IDCases最新文献

{"title":"Ictero-hemorrhagic leptospirosis -Weil’s disease","authors":"Johannes Heine , Benedikt Selbertinger , Benedicta Binder , Nadine Theissen , Stephan Schmid , Patricia Mester , Martina Müller , Vlad Pavel","doi":"10.1016/j.idcr.2026.e02515","DOIUrl":"10.1016/j.idcr.2026.e02515","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02515"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare co-occurrence of colon cancer and Gastrodiscoides hominis in a human host: A case report and literature review","authors":"Sandhya Chaurasiya ,&nbsp;Tuhina Banerjee ,&nbsp;Aakash Shah ,&nbsp;Anurag Tiwari","doi":"10.1016/j.idcr.2026.e02522","DOIUrl":"10.1016/j.idcr.2026.e02522","url":null,"abstract":"<div><div>A rising but underappreciated public health concern, gastrodiscoidiasis, is caused by a food-borne intestinal trematode. We report molecular identification of the parasite <em>Gastrodiscoides hominis,</em> from a patient of colon cancer, based on conserved ribosomal and mitochondrial DNA. Phylogeny revealed closed genetic relatedness with other Indian isolates.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02522"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myiasis as a portal for fatal sepsis with Proteus vulgaris bacteremia","authors":"Kazushi Takayama,&nbsp;Yuko Ono,&nbsp;Taku Oshima","doi":"10.1016/j.idcr.2026.e02531","DOIUrl":"10.1016/j.idcr.2026.e02531","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"43 ","pages":"Article e02531"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal ganglia cryptococcomas presenting as parkinsonism in an immunocompetent patient","authors":"Lorena Lucía Plazas Ruiz ,&nbsp;Paula Fernanda Arévalo-Carvajal ,&nbsp;Lorena García Agudelo ,&nbsp;Daniela Arias Mariño","doi":"10.1016/j.idcr.2026.e02592","DOIUrl":"10.1016/j.idcr.2026.e02592","url":null,"abstract":"<div><div>Cryptococcal disease typically presents as meningitis in immunocompromised hosts, whereas basal ganglia cryptococcomas causing parkinsonism in immunocompetent patients are uncommon and easily overlooked. We describe a 61-year-old apparently immunocompetent man with subacute meningoencephalitis, abnormal cerebrospinal fluid (CSF), and a pulmonary nodule initially managed as tuberculous meningitis, who subsequently developed severe asymmetric parkinsonism. Neuroimaging later demonstrated diffuse leptomeningeal enhancement and multiple basal ganglia and brainstem cryptococcomas and repeat CSF and lung biopsy confirmed cryptococcosis. Opening CSF pressure was elevated (24 cm H2O). Induction therapy consisted of liposomal amphotericin B (4 mg/kg/day) for two weeks, followed by high-dose fluconazole consolidation; flucytosine was not available in our institution. Despite guideline-oriented antifungal therapy and a levodopa trial, parkinsonism persisted, suggesting possible structural nigrostriatal injury; however, long-term follow-up and functional imaging were not available to confirm irreversibility. Serial CSF findings summarized (Table 1) highlight the importance of repeated lumbar punctures and targeted mycological testing in subacute meningitis with nondiagnostic initial studies. To contextualize this presentation, we reviewed previously reported cases of cryptococcal parkinsonism (Table 2), which delineate a spectrum from fully reversible to <span>L</span>-dopa–responsive or permanently disabling syndromes, largely determined by the extent and localization of basal ganglia involvement and timeliness of treatment. This integrated case and literature review emphasizes that cryptococcosis should be systematically considered in atypical or rapidly progressive parkinsonism with inflammatory CSF and basal ganglia lesions, even in apparently immunocompetent hosts, and underscores the need for early recognition, comprehensive evaluation of pulmonary and CNS disease, and prolonged antifungal therapy to prevent irreversible neurological sequelae.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02592"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilocular hepatic echinococcosis mimicking hepatic malignancy in a child: A diagnostic dilemma","authors":"Rupayan Kundu ,&nbsp;Himanshi Batra ,&nbsp;Anmol Kasera ,&nbsp;Akhila Prasad ,&nbsp;Akanksha Yadav ,&nbsp;Ankit Batra","doi":"10.1016/j.idcr.2026.e02596","DOIUrl":"10.1016/j.idcr.2026.e02596","url":null,"abstract":"<div><div>Multilocular (alveolar) hepatic echinococcosis is an uncommon parasitic disease that may closely resemble malignant hepatic tumors because of its infiltrative growth pattern and complex internal architecture. The condition is rare in India and is therefore frequently misdiagnosed, particularly in pediatric patients. Early and accurate diagnosis is essential, as treatment strategies differ markedly from those of hepatic malignancies and pyogenic infections. We report the case of a 13-year-old boy who presented with a four-month history of intermittent fever and right upper abdominal pain. Initial ultrasonography revealed a complex multiloculated hepatic lesion with internal septations and mass effect at the hepatic hilum, raising concern for a mesenchymal tumor. Contrast-enhanced computed tomography demonstrated a large multiloculated cystic mass with enhancing septa and peripheral walls, without solid enhancing nodules. Magnetic resonance imaging further characterized the lesion, showing T2-hyperintense cystic cavities, T2-hypointense septa, and diffusion restriction confined to the septa and peripheral walls, a pattern favoring echinococcal disease over abscess or malignancy. Serological testing confirmed hepatic echinococcosis. The patient was treated conservatively with albendazole, resulting in clinical improvement and interval reduction in lesion size on follow-up imaging. This case highlights the importance of multimodality imaging, particularly MRI with diffusionweighted sequences, in differentiating multilocular echinococcosis from malignant hepatic masses and avoiding unnecessary invasive procedures.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02596"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streptococcus Equi: A rare cause of cellulitis and bacteremia in human","authors":"Mayesha Sharaf,&nbsp;Arman Manjikian,&nbsp;Rakahn Haddadin,&nbsp;Michael Ghobrial,&nbsp;Victoria Diaz,&nbsp;Li-chien Chen","doi":"10.1016/j.idcr.2026.e02605","DOIUrl":"10.1016/j.idcr.2026.e02605","url":null,"abstract":"<div><div><em>Streptococcus equi</em> species is known to cause diseases in horses and other animals. This species, however, is a rare human pathogen and transmission usually occurs via direct interaction with horses or other domestic animal or unpasteurized dairy consumption. Reports of <em>S. equi</em> infections in human are relatively rare in the United States compared to the higher incidences in Europe. However, more and more cases of <em>S. equi</em> have been reported in the US as equine activities are gaining popularity. Whereas <em>Streptococcus equi</em> can involve any organ system, cellulitis caused by <em>Streptococcus equi</em> is hardly ever reported. As skin and soft tissue infection by <em>Streptococcus equi</em> is so rare and can pose fatal outcomes, it is imperative to keep this rare pathogen as a microbiologic differential of skin and soft tissue infection. We present a case of <em>Streptococcus equi</em> cellulitis and bacteremia in a patient with horse exposure<em>.</em> Considering how popular equine sports are becoming, <em>Streptococcus equi</em> infections are probably more widespread than we realize.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02605"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive Pasteurella multocida rhinosinusitis with orbital extension in a patient with liver cirrhosis: A case report and literature review","authors":"Kohei Kawabata ,&nbsp;Daichi Murakami ,&nbsp;Mai Miyamoto ,&nbsp;Taku Fujishiro ,&nbsp;Takuma Okada ,&nbsp;Chishin Yohda ,&nbsp;Fumiya Kitamura ,&nbsp;Ryo Ueda ,&nbsp;Muneki Hotomi ,&nbsp;Masamitsu Kono","doi":"10.1016/j.idcr.2026.e02549","DOIUrl":"10.1016/j.idcr.2026.e02549","url":null,"abstract":"<div><div><em>Pasteurella multocida</em> often causes skin and soft tissue infections associated with animal bites and scratches. However, aggressive respiratory tract infections without animal exposure have been reported in immunocompromised hosts. We report the case of a Japanese woman in her early 80 s with liver cirrhosis that developed acute rhinosinusitis caused by <em>P. multocida</em> without animal-related wounds. She presented with swelling and redness of the left eyelid, and subsequently developed decreased vision and impaired eye movement. Imaging studies revealed an ethmoid sinus abscess with a bony defect of the medial orbital wall and extension into the orbit. Emergency drainage by endoscopic sinus surgery led to complete resolution of the decreased vision and impaired eye movement. A strain of <em>P. multocida</em> was identified from the purulent discharge. To the best of our knowledge, this is the first reported case of aggressive <em>Pasteurella</em> rhinosinusitis with orbital extension. It suggests that <em>P. multocida</em> can cause invasive rhinosinusitis in immunocompromised hosts such as those with liver cirrhosis, and it demonstrates a potential osteolytic effect upon the paranasal bony structure.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02549"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147451679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report","authors":"Annie M. Geiger ,&nbsp;William J. House ,&nbsp;Armando Paez","doi":"10.1016/j.idcr.2026.e02526","DOIUrl":"10.1016/j.idcr.2026.e02526","url":null,"abstract":"<div><div>Human herpesvirus 6 (HHV-6) is a ubiquitous DNA virus most frequently associated with roseola infantum and implicated in encephalitis among immunocompromised patients. Notably, it can integrate into human telomeres, contributing to diagnostic complexities. Although herpes simplex virus is a recognized trigger of autoimmune encephalitis, a comparable relationship for HHV-6 remains unconfirmed. We present a case of a previously healthy 19-year-old woman who presented with altered mental status. Lumbar puncture revealed HHV-6 by polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF), and brain magnetic resonance imaging (MRI) findings were normal. Further testing confirmed anti- N-methyl-<span>D</span>-aspartate (NMDA) receptor antibodies in the serum and CSF. HHV-6 serum viral load testing resulted in over 2 million copies/mL, and chromosomal integration of HHV-6 was later confirmed. Four months after diagnosis, the patient’s cognition was approaching their prior baseline. This case underscores the importance of investigating alternative etiologies of encephalitis in immunocompetent patients with detectable HHV-6 DNA in the CSF. Our report further highlights a potential association between HHV-6B and anti-NMDA receptor encephalitis, even under chromosomal integration.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02526"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147451686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-standing, multifocal Tuberculosis verrucosa cutis: Undiagnosed for 40 years","authors":"Seblewengel Maru Wubalem ,&nbsp;Helina Melis Kefetew ,&nbsp;Saada Yasin Abduselam ,&nbsp;Shemsu Abraham Hussien","doi":"10.1016/j.idcr.2026.e02568","DOIUrl":"10.1016/j.idcr.2026.e02568","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) is a chronic infectious disease primarily affecting the lungs, with extrapulmonary TB comprising 20% of cases. Among these, cutaneous TB (CTB) accounts for 1–2%, often overlooked due to its rarity and varied presentations. This report highlights an unusual case of Tuberculosis verrucosa cutis (TVC)</div></div><div><h3>Case presentation</h3><div>A 60-year-old male, presented with non-healing skin lesion that remained undiagnosed for 40 years. The lesion, which involved multiple areas of the body, exhibited large annular plaques with indurated edges and atrophic scars. Diagnosis was made through a detailed clinical history and examination, confirmed by fine-needle aspiration cytology (FNAC), which revealed necrotizing granulomatous inflammation. The patient responded well to anti-TB treatment, showing significant improvement within two months.</div></div><div><h3>Conclusion</h3><div>This case underscores the importance of clinical suspicion in diagnosing CTB, particularly in endemic regions, and suggests that FNAC is a valuable diagnostic tool in resource-limited settings.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02568"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147657517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox with painless anogenital and palmar lesions","authors":"Kota Yoshida ,&nbsp;Takamasa Ishiuchi ,&nbsp;Satoshi Kutsuna","doi":"10.1016/j.idcr.2026.e02561","DOIUrl":"10.1016/j.idcr.2026.e02561","url":null,"abstract":"","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"44 ","pages":"Article e02561"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147657519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}