IDCases最新文献

{"title":"Early recognition and multidisciplinary care in a pediatric patient with acute infectious purpura fulminans due to MRSA: A rare case report","authors":"Mian Muhammad Hassan Ahmed ,&nbsp;Nighat Haider ,&nbsp;Samra Batool ,&nbsp;Muhammad Usman Ali ,&nbsp;Rafia Ishtiaq","doi":"10.1016/j.idcr.2025.e02486","DOIUrl":"10.1016/j.idcr.2025.e02486","url":null,"abstract":"<div><div>Acute infectious purpura fulminans (PF) is a rare but life-threatening condition characterized by rapidly progressive purpura, skin necrosis, and disseminated intravascular coagulation. We present a case of a 4-year-old male child who presented with a high-grade fever, maculopapular rash, encephalopathy, and gangrene of distal digits of hands and feet. The child had a tender right submandibular swelling and hepatomegaly. Laboratory findings included leukocytosis (26.48 × 10^9/L), thrombocytopenia (28,000/µL), an elevated C-reactive protein (296 mg/L), and coagulopathy (INR 1.84, <span>D</span>-dimer 540 ng/mL). Imaging revealed submandibular abscess and an extensive infiltrates in the right lower lobe of the lung. Blood culture and pus culture from neck swelling yielded methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) infection. The child was treated with intravenous vancomycin (15 mg/kg every 6 h) and linezolid (10 mg/kg every 8 h) for 4 weeks, heparin infusion (20 units/kg/hour), and supportive management, followed by oral rivaroxaban (1 mg/kg twice daily) for the next 6 months. Plastic surgery was consulted for gangrene. This case highlights the importance of early recognition, targeted antimicrobial therapy, and multidisciplinary management of PF secondary to MRSA infection in children.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02486"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of Streptomyces fradiae hand actinomycetoma","authors":"Ajithkumar Ittaman ,&nbsp;Hamad Abdel Hadi ,&nbsp;Azeel Alziddeh ,&nbsp;Mohammed Muneer ,&nbsp;Mohammad Z. Haider ,&nbsp;Muna Al. Maslamani","doi":"10.1016/j.idcr.2026.e02494","DOIUrl":"10.1016/j.idcr.2026.e02494","url":null,"abstract":"<div><div>Actinomycetoma is a rare, chronic, and progressive bacterial and fungal infection that affects subcutaneous tissues, fascia, and bones. This a case of a 27-year-old Sudanese male, shepherd, with a mycetoma lesion in the right hand caused by <em>Streptomyces fradiae</em>. He presented with swelling and deformity of the hand, and subsequent imaging showed soft tissue swelling, deep infiltration of the hand and sinus formation. A skin biopsy of the lesion confirmed the diagnosis of actinomycetoma, and the patient was treated with ceftriaxone IV for 14 days followed by oral amoxicillin clavulanic acid for a total of 3 months. Surgical excision followed by reconstruction of the hand was performed. Histopathological examination of the excised tissue showed abscess formation around colonies of actinomyces. The patient had significant clinical recovery with no recurrence of the infection. <em>Streptomyces fradiae</em> is a rare causative agent of actinomycetoma, and this case highlights the importance of early diagnosis and prolonged antibiotic therapy in the management of this infection.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02494"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital tuberculosis mimicking a vascular emergency: A case report of superior ophthalmic vein engorgement","authors":"Mansoor Shahriari ,&nbsp;Mohsen Zare ,&nbsp;Amirhossein Moghtader Mojdehi","doi":"10.1016/j.idcr.2026.e02534","DOIUrl":"10.1016/j.idcr.2026.e02534","url":null,"abstract":"<div><div>We report a rare case of orbital tuberculosis (O-TB) in an elderly diabetic patient that mimicked a variety of vascular, infectious, and inflammatory orbital diseases. A 73-year-old woman with uncontrolled diabetes, unilateral swelling of the left eye, proptosis, and binocular diplopia, as well as left superior ophthalmic vein (SOV) engorgement on an orbital CT scan, was referred to our center to rule out a carotid-cavernous fistula (CCF) or a cavernous sinus thrombosis (CST). An MRI, MRV, and cerebral angiography ruled out both diagnoses. Nasal endoscopy revealed septal necrosis, and biopsy demonstrated infectious necrosis. Initial bacterial and fungal smear and cultures were negative. However, Ziehl–Neelsen staining and culture on Lowenstein–Jensen medium were positive for acid-fast bacilli, and PCR confirmed <em>Mycobacterium tuberculosis</em>. The patient was treated with anti-tuberculosis treatment and recovered two months after treatment. O-TB may rarely mimic a vascular emergency through isolated superior ophthalmic vein engorgement. Clinicians should specifically consider orbital tuberculosis in patients with orbital inflammation and vascular-mimicking imaging findings when routine vascular evaluations are inconclusive, particularly in tuberculosis-endemic regions, to avoid diagnostic delay and ensure timely and appropriate treatment.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02534"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual case of Streptococcus pyogenes infective endocarditis demonstrating the usefulness of repeated echocardiography","authors":"Gabriel Hirdman ,&nbsp;Anders Roijer ,&nbsp;Magnus Paulsson ,&nbsp;Per Wierup ,&nbsp;Magnus Rasmussen","doi":"10.1016/j.idcr.2026.e02539","DOIUrl":"10.1016/j.idcr.2026.e02539","url":null,"abstract":"<div><div>Infective endocarditis (IE) is most often caused by alpha-hemolytic streptococci or <em>Staphylococcus aureus</em> and is characterized by the presence of vegetations on the heart valves. Here we present a case of IE caused by <em>Streptococcus pyogenes,</em> a distinctly uncommon IE-pathogen, where no vegetations could be visualized on repeated echocardiography. Diagnosis was instead evident from septic embolizations and progressive aortic insufficiency and IE was verified upon heart valve surgery. The patient was a 69-year-old man who presented with a two-day-history of fever and confusion. Several lesions on the skin and in the brain were suggestive of septic embolization and blood cultures grew <em>S. pyogenes</em> of sequence type 39, <em>emm4.</em> The patient developed progressive aortic insufficiency and was subjected to surgery at day seven after admittance. The aortic cusp showed signs of destructive IE and analysis of the valve demonstrated the presence of DNA from <em>S. pyogenes</em> ultimately confirming the diagnosis. The patient received a biological heart valve prosthesis and needed medical treatment for atrial fibrillation and heart failure post operatively. There was no relapse at six months post-surgery.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02539"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147417081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory exacerbation of hepatic alveolar echinococcosis during dupilumab therapy: A case report","authors":"Takumu Hasebe ,&nbsp;Honami Tanaka ,&nbsp;Masami Abe ,&nbsp;Chitomi Hasebe ,&nbsp;Shin Otake ,&nbsp;Hidemi Hayashi ,&nbsp;Yu Ota ,&nbsp;Koji Sawada ,&nbsp;Shoichiro Mizukami ,&nbsp;Hiroyuki Takahashi ,&nbsp;Masahiro Kitada ,&nbsp;Yasuhito Sako ,&nbsp;Akira Sakata ,&nbsp;Sayaka Yuzawa ,&nbsp;Hideki Yokoo","doi":"10.1016/j.idcr.2026.e02537","DOIUrl":"10.1016/j.idcr.2026.e02537","url":null,"abstract":"<div><h3>Background</h3><div>Alveolar echinococcosis is a rare but potentially fatal parasitic disease characterized by slow, infiltrative hepatic growth. Disease progression is strongly influenced by host immune status, and atypical courses have been reported in immunocompromised individuals. Dupilumab, a monoclonal antibody targeting interleukin-4 and interleukin-13 signaling, is increasingly used for atopic diseases; however, its impact on latent helminth infections remains unclear. We report a case of hepatic alveolar echinococcosis with pleural involvement occurring during dupilumab therapy, suggesting a possible interaction between targeted immune modulation and disease behavior.</div></div><div><h3>Case presentation</h3><div>A 29-year-old man presented with acute epigastric and left flank pain, fever, and inflammatory markers. Computed tomography revealed a calcified hepatic lesion protruding from the left lateral segment, accompanied by newly developed subdiaphragmatic and left pleural fluid collections suggestive of abscess formation. The patient had been receiving dupilumab for atopic dermatitis. Serological testing confirmed alveolar echinococcosis. Despite broad-spectrum antibiotic therapy, inflammation persisted, and surgical resection was performed, including partial hepatectomy with resection of the diaphragm and pleura. Histopathological examination demonstrated laminated parasitic structures consistent with echinococcal infection in hepatic and pleural tissues, without pulmonary parenchymal involvement. Postoperatively, the patient recovered well and was started on long-term antiparasitic therapy.</div></div><div><h3>Conclusions</h3><div>This case highlights an inflammatory exacerbation of hepatic alveolar echinococcosis with pleural extension during dupilumab therapy. Although causality cannot be established, inhibition of type 2 immune pathways may be associated with atypical inflammatory manifestations of latent helminth infections. Clinicians should remain vigilant for inflammatory presentations when prescribing biologic agents, particularly in endemic regions.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02537"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147417085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First molecular detection and characterization of Cyclospora cayetanensis in an Italian clinical case","authors":"Marianna Marangi ,&nbsp;Giorgia Lepore ,&nbsp;Felice Valzano ,&nbsp;Settimia Altamura ,&nbsp;Daniela Pisanelli ,&nbsp;Maria Rosaria Lipsi ,&nbsp;Donato Lacedonia ,&nbsp;Sonia Boughattas","doi":"10.1016/j.idcr.2026.e02542","DOIUrl":"10.1016/j.idcr.2026.e02542","url":null,"abstract":"<div><div>We report the first molecularly confirmed, genetically sequenced, and phylogenetically traced case of locally acquired <em>Cyclospora cayetanensis</em> infection in Italy. Earlier Italian reports described clinical cases of cyclosporiasis. However, sequence-based molecular confirmation and phylogenetic traceability were not available. An 86-year-old Italian woman with no recent travel history developed diarrhea during hospitalization. Routine microbiological investigations were negative, whereas multiplex real-time PCR detected <em>C. cayetanensis</em>. The diagnosis was confirmed by amplification and Sanger sequencing of the 18S rRNA gene. Phylogenetic analysis demonstrated that the Italian isolate clustered with strains associated with outbreaks linked to tropical and subtropical regions, suggesting a probable imported foodborne origin. Although cyclosporiasis is generally self-limiting, infection in frail elderly patients with multiple comorbidities may contribute to clinical deterioration. Diarrheal symptoms resolved after antimicrobial therapy, but the patient subsequently died due to pulmonary edema. While a direct causal relationship cannot be established, extra-intestinal involvement has been reported. This case highlights the importance of molecular diagnostics and phylogenetic analysis in non-endemic settings to improve surveillance and source attribution of <em>C. cayetanensis</em> infection.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02542"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147417083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saved by My Specs: Incidental central retinal vein occlusion uncovering infective endocarditis – A case report","authors":"Daniel Broderick ,&nbsp;Ciara Murray ,&nbsp;Padraig McGettrick ,&nbsp;James Woo ,&nbsp;Emer Kilbride ,&nbsp;James McCarthy ,&nbsp;Yvonne O’Meara ,&nbsp;Varisha Shahzad ,&nbsp;Carlos Mejia-Chew","doi":"10.1016/j.idcr.2025.e02484","DOIUrl":"10.1016/j.idcr.2025.e02484","url":null,"abstract":"<div><div>We describe a case of a 74-year-old man with a history of bioprosthetic aortic valve replacement who was diagnosed with <em>Granulicatella adiacens (G. adiacens)</em> infective endocarditis (IE) following an incidental finding of central retinal vein occlusion (CRVO) during a routine optician visit. Despite minimal symptoms on presentation, blood cultures grew <em>G. adiacens</em>, and imaging revealed a 1 × 1.2 cm aortic valve vegetation plus splenic and cerebral embolic complications. Management was complicated by drug-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, microangiopathic thrombocytopenia, anaemia, and possible subacute glomerulonephritis, leading to deferral of surgery until haematological parameters improved. Following a 9-week antibiotic course and stabilisation of platelet counts, he underwent a successful redo aortic valve replacement, highlighting the indolent yet clinically significant nature of <em>G. adiacens</em> IE and the importance of thorough, multidisciplinary care in complex prosthetic valve infections.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02484"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ictero-hemorrhagic leptospirosis -Weil’s disease","authors":"Johannes Heine ,&nbsp;Benedikt Selbertinger ,&nbsp;Benedicta Binder ,&nbsp;Nadine Theissen ,&nbsp;Stephan Schmid ,&nbsp;Patricia Mester ,&nbsp;Martina Müller ,&nbsp;Vlad Pavel","doi":"10.1016/j.idcr.2026.e02515","DOIUrl":"10.1016/j.idcr.2026.e02515","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02515"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare co-occurrence of colon cancer and Gastrodiscoides hominis in a human host: A case report and literature review","authors":"Sandhya Chaurasiya ,&nbsp;Tuhina Banerjee ,&nbsp;Aakash Shah ,&nbsp;Anurag Tiwari","doi":"10.1016/j.idcr.2026.e02522","DOIUrl":"10.1016/j.idcr.2026.e02522","url":null,"abstract":"<div><div>A rising but underappreciated public health concern, gastrodiscoidiasis, is caused by a food-borne intestinal trematode. We report molecular identification of the parasite <em>Gastrodiscoides hominis,</em> from a patient of colon cancer, based on conserved ribosomal and mitochondrial DNA. Phylogeny revealed closed genetic relatedness with other Indian isolates.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02522"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myiasis as a portal for fatal sepsis with Proteus vulgaris bacteremia","authors":"Kazushi Takayama,&nbsp;Yuko Ono,&nbsp;Taku Oshima","doi":"10.1016/j.idcr.2026.e02531","DOIUrl":"10.1016/j.idcr.2026.e02531","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02531"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}