IDCases最新文献

{"title":"Long-term oritavancin therapy for shoulder prosthetic joint infection: A case guided by therapeutic drug monitoring (TDM)","authors":"A.R. Buonomo ,&nbsp;L. Cattaneo ,&nbsp;G. Viceconte ,&nbsp;F. Calabria ,&nbsp;G. Di Troia ,&nbsp;A. Di Fusco ,&nbsp;J. Mula ,&nbsp;A. Cozzolino ,&nbsp;L. Ametrano ,&nbsp;A. D’Avolio ,&nbsp;I. Gentile","doi":"10.1016/j.idcr.2024.e02105","DOIUrl":"10.1016/j.idcr.2024.e02105","url":null,"abstract":"<div><div>Oritavancin is a novel long-acting lipoglycopeptide with in vitro activity against methicillin-resistant (MR) Gram-positive pathogens and a good bactericidal activity even in presence of biofilm forming bacteria. It has been approved for acute bacterial skin and skin structure infections (ABSSSI), but recent reports have demonstrated possible off-label uses, as for prosthetic joint infections (PJI), which, in more than half of cases, are caused by MR Gram positive organisms.</div><div>W<strong>e</strong> reported a case of a man in his eighties with a late shoulder PJI caused by methicillin resistant <em>Staphyloccus epidermidis</em> (MRSE) with contraindications for surgical replacement and few oral therapeutic options for a long term suppressive antibiotic therapy. The prosthesis was retained, and the patient received ten outpatient sequential doses of 1200 mg of oritavancin for 28 weeks, based on therapeutic drug monitoring (TDM) as a guide for correct timing of administration of each dose. During oritavancin administration, the patient achieved clinical cure, with disappearance of the pain and regaining pre-infection joint mobility, with no side effects reported and no further surgery or hospitalization needed. The treatment is ongoing as a long-lasting suppressive antimicrobial therapy. Oritavancin could represent an excellent solution for treating PJI caused by MR organism, especially in patients who need a long-term suppressive therapy.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"38 ","pages":"Article e02105"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Klebsiella pneumoniae liver abscess and infective endocarditis: A rare case report and literature review","authors":"Yuanwen Chen ,&nbsp;Yisheng Zhou ,&nbsp;Zhibin Xu","doi":"10.1016/j.idcr.2024.e02117","DOIUrl":"10.1016/j.idcr.2024.e02117","url":null,"abstract":"<div><h3>Background</h3><div>Investigating the clinical characteristics and treatment strategies of pyogenic liver abscess (PLA) complicated by infective endocarditis (IE), this study draws on a successfully treated case of PLA caused by Klebsiella pneumoniae, alongside a literature review of similar cases.</div></div><div><h3>Case Summary</h3><div>We report a 50-year-old male with type 2 diabetes who presented with acute fever, chills, and a liver abscess. The patient was initially treated with intravenous ceftriaxone (2 g daily). Due to the onset of septic shock, the antibiotic regimen was escalated to piperacillin-tazobactam (4.5 g every 8 h) and levofloxacin (0.5 g daily). Ultrasound-guided percutaneous drainage of the liver abscess was performed, and blood cultures confirmed <em>Klebsiella pneumoniae</em>. Upon the development of infective endocarditis, the treatment was adjusted to a combination of ceftriaxone and amikacin for one week, followed by six weeks of ceftriaxone monotherapy, resulting in full recovery.</div></div><div><h3>Conclusion</h3><div>This case report illustrates the rare association of Klebsiella pneumoniae-induced PLA with IE in a diabetic patient. It emphasizes the importance of individualized treatment strategies, with insights drawn from this case contributing to the understanding of managing such complex infections. While the successful outcome of this case provides valuable clinical insights, it highlights the need for careful consideration in treatment approaches. The findings from this single case should guide clinicians in similar scenarios but should not be generalized without further evidence.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"38 ","pages":"Article e02117"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Even a single positive blood culture may matter – A case of prosthetic valve infective endocarditis caused by Corynebacterium kroppenstedtii","authors":"Adam Cewers ,&nbsp;Torgny Sunnerhagen ,&nbsp;Patrik Gilje ,&nbsp;Fredrik Wannheden ,&nbsp;Jonas Bläckberg ,&nbsp;Per Wierup ,&nbsp;Mårten Larsson ,&nbsp;Magnus Rasmussen","doi":"10.1016/j.idcr.2024.e02049","DOIUrl":"10.1016/j.idcr.2024.e02049","url":null,"abstract":"<div><p><em>Corynebacterium</em> is a skin commensal bacterium that can contaminate blood cultures. It is however also a rare cause of infective endocarditis (IE). Here we report a case of <em>Corynebacterium kroppenstedtii</em> aortic prosthesis IE in a 76-year-old man where only a single blood culture bottle was positive initially. <em>C. kroppenstedtii</em> is a very rare cause of IE, only reported two times previously. The diagnosis in our case was confirmed by repeated blood culture positivity and eventually by detection of DNA from <em>C. kroppenstedtii</em> on heart valves after valve exchange surgery. At surgery an aortic root abscess was detected and the valve was replaced by a homograft. Recovery was complicated by antibiotic-induced nephrotoxicity and treatment was concluded with moxifloxacin in combination with rifampicin. Recovery was uneventful. This case demonstrates that growth in even a single blood culture bottle may be important in patients with prosthetic heart valves.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02049"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001252/pdfft?md5=a4b5a56a62d82aa038dbdb247a4c5abc&pid=1-s2.0-S2214250924001252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella infective endocarditis in a young diabetic lady with device closure of PDA and VSD: A rare case report","authors":"Md. Mehedi Hasan,&nbsp;Fariha Fairouz,&nbsp;Amit Banik,&nbsp;Md. Jubaidul Islam,&nbsp;Jamal Uddin Ahmed","doi":"10.1016/j.idcr.2024.e02039","DOIUrl":"10.1016/j.idcr.2024.e02039","url":null,"abstract":"<div><p>The risk of infective endocarditis remains a major concern in patients with congenital heart disease; nevertheless, use of devices and prostheses in corrective surgery may have contributed to an increased incidence. Infective endocarditis due to Salmonella species are infrequently reported, therefore, their clinical presentations, prognosis and optimal treatment guideline are poorly described in literature. Here, we report a case of an 18-year-old diabetic lady with history of device closure of Patent ductus arteriosus and closure of peri-membranous small Ventricular septal defect in the year of 2005 and 2018 respectively who presented to us with high-grade fever for 10 days without any focal symptom. She was initially diagnosed as a case of Enteric fever based on serological tests for Salmonella species, later Transesophageal echocardiography confirmed infective endocarditis. The patient was treated with combination of antibiotics for a total 6-week duration. Although very rare, Salmonella have a predilection for the heart valves, particularly mitral and aortic valves. Diagnosis may be difficult, blood culture is often negative and a Transesophageal echocardiography should be performed without delay particularly in high risk patients. In most cases Salmonella endocarditis can be successfully treated with antimicrobials alone<em>.</em></p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02039"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221425092400115X/pdfft?md5=1ea3c31bf7ad0c2f9c078e9c8195e60a&pid=1-s2.0-S221425092400115X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerococcus urinae endocarditis – A case report.","authors":"Helene G. Meyer ,&nbsp;Balthasar L. Hug","doi":"10.1016/j.idcr.2024.e02053","DOIUrl":"10.1016/j.idcr.2024.e02053","url":null,"abstract":"<div><p><em>Aerococcus urinae</em> is a gram-positive coccus bacterium with a previously underestimated prevalence due to morphological similarities to other gram-positive cocci. Development of newer diagnostic technologies (such as matrix-assisted laser desorption ionization time-of-flight mass spectrometry MALDI-TOF) led to increased recognition of <em>Aerococcus urinae</em> as causative organism mainly for urinary tract infections. Its antibiotic susceptibility poses some challenges, with resistance to some drugs of choice for urinary tract infection. We report a case of a 69-year-old male with infective endocarditis of the mitral valve, who initially presented with fever and shoulder pain to the emergency department. The patient reported an episode of obstructive renal infection two weeks earlier, which was treated with trimethoprim-sulfamethoxazole. The unusual presentation with shoulder pain and a new heart murmur led to suspicion of endocarditis. Urine and blood cultures were positive for <em>Aerococcus urinae</em>, echocardiography revealed vegetations on the mitral valve with severe mitral insufficiency. After two weeks of antibiotic treatment, mitral valve replacement was performed, from which the patient recovered. Reports of <em>Aerococcus urinae</em> endocarditis are still limited in number. On the other side, <em>Aerococcus urinae</em> is an emerging bacterial uropathogen with greater relevance than previously believed. We review the case reports of <em>Aerococcus urinae</em> endocarditis and newest literature about its presentation, course, and clinical management.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02053"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221425092400129X/pdfft?md5=3cdc09a7abc3a2d193b5f319fc6ee689&pid=1-s2.0-S221425092400129X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parvovirus B19 and Parvovirus 4 infections among healthy blood donors; A prevalence report from Iran","authors":"Mohammad Mehdi Sabahi ,&nbsp;Mehrdad Mosadegh ,&nbsp;Azin Kazemi ,&nbsp;Razieh Amini ,&nbsp;Shahab Mahmoudvand ,&nbsp;Mojtaba Hedayat Yaghoubi ,&nbsp;Mohammad Masoud Maleki ,&nbsp;Zahra Sanaei ,&nbsp;Farid Azizi Jalilian","doi":"10.1016/j.idcr.2024.e02055","DOIUrl":"10.1016/j.idcr.2024.e02055","url":null,"abstract":"<div><h3>Background</h3><p>Parvoviruses, characterized by their tropism for blood cells, can manifest as asymptomatic infections. With their ability to persist in blood, assessing the prevalence of Parvovirus B19 (B19V) and Parvovirus 4 (PARV4) among healthy blood donors is essential for evaluating the potential transmission risks through blood transfusions, emphasizing the need for comprehensive screening protocols.</p></div><div><h3>Methods</h3><p>Four hundred blood donors participated in the study, with their blood specimens subjected to Real-Time PCR analysis for B19V and PARV4 nucleic acids after obtaining informed consent. Additionally, Complete Blood Count (CBC) assessments and determination of anti-B19 V-IgM and anti-B19 V-IgG antibody titers were performed using Enzyme-Linked Immunosorbent Assay (ELISA) for all collected samples.</p></div><div><h3>Results</h3><p>The results reveal that 12 out of 400 individuals (3 %) exhibited positive results for B19V DNA, while 6 out of 400 individuals (1.5 %) tested positive for PARV4 DNA. Additionally, 8 out of 400 individuals (2 %) displayed positive results for anti-B19V IgM, and 306 out of 400 individuals (76.5 %) exhibited positive results for anti-B19 IgG. Notably, one donation from a donor presenting anti-IgM antibodies was subsequently confirmed as B19V DNA-positive through Real-Time PCR. In the analysis of CBC, a significant disparity in platelet levels was observed between B19V-positive donors, PARV4-positive donors, and B19V-negative donors.</p></div><div><h3>Conclusions</h3><p>The study suggests that individuals at high risk, lacking detectable B19V antibodies, should undergo systematic screening and exclusion. This precaution is intended to minimize potential contamination risks within the studied cohort, despite the undefined pathogenesis and clinical implications of PARV4.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02055"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001318/pdfft?md5=0ba6a3d7da2b6a5263e09bccc294ab83&pid=1-s2.0-S2214250924001318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The great imitator: Tuberculosis with lymphadenopathy and splenomegaly","authors":"Ashton D. Hall ,&nbsp;Laura Victoria Medina Rodriguez ,&nbsp;Jared Vearrier ,&nbsp;Kavya Patel ,&nbsp;Bryan C. Hambley ,&nbsp;Moises A. Huaman","doi":"10.1016/j.idcr.2024.e01968","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01968","url":null,"abstract":"<div><p>Tuberculosis (TB) is a leading infectious killer worldwide. Over two-thirds of new TB diagnoses in the United States occur among first-generation immigrants, especially within a year of migration. Hodgkin lymphoma (HL) accounts for a minority of lymphoma cases but presents similarly to disseminated or extrapulmonary TB. Clinical overlap between TB and HL increases patient risk of misdiagnosis. Concomitant presentation of both diseases is not uncommon but infrequently reported. We present a case of isoniazid-resistant TB with progressively worsening lymphadenopathy and splenomegaly despite appropriate TB treatment. The patient was diagnosed with HL following PET/CT and axillary lymph node biopsy.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01968"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000441/pdfft?md5=bd3ca549060c8ac8c507148049fda40e&pid=1-s2.0-S2214250924000441-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140607080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant syphilis requiring differentiation from Kaposi's sarcoma","authors":"Mieko Tokano ,&nbsp;Norihito Tarumoto ,&nbsp;Kazuo Imai ,&nbsp;Hiroshi Yamaguchi ,&nbsp;Masaaki Takeji ,&nbsp;Fumito Inayoshi ,&nbsp;Keita Okamoto ,&nbsp;Nobuhito Okumura ,&nbsp;Shigefumi Maesaki","doi":"10.1016/j.idcr.2024.e01943","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01943","url":null,"abstract":"<div><p>Malignant syphilis (MS) is a rare variant of secondary syphilis. Also known as rupioid syphilis, MS is characterized by the presence of multiple papules, papulopustules, black lamellate crust that may resemble an oyster shell, or nodules with ulceration lacking central clearing. MS is often associated with immunodeficiency and frequently co-occurs with HIV infection. We here report a case of MS in a patient with HIV infection. HIV infection can cause atypical clinical symptoms of syphilis. In this case, unlike previous cases, cutaneous lesions of MS were limited to the face, making the diagnosis challenging based on clinical findings alone. However, his laboratory findings, appearance of the Jarisch-Herxheimer reaction, and a dramatic response to antibiotic therapy are characteristic of MS, making the diagnosis even more certain. Our case suggests the importance of physicians considering the possibility of MS when observing black-crusted lesions.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01943"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000192/pdfft?md5=e43924ef738e4b4587de17471db24f03&pid=1-s2.0-S2214250924000192-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140607102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracheostomy wound myiasis in a patient with hypoxic encephalopathy","authors":"Kazuhiro Itoh ,&nbsp;Atsushi Kuwata ,&nbsp;Chiyo Kiriba ,&nbsp;Yukari Kuwata ,&nbsp;Tooru Enomoto ,&nbsp;Yukie Yoshioka ,&nbsp;Michie Nakayama ,&nbsp;Hiroshi Tsutani ,&nbsp;Yasuhiko Mitsuke ,&nbsp;Hiromichi Iwasaki","doi":"10.1016/j.idcr.2024.e01969","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01969","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01969"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000453/pdfft?md5=f56d9f7c0ed335153a2d9f4e593e7fb4&pid=1-s2.0-S2214250924000453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillus Calmette-Guérin (BCG) prostato-epididymitis in a patient treated for a non-invasive urothelial cancer: A case report","authors":"Ayemane Salif ,&nbsp;Ferdinand Bigirimana ,&nbsp;Sophie Willems ,&nbsp;Gina Reichman ,&nbsp;Johanna Noels ,&nbsp;Sigi Van Den Wijngaert ,&nbsp;Sophie Lecomte ,&nbsp;Evelyne Maillart ,&nbsp;Philippe Clevenbergh","doi":"10.1016/j.idcr.2024.e01967","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01967","url":null,"abstract":"<div><h3>Introduction</h3><p>The Bacillus Calmette-Guérin (BCG) used as anti-tuberculous vaccine is also a well-known therapy for superficial urothelial cancer. Local or general side effects can occur, although it is generally well tolerated.</p></div><div><h3>Case</h3><p>We present the case of a 65 year-old caucasian man consulting for gross hematuria and lower urinary tract symptoms. Magnetic resonance imaging (MRI) demonstrated a non-invasive urothelial carcinoma (NMIBC) and Prostate Imaging–Reporting and Data System (PIRADS) IV lesions. Transurethral resection of the bladder tumor revealed a non-invasive transitional cell carcinoma. Intravesical Bacillus Calmette Guerin (BCG) therapy was provided. After 6 intravesical instillations, the patient presented with prostato-epididymitis. Forthcoming BCG instillations were canceled, and cancer treatment was switched to epirubicine. Treatment with ethambutol, rifampicin and isoniazid was started with rapid resolution of the symptoms. Urinary and semen cultures grew <em>Mycobacterium tuberculosis</em> complex strain BCG. As prostate specific antigen (PSA) rose, prostate’s biopsies were performed showing extensive necrosis boarded by granulomas without signs of malignancy.</p></div><div><h3>Discussion</h3><p>BCGitis is a rare complication in patients treated for non-invasive urothelial cancer. Several risk factors, local and systemic, should be considered prior to this immunotherapy. BCGitis (local or disseminated) or hypersensitivity reactions to BCG must be included in the differential diagnosis even if therapy was administered several years before the symptoms. Adequate treatment must be started as fast as possible to avoid serious complications.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e01967"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221425092400043X/pdfft?md5=5ce31518f8239a15483b9921ab561dbc&pid=1-s2.0-S221425092400043X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140644331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}