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Invasive pneumococcal serotype 3 infection following pneumococcal vaccination in a hematopoietic stem cell transplant patient: A case report 造血干细胞移植患者接种肺炎球菌疫苗后感染侵袭性肺炎球菌血清 3 型:病例报告
IF 1.5
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01936
Kazuhiro Ishikawa, Nobuyoshi Mori
{"title":"Invasive pneumococcal serotype 3 infection following pneumococcal vaccination in a hematopoietic stem cell transplant patient: A case report","authors":"Kazuhiro Ishikawa,&nbsp;Nobuyoshi Mori","doi":"10.1016/j.idcr.2024.e01936","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01936","url":null,"abstract":"<div><p>Given the high mortality rate of invasive pneumococcal disease (IPD) in hematopoietic stem cell transplant (HSCT) recipients, vaccination is recommended. These recipients respond to most vaccines; however, their immune response is typically weaker during the first months or years after transplantation, compared with that of healthy individuals. Here, we report a case of IPD with serotype 3 pneumonia and empyema in an HSCT recipient who had received three doses of the 13-valent pneumococcal conjugate vaccine (PCV) and one dose of the 23-valent pneumococcal polysaccharide vaccine; furthermore, the recipient had no relapse, graft-versus-host disease, or use of immunosuppressive agents after allogeneic HSCT for acute myeloid leukemia. Moreover, we discussed the characteristics of serotype 3 <em>Streptococcus pneumoniae</em>, a case series of breakthrough infections with <em>S. pneumoniae</em> in HSCT recipients who received pneumococcal vaccines, and the potential implications for the upcoming PCV15 and PCV20 vaccines for serotype 3.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01936"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221425092400012X/pdfft?md5=ab24d60201e4aea11dadac120dbe38fc&pid=1-s2.0-S221425092400012X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A non-surgical approach: Ampicillin's success in Listeria monocytogenes endocarditis 非手术疗法:氨苄西林成功治疗单核细胞增多性李斯特菌心内膜炎
IF 1.5
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01965
Natalia Ramos-Ospina , Pablo Andrés Moncada-Vallejo
{"title":"A non-surgical approach: Ampicillin's success in Listeria monocytogenes endocarditis","authors":"Natalia Ramos-Ospina ,&nbsp;Pablo Andrés Moncada-Vallejo","doi":"10.1016/j.idcr.2024.e01965","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01965","url":null,"abstract":"<div><h3>Background</h3><p><em>Listeria monocytogenes</em>, a Gram-positive bacillus, primarily affects immunocompromised individuals. Endocarditis is a rare but severe complication of <em>L. monocytogenes</em> bacteremia, irrespective of native or prosthetic valves. While there is no standardized treatment, the use of ampicillin proves effective in most cases. Surgical intervention is reserved for cases involving valve dehiscence, heart failure, or myocardial abscess.</p></div><div><h3>Case presentation</h3><p>A 54-year-old female, with mitral valve replacement, presented with fever, chest pain and dyspnea at rest. Patient was initially diagnosed with bacterial pneumonia; however, subsequent evaluation revealed <em>L. monocytogenes</em> bacteremia, resulting in endocarditis. Surgical management was contraindicated due to multiple prior valve replacement surgeries. Symptoms resolution, along with improvements in echocardiographic and clinical parameters, was achieved through extended antibiotic treatment only with no surgical intervention.</p></div><div><h3>Conclusion - key takeaways</h3><p>This case underscores the critical importance of individualized treatment approaches in endocarditis, particularly in patients with surgery approach contraindication, and emphasized the success achieved through ampicillin-based management.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01965"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000416/pdfft?md5=a1ada8d1b2477d8f27fba33604e6140a&pid=1-s2.0-S2214250924000416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of prosthetic valve endocarditis and aortic abscess due to Bacillus cereus 一例由蜡样芽孢杆菌引起的人工瓣膜心内膜炎和主动脉脓肿病例
IF 1.5
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01940
Akina Fukushima , Takaaki Kobayashi , Yoshihito Otsuka , Naoto Hosokawa , Sandra Moody , Miyu Takagi , Akihito Yoshida
{"title":"A case of prosthetic valve endocarditis and aortic abscess due to Bacillus cereus","authors":"Akina Fukushima ,&nbsp;Takaaki Kobayashi ,&nbsp;Yoshihito Otsuka ,&nbsp;Naoto Hosokawa ,&nbsp;Sandra Moody ,&nbsp;Miyu Takagi ,&nbsp;Akihito Yoshida","doi":"10.1016/j.idcr.2024.e01940","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01940","url":null,"abstract":"<div><p><em>Bacillus cereus (B. cereus)</em> is commonly found in the environment and is often considered a blood culture contaminant. However, in patients with specific risk factors such as intravenous drug use, central venous access catheters, immunosuppression, or prosthetic valves, <em>B. cereus</em> can cause severe infections. Herein, we present a case of prosthetic valve endocarditis (PVE) caused by <em>B. cereus</em> in an 84-year-old woman with a history of aortic valve replacement for aortic stenosis five years earlier. She presented with anorexia, and her physical examination revealed tenderness in the left upper quadrant of the abdomen. Blood culture grew <em>B. cereus</em>, and a CT scan showed splenic infarction, raising suspicion of PVE. Transesophageal echocardiogram (TEE) revealed an abscess around the left coronary cusp of the aortic valve and a 15 mm vegetation. Due to the patient's high risk for post-operative complications and her unwillingness to undergo surgery, the surgery was deferred. Instead, she was successfully treated with six weeks of intravenous vancomycin and discharged home. Follow-up TEE demonstrated resolution of the vegetation and valvular abscess. At her six-month post-discharge evaluation, no signs of active infection were noted including fever or worsening heart failure. Although surgery is typically recommended for most cases of PVE, conservative treatment can be considered as an alternative option for selected patients.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01940"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000167/pdfft?md5=d27fb3f86b378affa50836a8b4c04969&pid=1-s2.0-S2214250924000167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infective endocarditis caused by Lactococcus garvieae: A case report and review of the literature 加维氏乳球菌引起的感染性心内膜炎:病例报告和文献综述
IF 1.5
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01941
Izumi Kitagawa , Noriyoshi Ishikawa , Ryohei Ono
{"title":"Infective endocarditis caused by Lactococcus garvieae: A case report and review of the literature","authors":"Izumi Kitagawa ,&nbsp;Noriyoshi Ishikawa ,&nbsp;Ryohei Ono","doi":"10.1016/j.idcr.2024.e01941","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01941","url":null,"abstract":"<div><p><em>Lactococcus garvieae</em> is a Gram-positive coccus that can be easily misidentified as <em>Enterococcus</em> spp. or streptococci. Infection with <em>L. garvieae</em> is associated with the consumption of raw fish and unpasteurized dairy products. Although rare, it can cause infective endocarditis (IE). Herein, we report a case in which aortic valve replacement (AVR) was required for IE caused by <em>L. garvieae</em>.</p><p>A 79-year-old Japanese man with a history of hypertension, myocardial infarction, gastroesophageal reflux disease (GERD), and abdominal aortic aneurysm presented with loss of appetite, myalgia, and difficulty in moving. Physical examination revealed a diastolic murmur, an Osler’s node on the right first toe, dental caries, and a palpable spleen, suggesting IE. Transthoracic echocardiography revealed a large, mobile vegetation on the aortic valve, which was associated with severe aortic regurgitation. Blood cultures revealed <em>L. garvieae</em>. The patient received antibiotic therapy, underwent AVR, and recovered without major complications. To date, 30 cases of <em>L. garvieae</em>-associated IE have been reported. We reviewed and summarized all cases of <em>L. garvieae</em>-associated IE including our case<em>.</em></p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01941"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000179/pdfft?md5=e7716c6a3820146aea1688366031af33&pid=1-s2.0-S2214250924000179-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare skin reaction in an elderly woman after exposure to prophylaxis for rabies: A case report 一名老年妇女在接触狂犬病预防药后出现罕见皮肤反应:病例报告
IF 1.5
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01974
Luiz Euribel Prestes-Carneiro , Paola Andressa Xavier Mente , Luana Dalla Costa , Ana Paula Lagisck , Eder Gatti Fernandes
{"title":"A rare skin reaction in an elderly woman after exposure to prophylaxis for rabies: A case report","authors":"Luiz Euribel Prestes-Carneiro ,&nbsp;Paola Andressa Xavier Mente ,&nbsp;Luana Dalla Costa ,&nbsp;Ana Paula Lagisck ,&nbsp;Eder Gatti Fernandes","doi":"10.1016/j.idcr.2024.e01974","DOIUrl":"10.1016/j.idcr.2024.e01974","url":null,"abstract":"<div><h3>Introduction</h3><p>Rabies is a zoonosis caused by viruses of the family Rhabdoviridae. Prophylaxis with the rabies vaccine and immunoglobulins, depending on the severity of the case, is recommended. After vaccination, mild, moderate, or severe adverse events (AE) are described. Although rare, severe skin reactions may occur, increasing the risk of anaphylaxis.</p></div><div><h3>Case report</h3><p>An 84-year-old woman was attacked by a stray unknown cat, leaving her with bites and scratches in the neck region and multiple injuries. The case was classified as severe. About 3 h after the first dose of the rabies vaccine, disseminated purplish spots appeared on her lower limbs, worsening significantly after the second dose, requiring hospitalization for the application of the third dose under observation, dermatology evaluation, and collection of skin tissue for biopsy. She was discharged 24 h after the third vaccination, and the purple spots cleared gradually. The biopsy suggested an adverse reaction to the vaccine components. Immunohistochemistry of the rabies virus antigen in dermal nerve fillets was negative. The seroconversion post rabies vaccine showed IgG antibody values below the reference levels.</p></div><div><h3>Conclusion</h3><p>Vaccination against rabies is extremely important; however, AEs may occur. Our patient developed an important AE and required hospitalization. After complete vaccination, the serum was not converted. A similar case was not previously described, and the case report is important for the creation of jurisprudence on rabies vaccination in elderly patients in Brazil.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01974"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000507/pdfft?md5=5c3cc0e889daefcb0c22f40ea379e733&pid=1-s2.0-S2214250924000507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two cases of misleading Epstein-Barr virus infection and the role of EBV-DNA 两例误导性 Epstein-Barr 病毒感染和 EBV DNA 的作用。
IF 1.5
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e02001
Luca Pipitò , Alessandra Murabito , Antonio Cascio
{"title":"Two cases of misleading Epstein-Barr virus infection and the role of EBV-DNA","authors":"Luca Pipitò ,&nbsp;Alessandra Murabito ,&nbsp;Antonio Cascio","doi":"10.1016/j.idcr.2024.e02001","DOIUrl":"10.1016/j.idcr.2024.e02001","url":null,"abstract":"<div><p>Two atypical cases of infectious mononucleosis in two teenagers with initially negative serology and non-evocative blood examinations are reported. The first patient had recently traveled to Africa, and Epstein-Barr virus negative serology led us to make many extensive investigations. The second patient complained of asthenia for a month, and PET/CT was performed to suspicion of lymphoma. PET scan revealed hypermetabolic lymph nodes in the supradiaphragmatic and subdiaphragmatic stations, along with<sup>18</sup>F-FDG uptake in the spleen and pharynx, raising more suspicion of lymphoma. Fortunately, Epstein-Barr virus DNA testing was performed and turned positive in both cases, and Epstein-Barr virus serology subsequently became positive. Diagnosing EBV infection can be challenging in rare cases, as EBV-specific serology may be negative in the early stages and confounding factors may be present. Therefore, Epstein-Barr virus DNA testing should be considered early in the diagnostic algorithm to prevent unnecessary investigations in similar cases.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e02001"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000775/pdfft?md5=a1b40af350f5e5ffcd7cfab3c7fd14c8&pid=1-s2.0-S2214250924000775-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated cysticercosis and neurocysticercosis with classic starry-sky appearance in an adolescent vegetarian Indian male 一名吃素的印度男性青少年身上伴有典型星空外观的散发性囊尾蚴病和神经囊尾蚴病
IF 1.1
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e02079
Himanshu Jindal , Priyanka Gupta , Hardika Arora , P. Purushothaman
{"title":"Disseminated cysticercosis and neurocysticercosis with classic starry-sky appearance in an adolescent vegetarian Indian male","authors":"Himanshu Jindal ,&nbsp;Priyanka Gupta ,&nbsp;Hardika Arora ,&nbsp;P. Purushothaman","doi":"10.1016/j.idcr.2024.e02079","DOIUrl":"10.1016/j.idcr.2024.e02079","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"38 ","pages":"Article e02079"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001550/pdfft?md5=04be2fba2ad202b3cfdee83702d6feab&pid=1-s2.0-S2214250924001550-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shoulder shake-up: Unveiling the unusual case of acute melioidosis 肩部震动揭开急性瓜虫病不寻常病例的面纱
IF 1.1
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e02040
Yash Khatod , Neetha Thayil Ramankutty , Deepak Kumar , Vibhor Tak , Neha Gupta , Rengarajan Rajagopal , Suvinay Saxena
{"title":"Shoulder shake-up: Unveiling the unusual case of acute melioidosis","authors":"Yash Khatod ,&nbsp;Neetha Thayil Ramankutty ,&nbsp;Deepak Kumar ,&nbsp;Vibhor Tak ,&nbsp;Neha Gupta ,&nbsp;Rengarajan Rajagopal ,&nbsp;Suvinay Saxena","doi":"10.1016/j.idcr.2024.e02040","DOIUrl":"10.1016/j.idcr.2024.e02040","url":null,"abstract":"<div><h3>Background</h3><p>Melioidosis is one of the emerging infections in India and is often neglected due to lack of awareness among clinicians. The diseases usually present as multifocal or focal abscesses with bacteremia, yet the isolated septic monoarthritic complicated with septic venous thrombosis is a rare presentation.</p></div><div><h3>Case</h3><p>This case report describes a 48-year-old male business executive with diabetes and alcoholism who developed septic arthritis caused by <em>Burkholderia pseudomallei</em> and no clear history of exposure to the organism. The patient initially experienced fever, chills, fatigue, reduced urine output, and signs of early sepsis. Despite initial improvement with fluid therapy and antibiotics, the patient's fever persisted. Meticulous clinical examination revealed signs of inflammation and movement restriction in the left shoulder which letter on became obvious and the main complaints of patient. Blood cultures confirmed the presence of <em>B. pseudomallei</em>. Imaging showed septic arthritis, osteomyelitis, lymphadenitis, and venous thrombosis in the left shoulder. Surgical debridement was performed, and the tissue cultures showed the growth of the same pathogen. This led to significant clinical improvement and with prolonged course of antibiotics, complete resolution of symptoms and normal joint function was achieved.</p></div><div><h3>Conclusion</h3><p>This case report serves to highlight the rare and atypical presentation of Melioidosis and the importance of suspecting this infection in nonendemic regions underscoring the probable impact of climate change. Early diagnosis, effective source control measures and prolonged antibiotic therapy, emerges as pivotal factors contributing to favorable outcomes in such cases.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02040"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001161/pdfft?md5=32f3abb30b06f2e81582c6b97dafbb62&pid=1-s2.0-S2214250924001161-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver’s hidden foe: A case study on Human Fasciolasis 肝脏的隐形敌人:人类法氏囊病案例研究
IF 1.1
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e02045
Abdulkerim Girma , Yegzeru Belete , Solomon Afework , Teshale Bisrat
{"title":"The Liver’s hidden foe: A case study on Human Fasciolasis","authors":"Abdulkerim Girma ,&nbsp;Yegzeru Belete ,&nbsp;Solomon Afework ,&nbsp;Teshale Bisrat","doi":"10.1016/j.idcr.2024.e02045","DOIUrl":"10.1016/j.idcr.2024.e02045","url":null,"abstract":"<div><p>Human fascioliasis, caused by Fasciola hepatica and Fasciolagigantica, is a neglected tropical disease of increasing public health significance. Reported cases are rare, with only one serologically confirmed instance in Ethiopia to date. We present the case of a male patient in his late twenties, without identified risk factors, who presented with bilateral upper quadrant pain persisting for a year and a history of repeated treatment for H. pylori gastritis. Initial ultrasound findings prompted further investigation with abdominal CT, contrast-enhanced MRI, and MRCP, leading to a diagnostic shift confirmed by a positive enzyme-linked assay for Fasciola hepatica. This case highlights the diagnostic challenges and the critical role of radiological imaging—ultrasound, CT, and MRIin identifying key features such as biliary dilation and parenchymal abnormalities, crucial for early detection and effective management of human fascioliasis.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02045"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001215/pdfft?md5=210a819a6d11a7f08cb631018985276f&pid=1-s2.0-S2214250924001215-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated Lomentospora prolificans infection that could have been predicted: A case report 本可预知的扩散性洛门托孢子菌感染:病例报告
IF 1.1
IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e02046
Koga Sato , Toshimasa Hayashi , Takuma Ishizaki , Masakazu Yoshida , Akira Watanabe
{"title":"Disseminated Lomentospora prolificans infection that could have been predicted: A case report","authors":"Koga Sato ,&nbsp;Toshimasa Hayashi ,&nbsp;Takuma Ishizaki ,&nbsp;Masakazu Yoshida ,&nbsp;Akira Watanabe","doi":"10.1016/j.idcr.2024.e02046","DOIUrl":"10.1016/j.idcr.2024.e02046","url":null,"abstract":"<div><p><em>Lomentospora prolificans</em> is a rare, filamentous fungus, that causes a disseminated infection in immunocompromised individuals. Disseminated infections caused by the fungus are difficult to diagnose early. It is resistant to multiple antifungal agents and has a high mortality rate. We encountered a case in which the involvement of this fungus was indicated by a history of antifungal prophylaxis and an elevated serum 1,3-beta-D-glucan (BDG) level. A 76-year-old female with myelodysplastic syndrome that developed into overt leukemia was administered oral posaconazole as antifungal prophylaxis. She was admitted to the hospital to determine the cause of her fever, where no new abnormalities other than an elevated serum BDG level were observed. Unfortunately, the patient died due to acute respiratory failure on the same day of admission. The day after her death, <em>L. prolificans</em> was detected in a blood culture taken upon her admission. <em>L. prolificans</em> should be suspected based on the history of antifungal prophylaxis and an elevated serum BDG level, as these are risk factors for infection by this pathogen. Blood cultures are useful to provide a diagnosis. If treated early, before it is detected in culture, the mortality rate can be decreased.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02046"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001227/pdfft?md5=63ee9cad073c641d3c7e4697a1031968&pid=1-s2.0-S2214250924001227-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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