{"title":"改良颊粘膜瓣瓣尿道内尿道成形术:一项初步研究。","authors":"Abhay Singh Gaur, Vivek Tarigopula, Swarnendu Mandal, Pavithra Ayyanar, Suvendu Purkait, Kirti Singh, C Sabique, Prasant Nayak","doi":"10.4103/iju.iju_519_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The minced buccal mucosal graft endourethral urethroplasty (MBGEU) is our novel technique of combining direct vision internal urethrotomy with buccal mucosal graft urethroplasty. We assessed success at 30-months of follow-up. Secondary objectives were to compare the changes in the American Urological Association (AUA) symptom score, peak flow rate (Qmax), and post-void residue (PVR) postoperatively.</p><p><strong>Methods: </strong>This pilot study (CTRI/2021/09/036651) was conducted at a tertiary-care center and included 30 male patients with primary, <2 cm bulbar urethral strictures. A 1 cm × 1 cm buccal mucosal graft was harvested, minced, centrifuged, and suspended in fibrin glue. After a cold knife urethrotomy, a 12-Fr Foley was placed. An 11-Fr cystourethroscope was passed by the side of the catheter, and the suspension was instilled through a 5-Fr ureteric catheter over the urethrotomy site.</p><p><strong>Results: </strong>The success rate of MBGEU was 93.33% at 12 months, 90% at 18 months, 83.3% at 24 months, and 76.6% at 30 months. The stricture recurred in seven patients. The AUA score reduced by 15, 15, 16, 16, 15.5, and 15.5 points from the baseline at 3, 6, 12, 18, 24, and 30 months (P < 0.01). There was a significant increase in the Qmax by 17 ml/s and a significant reduction in the PVR by 73.5 ml at 30 months (P < 0.01). No donor site morbidity was seen. There were no postoperative complications.</p><p><strong>Conclusion: </strong>The medium-term success of MBGEU is encouraging. However, a longer follow-up and further studies with a larger sample size and a comparative arm are required.</p>","PeriodicalId":47352,"journal":{"name":"Indian Journal of Urology","volume":"41 2","pages":"131-136"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021355/pdf/","citationCount":"0","resultStr":"{\"title\":\"Modification of minced buccal mucosal graft endourethral urethroplasty: A pilot study.\",\"authors\":\"Abhay Singh Gaur, Vivek Tarigopula, Swarnendu Mandal, Pavithra Ayyanar, Suvendu Purkait, Kirti Singh, C Sabique, Prasant Nayak\",\"doi\":\"10.4103/iju.iju_519_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The minced buccal mucosal graft endourethral urethroplasty (MBGEU) is our novel technique of combining direct vision internal urethrotomy with buccal mucosal graft urethroplasty. 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引用次数: 0
摘要
简介:口腔黏膜瓣内尿道成形术(MBGEU)是我们将直接视觉内尿道切开术与口腔黏膜瓣内尿道成形术相结合的新技术。我们在30个月的随访中评估成功程度。次要目的是比较美国泌尿协会(AUA)症状评分、峰值血流率(Qmax)和术后空腔残留(PVR)的变化。方法:本研究(CTRI/2021/09/036651)在某三级保健中心进行,纳入30例男性原发性患者。结果:12个月MBGEU成功率为93.33%,18个月为90%,24个月为83.3%,30个月为76.6%。7例患者狭窄复发。3、6、12、18、24、30个月时AUA评分较基线分别降低15、15、16、16、15.5、15.5分(P < 0.01)。30个月时Qmax显著增加17 ml/s, PVR显著降低73.5 ml (P < 0.01)。供体部位未见发病。无术后并发症。结论:MBGEU的中期成功是令人鼓舞的。然而,需要更长时间的随访和更大样本量和比较臂的进一步研究。
Modification of minced buccal mucosal graft endourethral urethroplasty: A pilot study.
Introduction: The minced buccal mucosal graft endourethral urethroplasty (MBGEU) is our novel technique of combining direct vision internal urethrotomy with buccal mucosal graft urethroplasty. We assessed success at 30-months of follow-up. Secondary objectives were to compare the changes in the American Urological Association (AUA) symptom score, peak flow rate (Qmax), and post-void residue (PVR) postoperatively.
Methods: This pilot study (CTRI/2021/09/036651) was conducted at a tertiary-care center and included 30 male patients with primary, <2 cm bulbar urethral strictures. A 1 cm × 1 cm buccal mucosal graft was harvested, minced, centrifuged, and suspended in fibrin glue. After a cold knife urethrotomy, a 12-Fr Foley was placed. An 11-Fr cystourethroscope was passed by the side of the catheter, and the suspension was instilled through a 5-Fr ureteric catheter over the urethrotomy site.
Results: The success rate of MBGEU was 93.33% at 12 months, 90% at 18 months, 83.3% at 24 months, and 76.6% at 30 months. The stricture recurred in seven patients. The AUA score reduced by 15, 15, 16, 16, 15.5, and 15.5 points from the baseline at 3, 6, 12, 18, 24, and 30 months (P < 0.01). There was a significant increase in the Qmax by 17 ml/s and a significant reduction in the PVR by 73.5 ml at 30 months (P < 0.01). No donor site morbidity was seen. There were no postoperative complications.
Conclusion: The medium-term success of MBGEU is encouraging. However, a longer follow-up and further studies with a larger sample size and a comparative arm are required.
期刊介绍:
Indian Journal of Urology-IJU (ISSN 0970-1591) is official publication of the Urological Society of India. The journal is published Quarterly. Bibliographic listings: The journal is indexed with Abstracts on Hygiene and Communicable Diseases, CAB Abstracts, Caspur, DOAJ, EBSCO Publishing’s Electronic Databases, Excerpta Medica / EMBASE, Expanded Academic ASAP, Genamics JournalSeek, Global Health, Google Scholar, Health & Wellness Research Center, Health Reference Center Academic, Hinari, Index Copernicus, IndMed, OpenJGate, PubMed, Pubmed Central, Scimago Journal Ranking, SCOLOAR, SCOPUS, SIIC databases, SNEMB, Tropical Diseases Bulletin, Ulrich’s International Periodical Directory