IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02152

Hrithik Dakssesh Putta Nagarajan , Balakrishnan Kamaraj , Keerthivasan Selvanathan , Shubham Kumar , Shilpa Gaidhane , Sanjit Sah , Prakasini Satapathy , Rachana Mehta , Rodrigue Ndabashinze , Amogh Verma

引用次数: 0

Elizabethkingia meningoseptica: Case report on an emerging pathogen and its associated treatment challenges 伊莉莎白脑膜炎败血症：一种新出现的病原体及其相关治疗挑战的病例报告

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02248

Fabrizio Tropea , David Fraulino , Jeffrey Aeschlimann , P. Rocco LaSala , Sonia Magano

{"title":"Elizabethkingia meningoseptica: Case report on an emerging pathogen and its associated treatment challenges","authors":"Fabrizio Tropea , David Fraulino , Jeffrey Aeschlimann , P. Rocco LaSala , Sonia Magano","doi":"10.1016/j.idcr.2025.e02248","DOIUrl":"10.1016/j.idcr.2025.e02248","url":null,"abstract":"<div><div><em>Elizabethkingia meningoseptica</em> is a Gram-negative bacillus that was previously thought to rarely infect humans but recently has been identified as an emerging pathogen in both community and nosocomial settings. Typically found in the environment, this organism has been shown to infect predisposed hosts with an immunocompromised status and/or a prolonged exposure to healthcare settings. Herein, we report a case of a 78-year-old male with newly diagnosed myelodysplastic syndrome initially admitted to the hospital with pneumonia and then re-admitted after discharge with septic shock and evidence of <em>E. meningoseptica</em> bacteremia isolated from blood cultures. Treatment with piperacillin-tazobactam was initiated and later escalated to dual-therapy with the addition of levofloxacin. After hemodynamic stability was achieved, the patient was discharged on oral levofloxacin to complete a 21-day course of therapy. <em>E. meningoseptica</em> displays a unique multi-drug resistant profile that often makes initial antimicrobial selection challenging. This case illustrates the importance of early detection and use of in vitro susceptibility testing to guide therapeutic decision-making in <em>E. meningoseptica</em> infections; a pathogen known to have both high morbidity and mortality particularly in the immunocompromised.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02248"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of sofosbuvir induced drug eruption and literature review 索非布韦致药疹1例报告并文献复习

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02249

Anyue Xia , Jinliang Liu , Cuilan Tang , Huan Xu

引用次数: 0

Nodular reverse halo sign in a hemodialysis patient with polycystic kidney disease and pulmonary tuberculosis 多囊肾病合并肺结核的血液透析患者的结节性反晕征

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02246

Guo Li , Shan Yuan , Peng Wang , Min Pang , Xianqiong Pang

引用次数: 0

Testicular schistosomiasis in a 5-year-old male Ethiopian child: A rare case report 埃塞俄比亚1例5岁男童睾丸血吸虫病：罕见病例报告

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02235

Hiwot Mehari Beyene , Zenebe Daniel Getachew , Adugnaw Atnafu Atalay , Selamawit Tadesse Wendimagegn , Zeru Seyoum Wondimagegn

引用次数: 0

Corynebacterium striatum as a rare cause of septic arthritis in a native joint: A case report and review of the literature 纹状棒状杆菌作为一种罕见的原因，败血性关节炎在天然关节：一个病例报告和文献复习

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02275

Sakthi Gautham , Kaushik Kumar , Shiavax J. Rao

{"title":"Corynebacterium striatum as a rare cause of septic arthritis in a native joint: A case report and review of the literature","authors":"Sakthi Gautham , Kaushik Kumar , Shiavax J. Rao","doi":"10.1016/j.idcr.2025.e02275","DOIUrl":"10.1016/j.idcr.2025.e02275","url":null,"abstract":"<div><div>Septic arthritis commonly occurs due to gram-positive cocci and usually presents as acute monoarticular swelling and tenderness, often associated with systemic signs of sepsis. In rare scenarios, <em>Corynebacterium striatum,</em> a gram-positive bacillus, can cause septic arthritis. We present a rare case of native joint septic arthritis caused by <em>C. striatum</em> in an immunocompetent patient. A 74-year-old man with history of ESRD receiving HD presented with hematuria. He was found to have anemia and pyuria and was admitted for management of hematuria and UTI with ceftriaxone. Five days later, he developed new persistent fever and worsening leukocytosis, while receiving antibiotics. Examination revealed right knee swelling, erythema, and tenderness, with decreased range of motion. X-ray showed joint effusion for which he underwent right knee arthrocentesis and aspiration. Synovial fluid culture grew <em>C. striatum</em>, initially disregarded as a contaminant. Repeat cultures again grew <em>C. striatum</em>. He was treated with IV vancomycin and oral colchicine along with arthroscopic irrigation and debridement, and discharged on a 4-week course of vancomycin. <em>C. striatum</em> is typically a considered pathogen in immunocompromised individuals; however, emerging reports describe its role in infections among immunocompetent hosts. While <em>C. striatum</em> remains a rare cause of native joint septic arthritis, its isolation in multiple specimens in the appropriate clinical context should prompt clinicians to consider a true infection rather than contamination. Prompt identification and appropriate management is key to improving patient outcomes. Susceptibility testing helps guide targeted treatment for this emerging pathogen with increasing multi-drug resistance.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02275"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculous pericarditis in a 71-year-old immunocompetent patient: Case report 一名 71 岁免疫功能正常患者的结核性心包炎：病例报告。

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2024.e02122

Carlos Mejia Irias , Odalis Cerrato , Estephany Díaz Mairena

{"title":"Tuberculous pericarditis in a 71-year-old immunocompetent patient: Case report","authors":"Carlos Mejia Irias , Odalis Cerrato , Estephany Díaz Mairena","doi":"10.1016/j.idcr.2024.e02122","DOIUrl":"10.1016/j.idcr.2024.e02122","url":null,"abstract":"<div><div>Tuberculosis is a transmissible disease caused by the bacterium <em>Mycobacterium tuberculosis</em>. It is the leading cause of mortality due to infectious diseases. Tuberculous pericarditis is one of the manifestations of extrapulmonary tuberculosis and represents the primary cause of pericardial effusion in developing countries. We present the case of a 71-year-old male patient with a history of 1 month of dyspnea, accompanied by paroxysmal nocturnal dyspnea and unintentional weight loss. An echocardiogram revealed the presence of severe pericardial effusion, for which pericardiocentesis was performed, and the pericardial fluid was analyzed using the Xpert MTB/RIF test, which confirmed the presence of <em>Mycobacterium tuberculosis</em> without resistance to Rifampicin. This is a case of Tuberculous Pericarditis as the cause of pericardial effusion, in which the etiological diagnosis was made possible through molecular biological analysis of the pericardial fluid. The importance of disseminating such cases lies in emphasizing that, even in the 21st century, in developing countries like Honduras, it is crucial not to dismiss tuberculosis infection, as it remains the leading cause of pericardial effusion in endemic regions.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02122"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe dual fungal infection after bispecific antibody therapy: A case of invasive aspergillosis and mucormycosis in immunocompromised patient 双特异性抗体治疗后严重双重真菌感染：免疫功能低下患者侵袭性曲霉病和毛霉病1例。

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2024.e02140

Sarah Sakalihasan , Frédéric Lifrange , Mathieu Czajkowski , Veronique Goncette , Bernard Duysinx , Pierre Lovinfosse , Damla Can , Raphael Schils , Marie-Pierre Hayette , Adrien De Voeght

{"title":"Severe dual fungal infection after bispecific antibody therapy: A case of invasive aspergillosis and mucormycosis in immunocompromised patient","authors":"Sarah Sakalihasan , Frédéric Lifrange , Mathieu Czajkowski , Veronique Goncette , Bernard Duysinx , Pierre Lovinfosse , Damla Can , Raphael Schils , Marie-Pierre Hayette , Adrien De Voeght","doi":"10.1016/j.idcr.2024.e02140","DOIUrl":"10.1016/j.idcr.2024.e02140","url":null,"abstract":"<div><div>Bispecific antibody is a new treatment for hematological disease, especially for lymphoma, myeloma and acute lymphoblastic leukemia. This class of treatment presents the same kind of side effect as CAR-T cell which are immune-mediated. Nevertheless, infectious complication remains a major concerns with related mortality. Fungal infection are rarely reported in clinical trial but remains a major concern. We report a case of a co-infection of <em>Aspergillus</em> and <em>Mucorales</em> in a patient with diffuse large B-cell lymphoma (DLBCL) following treatment with the bispecific antibody epcoritamab. The patient developed severe cytokine release syndrome (CRS) and subsequent fungal infections, which were challenging to diagnose and treat due to the complexities of managing immunocompromised patients and co-infection. Advanced diagnostics, including PET-CT, and a combination of antifungal therapies were crucial in achieving remission. The case underscores the need for early diagnosis, multidisciplinary management, and innovative treatment strategies in similar high-risk patients.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02140"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspergillus fumigatus pericarditis: A rare case in a lupus patient 烟曲霉心包炎：一例罕见的狼疮患者。

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02151

Yousra Sbibih , Abderrazak Saddari , Said Ezrari , Elmostapha Benaissa , Yassine Ben Lahlou , Aziza Hami , Mostafa Elouennass , Adil Maleb

{"title":"Aspergillus fumigatus pericarditis: A rare case in a lupus patient","authors":"Yousra Sbibih , Abderrazak Saddari , Said Ezrari , Elmostapha Benaissa , Yassine Ben Lahlou , Aziza Hami , Mostafa Elouennass , Adil Maleb","doi":"10.1016/j.idcr.2025.e02151","DOIUrl":"10.1016/j.idcr.2025.e02151","url":null,"abstract":"<div><div>Pericardial aspergillosis is a rare but potentially fatal opportunistic infection primarily affecting immunocompromised patients. Diagnosis is challenging due to nonspecific clinical manifestations and difficulties in obtaining definitive microbiological confirmation. Risk factors include immunosuppressive therapies, hematologic malignancies, and solid organ transplantation. While pulmonary involvement is most common, cardiac manifestations such as pericarditis are infrequent and often diagnosed post-mortem. We report a case of <em>Aspergillus fumigatus</em> pericarditis in a 45-year-old female with systemic lupus erythematosus on corticosteroids, presenting with dyspnea, hypotension, and pancytopenia. Diagnostic work-up revealed a large pericardial effusion with subsequent identification of <em>Aspergillus fumigatus</em> in pericardial fluid cultures despite initial negative results. Prompt initiation of empirical antifungal therapy led to clinical improvement, underscoring the importance of early recognition and aggressive management in similar cases. This case highlights the complexities of managing fungal pericarditis and underscores the need for heightened clinical suspicion and tailored therapeutic approaches in immunocompromised patients.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02151"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report 水痘带状疱疹病毒引发成人过敏性紫癜1例报告

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02174

Kevin Chung , Natasha Priya Dyal , Sandhya Nagarakanti

{"title":"Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report","authors":"Kevin Chung , Natasha Priya Dyal , Sandhya Nagarakanti","doi":"10.1016/j.idcr.2025.e02174","DOIUrl":"10.1016/j.idcr.2025.e02174","url":null,"abstract":"<div><div>This case reports highlights a 37-year-old woman who was transferred to Mayo Clinic Arizona for care after development of seizures, altered mental status, and a diffuse petechial rash, along with vesicular lesions near the groin. She received broad-spectrum antimicrobial therapy. CSF testing showed lymphocytic pleocytosis and elevated protein levels, and PCR testing confirmed varicella zoster virus (VZV) infection. MRI of the brain demonstrated chronic microhemorrhages, indicative of vasculitis secondary to disseminated VZV. Dermatology consultation and subsequent biopsy of the skin lesions revealed leukocytoclastic vasculitis with IgA deposition, consistent with Henoch-Schonlein Purpura (HSP). A VZV-positive PCR from the rash further corroborated the diagnosis. This case highlights the first reported instance of VZV induced HSP in an adult. Although this patient had no complications from HSP, early recognition and targeted treatment are necessary in some cases to prevent severe conditions. This case underscores the importance of maintaining a broad differential diagnosis and the importance of biopsy lesions for prompt recognition of uncommon conditions in high-risk patients.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02174"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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