IDCasesPub Date : 2024-12-12eCollection Date: 2025-01-01DOI: 10.1016/j.idcr.2024.e02126
Alex Belote, Kassem Hammoud
{"title":"A rare case of <i>Gardnerella vaginalis</i> spondylodiscitis.","authors":"Alex Belote, Kassem Hammoud","doi":"10.1016/j.idcr.2024.e02126","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e02126","url":null,"abstract":"<p><p>A 55-year-old-male with a chronic left uretero-pelvic junction (UPJ) obstruction managed with intermittent stent exchanges presented with low midline back pain. CT Abdomen/Pelvis revealed spondylodiscitis at L4-L5, further demonstrated on MRI Lumbar spine. Imaging also revealed the left nephro-ureteral stent was mispositioned, with some mild wall thickening of the left ureter. He was not systemically ill, and antimicrobials were held. He underwent a L4/5 disc biopsy, and pathology revealed acute discitis. Blood and biopsy cultures remained negative through hospital day 5. He then underwent repeat L4/5 disc biopsy. Cultures of repeat biopsy resulted in <i>Gardnerella vaginalis</i>. IV antimicrobials were stopped, and oral Metronidazole was started. He completed 10 weeks of Metronidazole therapy, with significant clinical improvement. <i>G. vaginalis</i> is a rare cause of bone and joint infections. It is difficult to culture and is less virulent than common bacteria associated with native vertebral osteomyelitis. There have been few case reports of <i>G. vaginalis</i> osteomyelitis or prosthetic joint infection, especially in males. <i>G. vaginalis</i> can rarely colonize the urethra in men and has been known to form biofilm on foreign material in the female genitourinary system. We suspect our patient had developed colonization of his ureteral stent, predisposing him to osteomyelitis. Were repeat biopsy not pursued in this case, our patient likely could have developed empiric treatment failure. Holding antibiotics after initial biopsy proved highly beneficial.</p>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"e02126"},"PeriodicalIF":1.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-12-06eCollection Date: 2025-01-01DOI: 10.1016/j.idcr.2024.e02123
Hao Wang, Hongna Yang
{"title":"A case of acute community-acquired pneumonia caused by <i>Tropheryma whipplei</i> in pregnant woman without predisposing medical conditions.","authors":"Hao Wang, Hongna Yang","doi":"10.1016/j.idcr.2024.e02123","DOIUrl":"10.1016/j.idcr.2024.e02123","url":null,"abstract":"<p><p><i>Tropheryma whipplei</i> (<i>T. whipplei</i>) is extensively known as the etiological bacterium of Whipple's disease (WD). Here, we reported a case of community-acquired pneumonia caused by <i>T. whipplei</i> in a young pregnant woman without predisposing medical conditions. This case indicated that <i>T. whipplei</i> might be also transmitted via respiratory droplet.</p>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"e02123"},"PeriodicalIF":1.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-12-04eCollection Date: 2025-01-01DOI: 10.1016/j.idcr.2024.e02124
Brenden Nago, Jeffrey E Liu
{"title":"An unusual case of varicella zoster encephalitis mimicking a glioblastoma on magnetic resonance imaging and magnetic resonance spectroscopy.","authors":"Brenden Nago, Jeffrey E Liu","doi":"10.1016/j.idcr.2024.e02124","DOIUrl":"10.1016/j.idcr.2024.e02124","url":null,"abstract":"<p><p>The authors report a case of varicella zoster encephalitis, mimicking a glioblastoma on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). The limitations of MRI/MRS, may lead to delayed treatment with antiviral agents, which can result in increased morbidity and mortality. The possibility of viral encephalitis should remain in the differential diagnosis of all patients presenting with headaches and confusion, even when imaging results are indicative of a neoplastic process.</p>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"e02124"},"PeriodicalIF":1.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-12-04eCollection Date: 2025-01-01DOI: 10.1016/j.idcr.2024.e02120
Oviya Selvam, Yogindher Singh R, M D Gowthaman, Manobalan K, K Subashree
{"title":"Mycotic cyst: Case report.","authors":"Oviya Selvam, Yogindher Singh R, M D Gowthaman, Manobalan K, K Subashree","doi":"10.1016/j.idcr.2024.e02120","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e02120","url":null,"abstract":"<p><p>Phaeohyphomycotic cyst is a common subcutaneous form of phaeohyphomycosis in which patients can present with subcutaneous plaques, nodules, etc., It is an infrequent presentation and is most reported in immunocompromised individuals. Diagnosis is confirmed by histopathological and mycological demonstration of the organism. The treatment is by surgical excision with systemic antifungals. We report a rare case of asymptomatic Mycotic cyst in an immunocompetent individual.</p>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"e02120"},"PeriodicalIF":1.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-11-30eCollection Date: 2025-01-01DOI: 10.1016/j.idcr.2024.e02122
Carlos Mejia Irias, Odalis Cerrato, Estephany Díaz Mairena
{"title":"Tuberculous pericarditis in a 71-year-old immunocompetent patient: Case report.","authors":"Carlos Mejia Irias, Odalis Cerrato, Estephany Díaz Mairena","doi":"10.1016/j.idcr.2024.e02122","DOIUrl":"10.1016/j.idcr.2024.e02122","url":null,"abstract":"<p><p>Tuberculosis is a transmissible disease caused by the bacterium <i>Mycobacterium tuberculosis</i>. It is the leading cause of mortality due to infectious diseases. Tuberculous pericarditis is one of the manifestations of extrapulmonary tuberculosis and represents the primary cause of pericardial effusion in developing countries. We present the case of a 71-year-old male patient with a history of 1 month of dyspnea, accompanied by paroxysmal nocturnal dyspnea and unintentional weight loss. An echocardiogram revealed the presence of severe pericardial effusion, for which pericardiocentesis was performed, and the pericardial fluid was analyzed using the Xpert MTB/RIF test, which confirmed the presence of <i>Mycobacterium tuberculosis</i> without resistance to Rifampicin. This is a case of Tuberculous Pericarditis as the cause of pericardial effusion, in which the etiological diagnosis was made possible through molecular biological analysis of the pericardial fluid. The importance of disseminating such cases lies in emphasizing that, even in the 21st century, in developing countries like Honduras, it is crucial not to dismiss tuberculosis infection, as it remains the leading cause of pericardial effusion in endemic regions.</p>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"e02122"},"PeriodicalIF":1.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-11-26DOI: 10.1016/j.idcr.2024.e02119
Susanne O Ajao , Nehar Damle , Michelle Zhao , Gabriela Ferreira , Keith K Kaye , John P Mills
{"title":"Disseminated histoplasmosis with oral involvement and co-infection with Pneumocystis in a patient with HIV: A case report","authors":"Susanne O Ajao , Nehar Damle , Michelle Zhao , Gabriela Ferreira , Keith K Kaye , John P Mills","doi":"10.1016/j.idcr.2024.e02119","DOIUrl":"10.1016/j.idcr.2024.e02119","url":null,"abstract":"<div><div>Oral manifestations of disseminated histoplasmosis are rare but can present in immunocompromised individuals. We report a case of disseminated Histoplasmosis presenting with presumed oral involvement and <em>Pneumocystis jirovecii</em> pneumonia in a seropositive HIV individual. A 32-year-old male with HIV presented to the emergency department for a two-week history of abdominal pain and a tongue ulcer in the setting of significant weight loss, blood-tinged sputum, and non-adherence with antiretroviral therapy for three years. Physical exam revealed a verrucous ulcer on the lateral aspect of the tongue. CT scan of the chest revealed diffuse bilateral pulmonary nodules and ground glass opacities. At presentation, his CD4 + count was 12 cells/mm<sup>3</sup>. During his hospitalization, he developed acute hypoxic respiratory failure requiring non-invasive ventilation. His urine histoplasma antigen was positive at greater than 25 ng/mL and liposomal amphotericin was started. Shortly thereafter, <em>Pneumocystis jirovecii</em> PCR on bronchoalveolar lavage returned positive prompting additional therapy with trimethoprim-sulfamethoxazole. At discharge, the patient had no respiratory symptoms and near-resolution of his tongue ulcer.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02119"},"PeriodicalIF":1.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-01-01DOI: 10.1016/j.idcr.2024.e02073
Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett
{"title":"Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review","authors":"Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett","doi":"10.1016/j.idcr.2024.e02073","DOIUrl":"10.1016/j.idcr.2024.e02073","url":null,"abstract":"<div><p>Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by <em>Clostridium septicum</em>, whereas traumatic infection is associated with <em>Clostridium perfringens</em>. Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by <em>C. perfringens</em> in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"38 ","pages":"Article e02073"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924001495/pdfft?md5=0f086d239b55083580bb1cff5f7ad56d&pid=1-s2.0-S2214250924001495-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare case of Bacillus subtilis variant natto-induced persistent bacteremia with liver and splenic abscesses in an immunocompetent patient","authors":"Tetsuro Amemiya , Kiyofumi Ohkusu , Miku Murayama , Tomokiyo Yamamoto , Naoya Itoh","doi":"10.1016/j.idcr.2024.e01925","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01925","url":null,"abstract":"<div><p><em>Bacillus subtilis var. natto</em>, a low-pathogenic bacterium used in the traditional Japanese food \"natto\" (fermented soybeans), has rarely been reported as a pathogen of infectious diseases in humans. Herein, we report the first case of persistent bacteremia caused by <em>B. subtilis var. natto</em> in an immunocompetent patient without any gastrointestinal involvement. A 53-year-old Japanese woman who had been consuming natto every day was admitted to our hospital with complaints of fever and chills. <em>B. subtilis</em> was isolated from blood cultures collected during the initial visit. Abdominal contrast-enhanced computed tomography (CT) showed multiple low-absorption areas in the liver and spleen. Treatment commenced with vancomycin; however, <em>Bacillus sp.</em> was re-detected in the blood culture on day 4 after treatment initiation. The blood culture on day 8 was negative. Subsequently, the treatment was switched to ampicillin-sulbactam and oral amoxicillin-clavulanic acid, and the patient recovered after 28 days of treatment from the time the blood cultures became negative. Contrast-enhanced CT of the abdomen at the end of treatment showed that the multiple low-absorption areas in the liver and spleen had disappeared. Later, the variant of the bacteria was identified as <em>B. subtilis var. natto</em> by DNA analysis. <em>B. subtilis var. subtilis</em> and <em>B. subtilis var. natto</em> cannot be distinguished using matrix-assisted laser desorption/ionization-time of flight mass spectrometry or 16S rRNA analysis. Biotin auxotrophy of <em>B. subtilis var. natto</em> is used to distinguish between the two variants.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"35 ","pages":"Article e01925"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000015/pdfft?md5=a945a8508e139d40307a82fc0daf4b1d&pid=1-s2.0-S2214250924000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139487562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of Staphylococcus epidermidis osteomyelitis in the absence of spine hardware","authors":"Erin Coonahan , Bita Shahrvini , Morgan Birabaharan , Nikdokht Farid , Annie Cowell","doi":"10.1016/j.idcr.2024.e01928","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e01928","url":null,"abstract":"<div><p><em>Staphylococcus epidermidis</em> is a typically indolent pathogen that is often considered a blood culture contaminant. It is a rare and unexpected cause of osteomyelitis, especially in the absence of recent surgical intervention or orthopedic implants. We highlight a case in which a 90-year-old Caucasian male with no recent spine surgery was found to have osteomyelitis of the lumbar spine and repeat positive blood cultures for methicillin resistant <em>Staphylococcus epidermidis</em> (MRSE). Further investigation revealed a history of mitral valve replacement and a new diagnosis of endocarditis leading to persistent bacteremia and seeding of his lumbar vertebrae. This case demonstrates that <em>S. epidermidis</em> can cause vertebral osteomyelitis resulting in severe complications that are more similar to highly pathogenic bacteria. We describe the steps to diagnosing this chronic undetected infection and related comorbidities.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"35 ","pages":"Article e01928"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000040/pdfft?md5=cfdd5cb8158848fb335d83e108f2dd73&pid=1-s2.0-S2214250924000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139493224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IDCasesPub Date : 2024-01-01DOI: 10.1016/j.idcr.2024.e02007
Seohyeon Im , Ariane Paz y Mino , Estefany Garces , Sarah Altamimi
{"title":"Latent melioidosis activation presenting with urinary tract infection and bacteremia","authors":"Seohyeon Im , Ariane Paz y Mino , Estefany Garces , Sarah Altamimi","doi":"10.1016/j.idcr.2024.e02007","DOIUrl":"https://doi.org/10.1016/j.idcr.2024.e02007","url":null,"abstract":"<div><p>We report a rare case of latent melioidosis activation in a patient with a distant travel history to an endemic region. Melioidosis is an infection caused by <em>Burkholderia pseudomallei</em> which is highly endemic in Southeast Asia and northern Australia. The patient exhibited common clinical risk factors, presenting with urinary tract infection and bacteremia. The treatment course was complicated by the adverse effect of trimethoprim/sulfamethoxazole. This case underscores the importance of early detection and appropriate treatment of melioidosis, particularly given its expanding global distribution.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"36 ","pages":"Article e02007"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000830/pdfft?md5=589a8f6f4c2de0577da80dfb9e51071b&pid=1-s2.0-S2214250924000830-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}