IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.idcr.2026.e02496

Osamu Okamoto , Kayo Yokoyama , Teruko Suematsu , Kosuke Akishino , Sekinori Munemoto , Yoshitaka Kai

引用次数: 0

Aggressive Pasteurella multocida rhinosinusitis with orbital extension in a patient with liver cirrhosis: A case report and literature review 肝硬化患者侵袭性多杀性巴氏杆菌性鼻窦炎伴眼眶扩张1例报告并文献复习

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-03-12 DOI: 10.1016/j.idcr.2026.e02549

Kohei Kawabata , Daichi Murakami , Mai Miyamoto , Taku Fujishiro , Takuma Okada , Chishin Yohda , Fumiya Kitamura , Ryo Ueda , Muneki Hotomi , Masamitsu Kono

{"title":"Aggressive Pasteurella multocida rhinosinusitis with orbital extension in a patient with liver cirrhosis: A case report and literature review","authors":"Kohei Kawabata , Daichi Murakami , Mai Miyamoto , Taku Fujishiro , Takuma Okada , Chishin Yohda , Fumiya Kitamura , Ryo Ueda , Muneki Hotomi , Masamitsu Kono","doi":"10.1016/j.idcr.2026.e02549","DOIUrl":"10.1016/j.idcr.2026.e02549","url":null,"abstract":"<div><div><em>Pasteurella multocida</em> often causes skin and soft tissue infections associated with animal bites and scratches. However, aggressive respiratory tract infections without animal exposure have been reported in immunocompromised hosts. We report the case of a Japanese woman in her early 80 s with liver cirrhosis that developed acute rhinosinusitis caused by <em>P. multocida</em> without animal-related wounds. She presented with swelling and redness of the left eyelid, and subsequently developed decreased vision and impaired eye movement. Imaging studies revealed an ethmoid sinus abscess with a bony defect of the medial orbital wall and extension into the orbit. Emergency drainage by endoscopic sinus surgery led to complete resolution of the decreased vision and impaired eye movement. A strain of <em>P. multocida</em> was identified from the purulent discharge. To the best of our knowledge, this is the first reported case of aggressive <em>Pasteurella</em> rhinosinusitis with orbital extension. It suggests that <em>P. multocida</em> can cause invasive rhinosinusitis in immunocompromised hosts such as those with liver cirrhosis, and it demonstrates a potential osteolytic effect upon the paranasal bony structure.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02549"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147451679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report 遗传染色体整合型人疱疹病毒6B （iciHHV-6B）患者抗nmda受体脑炎1例报告

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1016/j.idcr.2026.e02526

Annie M. Geiger , William J. House , Armando Paez

{"title":"Anti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report","authors":"Annie M. Geiger , William J. House , Armando Paez","doi":"10.1016/j.idcr.2026.e02526","DOIUrl":"10.1016/j.idcr.2026.e02526","url":null,"abstract":"<div><div>Human herpesvirus 6 (HHV-6) is a ubiquitous DNA virus most frequently associated with roseola infantum and implicated in encephalitis among immunocompromised patients. Notably, it can integrate into human telomeres, contributing to diagnostic complexities. Although herpes simplex virus is a recognized trigger of autoimmune encephalitis, a comparable relationship for HHV-6 remains unconfirmed. We present a case of a previously healthy 19-year-old woman who presented with altered mental status. Lumbar puncture revealed HHV-6 by polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF), and brain magnetic resonance imaging (MRI) findings were normal. Further testing confirmed anti- N-methyl-<span>D</span>-aspartate (NMDA) receptor antibodies in the serum and CSF. HHV-6 serum viral load testing resulted in over 2 million copies/mL, and chromosomal integration of HHV-6 was later confirmed. Four months after diagnosis, the patient’s cognition was approaching their prior baseline. This case underscores the importance of investigating alternative etiologies of encephalitis in immunocompetent patients with detectable HHV-6 DNA in the CSF. Our report further highlights a potential association between HHV-6B and anti-NMDA receptor encephalitis, even under chromosomal integration.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02526"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147451686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-standing, multifocal Tuberculosis verrucosa cutis: Undiagnosed for 40 years 长期多灶性皮肤疣状结核：40年未确诊

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-04-06 DOI: 10.1016/j.idcr.2026.e02568

Seblewengel Maru Wubalem , Helina Melis Kefetew , Saada Yasin Abduselam , Shemsu Abraham Hussien

{"title":"Long-standing, multifocal Tuberculosis verrucosa cutis: Undiagnosed for 40 years","authors":"Seblewengel Maru Wubalem , Helina Melis Kefetew , Saada Yasin Abduselam , Shemsu Abraham Hussien","doi":"10.1016/j.idcr.2026.e02568","DOIUrl":"10.1016/j.idcr.2026.e02568","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) is a chronic infectious disease primarily affecting the lungs, with extrapulmonary TB comprising 20% of cases. Among these, cutaneous TB (CTB) accounts for 1–2%, often overlooked due to its rarity and varied presentations. This report highlights an unusual case of Tuberculosis verrucosa cutis (TVC)</div></div><div><h3>Case presentation</h3><div>A 60-year-old male, presented with non-healing skin lesion that remained undiagnosed for 40 years. The lesion, which involved multiple areas of the body, exhibited large annular plaques with indurated edges and atrophic scars. Diagnosis was made through a detailed clinical history and examination, confirmed by fine-needle aspiration cytology (FNAC), which revealed necrotizing granulomatous inflammation. The patient responded well to anti-TB treatment, showing significant improvement within two months.</div></div><div><h3>Conclusion</h3><div>This case underscores the importance of clinical suspicion in diagnosing CTB, particularly in endemic regions, and suggests that FNAC is a valuable diagnostic tool in resource-limited settings.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02568"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147657517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mpox with painless anogenital and palmar lesions Mpox伴无痛性肛门生殖器和手掌病变

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-04-05 DOI: 10.1016/j.idcr.2026.e02561

Kota Yoshida , Takamasa Ishiuchi , Satoshi Kutsuna

引用次数: 0

Mycobacterium abscessus lumbar osteomyelitis: A rare and challenging case with review of literature 脓肿分枝杆菌腰椎骨髓炎：一个罕见且具有挑战性的病例与文献回顾

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.idcr.2026.e02495

Mohammed S. Zaman , Rootul Kakadia , Abhinav Kakuturu , Moamen Al Zoubi

{"title":"Mycobacterium abscessus lumbar osteomyelitis: A rare and challenging case with review of literature","authors":"Mohammed S. Zaman , Rootul Kakadia , Abhinav Kakuturu , Moamen Al Zoubi","doi":"10.1016/j.idcr.2026.e02495","DOIUrl":"10.1016/j.idcr.2026.e02495","url":null,"abstract":"<div><div>A 65-year-old male presented with a three-month history of back pain, increased urinary frequency and lower extremity edema. MRI spine suggested discitis/osteomyelitis at L3-L4 (Fig. 1), and blood cultures and lumbar biopsy grew gram-positive bacilli. Despite IV antibiotics, the patient continued to experience back pain. Subsequent cultures identified <em>Mycobacterium abscessus</em>. He was initially treated with IV amikacin, IV meropenem, IV tigecycline, and oral linezolid. He also underwent L3-L4 discectomy, fusion, and posterior L2-L5 fusion with drain placement. He was discharged on IV tigecycline, imipenem, amikacin, and oral linezolid, later transitioning to oral omadacycline, azithromycin, and linezolid (Table 1). This case illustrates the challenges of managing <em>Mycobacterium abscessus</em> (MAB) infections, which require a multi-drug approach due to intrinsic and acquired antibiotic resistance. Therapy should begin with in-vitro guided IV antibiotics and transition to oral drugs for the continuation phase, optimizing therapeutic efficacy and overcoming resistance mechanisms.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02495"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Misleading presentation of tuberculosis in a child with CGD revealing invasive aspergillosis: A molecularly confirmed case CGD患儿结核的误导表现显示侵袭性曲霉病：一个分子确诊病例

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-01-21 DOI: 10.1016/j.idcr.2026.e02499

Marjan Aghajani , Nima Parvaneh , Shahram Mahmoudi , Mahmoud Khansari , Fuad Haghighat , Kimia Kamali Sarvestani , Romina Ghazi Mirsaid , Hasti Kamali Sarvestani

{"title":"Misleading presentation of tuberculosis in a child with CGD revealing invasive aspergillosis: A molecularly confirmed case","authors":"Marjan Aghajani , Nima Parvaneh , Shahram Mahmoudi , Mahmoud Khansari , Fuad Haghighat , Kimia Kamali Sarvestani , Romina Ghazi Mirsaid , Hasti Kamali Sarvestani","doi":"10.1016/j.idcr.2026.e02499","DOIUrl":"10.1016/j.idcr.2026.e02499","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Patients with chronic granulomatous disease (CGD) are susceptible to serious infections including, invasive aspergillosis (IA), which remains a major cause of morbidity and mortality. The diagnosis and management are often challenging due to overlapping clinical features and variable treatment responses.</div></div><div><h3>Case report</h3><div>Here we report a 4-year-old girl with CGD who admitted with cellulitis, a chest wall abscess, and fever. She had a history of recurrent pneumonia since infancy and a prior diagnosis of tuberculosis (TB). Despite broad-spectrum antibacterial, her condition did not improve. Direct microscopic and macroscopic investigations revealed fungal infection with <em>Aspergillus</em> species.</div></div><div><h3>Conclusion</h3><div>Molecular identification confirmed the isolates as <em>A</em>. <em>fumigatus.</em> According to the antifungal susceptibility testing, amphotericin B and posaconazole demonstrated strongest activity and the patient was successfully treated by liposomal amphotericin B (50 mg/day) and caspofungin (35 mg/day).</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02499"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subretinal parasitic lesion mimicking viral retinitis managed with combined medical therapy and laser photocoagulation 模拟病毒性视网膜炎的视网膜下寄生病变采用药物治疗和激光光凝治疗

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2026-03-09 DOI: 10.1016/j.idcr.2026.e02543

Thanh Ngoc Tran , Hai Xuan Ho , Thoa Thi Doan , Hong Son Cung

{"title":"Subretinal parasitic lesion mimicking viral retinitis managed with combined medical therapy and laser photocoagulation","authors":"Thanh Ngoc Tran , Hai Xuan Ho , Thoa Thi Doan , Hong Son Cung","doi":"10.1016/j.idcr.2026.e02543","DOIUrl":"10.1016/j.idcr.2026.e02543","url":null,"abstract":"<div><div>Parasitic infections can present with variable manifestations and may mimic viral retinitis, particularly when intraocular inflammation is prominent. We report a case of a 54-year-old woman experiencing worsening blurred vision in her right eye for over a month. She was previously diagnosed with acute retinal necrosis and treated with corticosteroids and acyclovir, but her condition continued to decline. Fundus examination showed dense vitritis and an ill-defined area of retinitis along the superior temporal arcade. Serologic tests were positive for <em>Toxocara</em> IgG and <em>Toxoplasma gondii</em> IgG, while PCR testing of aqueous humor for viral pathogens was negative. Antihelminthic therapy was initiated, resulting in gradual improvement in media clarity and revealing a subretinal parasitic lesion within the area of retinitis. Once confirmed to be extramacular, focal laser photocoagulation was performed. During follow-up, intraocular inflammation subsided, the subretinal parasite fragmented, and best-corrected visual acuity improved to 20/25 and remained stable. This case highlights that parasitic infections should be considered in the differential diagnosis of infectious uveitis that does not respond to initial treatment in regions where parasitic infections are common. Combining focal laser photocoagulation with medical therapy may help control inflammation and preserve vision when a distinct extramacular subretinal parasite is detected.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02543"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147417084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of non-wound tetanus mimicking botulism successfully managed in the ICU 一例罕见的非创伤性破伤风模拟肉毒杆菌中毒在ICU成功处理

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1016/j.idcr.2025.e02476

Erdem Yalcinkaya , Umut Sabri Kasapoğlu , Hasan Basri Yapici , Begum Tamer

{"title":"A rare case of non-wound tetanus mimicking botulism successfully managed in the ICU","authors":"Erdem Yalcinkaya , Umut Sabri Kasapoğlu , Hasan Basri Yapici , Begum Tamer","doi":"10.1016/j.idcr.2025.e02476","DOIUrl":"10.1016/j.idcr.2025.e02476","url":null,"abstract":"<div><h3>Background</h3><div>Tetanus and botulism are neurotoxin-mediated diseases caused by <em>Clostridium species but differ in their clinical manifestations and mechanisms of paralysis.</em></div></div><div><h3>Case</h3><div>A 36-year-old woman presented with presented with rapidly progressive trismus, dysarthria, and facial paresthesia without an identifiable wound. Neuroimaging was normal. She had undergone laser eye surgery two days earlier and consumed home-canned food two weeks before admission. One month prior, her house had been flooded, and she recalled possible minor hand injuries sustained during post-flood cleaning. Given the typical rigidity and absence of focal neurological lesions, tetanus was suspected. Human tetanus immunoglobulin (HTIG, 500 IU intramuscularly) and intravenous metronidazole were administered, leading to complete resolution of symptoms within 24 h.</div></div><div><h3>Conclusion</h3><div>This case illustrates that even minimal or unnoticed injuries can serve as a portal of entry for <em>Clostridium tetani</em>. Non-wound tetanus should be considered in patients presenting with trismus and cranial symptoms, even when no wound is apparent.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02476"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of osteoarticular melioidosis misdiagnosed as extra-pulmonary tuberculosis from low endemicity region in North-western India 印度西北部低流行区一例骨关节类鼻疽误诊为肺外结核

IF 1

IDCases Pub Date : 2026-01-01 Epub Date: 2025-12-21 DOI: 10.1016/j.idcr.2025.e02472

Rushika Saksena , Disha Gautam , Kavita Sisodia , Ashish Jaiman , Vivek Yadav , Dharmendra Kumar Singh , Rohit Kumar

{"title":"A case of osteoarticular melioidosis misdiagnosed as extra-pulmonary tuberculosis from low endemicity region in North-western India","authors":"Rushika Saksena , Disha Gautam , Kavita Sisodia , Ashish Jaiman , Vivek Yadav , Dharmendra Kumar Singh , Rohit Kumar","doi":"10.1016/j.idcr.2025.e02472","DOIUrl":"10.1016/j.idcr.2025.e02472","url":null,"abstract":"<div><div>We report a rare case of melioidosis involving femur and knee in a 62-year old diabetic male patient from low endemic region (Kota, Rajasthan, India). He was previously misdiagnosed as case of extra-pulmonary tuberculosis (EPTB). Patient’s occupation (house building contractor) involving damp and humid soil for construction and non-response to anti-tubercular treatment aroused suspicion of melioidosis. <em>Burkholderia pseudomallei</em> was isolated on culture of pus aspirated from the non-healing osteo-articular lesions and confirmed by real-time PCR targeting T3SS1 gene (Type-3 secretion system 1). Although melioidosis is classified as a tropical disease of wet and humid climate, rare autochthonous cases have also been reported from arid regions in India (Rajasthan, Gujarat and Punjab). We propose that there might be environmental presence of <em>B. pseudomallei</em> in otherwise arid regions, demonstrated in this case where construction sites involving old or new buildings with predominantly moist soil was the likely source of infection. Therefore, a high index of suspicion for melioidosis in non-endemic areas is essential for early detection and treatment of melioidosis.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02472"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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