Indian Journal of Urology最新文献

{"title":"Sestamibi scans for renal oncocytomas: Promising potential, but limitations remain.","authors":"Basil Joy","doi":"10.4103/iju.iju_355_24","DOIUrl":"10.4103/iju.iju_355_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"77-78"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of <i>Oxalobacter formigenes</i> in patients with primary hyperoxaluria: A systematic review and meta-analysis of randomized controlled trials.","authors":"Ubaid Khan, Muhammad Mubariz, Hazem Rezq, Abdelrahman Mahmoud, Muhammad Moiz Nasir, Noor Ul Ain, Umar Khan Bazai, Maleeka Zamurad Khan, Mohamed Abuelazm","doi":"10.4103/iju.iju_359_24","DOIUrl":"10.4103/iju.iju_359_24","url":null,"abstract":"<p><strong>Background and objective: </strong>Primary hyperoxaluria (PH), a rare autosomal recessive disorder, results in defective metabolism of oxalate, leading to increased oxalate levels. <i>Oxalobacter formigenes (O. formigenes)</i> is a nonpathological anaerobic bacterium that uses oxalate for its survival and thus decreases the plasma oxalate levels. We aimed to use randomized controlled trials (RCTs) to evaluate the efficacy of <i>O. formigenes</i> in treating PH.</p><p><strong>Methods: </strong>A literature review was conducted for synthesizing the evidence from RCTs on Scopus, Web of Science, Embase, PubMed, and CENTRAL until January 2023. The outcomes were pooled using mean difference (MD) for continuous data and odds ratios (OR) for dichotomous data along with confidence interval (CI). The systematic review is registered with Prospero ID CRD42023404421.</p><p><strong>Results: </strong>We included five RCTs with 208 patients. The pooled analysis did not favor <i>O. formigenes</i> over placebo in reducing the plasma oxalate levels (MD: -0.00 mmol/day; 95% CI: [ - 0.01-0.00]; <i>P</i> = 0.06). Similar results were observed for urinary oxalate levels (MD: -0.01 mmol/day; 95% CI: [ - 0.12-0.10]; <i>P</i> = 0.86). There were no significant adverse events (OR: 0.44; 95% CI: [0.14-1.39]; <i>P</i> = 0.16) or serious adverse events (OR: 0.80; 95% CI: [0.29-2.25]; <i>P</i> = 0.67).</p><p><strong>Conclusion: </strong><i>O. formigenes</i> was ineffective in reducing the serum and urine oxalate levels in patients with PH but has an acceptable safety profile. As PH is a relatively rare disease and few patients consent for the trials, stringent protocols are required in the future to achieve data accuracy pertinent for making conclusive recommendations on the efficacy of <i>O. formigenes</i> in patients with PH.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"11-19"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncological outcomes and complications following radical cystectomy with or without neoadjuvant chemotherapy - A retrospective comparative cohort study from a single-center in South India.","authors":"E Selvin Theodore Jayanth, Subhash L Jat, Benedict P Samuel, Ashish Singh, Nirmal Thampi John, Anjana Joel, Rajiv Paul Mukha, Grace Rebecca, Gowri Mahasampath, Chandrasingh Jeyachandra Berry, Antony Devasia, Nitin Kekre, Santosh Kumar","doi":"10.4103/iju.iju_214_24","DOIUrl":"10.4103/iju.iju_214_24","url":null,"abstract":"<p><strong>Introduction: </strong>Neoadjuvant chemotherapy (NAC) in the management of muscle-invasive bladder carcinoma has not been adopted universally. We studied the oncological outcomes and complications in patients who underwent radical cystectomy (RC) with or without NAC.</p><p><strong>Methods: </strong>A retrospective review of patients who underwent RC with or without NAC from June 2009 to June 2020 was conducted. Oncological outcomes, overall survival (OS) and recurrence-free survival (RFS), complications, and prognostic factors were analyzed.</p><p><strong>Results: </strong>Of the 314 patients who underwent RC, 83 patients received NAC (Group A), and 231 underwent RC alone (Group B). The median age was 58 years. The median follow-up duration was 22 (3-64) and 24 (3-62) months, respectively. The median OS in Group A was significantly higher than Group B (38 months [confidence interval (CI): 34-42] and 32 [CI: 29-35], respectively, [<i>P</i> = 0.033]). The RFS in Groups A and B was 34 (CI: 30-39) and 31 (CI: 28-34) months, respectively (<i>P</i> = 0.47). Higher pathological T stage (T3/4), node positivity and lymphovascular invasion (LVI) were predictors of poor OS and RFS (<i>P</i> < 0.0001). Clavien grades 3/4 complications were comparable (8% vs. 15%; <i>P</i> = 0.19). Glomerular filtration rate (GFR) <60 mL/min/1.73 m² was associated with higher postoperative complications in both groups (<i>P</i> = 0.012).</p><p><strong>Conclusion: </strong>The OS with NAC was superior to upfront RC. RFS was, however, comparable. NAC was safe and well-tolerated. Pathologically, higher T stage, node positivity, and LVI were associated with poorer OS and RFS. Low GFR negatively influenced postoperative complications.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"20-27"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography - Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy.","authors":"P Taur Pratik, Deerush Kannan Sakthivel, S Tiwari Madhav, P Bafna Sandeep, Narasimhan Ragavan","doi":"10.4103/iju.iju_143_24","DOIUrl":"10.4103/iju.iju_143_24","url":null,"abstract":"<p><strong>Introduction: </strong>Gallium-68 prostate-specific membrane antigen positron emission tomography (⁶⁸Ga-PSMA PET) is being increasingly used in patients with prostate cancer (PCa) for the staging and detection of lymph node (LN) metastases, despite a lack of prospective, validated evidence. We aimed to investigate the relationship between the PSMA PET findings (maximum standardized uptake [SUV_max] value) and the final histopathology results (Gleason Grade [GG], and LN positivity) in patients undergoing radical prostatectomy.</p><p><strong>Methods: </strong>This is a single centre, prospective, observational study of 63 consecutive eligible patients treated at a tertiary care centre in India. Patients underwent ⁶⁸Ga-PSMA PET computed tomography with fusion magnetic resonance imaging for staging, followed by a Transrectal ultrasound guided prostate biopsy. All patients underwent robotic-assisted radical prostatectomy with extended pelvic LN dissection as per the standard protocol. Clinical parameters and SUV_max values were collected and analysed.</p><p><strong>Results: </strong>The median preoperative prostate specific antigen (PSA) was 15.0 ng/ml (interquartile range: 9.4-28.0). A statistically significant correlation was observed between the PSA values and the SUV_max uptake (<i>P</i> < 0.001). Additionally, there was a statistically significant correlation between the SUV_max of the prostatic lesion and the GG on the radical prostatectomy specimens (<i>P</i> = 0.025), and SUV_max of LN and LN involvement (<i>P</i> < 0.001). The sensitivity and specificity of the ⁶⁸Ga-PSMA PET scan were 77.8% and 88.7%, respectively.</p><p><strong>Conclusions: </strong>SUVmax of the PCa lesion and the GG Group on the final histopathology correlates significantly. There is an increased SUV uptake in Gleason's Score (GS) 8, 9 tumours as compared to GS 6 and 7.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 1","pages":"40-44"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Ravimohan Suryanarayan Mavuduru","doi":"10.4103/iju.iju_342_24","DOIUrl":"10.4103/iju.iju_342_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"40 4","pages":"271-272"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Shah AS. Is rucaparib the definite direction for metastatic prostate cancer? - TRITON3 results decoded. Indian J Urol 2024;40:70-1.","authors":"Vivaan Dutt, Shalini Shree Krishnamurthy, Anand Raja","doi":"10.4103/iju.iju_83_24","DOIUrl":"10.4103/iju.iju_83_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"40 4","pages":"289-290"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthotopic renal autotransplantation: A step forward during postchemotherapy retroperitoneal lymph node dissection for germ cell tumor.","authors":"Akash Mor, Ajit Gujela, Sachin Patel, Vineet Kumar, Gagan Prakash","doi":"10.4103/iju.iju_48_24","DOIUrl":"10.4103/iju.iju_48_24","url":null,"abstract":"<p><p>We present the first and a rare case of orthotopic renal auto-transplantation in the management of postchemotherapy residual retroperitoneal mass encasing the left renal vessels but sparing the parenchyma in a 24-year-old patient with Stage IIIC nonseminomatous germ cell tumor after 4 cycles of chemotherapy. Immediate postoperative and 6 months' follow-up renograms confirmed the maintained glomerular filtration rate of the transplanted kidney with no residual disease. This case report shows the feasibility of renal autotransplantation in carefully selected patients as they are young and have long-term survival.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"40 4","pages":"273-275"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Venkat Arjunrao Gite","doi":"10.4103/iju.iju_308_24","DOIUrl":"10.4103/iju.iju_308_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"40 4","pages":"259"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Purushothaman J, Kalra S, Dorairajan LN, Selvarajan S, Sreerag KS, Aggarwal D. Intravesical bupivacaine in reducing catheter-related bladder discomfort and lower urinary tract symptoms after transurethral surgery: A randomized controlled trial. Indian J Urol 2024;40:161-6.","authors":"Kirti Singh, Swarnendu Mandal, Manoj K Das, Prasant Nayak","doi":"10.4103/iju.iju_273_24","DOIUrl":"10.4103/iju.iju_273_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"40 4","pages":"287-288"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Round up.","authors":"Swarnendu Mandal","doi":"10.4103/iju.iju_357_24","DOIUrl":"10.4103/iju.iju_357_24","url":null,"abstract":"","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"40 4","pages":"215-217"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}