miRNA在膀胱癌中的研究现状:综述及优势、劣势、机会和威胁分析

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Rachana Tripathy, Lalit Kumar, Sukhad Kural, Anuja Thakur, Sameer Trivedi, Satya Narayan Sankhwar
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引用次数: 0

摘要

MicroRNAs是一种小的非编码RNA分子,在调节基因表达方面至关重要,并在膀胱癌(UBCa)的发生和发展中起着重要作用,这是一种影响全球人群的主要恶性肿瘤。UBCa以其高复发率和显著异质性而闻名。体液(如尿液和血液)中mirna的稳定性是早期发现、监测治疗进展和预测UBCa患者预后的极好的潜在无创标志物。此外,mirna还可以提高免疫治疗的有效性,支持个性化治疗策略的发展。尽管它们具有巨大的潜力,但必须认真解决mirna表达的可变性和其递送系统的缺点等挑战。这种优势、劣势、机会和威胁(SWOT)分析强调了mirna在UBCa中的关键作用,并探讨了它们在推进精准肿瘤学方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The current status of miRNA in urinary bladder cancer: A minireview and strength, weakness, opportunity, and threat analysis.

MicroRNAs, small noncoding RNA molecules, are critical in modulating gene expression and contribute substantially to the initiation and progression of urinary bladder cancer (UBCa), a major malignancy affecting people globally. UBCa is known for its high recurrence rates and significant heterogeneity. The stability of miRNAs in body fluids such as urine and blood are excellent potential noninvasive markers for early detection, monitoring treatment progress, and predicting outcomes of patients with UBCa. In addition, miRNAs could also improve the effectiveness of immunotherapy and support the development of personalized treatment strategies. Despite their significant potential, challenges such as variability in the expression of miRNAs and shortcomings in their delivery systems must be carefully addressed. This strength, weakness, opportunity, and threat (SWOT) analysis highlights the crucial role of miRNAs in UBCa and explores their potential in advancing precision oncology.

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来源期刊
Indian Journal of Urology
Indian Journal of Urology UROLOGY & NEPHROLOGY-
CiteScore
1.90
自引率
0.00%
发文量
62
审稿时长
33 weeks
期刊介绍: Indian Journal of Urology-IJU (ISSN 0970-1591) is official publication of the Urological Society of India. The journal is published Quarterly. Bibliographic listings: The journal is indexed with Abstracts on Hygiene and Communicable Diseases, CAB Abstracts, Caspur, DOAJ, EBSCO Publishing’s Electronic Databases, Excerpta Medica / EMBASE, Expanded Academic ASAP, Genamics JournalSeek, Global Health, Google Scholar, Health & Wellness Research Center, Health Reference Center Academic, Hinari, Index Copernicus, IndMed, OpenJGate, PubMed, Pubmed Central, Scimago Journal Ranking, SCOLOAR, SCOPUS, SIIC databases, SNEMB, Tropical Diseases Bulletin, Ulrich’s International Periodical Directory
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