Journal of Addictive Diseases最新文献

{"title":"Healthcare professionals' experiences in preparing patients for elective alcohol detoxification - a service-level qualitative case-study.","authors":"Darren Quelch, Nyle Davies, Gareth Roderique-Davies, Mark Pucci, Bev John","doi":"10.1080/10550887.2025.2538259","DOIUrl":"https://doi.org/10.1080/10550887.2025.2538259","url":null,"abstract":"<p><strong>Background: </strong>Services for individuals severely physically dependent on alcohol, wishing to undergo detoxification are limited. This is partly due to a lack of evidence surrounding safe alcohol reduction advice.</p><p><strong>Objectives: </strong>To summarize the practices from an elective alcohol detoxification service provided by Sandwell and West Birmingham NHS Trust (SWB) (Birmingham, United Kingdom) aimed at preparing high-risk individuals for detoxification.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with healthcare professionals working at the SWB elective detoxification service, representing a collective experience of 50+ years in the management of alcohol related presentations. A descriptive qualitative analysis approach was adopted.</p><p><strong>Results: </strong>Four categories of discourse were observed: 1) establishing a motivation to change, 2) the importance of an in-depth alcohol history, and 3) an individualized approach to patients, and 4) the role that readiness to change attitudes play in preparedness for detoxification. Practical advice relating to alcohol reduction included: consolidation of multiple beverages to fewer, 'measure and discard' techniques, and spacing out consumption/diluting beverages.</p><p><strong>Conclusions: </strong>Core components to elective detoxification preparation were: 1) safety, 2) the requirement of an individualized approach and 3) a willingness to take ownership of recovery. The approaches discussed may help improve translation of alcohol detoxification services to those considered high-risk. The Standards for Reporting Qualitative Research framework was applied throughout.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-16"},"PeriodicalIF":1.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta burst stimulation (TBS) in methamphetamine use disorder: a meta-analysis and systematic review.","authors":"Gopalkumar Rakesh, Thomas G Adams, Dylan H Ballard, Christopher J McLouth, Craig R Rush","doi":"10.1080/10550887.2025.2541165","DOIUrl":"10.1080/10550887.2025.2541165","url":null,"abstract":"<p><p>Methamphetamine use disorder (MUD) currently lacks FDA-approved treatments. Previous studies involving transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (L.dlPFC) have shown promise in TMS's effectiveness at decreasing craving for methamphetamine. Theta burst stimulation (TBS), which includes intermittent (iTBS) and continuous (cTBS) protocols, is increasingly being used for substance use disorders, including MUD. Previous reviews of TMS in MUD performed subgroup meta-analyses of studies that delivered TBS in MUD. However, these meta-analyses included studies with overlapping participant cohorts, limiting their validity. To address this limitation, we reviewed randomized controlled trials (RCTs) using unique patient cohorts from PubMed/Medline, EMBASE, and Google Scholar until September 1, 2024, comparing the impact of TBS versus sham on cue-induced methamphetamine craving in patients with MUD. We performed a meta-analysis with four eligible RCTs that delivered iTBS. Results suggest iTBS was more effective in reducing cue-induced methamphetamine craving than sham iTBS (standardized mean difference [SMD] in change = 1.04; 95% CI [0.16, 1.92]). Two additional RCTs without sham control arms were reviewed, and one demonstrated a significant reduction in craving following accelerated iTBS. Future studies should examine whether neuroimaging-targeted iTBS can impact outcome measures other than craving, such as methamphetamine use, by measuring return to use. Exploring accelerated iTBS and cTBS for MUD, targeting alternative cortical sites such as the frontal pole, and studying their effects on relevant MUD biomarkers is also pertinent. This review demonstrates the effectiveness of TBS for MUD, emphasizing its potential to advance treatment options for MUD.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-13"},"PeriodicalIF":1.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence that hedonic response toward sugar in alcohol use disorder is mediated by antidepressant use and does not constitute an endophenotype.","authors":"Alexandra Dereux, Clément Vansteene, Stéphanie Dubal, Héline Kaya Lefevre, Daphnée Poupon, Nicolas Ramoz, Philip Gorwood","doi":"10.1080/10550887.2025.2533575","DOIUrl":"https://doi.org/10.1080/10550887.2025.2533575","url":null,"abstract":"<p><strong>Background: </strong>Literature highlighted a higher sweet preference among patients with alcohol use disorder (AUD) that may act as an endophenotypical vulnerability. However, results remain heterogenous and seldom information is available regarding possible origins, such as hedonic abilities, reward sensitivity or impulsivity.</p><p><strong>Objective: </strong>This cross-sectional study aims to explore the relationship between AUD and sweet preference as well as its endophenotypical properties.</p><p><strong>Methods: </strong>Ninety-two participants were divided into three groups (36 patients with AUD, 29 healthy controls and 27 healthy first-degree relatives), and were asked to take a sweet preference test, a hedonic test, the <i>Iowa Gambling Task</i> (IGT) and self-reported inventories measuring impulsivity (<i>Barratt Impulsiveness Scale</i> [BIS-11]), anxiety and depression (<i>Hospital Anxiety and Depression scale</i> [HADS]). A stepwise linear regression with all available variables was performed to compare patients and controls. Factors included in the retained model were then added as mediators in a path analysis.</p><p><strong>Results: </strong>Compared to healthy controls, patients with AUD had a lower sweet score. The difference lost its significance in the linear regression: the retained model only included antidepressant use (<i>p</i> = .016) and tobacco use status (<i>p</i> = 0.074). The path analysis showed that antidepressant use, but not tobacco use status, significantly mediated the effect of AUD on sweet preference. Sweet score did not significantly differ between first-degree relatives and the two other groups.</p><p><strong>Conclusions: </strong>Our results do not support the hypothesis that sweet preference is an endophenotype of AUD. Instead, they suggest that the association between sweet preference and AUD may be mediated by confounding factors such as antidepressant use.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coenzyme Q10 as an adjunctive treatment for substance use disorders: a preclinical review.","authors":"Razieh Adabi, Alireza Masoudi, Raheleh Rafaiee, Fahimeh Mohseni","doi":"10.1080/10550887.2025.2521561","DOIUrl":"https://doi.org/10.1080/10550887.2025.2521561","url":null,"abstract":"<p><p>Substance use disorders (SUDs) are chronic, relapsing conditions characterized by significant neurobiological and behavioral disruptions. Emerging evidence highlights the critical roles of oxidative stress, mitochondrial dysfunction, and neuroinflammation in the pathophysiology of drug misuse. Coenzyme Q10 (CoQ10), a mitochondrial cofactor with potent antioxidant and anti-inflammatory properties, has gained attention as a potential adjunctive therapy for managing substance-related neurotoxicity. This review explores the mechanistic role of CoQ10 in mitigating the oxidative damage and neuroinflammation induced by substances misuse, emphasizing its ability to restore mitochondrial function and support neuronal health. Preclinical studies demonstrate that CoQ10 supplementation reduces apoptosis, preserves neurotransmitter systems, and improves behavioral outcomes in models of cocaine, alcohol, nicotine, and opioid addiction. Clinical evidence, though limited, suggests CoQ10's safety and therapeutic potential in oxidative stress-related conditions, reinforcing its relevance to addiction. Despite these promising findings, challenges such as low bioavailability and the lack of SUD-specific clinical trials remain significant barriers. This review underscores the need for further research to optimize CoQ10's formulation, dosing strategies, and clinical applications in the treatment of SUDs. Integrating CoQ10 into multidisciplinary approaches could advance our ability to address the complex neurobiological challenges of SUDs and improve long-term recovery outcomes.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing cannabis use among adolescents seeking treatment for their substance use.","authors":"Prianka Kumar, Emma Straton, Sivabalaji Kaliamurthy","doi":"10.1080/10550887.2025.2528314","DOIUrl":"https://doi.org/10.1080/10550887.2025.2528314","url":null,"abstract":"<p><strong>Introduction: </strong>The evolving landscape of laws and policies related to cannabis can inform patterns and trends in adolescent cannabis use. Today, a wide variety of cannabis products and alternatives are available in the legal and illicit markets. Harms associated with their use may vary depending on the amount and type of tetrahydrocannabinol (THC) they contain. Few studies have examined the awareness of and use of these different cannabis products among adolescents.</p><p><strong>Methods: </strong>Our study examined patterns of cannabis use in adolescent patients of an urban pediatric addiction clinic.</p><p><strong>Results: </strong>Most adolescents seen at the clinic use multiple cannabis products, and many adolescents use cannabinoid derivatives such as delta-8 and delta-10 THC.</p><p><strong>Discussion: </strong>These results highlight the need for providers to explore in depth the various cannabis products used by adolescents, educate adolescents on the products, especially due to unknown risks associated with cannabinoid derivatives, and advocate for further regulation of alternative cannabis products.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-4"},"PeriodicalIF":1.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consider vitamin C in the armamentarium of alcohol withdrawal management.","authors":"David Metsu, Pierre Berthomès, Marie Cécile Pierre","doi":"10.1080/10550887.2025.2534193","DOIUrl":"https://doi.org/10.1080/10550887.2025.2534193","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-2"},"PeriodicalIF":1.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking initiation as a mediator: investigating the causal relationship between sedentary lifestyles and cannabis use disorder through Mendelian randomization.","authors":"Deyu Meng, Meiqi Wei, Shichun He, Zongnan Lv, Hongtu Zhang, Guang Yang, Ziheng Wang","doi":"10.1080/10550887.2025.2516290","DOIUrl":"https://doi.org/10.1080/10550887.2025.2516290","url":null,"abstract":"<p><strong>Background: </strong>Cannabis Use Disorder (CUD) involves compulsive cannabis use, leading to significant impairment and distress. Previous research indicates lower physical activity and higher sedentary behavior among cannabis users, but the causal relationship remains unclear. This study aims to use Mendelian randomization (MR) to investigate the causal link between exercise, sedentariness, and CUD.</p><p><strong>Methods: </strong>We analyzed genetic associations for (1) moderate-to-vigorous physical activity (MVPA), (2) leisure screen time (LST), (3) sedentary commuting behavior (SCB), and (4) sedentary behavior at work (SBW). Genetic instruments for smoking initiation were identified from the GSCAN study. Genetic associations for CUD were derived from the largest Genome-wide association studies (GWAS) of CUD. We selected significant genetic variants, harmonized data. We conducted MR analyses using IVW, assessing heterogeneity and pleiotropy with Cochran's Q test and MR-Egger regression, and performed leave-one-out analyses.</p><p><strong>Results: </strong>SBW showed a protective causal relationship with CUD (OR = 0.61, 95% CI = 0.42-0.90, <i>p</i> = 0.012). LST increased the risk of CUD (OR = 1.43, 95% CI = 1.20-1.70, <i>p</i> < 0.001). LST also showed a significant causal relationship with smoking initiation (OR = 1.28, 95% CI = 1.21-1.36, <i>p</i> < 0.001), which was associated with increased CUD risk. Smoking initiation mediated 54.08% of the increased CUD risk associated with LST (95% CI = 53.72-54.44%).</p><p><strong>Conclusions: </strong>A sedentary lifestyle may lead to CUD through smoking. Addressing sedentariness and promoting physical activity may reduce the risk of smoking initiation and subsequent cannabis-related problems.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical detoxification of bromazolam using diazepam: a case report.","authors":"Daan Buitenhuis, David P Herdes, Sebastiaan O Verboeket","doi":"10.1080/10550887.2024.2365006","DOIUrl":"10.1080/10550887.2024.2365006","url":null,"abstract":"<p><p>An increasing number of new psychoactive substances (NPS), such as designer benzodiazepines, are becoming available on the recreational drug market. These are new unregistered substances and thereby an attempt to evade legislation. Often there is very limited clinical information available regarding these NPS, which could result in undesirable clinical outcomes in the management of intoxications, dependencies and withdrawals following NPS use. In this case report we describe a 23-year-old woman, who was admitted to our residential addiction care facility for the detoxification of the designer benzodiazepine bromazolam. Her daily use of 6 mg bromazolam was converted to 20 mg diazepam. Although we expected a higher dose would have been needed, 20 mg was sufficient and was tapered without complications. This case report demonstrates the safe conversion of 6 mg of bromazolam to 20 mg of diazepam by combining the use of fixed-dose and symptom-triggered-dose regimens. More clinical data is necessary to formulate advisory management for the detoxification of bromazolam and other designer benzodiazepines.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"282-287"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/10550887.2024.2366699","DOIUrl":"10.1080/10550887.2024.2366699","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"294"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"President's message: the dangerous mirage of medical marijuana.","authors":"Darrin Mangiacarne","doi":"10.1080/10550887.2025.2504237","DOIUrl":"10.1080/10550887.2025.2504237","url":null,"abstract":"","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"199-200"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}