our findings highlight that maternal age, race, education, and type of health insurance are associated with maternal HCV infection. The magnitude of association was highest for pregnant individual(s) who smoked and used opioids and stimulants during pregnancy in WV.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"232-243"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referrals offered to affected family members: a cross-sectional analysis of a substance use program register.","authors":"Júlia Ramil Soeiro E Silva, Ronaldo Laranjeira, Martha Canfield, Claudio Jerônimo da Silva, Raquel Radaeli de Figueiredo Molen, Helena Takeyama Sakiyama, Douglas José Resende Lima, Maria de Fatima Rato Padin","doi":"10.1080/10550887.2025.2514325","DOIUrl":"10.1080/10550887.2025.2514325","url":null,"abstract":"<p><p><b>Background:</b> Demand is growing for support services for affected family members (AFM) of relatives with a substance use disorder or problematic substance use. This study examined referral patterns and factors influencing referral types of AFM who sought support through the program '<i>Recomeço Família'</i> in São Paulo, Brazil. <b>Methods</b>: A cross-sectional retrospective analysis of 5,192 records of family members registered in the program between 2014 and 2018. Referrals made by health professionals to external services were assessed and factors associated with referral types were assessed through univariate binary logistic regressions. <b>Results:</b> Most of the referrals were to individual therapies (counseling/psychotherapy)(64.30%), followed by family support groups (21.15%) and psychoeducational programs (14.55%). Referral destinations varied by AFM and their relative characteristics, including gender, age, kinship, levels of emotional distress, help-seeking history and substance type. <b>Conclusion</b>: The findings highlight factors that may influence referral decisions and underscore the need for further investigation into whether these referrals effectively address the specific needs of AFM.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mephentermine misuse: an emerging challenge and the potential role of mirtazapine-a case report.","authors":"Reshma Dcruz, Aravind Karunakaran, Aparna Sasikumar, Sandeep Alex, Smitha Ramadas","doi":"10.1080/10550887.2025.2514287","DOIUrl":"10.1080/10550887.2025.2514287","url":null,"abstract":"<p><p>Mephentermine is a sympathomimetic amine with structural and pharmacological similarities to amphetamines. Despite its increasing misuse, particularly among athletes and bodybuilders, there is limited literature on its management. No pharmacological treatments have been approved for mephentermine misuse. We describe two cases of young adult males presenting with symptoms of mephentermine withdrawal, including insomnia, anxiety, and craving. Both had histories of prolonged intravenous mephentermine use, with one managed on an outpatient basis and the other as an inpatient. Mirtazapine was initiated in both cases and was associated with improvements in sleep, anxiety, craving and hyperarousal. Psychotic symptoms in one patient resolved with short-term risperidone. Both patients received brief motivational enhancement therapy and remained abstinent from all substances except tobacco during two months of follow-up. These cases highlight the potential utility of mirtazapine in managing mephentermine misuse, particularly for addressing withdrawal symptoms and craving. Given its noradrenergic and serotonergic profile and its demonstrated efficacy in methamphetamine use, mirtazapine may be a promising candidate for treatment. However, the findings are limited by the case series design and larger, controlled studies are needed to confirm its role in clinical management.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersectional disparities in illicit drug use by race/ethnicity and sexual orientation among U.S. adults: Results from a large secondary sample.","authors":"Jung-Chi Chew, Yen-Chang Chang, Yen-Han Lee","doi":"10.1080/10550887.2025.2514322","DOIUrl":"https://doi.org/10.1080/10550887.2025.2514322","url":null,"abstract":"<p><strong>Background: </strong>Illicit drug use disparities persist across racial and ethnic and sexual identity groups. This study examined associations between sexual identity, race/ethnicity, and drug use patterns, focusing on types and usage within the past year.</p><p><strong>Methods: </strong>Using data from the 2021-2023 National Survey on Drug Use and Health (<i>n</i> = 129,823), multinomial logistic regression was used to assess drug use patterns. Key predictors included sexual identity (heterosexual, lesbian/gay, and bisexual) and race/ethnicity (White, Black, Asian, Hispanic, and Others), controlling for socioeconomic factors.</p><p><strong>Results: </strong>Bisexual individuals had the highest drug use rates among sexual minority groups, particularly for polysubstance use (14.29%). White individuals reported the highest overall prevalence (72.55%), while Black and Asian individuals had lower rates. Drug use was highest among young adults (32.01%) and declined with age. Among racial groups, Black individuals exhibited the highest drug misuse risk (interaction model: single-drug use RRR = 2.70, 95% CI = [2.38, 3.05]; polysubstance use RRR = 1.70, 95% CI = [1.48, 1.95]), followed by Asian individuals (single-drug use RRR = 2.21, 95% CI = [1.72, 2.85]; polysubstance use RRR = 1.78, 95% CI = [1.38, 2.30]). Among sexual identity groups, Black bisexual individuals were the most vulnerable (RRR = 1.50, 95% CI = [1.03, 2.19]), highlighting the compounded risks faced by individuals at the intersection of racial and sexual minority identities.</p><p><strong>Conclusions: </strong>Findings emphasize the need for culturally responsive interventions targeting bisexual individuals and racial/ethnic minorities to reduce disparities and improve public health outcomes.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buprenorphine-naloxone vs methadone for opioid use disorder: a systematic review and meta-analysis of randomized clinical trials.","authors":"Anderson Matheus Pereira da Silva, Mariana Leticia de Bastos Maximiano, Lucas Silva Cabeça, Levi Leal Silva, Elizabeth Honorato de Faria, Matheus Nepomuceno Fernandes, Ariane Barros Mesquita Cunha, Gabrielle Silva Vieira, Thierry Duarte Ribeiro Sobral, Daniel Vicente de Siqueira Lima Júnior, Maria Bernadete de Sousa Maia, Eryvelton de Souza Franco","doi":"10.1080/10550887.2025.2514308","DOIUrl":"https://doi.org/10.1080/10550887.2025.2514308","url":null,"abstract":"<p><p><b>Background:</b> This meta-analysis evaluated the efficacy and safety of buprenorphine-naloxone compared to methadone in the treatment of Opioid Use Disorder (OUD), with a focus on treatment retention, attrition rates, and serious adverse events. OUD remains a major public health concern, necessitating effective pharmacological interventions to improve adherence and minimize adverse outcomes.<b>Methods:</b> A systematic search of PubMed, Embase, Cochrane CENTRAL, Web of Science, and Scopus identified randomized controlled trials comparing both treatments. The study adhered to PRISMA guidelines, and data were analyzed using a random-effects model with Odds Ratios (OR) and 95% Confidence Intervals (CI). Heterogeneity was assessed using the I² statistic.<b>Results:</b> Seven randomized controlled trials involving 3,622 patients were included. Methadone doses ranged from 5 to 397 mg/day and buprenorphine-naloxone from 2 to 32 mg/day. Methadone showed significantly higher treatment retention at six months compared to buprenorphine-naloxone (OR 0.43; 95% CI 0.27-0.67; I² = 62.2%). Attrition was higher in the buprenorphine-naloxone group (OR 2.47; 95% CI 1.42-4.30; I² = 68.4%). In contrast, serious adverse events occurred less frequently with buprenorphine-naloxone (OR 0.72; 95% CI 0.48-1.09; I² = 0.0%).<b>Conclusion:</b> In conclusion, methadone is associated with superior retention, while buprenorphine-naloxone presents a more favorable safety profile. These findings highlight the need for individualized treatment decisions based on clinical context and patient-specific risks. Future large-scale, high-quality studies are recommended to guide optimal pharmacological strategies for managing OUD.</p><p><strong>Registration: </strong>PROSPERO protocol number: CRD 42025634919.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe intravenous buprenorphine/suboxone^® use disorder: a case report.","authors":"Fahad Qureshi, Shannon Miller","doi":"10.1080/10550887.2025.2464350","DOIUrl":"https://doi.org/10.1080/10550887.2025.2464350","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological contributions to addiction: a narrative review of adolescent and adult vulnerabilities.","authors":"Abhijeet Singh, Arif Ali, Fayaz Ahmad Paul","doi":"10.1080/10550887.2025.2513142","DOIUrl":"10.1080/10550887.2025.2513142","url":null,"abstract":"<p><strong>Background: </strong>Addiction is a multidimensional disorder largely influenced by biological, psychological, and social factors, presenting distinct manifestations in adolescents and adults. At different stages of brain development, neurobiological mechanisms play a central role in the development and persistence of addictive behaviors.</p><p><strong>Objectives: </strong>This review synthesizes recent studies indexed in Scopus, focusing on biological contributions to addiction in adolescents and adults.</p><p><strong>Materials and methods: </strong>The Scopus database was systematically searched and retrieved studies using predetermined inclusion criteria. The overall neurobiological factors that determine vulnerability to addiction among both adolescents and adults were analyzed; these include neurodevelopmental factors, neuroadaptive changes through chronic substance use, and genetic influences.</p><p><strong>Results: </strong>The findings indicate that adolescents, with heightened dopaminergic activity and synaptic plasticity, are particularly sensitive to addictive behaviors, while adults, after prolonged substance use, experience neuroadaptations leading to tolerance and dependence. Genetic predispositions and epigenetic changes also contribute to addiction vulnerability in both groups. These insights suggest the need for targeted prevention and treatment strategies that address the unique neurobiological profiles of adolescents and adults to reduce the overall impact of addiction.</p><p><strong>Conclusion: </strong>Understanding the biological basis of addiction in adolescents and adults is important to advise successful public health policies and clinical interventions.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doomscrolling and social media addiction in adolescents: a two-wave longitudinal study.","authors":"Muhammed Akat, Erdal Hamarta","doi":"10.1080/10550887.2025.2504231","DOIUrl":"https://doi.org/10.1080/10550887.2025.2504231","url":null,"abstract":"<p><p>In recent years, various traumatic events such as pandemics, earthquakes, wars, and migration have occurred worldwide. Negative news and content related to these events can be easily accessed on social media, leading to the concept of doomscrolling. Doomscrolling is a recent phenomenon in mental health research and has not yet been sufficiently studied. Therefore, in this study, the longitudinal relationship between social media addiction and doomscrolling was examined. In this study, data were collected at two time points, time 1 (T1) and time 2 (T2), separated by a two-month interval. The study sample comprised 301 adolescents (48.5% female; 51.5% male) from 20 cities in Turkey. Participants were aged 12 to 19 (M_age = 15.55, SD = 1.09). The study employed a Cross-lagged path analytic model for the analysis. The analyses revealed positive and significant relationships between social media addiction and doomscrolling. It was concluded that at T1, addiction to social media had a positive correlation with doomscrolling at T2. Furthermore, the analysis revealed that social media addiction at T1 had a positive correlation with social media addiction at T2. However, the study found that engaging in doomscrolling at T1 did not significantly predict the development of social media addiction at T2. In conclusion, adolescents' social media addiction levels increase the risk of doomscrolling. These results demonstrate the importance of interventions that include social media addiction in the prevention and treatment of doomscrolling. Mental health professionals can provide interventions that include healthy social media use skills in adolescents to prevent doomscrolling.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated HD-tACS for craving and cognition in synthetic cannabinoid use disorder: a case report.","authors":"Yan Long, Qianlan Yin, Daqing Shi, Tianzhen Chen, Jiang Du, Min Zhao","doi":"10.1080/10550887.2025.2483052","DOIUrl":"https://doi.org/10.1080/10550887.2025.2483052","url":null,"abstract":"<p><strong>Introduction: </strong>Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique, has been demonstrated to improve cognitive function. Recent advances in neuromodulation protocols have introduced an accelerated intervention paradigm, which has shown promising therapeutic outcomes across various noninvasive brain stimulation modalities. Despite these encouraging developments in cognitive enhancement, there remains a significant gap in the literature regarding the potential therapeutic applications of accelerated tACS protocols in substance use disorders.</p><p><strong>Case summary: </strong>We present the case of a 22-year-old man diagnosed with synthetic cannabinoid use disorder (SCUD), who underwent accelerated high-definition tACS (HD-tACS) over two days. Changes in attention bias, craving, and impulsivity were assessed by electroencephalography (EEG), standardized scale, and behavioral test. The results revealed that the patient experienced reductions in pathological attention bias, drug craving, and impulsive and risk-taking behaviors following the accelerated HD-tACS intervention, with reductions in drug craving and behavior control sustained for five weeks post-treatment.</p><p><strong>Conclusion: </strong>This is the first case to confirm the feasibility, safety, and efficacy of accelerated HD-tACS in treating SCUD, with therapeutic effects sustained for up to five weeks, highlighting the need for further systematic investigations in substance use disorders.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-frequency binge drinking: associated factors and consequences.","authors":"Alexandra Dereux, Daphnée Poupon, Stéphanie Nann, Pierre-Alexis Geoffroy, Lucia Romo, Philip Gorwood","doi":"10.1080/10550887.2025.2477350","DOIUrl":"https://doi.org/10.1080/10550887.2025.2477350","url":null,"abstract":"<p><strong>Background: </strong>Binge drinking (BD) is a public health concern among young adults. Whether it is harmful even at a low frequency remains unclear.</p><p><strong>Objectives: </strong>To test if even low-frequency (less than once a month) BD is associated with a higher likelihood of alcohol use disorder (AUD), and if some key environmental and psychological features characterize low-frequency binge drinkers.</p><p><strong>Methods: </strong>Alcohol-related, environmental and psychological data were collected from university students aged 18-25 who drank alcohol. Students were divided into four groups according to their BD frequency: <i>non-binge drinkers</i> (never had six or more drinks on one occasion), and binge drinkers with <i>low</i> (at least once lifetime but less than once a month), <i>medium</i> (at least once a month but less than once a week), or <i>high</i> (at least once a week) frequency.</p><p><strong>Results: </strong>Among the 3308 students included in this cross-sectional study, 473 never binged alcohol, while 1204, 1001, and 630 were low-, medium-, and high-frequency binge drinkers, respectively. Even low-frequency BD was associated with higher AUDIT scores and a larger prevalence of harmful drinking. Compared to non-binge drinkers, low-frequency binge drinkers also reported higher rates of smoking, sensation seeking, and endorsement of enhancement and social drinking motives.</p><p><strong>Conclusions: </strong>Among 18-25-year-old students exposed to alcohol, even infrequent BD is associated with more harmful drinking. The findings highlight the importance of prevention strategies since BD less than once a month, which concerns a third of this population, is already associated with a higher likelihood of AUD.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}