IDCases最新文献 - Book学术

Nontuberculous mycobacterial infections in the setting of immune checkpoint inhibitor therapy: A case series. 免疫检查点抑制剂治疗下的非结核分枝杆菌感染：一个病例系列。

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IDCases Pub Date : 2026-09-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02746

Joelle N Friesen, Cassandra Braun, Ashley Egan

{"title":"Nontuberculous mycobacterial infections in the setting of immune checkpoint inhibitor therapy: A case series.","authors":"Joelle N Friesen, Cassandra Braun, Ashley Egan","doi":"10.1016/j.idcr.2026.e02746","DOIUrl":"10.1016/j.idcr.2026.e02746","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. While ICIs have shown efficacy across a range of malignancies, they have also been associated with immune-related adverse events (irAEs) and there is increasing concern that ICIs may predispose patients to opportunistic infections. We report six cases of clinically significant nontuberculous mycobacterial (NTM) infections occurring during or after ICI therapy. Key findings include the prevalence of underlying lung disease in patients diagnosed with NTM infection (including primary pulmonary malignancy or metastases), predominance of anti-PD-1/PD-L1 exposure in our cohort, wide range of NTM species identified, wide temporal windows between ICI therapy and NTM infection, and overall good outcomes after NTM-directed therapy with four of five patients who received NTM-directed therapy alive at one year after NTM diagnosis. We recommend that clinicians maintain a high index of suspicion for NTM infections in the differential for patients who have received ICI therapy and we recommend ongoing investigation into the potential correlation between ICI therapy and NTM infection.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02746"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13564049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy with cefiderocol and minocycline for Stenotrophomonas maltophilia bacteremia in an obese patient on maintenance hemodialysis: A case report. 头孢地罗和米诺环素联合治疗维持血液透析的肥胖患者嗜麦芽窄养单胞菌菌血症1例。

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IDCases Pub Date : 2026-08-31 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02742

Kosuke Kameda, Keisuke Sawada, Kuniaki Sano, Nobuyuki Suzuki, Natsue Honda, Kosuke Haruki

{"title":"Combination therapy with cefiderocol and minocycline for Stenotrophomonas maltophilia bacteremia in an obese patient on maintenance hemodialysis: A case report.","authors":"Kosuke Kameda, Keisuke Sawada, Kuniaki Sano, Nobuyuki Suzuki, Natsue Honda, Kosuke Haruki","doi":"10.1016/j.idcr.2026.e02742","DOIUrl":"10.1016/j.idcr.2026.e02742","url":null,"abstract":"Stenotrophomonas maltophilia bacteremia is associated with high mortality and multidrug resistance and has limited treatment options. Clinical evidence for cefiderocol (CFDC) and combination regimens remains scarce. Herein, we report a case of S. maltophilia bacteremia, which emerged following initial polymicrobial bloodstream, intra-abdominal, and pleural infections, successfully treated with a combination of CFDC and minocycline (MINO) in a man in his 40s. Faced with constraints such as obesity (body mass index, 35 kg/m2), maintenance hemodialysis, and a temporary CFDC shortage, the dosage was optimized stepwise based on pharmacokinetic principles and the dialysis modality, alongside appropriate source control. Bacterial clearance was achieved without recurrence. This case adds valuable clinical insight to the literature by suggesting that combination therapy with CFDC and MINO may serve as a feasible, safe, and effective therapeutic option for S. maltophilia bacteremia in obese patients undergoing maintenance hemodialysis. Additionally, it provides a practical example of a rational, pharmacokinetic/pharmacodynamic-based decision-making process under multiple concurrent constraints, including drug shortages and uncertain antimicrobial susceptibility. However, given the inherent limitations of a single case report, prospective pharmacokinetic studies and comparative clinical data are needed before generalized recommendations can be made.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02742"},"PeriodicalIF":0.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13564068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unresolving pneumonia in type 2 diabetes, think fungus: A case report of polymicrobial lung disease. 2型糖尿病难治性肺炎，疑为真菌：多微生物肺部疾病1例报告。

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IDCases Pub Date : 2026-08-31 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02743

Bob Rolex Opio, Benet Tumusime Kambale, Beatrice Achan

{"title":"Unresolving pneumonia in type 2 diabetes, think fungus: A case report of polymicrobial lung disease.","authors":"Bob Rolex Opio, Benet Tumusime Kambale, Beatrice Achan","doi":"10.1016/j.idcr.2026.e02743","DOIUrl":"10.1016/j.idcr.2026.e02743","url":null,"abstract":"Background: Polymicrobial pneumonia caused by multiple pathogens is increasingly recognized in immune compromised individuals with comorbidities such as type 2 diabetes mellitus (T2DM). The immunocompromised state associated with T2DM predisposes patients to polymicrobial opportunistic infections, including multidrug-resistant bacteria and fungi. Prompt laboratory diagnosis and organism-specific treatment are critical for optimal outcomes.Case presentation: We report the case of a 53-year-old male with newly diagnosed T2DM who presented with a three-month history of left-sided chest pain, dry cough, dyspnoea, and persistent fever. Initial empirical antibiotic therapy with intravenous ceftriaxone was ineffective. Computed tomography (CT) with contrast imaging revealed a massive loculated left pleural effusion with compressive atelectasis. Analysis of microbiological culture and sensitivity results revealed a polymicrobial infection involving multidrug-resistant Klebsiella pneumoniae, Enterobacter spp with inducible AmpC resistance, and fluconazole-susceptible dose dependent Candida glabrata. Based on the laboratory results, intravenous meropenem, high dose antifungal therapy, and subsequent oral fluconazole were recommended and led to successful treatment. Glycaemic control was concurrently optimized with insulin therapy and initial random blood sugar levels were 16.7 mmole per l, and at discharge was 9.3 mmoles per l.Conclusion: This case emphasizes the importance of considering polymicrobial infections in diabetic patients presenting with unresolving pneumonia. Early use of imaging and microbiological analysis of the pleural fluid enabled prompt identification of the polymicrobial causative organisms, guiding tailored antimicrobial therapy. Multidisciplinary management is essential in improving outcomes in such complex cases.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02743"},"PeriodicalIF":0.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13564053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffuse large B-cell lymphoma mimicking musculoskeletal nontuberculous mycobacterial infection: A fatal diagnostic challenge. 弥漫大b细胞淋巴瘤模拟肌肉骨骼非结核分枝杆菌感染：一个致命的诊断挑战。

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IDCases Pub Date : 2026-08-26 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02737

Seulki Kim, Su Jin Lee

{"title":"Diffuse large B-cell lymphoma mimicking musculoskeletal nontuberculous mycobacterial infection: A fatal diagnostic challenge.","authors":"Seulki Kim, Su Jin Lee","doi":"10.1016/j.idcr.2026.e02737","DOIUrl":"10.1016/j.idcr.2026.e02737","url":null,"abstract":"Background: Musculoskeletal infections caused by nontuberculous mycobacteria (NTM) can clinically and radiologically mimic malignant disorders. Accurate diagnosis requires correlation between microbiological, histopathological, and clinical findings. We report a case of diffuse large B-cell lymphoma (DLBCL) initially misdiagnosed as NTM infection based on polymerase chain reaction (PCR) positivity despite negative cultures.Case report: A 58-year-old man with diabetes mellitus and prior coronary artery bypass grafting presented with a progressively enlarging painful right flank mass. Magnetic resonance imaging (MRI) showed an infiltrative lesion involving multiple abdominal wall muscles and extension to the L2 vertebral body. Initial bone and soft tissue biopsies revealed chronic inflammation with necrosis. NTM PCR was positive; however, acid-fast bacillus (AFB) staining and culture were negative. Empirical antimycobacterial therapy was initiated.After three months, the lesion progressed, and repeat biopsy confirmed Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma, stage IV. The patient received six cycles of R-CHOP chemotherapy with an initial metabolic response on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), followed by early relapse despite salvage chemotherapy and palliative radiotherapy. He ultimately died of refractory lymphoma.Conclusions: This case underscores the importance of re-evaluating suspected NTM infection with negative cultures when the clinical course is atypical or unresponsive to therapy. PCR positivity alone, in the absence of microbiological culture confirmation and compatible clinicopathological findings, should not be considered sufficient to establish a diagnosis of NTM infection. Diagnostic anchoring to molecular test results without clinicopathological reassessment may lead to critical delays and death.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02737"},"PeriodicalIF":0.9,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of severe influenza-associated pulmonary aspergillosis with invasive tracheobronchitis and bronchial asthma using combination antifungals and omalizumab: A case report. 使用抗真菌药物和奥玛单抗联合成功治疗侵袭性气管支气管炎和支气管哮喘的严重流感相关肺曲霉病：1例报告

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IDCases Pub Date : 2026-08-26 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02740

Wei Du, Hong Lv, Yingmeng Ni, Yongjie Ding

{"title":"Successful treatment of severe influenza-associated pulmonary aspergillosis with invasive tracheobronchitis and bronchial asthma using combination antifungals and omalizumab: A case report.","authors":"Wei Du, Hong Lv, Yingmeng Ni, Yongjie Ding","doi":"10.1016/j.idcr.2026.e02740","DOIUrl":"10.1016/j.idcr.2026.e02740","url":null,"abstract":"Influenza-associated pulmonary aspergillosis (IAPA) is a secondary pulmonary aspergillosis following influenza, predominantly occurring in critically ill influenza patients requiring intensive care unit admission. It carries a high mortality rate, particularly in patients with invasive Aspergillus tracheobronchitis (IATB), where the fatality rate can reach up to 90%. This article reports a case of severe IAPA complicated by IATB and bronchial asthma and successfully treated with combination therapy of high dose antifungals and biologic. The patient had failed multiple antifungal therapies at another hospital and rapidly progressed to respiratory failure, necessitating endotracheal intubation before being transferred to our institution. Through a treatment regimen comprising a loading dose of caspofungin, triazole antifungals, inhaled amphotericin B, and omalizumab, the patient was successfully weaned off mechanical ventilation, extubated, and eventually discharged in improved condition. During treatment, voriconazole blood concentration was found to be extremely low, and CYP2C19 genotyping suggested a rare rapid/ultrarapid metabolizer variant.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02740"},"PeriodicalIF":0.9,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of immunosuppressants fails to clear hepatitis E virus infection in a heart transplant recipient. 减少免疫抑制剂不能清除心脏移植受者的戊型肝炎病毒感染。

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IDCases Pub Date : 2026-08-23 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02738

Zihao Chen, Wenxia Niu, Guanghui Li, Xianli Chen, Shuhua Chen, Kai Zhang, Mujin Fang, Yingbin Wang, Lijuan Fu, Zizheng Zheng, Ningshao Xia

{"title":"Reduction of immunosuppressants fails to clear hepatitis E virus infection in a heart transplant recipient.","authors":"Zihao Chen, Wenxia Niu, Guanghui Li, Xianli Chen, Shuhua Chen, Kai Zhang, Mujin Fang, Yingbin Wang, Lijuan Fu, Zizheng Zheng, Ningshao Xia","doi":"10.1016/j.idcr.2026.e02738","DOIUrl":"10.1016/j.idcr.2026.e02738","url":null,"abstract":"Hepatitis E virus (HEV) infection poses a significant public health burden in immunosuppressed individuals. Here, we report a 41-year-old male patient with a history of orthotopic heart transplantation, who develop HEV genotype 4 (subtype 4d) infection one-and-a-half-year post-transplantation. The patient exhibits a very weak anti-HEV IgG response. Abnormal liver function parameters persist for one month without evidence of clinical improvement. Therefore, the immunosuppressant dosage is halved to promote effective antiviral response. The anti-HEV IgG response gradually increases; however, abnormal liver function parameters persist into the second month, and HEV infection fails to clear. The patient is administered ribavirin at a dose of 600 mg/d, and by the third month, the viral load significantly decreases. By the fourth month, HEV infection is successfully cleared, liver function parameters returned to normal, and no viral reactivation is observed through the eighth month. This work highlights therapeutic approaches for managing HEV infection in solid organ transplantation (SOT) recipients.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02738"},"PeriodicalIF":0.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary diaphragmatic hydatid cyst: A rare location of echinococcosis. 原发性横膈膜包虫病：一种罕见的包虫病。

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IDCases Pub Date : 2026-08-22 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02734

Hazem Alouani, Ghazi Lâamiri, Hibetallah Ktata, Nada Ltifi, Mahdi Bouassida, Hassen Touinsi

{"title":"Primary diaphragmatic hydatid cyst: A rare location of echinococcosis.","authors":"Hazem Alouani, Ghazi Lâamiri, Hibetallah Ktata, Nada Ltifi, Mahdi Bouassida, Hassen Touinsi","doi":"10.1016/j.idcr.2026.e02734","DOIUrl":"10.1016/j.idcr.2026.e02734","url":null,"abstract":"Introduction: Hydatid disease most commonly affects the liver and lungs. Primary diaphragmatic involvement is exceptionally rare and often misdiagnosed as hepatic or pulmonary hydatidosis on imaging due to anatomic proximity.Case presentation: We report a 47-year-old Tunisian woman presenting with intermittent right hypochondrium pain. Laboratory tests and hydatid serology were normal. Computed tomography (CT) imaging revealed a cystic lesion at the dome of the right hemidiaphragm with close contact to the liver, raising suspicion of a hepatic-origin hydatid cyst. Surgical exploration through a right subcostal laparotomy revealed that the cyst arose primarily from the diaphragm, with no hepatic or pulmonary involvement. The cyst was excised completely without rupture. Postoperative recovery was uneventful, and no recurrence occurred during 18 months of follow-up.Discussion: Primary diaphragmatic hydatid cysts are rare, representing an unusual localization of Echinococcus granulosus. Preoperative imaging often leads to diagnostic confusion with hepatic dome cysts because precise diaphragmatic origin is difficult to establish. Surgical resection remains the treatment of choice. This case highlights the diagnostic challenges and the importance of intraoperative confirmation.Conclusion: Primary diaphragmatic hydatid cysts must be considered in endemic areas when cystic lesions arise near the hepatic dome. Accurate diagnosis is difficult preoperatively, and definitive localization is frequently established during surgery.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02734"},"PeriodicalIF":0.9,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiclass HIV drug resistance: Case series of treatment-experienced PLHIV with resistance to all antiretroviral classes in Northern Uganda. 多类艾滋病毒耐药：乌干达北部对所有抗逆转录病毒耐药的经过治疗的艾滋病毒感染者病例系列。

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IDCases Pub Date : 2026-08-20 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02736

Francis Kayinda, Lillian Betty Bakunzi, Edmund Okello, Charity Jurua, Esther M Nasuuna

{"title":"Multiclass HIV drug resistance: Case series of treatment-experienced PLHIV with resistance to all antiretroviral classes in Northern Uganda.","authors":"Francis Kayinda, Lillian Betty Bakunzi, Edmund Okello, Charity Jurua, Esther M Nasuuna","doi":"10.1016/j.idcr.2026.e02736","DOIUrl":"10.1016/j.idcr.2026.e02736","url":null,"abstract":"Introduction: Multiclass HIV drug resistance (HIVDR) is an emerging public health challenge in Uganda, especially among treatment-experienced individuals with long antiretroviral therapy (ART) histories. Resistance across nucleoside reverse transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRTI), protease inhibitors (PI), and integrase strand transfer inhibitors (INSTI) limits treatment options and threatens program sustainability. This study describes three cases of multiclass HIVDR in West-Nile region of Uganda.Methods: A descriptive case series was conducted among people living with HIV (PLHIV) with documented virological failure and confirmed resistance to all four ART classes between January 2023 and December 2024. HIVDR testing used next-generation sequencing, and resistance mutations were interpreted with Stanford HIVDR database. Clinical data were abstracted and analyzed descriptively.Results: Three cases were identified: two females (20 and 42 years) and one male (14 years), after approximately 10 years on ART. Shared factors included delayed viral load (VL) monitoring, prolonged exposure to failing regimens, delayed resistance testing and adherence challenges related to stigma and psychosocial barriers. All had been exposed to dolutegravir (DTG)-based regimens and developed intermediate-to-high level resistance to DTG alongside mutations in the other classes. Two cases achieved viral suppression < 1000 copies/ml on salvage therapy.Conclusion: These cases demonstrate that high-barrier drugs like DTG and Darunavir remain vulnerable when virological failure persists and adherence is suboptimal. Strengthening VL monitoring, access to genotypic testing and adherence support is essential to prevent Multiclass HIVDR.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02736"},"PeriodicalIF":0.9,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary polymicrobial infection of a giant nasal pyogenic granuloma with Pasteurella multocida: A case report. 巨鼻化脓性肉芽肿伴多杀性巴氏杆菌继发多微生物感染1例。

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IDCases Pub Date : 2026-08-19 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02729

Takahito Kimura, Eri Kimura, Hiroki Kuwazoe, Sachiko Hayata, Takashi Ozaki, Fumie Kaneko, Naoko Iwai-Kumashiro, Tetsuya Kinoshita, Tatsuya Shiga, Hideki Sakatani, Daichi Murakami, Muneki Hotomi, Masamitsu Kono

引用次数: 0

Detection of toxigenic Vibrio cholerae in a traveler with diarrhea lacking classic features, returning from Delhi, India. 从印度德里返回的一名腹泻旅客中检测出无典型特征的产毒霍乱弧菌。

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IDCases Pub Date : 2026-08-19 eCollection Date: 2026-01-01 DOI: 10.1016/j.idcr.2026.e02728

Ryo Mizushima, Masahiro Ishikane, Hidetoshi Nomoto, Masami Kurokawa, Eiji Arakawa, Hidemasa Izumiya, Yukihiro Akeda, Norio Ohmagari

{"title":"Detection of toxigenic Vibrio cholerae in a traveler with diarrhea lacking classic features, returning from Delhi, India.","authors":"Ryo Mizushima, Masahiro Ishikane, Hidetoshi Nomoto, Masami Kurokawa, Eiji Arakawa, Hidemasa Izumiya, Yukihiro Akeda, Norio Ohmagari","doi":"10.1016/j.idcr.2026.e02728","DOIUrl":"10.1016/j.idcr.2026.e02728","url":null,"abstract":"Cholera is an infectious disease caused by Vibrio cholerae which has caused several global pandemics since 1817. Currently, Japan is not a cholera-endemic country, and only a few cases of imported disease are reported annually. Vibrio cholerae is classified into more than 200 serogroups according to the differences in the O antigen on the cell surface, and only the O1 or O139 groups that produce cholera toxins are called cholera. We report a case in which toxigenic Vibrio cholerae O1 was detected in a 64-year-old Japanese traveler returning from Delhi, India, who presented with diarrhea without rice-water stools. Multiple potential diarrheal pathogens were simultaneously detected, including Clostridioides difficile toxin A/B and pathogenic Escherichia coli (E. coli) including enteroaggregative, enteropathogenic, and enterotoxigenic E. coli, making definitive attribution of symptoms to a single pathogen difficult by Genetic testing (BioFire FilmArray Gastrointestinal Panel). This case highlights the diagnostic uncertainty that arises with multiplex PCR-based stool testing: while such panels improve detection sensitivity, distinguishing true infection from colonization remains a clinical challenge. Clinicians should integrate laboratory findings with travel history and clinical course rather than relying solely on molecular test results.","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"45 ","pages":"e02728"},"PeriodicalIF":0.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0