IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02147

Kento Furuya , Naoya Itoh

{"title":"Urethrocutaneous fistula and subcutaneous abscess in the inguinal region with bacteremia caused by Bilophila wadsworthia in a Japanese patient: A case report","authors":"Kento Furuya , Naoya Itoh","doi":"10.1016/j.idcr.2025.e02147","DOIUrl":"10.1016/j.idcr.2025.e02147","url":null,"abstract":"<div><div><em>Bilophila wadsworthia</em> is an anaerobic, gram-negative bacillus commonly associated with acute appendicitis. However, bacteremia is exceedingly rare. Herein, we report a case of <em>B. wadsworthia</em> bacteremia associated with a urethrocutaneous fistula and a subcutaneous abscess in the left inguinal region. A 75-year-old man was referred to our hospital due to persistent fever despite piperacillin treatment. The patient was diagnosed with a urethrocutaneous fistula and a subcutaneous abscess in the left inguinal region. <em>B. wadsworthia</em> was isolated from his blood culture and identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Subsequently, the patient underwent a four-week course of piperacillin-tazobactam therapy. Since a susceptibility breakpoint has not been established for <em>B. wadsworthia</em>, standardized treatment guidelines are currently unavailable. This case represents the first successful treatment of <em>B. wadsworthia</em> bacteremia with piperacillin-tazobactam, suggesting it may be an effective therapeutic option for infections caused by <em>B. wadsworthia</em>.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02147"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Peril: A rare case of simultaneous Bartonella and Brucella Endocarditis with unique epidemiological and clinical challenges

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02161

Qusai Alqudah , Akankcha Alok , Vidya S. Kollu

引用次数: 0

A case of typhoid fever with neurological presentation

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02203

Nikhat Shahla Afsar, Sumaiya Farah Marisa, Sayat Quayum Mohona, Sohely Ashraf, Mahfuzur Rahman, Chowdhury Adnan Sami

{"title":"A case of typhoid fever with neurological presentation","authors":"Nikhat Shahla Afsar, Sumaiya Farah Marisa, Sayat Quayum Mohona, Sohely Ashraf, Mahfuzur Rahman, Chowdhury Adnan Sami","doi":"10.1016/j.idcr.2025.e02203","DOIUrl":"10.1016/j.idcr.2025.e02203","url":null,"abstract":"<div><h3>Introduction</h3><div>Typhoid fever, leading to systemic disease due to Salmonella enterica serotype Typhi, typically has gastrointestinal manifestation, however, neurologic complications—although uncommon, can arise. Aseptic meningitis and optic neuritis are rare manifestations that can be challenging to diagnose.</div></div><div><h3>Case summary</h3><div>Our patient a 31-year male presented with fever for 18 days associated with headache, rash, vomiting, diarrhea and progressive neurological symptoms in form of disorientation and blurred vision. On examination there was bilateral sixth cranial nerve palsy. Investigations were positive for typhoid fever with aseptic meningitis and optic neuritis. He was successfully treated with intravenous ceftriaxone and corticosteroids.</div></div><div><h3>Conclusion</h3><div>Atypical neurological symptoms of typhoid fever must be recognized. To prevent complications, early diagnosis and treatment are important. Typhoid fever should be considered in febrile patients with unexplainable neurological symptoms, especially in an endemic region.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02203"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Helicobacter cinaedi pleuritis and continuous ambulatory peritoneal dialysis-related peritonitis diagnosed by simultaneous-onset bacteremia

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02197

Kei Yamamoto , Daisuke Ono , Yujin Nozaki , Yusuke Nishida , Jun Sakai , Kazuyuki Mimura , Masaaki Terao , Hajime Hasegawa , Hideaki Ohno , Hideaki Oka

{"title":"A case of Helicobacter cinaedi pleuritis and continuous ambulatory peritoneal dialysis-related peritonitis diagnosed by simultaneous-onset bacteremia","authors":"Kei Yamamoto , Daisuke Ono , Yujin Nozaki , Yusuke Nishida , Jun Sakai , Kazuyuki Mimura , Masaaki Terao , Hajime Hasegawa , Hideaki Ohno , Hideaki Oka","doi":"10.1016/j.idcr.2025.e02197","DOIUrl":"10.1016/j.idcr.2025.e02197","url":null,"abstract":"<div><div>A 42-year-old man undergoing peritoneal dialysis due to a chronic kidney disease of unknown etiology complained of fever and chills. Oral levofloxacin was started, but the symptoms did not improve. He was admitted, and the levofloxacin was switched to intravenous ciprofloxacin. Without improvement, the antibiotic was changed to intravenous meropenem, and he gradually got afebrile. Blood culture on admission yielded a Gram-negative rod (GNR), which was identified as <em>Helicobacter cinaedi</em> by Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI TOF-MS). Additionally, after admission, pleural effusion on the left side increased. The pleural effusion was determined as exudative, but the Gram stain and culture were negative. He was diagnosed with <em>H. cinaedi</em> pleuritis and bacteremia. After three-weeks of intravenous meropenem, he was discharged. However, he complained of fever and chills again and was re-admitted. Intravenous meropenem was re-started, and he got afebrile. Ascites test via peritoneal dialysis tube was conducted. The ascitic fluid was turbid, and the white blood cell count was elevated predominantly with neutrophils. Blood culture on re-admission yielded a GNR, identified as <em>H. cinaedi</em> by MALDI TOF-MS. After three-week intravenous meropenem administration, ten-days of intravenous tazobactam/piperacillin plus vancomycin plus oral minocycline, followed by twelve-days of intravenous cefepime plus oral minocycline were administrated due to hospital-acquired pneumonia. This was followed by a two-week oral minocycline intake. <em>H. cinaedi</em> infection did not recur thereafter. To our knowledge, this report is the first case of <em>H. cinaedi</em> pleuritis and continuous ambulatory peritoneal dialysis-related peritonitis diagnosed by simultaneous-onset of bacteremia.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02197"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A children patient with intracranial infection after brain surgery associated with elevated Torque Teno Virus

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02196

Zicong Wang , Zewei Liu , Kexin Yuan , Dezhi Li , Song Liu , Tao Jiang , Yahui Zhao

{"title":"A children patient with intracranial infection after brain surgery associated with elevated Torque Teno Virus","authors":"Zicong Wang , Zewei Liu , Kexin Yuan , Dezhi Li , Song Liu , Tao Jiang , Yahui Zhao","doi":"10.1016/j.idcr.2025.e02196","DOIUrl":"10.1016/j.idcr.2025.e02196","url":null,"abstract":"<div><h3>Introduction</h3><div>Intracranial infections are challenging to diagnose, especially in immunocompromised patients. Next-generation sequencing (NGS) has emerged as a powerful tool for broad pathogen detection, including Torque Teno Virus (TTV). Elevated TTV loads have been associated with immune dysfunction, potentially serving as a biomarker for opportunistic infections. However, the clinical significance of TTV in intracranial infections remains unclear.</div></div><div><h3>Case presentation</h3><div>An 8-year-old boy developed a complex intracranial infection following craniotomy, characterized by elevated TTV levels in cerebrospinal fluid (CSF) and subsequent fungal co-infection. Initial empirical antibiotics failed to fully control the infection. NGS identified TTV in the CSF, prompting the addition of intravenous immunoglobulin. Recurrent infection led to the suspicion of a fungal infection, confirmed by positive G/GM tests and successful treatment with fluconazole.</div></div><div><h3>Conclusion</h3><div>Elevated TTV levels in CSF may indicate underlying immunodeficiency and predispose patients to opportunistic fungal infections. Prompt fungal testing including qPCR is recommended when TTV is detected in CSF. Further research is needed to elucidate the role of TTV in clinical infections and optimize management strategies.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02196"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An autochthonous case of severe tick-borne encephalitis virus associated meningoencephalitis in France: Is there a place for polyvalent intravenous immunoglobulins?

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02213

Paul Dalmas , Elsa Kaphan , Coline Mortier , Margaux Froidefond , Barbara Doudier , Laeticia Ninove , Antoine Nougairede , Guillaume André Durand , Jean-Christophe Lagier , Nadim Cassir

引用次数: 0

Disseminated histoplasmosis with oral involvement and co-infection with Pneumocystis in a patient with HIV: A case report 播散性组织胞浆菌病伴口腔感染并合并肺囊虫病1例

IF 1.1

IDCases Pub Date : 2024-11-26 DOI: 10.1016/j.idcr.2024.e02119

Susanne O Ajao , Nehar Damle , Michelle Zhao , Gabriela Ferreira , Keith K Kaye , John P Mills

{"title":"Disseminated histoplasmosis with oral involvement and co-infection with Pneumocystis in a patient with HIV: A case report","authors":"Susanne O Ajao , Nehar Damle , Michelle Zhao , Gabriela Ferreira , Keith K Kaye , John P Mills","doi":"10.1016/j.idcr.2024.e02119","DOIUrl":"10.1016/j.idcr.2024.e02119","url":null,"abstract":"<div><div>Oral manifestations of disseminated histoplasmosis are rare but can present in immunocompromised individuals. We report a case of disseminated Histoplasmosis presenting with presumed oral involvement and <em>Pneumocystis jirovecii</em> pneumonia in a seropositive HIV individual. A 32-year-old male with HIV presented to the emergency department for a two-week history of abdominal pain and a tongue ulcer in the setting of significant weight loss, blood-tinged sputum, and non-adherence with antiretroviral therapy for three years. Physical exam revealed a verrucous ulcer on the lateral aspect of the tongue. CT scan of the chest revealed diffuse bilateral pulmonary nodules and ground glass opacities. At presentation, his CD4 + count was 12 cells/mm<sup>3</sup>. During his hospitalization, he developed acute hypoxic respiratory failure requiring non-invasive ventilation. His urine histoplasma antigen was positive at greater than 25 ng/mL and liposomal amphotericin was started. Shortly thereafter, <em>Pneumocystis jirovecii</em> PCR on bronchoalveolar lavage returned positive prompting additional therapy with trimethoprim-sulfamethoxazole. At discharge, the patient had no respiratory symptoms and near-resolution of his tongue ulcer.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02119"},"PeriodicalIF":1.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review 累及大脑、胆囊、心脏和软组织的梭状芽孢杆菌气性坏疽：病例报告和文献综述

IF 1.1

IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e02073

Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett

{"title":"Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review","authors":"Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett","doi":"10.1016/j.idcr.2024.e02073","DOIUrl":"10.1016/j.idcr.2024.e02073","url":null,"abstract":"<div><p>Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by <em>Clostridium septicum</em>, whereas traumatic infection is associated with <em>Clostridium perfringens</em>. Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by <em>C. perfringens</em> in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"38 ","pages":"Article e02073"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001495/pdfft?md5=0f086d239b55083580bb1cff5f7ad56d&pid=1-s2.0-S2214250924001495-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of Bacillus subtilis variant natto-induced persistent bacteremia with liver and splenic abscesses in an immunocompetent patient 一例罕见的枯草芽孢杆菌变异纳豆诱发的持续性菌血症，免疫功能正常的患者伴有肝脾脓肿

IF 1.5

IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01925

Tetsuro Amemiya , Kiyofumi Ohkusu , Miku Murayama , Tomokiyo Yamamoto , Naoya Itoh

{"title":"A rare case of Bacillus subtilis variant natto-induced persistent bacteremia with liver and splenic abscesses in an immunocompetent patient","authors":"Tetsuro Amemiya , Kiyofumi Ohkusu , Miku Murayama , Tomokiyo Yamamoto , Naoya Itoh","doi":"10.1016/j.idcr.2024.e01925","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01925","url":null,"abstract":"<div><p><em>Bacillus subtilis var. natto</em>, a low-pathogenic bacterium used in the traditional Japanese food \"natto\" (fermented soybeans), has rarely been reported as a pathogen of infectious diseases in humans. Herein, we report the first case of persistent bacteremia caused by <em>B. subtilis var. natto</em> in an immunocompetent patient without any gastrointestinal involvement. A 53-year-old Japanese woman who had been consuming natto every day was admitted to our hospital with complaints of fever and chills. <em>B. subtilis</em> was isolated from blood cultures collected during the initial visit. Abdominal contrast-enhanced computed tomography (CT) showed multiple low-absorption areas in the liver and spleen. Treatment commenced with vancomycin; however, <em>Bacillus sp.</em> was re-detected in the blood culture on day 4 after treatment initiation. The blood culture on day 8 was negative. Subsequently, the treatment was switched to ampicillin-sulbactam and oral amoxicillin-clavulanic acid, and the patient recovered after 28 days of treatment from the time the blood cultures became negative. Contrast-enhanced CT of the abdomen at the end of treatment showed that the multiple low-absorption areas in the liver and spleen had disappeared. Later, the variant of the bacteria was identified as <em>B. subtilis var. natto</em> by DNA analysis. <em>B. subtilis var. subtilis</em> and <em>B. subtilis var. natto</em> cannot be distinguished using matrix-assisted laser desorption/ionization-time of flight mass spectrometry or 16S rRNA analysis. Biotin auxotrophy of <em>B. subtilis var. natto</em> is used to distinguish between the two variants.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"35 ","pages":"Article e01925"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000015/pdfft?md5=a945a8508e139d40307a82fc0daf4b1d&pid=1-s2.0-S2214250924000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139487562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Staphylococcus epidermidis osteomyelitis in the absence of spine hardware 一例无脊柱硬件的表皮葡萄球菌骨髓炎病例

IF 1.5

IDCases Pub Date : 2024-01-01 DOI: 10.1016/j.idcr.2024.e01928

Erin Coonahan , Bita Shahrvini , Morgan Birabaharan , Nikdokht Farid , Annie Cowell

{"title":"A case of Staphylococcus epidermidis osteomyelitis in the absence of spine hardware","authors":"Erin Coonahan , Bita Shahrvini , Morgan Birabaharan , Nikdokht Farid , Annie Cowell","doi":"10.1016/j.idcr.2024.e01928","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01928","url":null,"abstract":"<div><p><em>Staphylococcus epidermidis</em> is a typically indolent pathogen that is often considered a blood culture contaminant. It is a rare and unexpected cause of osteomyelitis, especially in the absence of recent surgical intervention or orthopedic implants. We highlight a case in which a 90-year-old Caucasian male with no recent spine surgery was found to have osteomyelitis of the lumbar spine and repeat positive blood cultures for methicillin resistant <em>Staphylococcus epidermidis</em> (MRSE). Further investigation revealed a history of mitral valve replacement and a new diagnosis of endocarditis leading to persistent bacteremia and seeding of his lumbar vertebrae. This case demonstrates that <em>S. epidermidis</em> can cause vertebral osteomyelitis resulting in severe complications that are more similar to highly pathogenic bacteria. We describe the steps to diagnosing this chronic undetected infection and related comorbidities.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"35 ","pages":"Article e01928"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000040/pdfft?md5=cfdd5cb8158848fb335d83e108f2dd73&pid=1-s2.0-S2214250924000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139493224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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