{"title":"Therapeutic role of fluconazole in immunocompetent patients with pulmonary cryptococcosis: A case report","authors":"Huimin Yu , Shuang Hua , Qifei Sha , Tang Tang , Yuzhu Cao","doi":"10.1016/j.idcr.2025.e02188","DOIUrl":"10.1016/j.idcr.2025.e02188","url":null,"abstract":"<div><div>The present investigation examines the potential for customized treatment of pulmonary cryptococcosis using fluconazole in an immunocompetent individual. Therapeutic drug monitoring (TDM) was utilized throughout treatment to assess fluconazole levels. Research indicated that the MIC<sub>90</sub> for cryptococcus in China is around 8 mg/L. We evaluated the area under the curve (AUC) relative to the minimal inhibitory concentration (MIC), focusing on the AUC from 0 to 24 h (AUC0–24 h/MIC). Fluconazole's dosage was adjusted according to pharmacokinetics/pharmacodynamics (PK/PD) principles to enhance therapeutic efficacy. Post-treatment evaluation showed marked improvement in the patient's condition, with lesions exhibiting partial absorption.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02188"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02207
Mikiyas G. Teferi , Abel K. Gulma , Meron T. Akalu , Getaw W. Hassen , Elias M. Gashaw , Nahom D. Gerer
{"title":"Mumps-associated hepatitis: A rare clinical presentation","authors":"Mikiyas G. Teferi , Abel K. Gulma , Meron T. Akalu , Getaw W. Hassen , Elias M. Gashaw , Nahom D. Gerer","doi":"10.1016/j.idcr.2025.e02207","DOIUrl":"10.1016/j.idcr.2025.e02207","url":null,"abstract":"<div><h3>Introduction</h3><div>Mumps is a viral infection that principally affects the salivary glands, but it results in a range of complications, including orchitis, pancreatitis, and meningoencephalitis. Hepatic involvement is exceedingly rare and underreported in adults. Here, we present a peculiar case of mumps-associated hepatitis, highlighting its diagnostic challenges, clinical course, and management.</div></div><div><h3>Case presentation</h3><div>An unvaccinated 20-year-old male presented with a two-week history of fever, malaise, and bilateral parotid gland swelling, along with nausea, anorexia, and right upper quadrant discomfort. Tender parotid gland enlargement, scleral icterus, and bilateral testicular tenderness were noted on examination. The laboratory results revealed that the liver enzymes were significantly high, with a positive mumps virus IgM serology test; the following conditions were excluded: hepatitis A, B, C, Epstein–Barr, and cytomegalovirus. The patient was treated conservatively through hydration maintenance, pain relief, and rest. Consistent with a self-limiting course of mumps associated with hepatitis, liver functions normalized over four weeks.</div></div><div><h3>Discussion</h3><div>Mumps virus is an RNA paramyxovirus that affects glandular tissues. Although rare, case reports suggest that transient hepatitis can result from direct viral invasion or immune-mediated injury. The diagnosis requires high clinical suspicion, as symptoms overlap with other causes of viral hepatitis. The main treatment focuses on providing constant supportive care, which is usually sufficient, and the prognosis tends to be favorable.</div></div><div><h3>Conclusion</h3><div>Hepatitis is a rare but possible complication of mumps, especially in patients who have elevated liver enzymes. This case serves as a reminder that all healthcare professionals must be vigilant in atypical presentations of mumps to guarantee appropriate treatment and avoid unnecessary tests.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02207"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gallbladder schistosomiasis as an uncommon cause of recurrent cholecystitis","authors":"Seid Getahun Abdela , Suleiman Ayalew Belay , Abdu Assen Ahmed","doi":"10.1016/j.idcr.2025.e02331","DOIUrl":"10.1016/j.idcr.2025.e02331","url":null,"abstract":"<div><div>Gallbladder schistosomiasis is an extremely rare manifestation of <em>Schistosoma mansoni</em> infection, typically overshadowed by hepatic, intestinal, or urogenital involvement. We report a case of a 28-year-old woman from Ethiopia with a two-year history of recurrent right upper quadrant abdominal pain. Ultrasound suggested acalculous cholecystitis with a possible gallbladder polyp, and she underwent elective open cholecystectomy. Histopathology confirmed the presence of granulomatous inflammation and calcified <em>Schistosoma mansoni</em> ova embedded in the gallbladder wall. The patient recovered fully following praziquantel therapy.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02331"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02335
Xiaoning Liu , Heng Mei , Bangmin Huang, Liangzhu Zhang, Ye Li
{"title":"An elderly couple suffers from tuberculosis of the reproductive system","authors":"Xiaoning Liu , Heng Mei , Bangmin Huang, Liangzhu Zhang, Ye Li","doi":"10.1016/j.idcr.2025.e02335","DOIUrl":"10.1016/j.idcr.2025.e02335","url":null,"abstract":"<div><h3>Introduction</h3><div>Genitourinary tuberculosis is often secondary to tuberculosis in other parts of the body, and transmits through blood, direct spread, and lymphatic pathway. Female primary infection through sexual intercourse with an active reproductive tuberculosis spouse in an upward transmission way is rare.</div></div><div><h3>Case report</h3><div>There is an elderly couple with testicular tuberculosis in the male and endometrial tuberculosis in the female. The onset of male patients precedes female patients, and there is no protected sexual intercourse. The possibility of direct sexual transmission and primary infection of genitourinary tuberculosis is considered.</div></div><div><h3>Conclusions</h3><div>Our findings raise awareness of the transmission route of reproductive system tuberculosis, attach importance to prevention and reduce damage, which is of great significance to reducing infertility and the resulting family problems.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02335"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02341
Jiongfei Jin , Fei Dong , Er Xu , Dandan Wu
{"title":"Central infection with Rickettsia felis complicated with stroke: A case series and review","authors":"Jiongfei Jin , Fei Dong , Er Xu , Dandan Wu","doi":"10.1016/j.idcr.2025.e02341","DOIUrl":"10.1016/j.idcr.2025.e02341","url":null,"abstract":"<div><div><em>Rickettsia felis</em> (<em>R. felis</em>) is an emerging pathogen primarily transmitted by fleas, with clinical manifestations similar to other rickettsial infections. Although rare, severe cases involving central nervous system complications, such as meningoencephalitis, have been reported. This article presents three cases of <em>R. felis</em> central infections complicated by stroke. Two patients experienced cerebral infarctions, while another had a subarachnoid hemorrhage. Analysis of cerebrospinal fluid revealed common features, including elevated protein levels and increased nucleated cells with lymphocytic predominance. This report emphasizes the importance of considering <em>R. felis</em> as a potential cause of stroke in febrile patients, and highlights the role of advanced diagnostic techniques, such as next-generation sequencing (NGS), in the timely identification of rare pathogens. Early detection and appropriate treatment are crucial for optimizing patient outcomes.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02341"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02284
Shekina Gonzalez-Ferrer , Lauren Yanagimoto-Ogawa , Ran Zhuo , Colette J. Matysiak Match , Ashley Dayo , Yuna Kang , Shangxin Yang
{"title":"Rare mycetoma caused by Raghukumaria species, a mangrove-derived dematiaceous fungus in a kidney transplant patient","authors":"Shekina Gonzalez-Ferrer , Lauren Yanagimoto-Ogawa , Ran Zhuo , Colette J. Matysiak Match , Ashley Dayo , Yuna Kang , Shangxin Yang","doi":"10.1016/j.idcr.2025.e02284","DOIUrl":"10.1016/j.idcr.2025.e02284","url":null,"abstract":"<div><div>We report a rare case of mycetoma after renal transplant in a patient with distant exposure to mangroves during disaster relief efforts in the Caribbean. Histopathology and fungal culture from the skin biopsy revealed findings consistent with chronic mycetoma caused by a dematiaceous mold. Next Generation Sequencing (NGS) identified the organism as closely related to <em>Raghukumaria keshaphalae</em>, a fungus originally isolated from mangroves. This case highlights the emerging threat posed by environmental dematiaceous fungi as obscure opportunistic pathogens in the setting of natural disasters, especially for immunocompromised patients, and the pivotal diagnostic role of NGS in invasive fungal infections.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02284"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02292
Zarif Kazi, Asbah Rahman, Branden Biegert, Jordan Daloya, Chanaka Seneviratne
{"title":"Crossing boundaries: E. coli meningitis as an uncommon complication of hemorrhoidectomy","authors":"Zarif Kazi, Asbah Rahman, Branden Biegert, Jordan Daloya, Chanaka Seneviratne","doi":"10.1016/j.idcr.2025.e02292","DOIUrl":"10.1016/j.idcr.2025.e02292","url":null,"abstract":"<div><div><em>Escherichia coli</em> meningitis is a rare cause of meningitis in adults. Overall, mortality due to meningitis is improving, but remains high for gram negative bacteria. It often progresses rapidly, and even if treated appropriately, can lead to long-term complications. An emerging concern is bacterial resistance to the empiric antibiotic regimen used in meningitis. The effect of adjunct dexamethasone on reducing mortality or preventing complications remains inconclusive. Here, we discuss a case of severe <em>E. coli</em> meningitis in a 56-year-old woman after a hemorrhoidectomy, leading to brain herniation and cardiac arrest.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02292"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02294
Gabriele Pagani , Francesco Bassani , Paola Mirri , Bianca Osnaghi , Elena Delmastro , Stefano Rusconi
{"title":"Early Scedosporium apiospermium infection of a soil-contaminated traumatic injury successfully treated with isavuconazole: A case report","authors":"Gabriele Pagani , Francesco Bassani , Paola Mirri , Bianca Osnaghi , Elena Delmastro , Stefano Rusconi","doi":"10.1016/j.idcr.2025.e02294","DOIUrl":"10.1016/j.idcr.2025.e02294","url":null,"abstract":"<div><div>Scedosporium apiospermium, a rare fungal pathogen from soil and stagnant water, can cause invasive infections, particularly in immunocompromised patients. An 83-year-old male with a soil-contaminated traumatic wound developed persistent inflammation despite antibiotic therapy. <em>Scedosporium apiospermium</em> was identified, and systemic isavuconazole led to significant wound improvement after eight weeks. This case emphasizes the need to consider fungal infections in traumatic wounds. Isavuconazole was effective and safe, offering a valuable alternative to voriconazole</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02294"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dengue in older inpatients in the post-COVID-19 Period: a case series from a North Indian tertiary center","authors":"Abhimanyu Velmurugan , Shivangi Pandey , Aayushi Owdhwal , Anup Singh , Sankha Shubhra Chakrabarti , Upinder Kaur","doi":"10.1016/j.idcr.2025.e02323","DOIUrl":"10.1016/j.idcr.2025.e02323","url":null,"abstract":"<div><div>Studies on dengue in older patients are scarce from India. The patterns of dengue in the post-COVID-19 period have been poorly studied globally. Our case series describes the patterns and outcomes of dengue in inpatients of the geriatric unit of a tertiary university hospital in North India during the period of August -December 2023. Twenty-four patients were diagnosed with dengue out of 182 admissions during the study period (13.2 %). The median (Q1-Q3) age of patients was 67.5 (64.75–75) years. Fever was present in all except one patient (95.8 %). Weakness, vomiting, dyspnea, and altered sensorium occurred in 41.7 %, 37.5 %, 29.2 %, and 20.8 %, respectively. Hyponatremia, thrombocytopenia, and anemia were observed in 58.3 %, 45.8 %, and 25 % of cases, and nearly one-third developed hepatitis. Leucopenia rates were relatively low. Dengue was severe in two-thirds, and acute kidney injury was the commonest complication. Three fatalities were observed<strong>.</strong> In summary, many older patients had atypical presentations of dengue, and the disease was severe in a significant proportion. Larger multi-centric surveillance studies with the inclusion of immunogenic correlates of COVID-19 are needed to understand its effects if any on the age and region-specific variations of dengue in the elderly.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02323"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2025-01-01DOI: 10.1016/j.idcr.2025.e02309
Hani S. Al-Jahdali , Huda S. Al Ghamdi , Bothayna I. Saleh , Mohammed F. Merza , Bushra H. Alqurashy , Layali S. Abdurabo , Zahra A. Albishi , Rasha Binmahfouz
{"title":"A case report of Cedecea davisae infection in a patient with chronic kidney disease in Saudi Arabia","authors":"Hani S. Al-Jahdali , Huda S. Al Ghamdi , Bothayna I. Saleh , Mohammed F. Merza , Bushra H. Alqurashy , Layali S. Abdurabo , Zahra A. Albishi , Rasha Binmahfouz","doi":"10.1016/j.idcr.2025.e02309","DOIUrl":"10.1016/j.idcr.2025.e02309","url":null,"abstract":"<div><div><em>Cedecea,</em> a genus belonging to the family Enterobacteriaceae, are uncommonly attributed as causative agents of human infections. <em>Cedecea davisae</em> is considered as an opportunistic pathogen that was isolated from a different acute infection in advanced-aged patients with many comorbid diseases or from immunocompromised hosts. Fourteen cases of proved <em>C. davisae</em> infections were published up till now. We isolated <em>C. davisae</em> from chronic kidney disease patient who presented with purulent discharge from dialysis catheter, and the result of microbiology culture and identification on automated microbiology identification system, MicroScan WalkAway using NBC50 panel revealed <em>C. davisae</em> as a causative agent of catheter related infection. The patient improved on receiving antibiotic treatment according to culture and sensitivity results. Awareness of the clinical significance of this low incidence bacterial infection and their antibiotic resistance and sensitivity pattern is crucial in the medical field.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02309"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}