IDCases最新文献_第10页

Subacute sclerosing panencephalitis in a child six years after measles infection 儿童麻疹感染6年后发生亚急性硬化性全脑炎。

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1016/j.idcr.2026.e02528

Laura Le Feur , Steven Henry , Eric Jeziorski , Julia Dina , Julie Piarroux , Pierre Meyer , Vincent Foulongne

引用次数: 0

Paeniclostridium sordelli toxic shock syndrome after a septic abortion – A case report 败血性流产后索德利小梭菌中毒性休克综合征1例

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IDCases Pub Date : 2026-01-01 Epub Date: 2025-12-26 DOI: 10.1016/j.idcr.2025.e02467

Greeshmasree Kambam , Robbert Crusio

{"title":"Paeniclostridium sordelli toxic shock syndrome after a septic abortion – A case report","authors":"Greeshmasree Kambam , Robbert Crusio","doi":"10.1016/j.idcr.2025.e02467","DOIUrl":"10.1016/j.idcr.2025.e02467","url":null,"abstract":"<div><div><em>Paeniclostridium sordellii</em> is a highly virulent, spore-forming, Gram-positive anaerobe responsible for life-threatening infections, including endocarditis, myositis, and toxic shock syndrome. Although less well known than other clostridial species, it poses a significant risk, particularly to postpartum women, intravenous drug users, and the immunocompromised. In recent times, clostridial sepsis with toxic shock syndrome is more commonly seen in patients who underwent medical abortion and IV drug users, with mortality as high as 70 % within a few days of symptom onset. Here, we present a case of severe toxic shock syndrome caused by <em>P.sordellii</em> in a young woman presenting 6 days after medical abortion, with a leukemoid reaction (max WBC 53,000/µL) and rapidly progressive shock due to Toxic shock syndrome (TSS). Despite initial medical management with broad-spectrum antibiotics and supportive care, she required hysterectomy for definitive source control and 29 days of hospitalization, including ECMO support for refractory shock. The hospital course was further complicated by acute kidney injury, anemia, thrombocytopenia and volume overload. A high degree of suspicion, the prompt initiation of broad-spectrum antibiotics, and timely source control are essential in preventing mortality.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02467"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing concurrent nephrotic syndrome, spontaneous bacterial peritonitis, and herpes zoster in an immunocompromised child: Diagnostic difficulties and treatment outcomes 免疫功能低下儿童并发肾病综合征、自发性细菌性腹膜炎和带状疱疹的治疗：诊断困难和治疗结果

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.idcr.2026.e02489

Riyadi Adrizain , Ismiana Modjaningrat , Winyarti , Fadila Dyah Trie Utami , Wilson Surya Lesmana , Vita Indriasari , Dedi Rachmadi Sjambas

{"title":"Managing concurrent nephrotic syndrome, spontaneous bacterial peritonitis, and herpes zoster in an immunocompromised child: Diagnostic difficulties and treatment outcomes","authors":"Riyadi Adrizain , Ismiana Modjaningrat , Winyarti , Fadila Dyah Trie Utami , Wilson Surya Lesmana , Vita Indriasari , Dedi Rachmadi Sjambas","doi":"10.1016/j.idcr.2026.e02489","DOIUrl":"10.1016/j.idcr.2026.e02489","url":null,"abstract":"<div><div>Nephrotic syndrome (NS) is a disease characterized by heavy protein loss in the urine due to increased permeability of the glomerular membrane, leading to low levels of albumin in the blood. Several studies have shown that primary or secondary kidney disease, congenital infections, diabetes, lupus, cancer, or the use of certain medications can cause it. Therefore, this study aims to present a case of NS in a 9-year-old boy complicated by spontaneous bacterial peritonitis and herpes zoster. The patient presented to the emergency department with a 2-day history of worsening abdominal pain accompanied by fever, nausea, vomiting, and facial oedema. Assessment showed a previous diagnosis of NS at the age of 7, but the condition remained poorly controlled due to irregular medication compliance. As the condition worsened, lavage drainage was performed, and the patient was later diagnosed with septic shock. Antibiotics therapies were administered to address the underlying infection. During hospitalization, the patient developed skin lesions that appeared to be herpes zoster, which was related to an immunocompromised condition. The patient was discharged after clinical improvement, and treatment was continued through outpatient monitoring. This current study emphasized the importance of early and aggressive intervention, particularly in immunocompromised pediatric patients with double burdens, to achieve better clinical outcomes.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02489"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The wandering hydatid cyst with arterial embolization: Diagnostic pitfalls and management strategies in resource-limited healthcare – A case report 游离包虫囊肿动脉栓塞：诊断陷阱和管理策略在资源有限的医疗保健- 1例报告

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IDCases Pub Date : 2026-01-01 Epub Date: 2025-12-21 DOI: 10.1016/j.idcr.2025.e02465

Yegzeru Belete , Abdulkerim Girma , Amanuel Anegagregn , Biruh Alemu Ashine , Ermiyas Sintayehu

引用次数: 0

Pneumocystis jirovecii pneumonia in a human caused by long-term use of veterinary drug oclacitinib: A case report 长期使用兽药奥拉西替尼致人乙基肺囊虫肺炎1例

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IDCases Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.idcr.2025.e02459

Keisuke Oshima , Ryo Koyama , Takashi Akimoto , Toshihiko Nishioki , Tomohito Takeshige , Junko Watanabe , Daisuke Usuda , Kazuhisa Takahashi

{"title":"Pneumocystis jirovecii pneumonia in a human caused by long-term use of veterinary drug oclacitinib: A case report","authors":"Keisuke Oshima , Ryo Koyama , Takashi Akimoto , Toshihiko Nishioki , Tomohito Takeshige , Junko Watanabe , Daisuke Usuda , Kazuhisa Takahashi","doi":"10.1016/j.idcr.2025.e02459","DOIUrl":"10.1016/j.idcr.2025.e02459","url":null,"abstract":"<div><div><em>Pneumocystis jirovecii</em> pneumonia (PJP), an opportunistic fungal infection, typically occurs in immunocompromised patients, such as those with human immunodeficiency virus (HIV) infection or those receiving prolonged immunosuppressive therapy. Recently, PJP in non-HIV patients treated with novel immunomodulatory agents, including Janus kinase (JAK) inhibitors, has been increasingly reported. Here, we report a case of PJP in a 53-year-old HIV-negative Japanese man with no recognized immunosuppressive comorbidities. The patient, a veterinarian, had been self-administering oclacitinib (16–64 mg/day), a selective JAK1 inhibitor approved for the treatment of atopic dermatitis in dogs, daily for approximately 2 years to manage atopic dermatitis. He presented with progressive exertional dyspnea and fever. Chest computed tomography revealed bilateral ground-glass opacities with patchy consolidations. The diagnosis of PJP was confirmed by polymerase chain reaction of bronchoalveolar lavage fluid and Grocott’s methenamine silver staining of transbronchial lung biopsy specimens. He was initially treated with trimethoprim-sulfamethoxazole and corticosteroids; however, the regimen was switched to atovaquone owing to hepatotoxicity. The patient recovered fully and remained recurrence-free at 1-year follow-up. No other causes of immunosuppression were identified, and oclacitinib use was considered the likely precipitating factor. To our knowledge, this is the first reported case of PJP associated with oclacitinib use in humans. As JAK inhibitors are increasingly being used, clinicians should be aware of their potential to cause opportunistic infections, even with veterinary formulations without approved human indications.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02459"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical genital mpox mimicking a sexually transmitted infection with secondary Staphylococcus aureus infection: A case report 模拟性传播感染伴继发性金黄色葡萄球菌感染的非典型生殖器痘一例报告

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.1016/j.idcr.2026.e02503

Douglas Jaxon Vadner , Monica Bailey , Sidney Smith

{"title":"Atypical genital mpox mimicking a sexually transmitted infection with secondary Staphylococcus aureus infection: A case report","authors":"Douglas Jaxon Vadner , Monica Bailey , Sidney Smith","doi":"10.1016/j.idcr.2026.e02503","DOIUrl":"10.1016/j.idcr.2026.e02503","url":null,"abstract":"<div><h3>Introduction</h3><div>Mpox is an Orthopoxvirus infection with evolving clinical presentations, including genital-dominant disease that can resemble common sexually transmitted infections (STIs). Secondary bacterial superinfection is uncommon but may alter lesion morphology and delay diagnosis.</div></div><div><h3>Case Presentation</h3><div>A 64-year-old unhoused heterosexual male presented with a two-week history of painful, malodorous groin ulcers after unprotected intercourse. Lesions began as groin-confined vesicles and later spread to the face and peri-auricular area. Because of ulceration, purulence, and sexual exposure, initial evaluation focused on more common sexually transmitted infections, all of which tested negative. Dermatology was consulted when the eruption showed umbilicated vesiculopustules at uniform developmental stages. Punch biopsies demonstrated neutrophilic pustules consistent with Orthopoxvirus infection, and PCR confirmed mpox. During hospitalization, several lesions became purulent with foul odor; culture grew methicillin-sensitive <em>Staphylococcus aureus</em>. Linezolid therapy produced rapid improvement.</div></div><div><h3>Discussion</h3><div>This case demonstrates genital-dominant mpox in a heterosexual male, a less commonly reported demographic, and highlights how lesion morphology may mimic bacterial or viral STIs. Bacterial superinfection can obscure classic diagnostic features, contribute to malodor and purulence, and delay recognition. PCR remains essential for confirmation, particularly when presentation overlaps with other genital ulcer etiologies.</div></div><div><h3>Conclusion</h3><div>Clinicians should include mpox in the differential diagnosis of genital ulcer disease regardless of sexual orientation and maintain vigilance for bacterial superinfection in non-healing or purulent lesions. Early PCR testing and culture-directed therapy are essential for accurate diagnosis and optimal management.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02503"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nodular and abscessed pinna in lepromatous leprosy with Type 2 lepra reaction 2型麻风反应的麻风性耳廓结节和脓肿

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-01-28 DOI: 10.1016/j.idcr.2026.e02506

Naga Nitya Vangala , Manisha Gedam , Adarshlata Singh , Bhushan Madke , Varun H

{"title":"Nodular and abscessed pinna in lepromatous leprosy with Type 2 lepra reaction","authors":"Naga Nitya Vangala , Manisha Gedam , Adarshlata Singh , Bhushan Madke , Varun H","doi":"10.1016/j.idcr.2026.e02506","DOIUrl":"10.1016/j.idcr.2026.e02506","url":null,"abstract":"<div><div>Leprosy is a chronic granulomatous infection caused by <em>Mycobacterium leprae</em>, with a predilection for cooler areas of the body such as the external ear. We report a man in his late thirties with lepromatous leprosy, presenting with an eight-month history of facial and auricular nodules that progressed to erythema, ulceration, and sensory impairment. The clinical examination revealed infiltrated, nodular pinnae, a cheek ulcer, and bilateral ulnar neuritis. Slit-skin smear revealed abundant acid-fast bacilli (BI 6 +), and histopathology confirmed the multibacillary spectrum. The acute erythema, painful tender nodules, and neuritis were consistent with a Type 2 lepra reaction (erythema nodosum leprosum, ENL). The patient was treated with the WHO-recommended multidrug therapy for multibacillary leprosy (MB-MDT) and oral corticosteroids, showing progressive clinical improvement. This case underscores that external ear involvement, though a recognized feature of multibacillary leprosy, may be easily overlooked, particularly when complicated by lepra reactions. Timely recognition and prompt management of lepra reactions are essential to prevent irreversible neuropathy and disfigurement.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02506"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudomonas aeruginosa meningitis complicated by cerebral vasculitis and ecthyma gangrenosum in a child: A case report and literature review 铜绿假单胞菌性脑膜炎并发脑血管炎和坏疽性湿疹1例报告并文献复习

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-03-23 DOI: 10.1016/j.idcr.2026.e02553

Zohreh Shalchi, Nasibeh Ghalandari

引用次数: 0

Treatment limited neurocysticercosis in an incarcerated 24-year-old male: A case illustration 治疗局限性神经囊虫病在监禁24岁男性：一个案例说明

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-05-07 DOI: 10.1016/j.idcr.2026.e02599

Katia Castillo , Jacob Morgan , Praveen Budde

{"title":"Treatment limited neurocysticercosis in an incarcerated 24-year-old male: A case illustration","authors":"Katia Castillo , Jacob Morgan , Praveen Budde","doi":"10.1016/j.idcr.2026.e02599","DOIUrl":"10.1016/j.idcr.2026.e02599","url":null,"abstract":"<div><div>Neurocysticercosis (NCC) is a parasitic infection of the central nervous system caused by the larval stage of <em>Taenia solium</em>. Individuals migrating from or traveling to endemic regions may acquire the infection through ingestion of undercooked pork or consumption of water contaminated with <em>T. solium</em> eggs. Although relatively uncommon in the United States, clinical suspicion should be heightened in patients with relevant epidemiologic exposure who present with seizures, signs of increased intracranial pressure, recurrent headaches, or decreased visual acuity with papilledema. Diagnosis is established through neuroimaging, including computed tomography (CT) and magnetic resonance imaging (MRI), often supplemented by serologic testing. Management requires a multidisciplinary approach, incorporating ophthalmologic evaluation to rule out intraocular cysts prior to initiating antiparasitic therapy, along with adjunctive corticosteroids and antiseizure medication. We present the case of a 24-year-old incarcerated male who experienced a generalized tonic-clonic seizure. MRI revealed multiple ring-enhancing cystic lesions with surrounding vasogenic edema, leading to a diagnosis of NCC. Treatment was delayed due to unavailability of in-house ophthalmology capable of performing a fundoscopic examination. Given the patient’s status as a ward of the state, coordination with the detaining law enforcement agency was required to facilitate ophthalmologic assessment and ensure continuity of care. Additionally, medical interpretation services were utilized to provide bilingual discharge instruction emphasizing the need for follow-up ophthalmologic evaluation, antiparasitic and corticosteroid therapy, and repeat brain MRI in six months to assess lesion resolution.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02599"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoracoscopic crush biopsy unmasking drug resistant extrapulmonary tuberculosis 胸腔镜挤压活检揭露耐药肺外结核

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IDCases Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.1016/j.idcr.2026.e02607

Poonam Patil , Babaji Ghewade , Ulhas Jadhav , Amit Toshniwal , Amisha Soni

{"title":"Thoracoscopic crush biopsy unmasking drug resistant extrapulmonary tuberculosis","authors":"Poonam Patil , Babaji Ghewade , Ulhas Jadhav , Amit Toshniwal , Amisha Soni","doi":"10.1016/j.idcr.2026.e02607","DOIUrl":"10.1016/j.idcr.2026.e02607","url":null,"abstract":"<div><div>Tuberculosis remains a major global health concern with extrapulmonary manifestations contributing to approximately 15–20% of cases in immune-competent hosts. In 2022, National Tuberculosis Elimination Program (NTEP) reported multidrug resistance in 2.5% of new tuberculosis cases and 13% in previously treated cases. Among extrapulmonary tuberculosis pleural tuberculosis is one of the most common forms. It becomes a diagnostic challenge when microbiological tests are inconclusive. In most developing countries, antitubercular drugs are initiated empirically in patients on the basis of clinical decision. In today’s day and age, physicians emphasize more on evidence-based medicine practice. We report a case of a young man who presented with exudative pleural effusion unresponsive to empirical antibiotics. Thoracoscopic pleural crush biopsy showed granulomatous inflammation with caseating necrosis and acid-fast bacilli, confirming tuberculous pleuritis that was multidrug resistant. This case illustrates the role of medical thoracoscopy in patients where suspicions for tuberculosis are raised without clear answers from the initial tests. Relying only on standard antitubercular treatment may delay the detection of underlying drug resistance that is a growing public health challenge. Early tissue diagnosis through thoracoscopy allowed timely identification of multidrug resistance and directed proper management.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02607"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0