IDCases最新文献_第5页

Necrotizing soft tissue infection due to Nocardia brasiliensis in an immunocompetent host

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02162

Malleswari Ravi , Denis Asiimwe , Virin Ramoutar

引用次数: 0

Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02175

Ruth C. Angrand , Lauren Telesca , Muhammad Aslam

引用次数: 0

Unresolved fever in methicillin-sensitive Staphylococcus aureus bacteremia: Insights from a case without an identifiable source

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02183

Moiz Topiwala , Mahender Kumar Medisetty , Deependra Verma , Sanjay Yadav

{"title":"Unresolved fever in methicillin-sensitive Staphylococcus aureus bacteremia: Insights from a case without an identifiable source","authors":"Moiz Topiwala , Mahender Kumar Medisetty , Deependra Verma , Sanjay Yadav","doi":"10.1016/j.idcr.2025.e02183","DOIUrl":"10.1016/j.idcr.2025.e02183","url":null,"abstract":"<div><h3>Background</h3><div>Methicillin-sensitive <em>Staphylococcus aureus</em> (MSSA) bacteremia is a serious infection that requires timely diagnosis and treatment to prevent complications. Persistent fever after clearing bacteremia is uncommon, especially with normal inflammatory markers and no clear source of infection. This presents a significant diagnostic and management challenge.</div></div><div><h3>Case presentation</h3><div>A 36-year-old man presented with a three-day history of intermittent fever and was diagnosed with MSSA bacteremia. Initial investigations revealed mild splenomegaly. Despite treatment with intravenous flucloxacillin and negative repeat blood cultures, the fever persisted, prompting further evaluation. Advanced imaging did not reveal the source of infection. After completing a 14-day course of flucloxacillin, the fever resolved, and the patient recovered completely.</div></div><div><h3>Conclusion</h3><div>This case highlights the challenges in managing MSSA with persistent fever and no clear source of infection. This emphasizes the importance of adhering to evidence-based therapy and thorough evaluations, even when clinical presentations deviate from the typical course.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02183"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 induced abducens nerve palsy: A case report and response to methylprednisolone

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02201

João Hugo Abdalla Santos , Ligia Fernandes Abdalla , Cleitiene de Souza Sierpinski , Camila Feldberg Porto , Felipe Gomes Naveca

{"title":"SARS-CoV-2 induced abducens nerve palsy: A case report and response to methylprednisolone","authors":"João Hugo Abdalla Santos , Ligia Fernandes Abdalla , Cleitiene de Souza Sierpinski , Camila Feldberg Porto , Felipe Gomes Naveca","doi":"10.1016/j.idcr.2025.e02201","DOIUrl":"10.1016/j.idcr.2025.e02201","url":null,"abstract":"<div><h3>Introduction</h3><div>The abducens nerve (sixth cranial nerve) is a motor nerve that innervates the lateral rectus muscle, playing a key role in ocular abduction. Palsy of this nerve leads to convergent strabismus and diplopia. Common causes include strokes, trauma, inflammation, and infections, though in some cases, the etiology remains undetermined. With the emergence of COVID-19, neurological manifestations such as cranial neuropathies, including abducens nerve palsy, have been reported.</div></div><div><h3>Case presentation</h3><div>We present a case of a previously healthy 48-year-old male diagnosed with SARS-CoV-2 infection who developed abducens nerve palsy in the left eye. Following the resolution of respiratory symptoms, strabismus persisted. Treatment with methylprednisolone was initiated, resulting in partial recovery within one week and complete resolution after three months.</div></div><div><h3>Conclusion</h3><div>SARS-CoV-2-induced abducens nerve palsy can be reversible with conservative treatment using methylprednisolone. Early recognition and appropriate management are crucial for achieving a favorable prognosis.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02201"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report: Persistent COVID-19 in a patient with B cell lymphoma refractory to antiviral treatment due to resistance to Remdesivir

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02199

Luiz Eduardo Ceccon Calil de Assumpção , Bruno Graciano Ponce Romeo , João Carlos de Campos Guerra , Luis Fernando Aranha Camargo , Marcelo Akira Nagaoka , Deyvid Emanuel Amgarten , Erick Gustavo Dorlass , Roberta Cardoso Petroni , Afonso Celso Almeida Cardoso , Renato de Mello Ruiz , Carolina Devite Bittante , Vanessa Damazio Teich , João Renato Rebello Pinho , André Mario Doi

{"title":"Case report: Persistent COVID-19 in a patient with B cell lymphoma refractory to antiviral treatment due to resistance to Remdesivir","authors":"Luiz Eduardo Ceccon Calil de Assumpção , Bruno Graciano Ponce Romeo , João Carlos de Campos Guerra , Luis Fernando Aranha Camargo , Marcelo Akira Nagaoka , Deyvid Emanuel Amgarten , Erick Gustavo Dorlass , Roberta Cardoso Petroni , Afonso Celso Almeida Cardoso , Renato de Mello Ruiz , Carolina Devite Bittante , Vanessa Damazio Teich , João Renato Rebello Pinho , André Mario Doi","doi":"10.1016/j.idcr.2025.e02199","DOIUrl":"10.1016/j.idcr.2025.e02199","url":null,"abstract":"<div><h3><em>Background</em></h3><div>There is a significant concern of the pandemic impact of SARS-CoV-2 infection in immunocompromised patients. These patients can develop long COVID-19 due to impairment of cellular and humoral immunity. On the other hand, prolonged infection can lead to mutations in the SARS CoV-2 genome that can impact on the resistance to antiviral therapy. Remdesivir cases have been reported in patients receiving antiviral drug treatment.</div></div><div><h3>Case presentation</h3><div>A 46-year-old male with previous mantle cell lymphoma resolved by autologous bone marrow transplantation without other comorbidities had SARS-CoV-2 detected in February 2022 and received the recommended antiviral treatment with Remdesivir. COVID-19 evolved in four months with worsening of the symptoms, despite an initial rapid improvements and high RT-PCR Ct values. The patient was relieved from hospital care stable and well but still maintaining positive test results.</div></div><div><h3>Conclusions</h3><div>the patient presented prolonged COVID-19 with persistence of virus detected by RT-PCR for several months. The strain sequenced presented a mutation different from all reported previously. Although it was no possible to sequence the initial strain without these mutations, our data suggests that immunocompromised patient with prolonged COVID-19 may serve as reservoir for strains of SARS-CoV-2 with resistant components in his genome.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"40 ","pages":"Article e02199"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prosthetic joint infection as an unusual presentation of Francisella tularensis causing exposure of laboratory personnel

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02195

Huma Aftab , Aoife Ronayne , Anders El-Galaly , Camilla Foged , Kristian Schønning

{"title":"Prosthetic joint infection as an unusual presentation of Francisella tularensis causing exposure of laboratory personnel","authors":"Huma Aftab , Aoife Ronayne , Anders El-Galaly , Camilla Foged , Kristian Schønning","doi":"10.1016/j.idcr.2025.e02195","DOIUrl":"10.1016/j.idcr.2025.e02195","url":null,"abstract":"<div><h3>Background</h3><div>Infections with <em>Francisella tularensis</em> subsp. <em>tularensis</em> (type A) is highly virulent with mortality up to 30 % in untreated cases. <em>Francisella tularensis</em> subsp. <em>holarctica</em> (type B) is both less infectious and virulent. Physicians/clinicians are often unfamiliar with epidemiological and clinical characteristics of tularaemia. <em>F. tularensis</em> type A has caused laboratory-acquired infections therefore diagnostic laboratories should be notified of samples from patients with suspected tularaemia, but breaches of laboratory safety measures still occur as tularaemia is not always recognised as a potential differential diagnosis.</div></div><div><h3>Case presentation</h3><div>A 70-year-old male with a history of type-2 diabetes and a primary total knee arthroplasty (TKA) 18 years earlier, was hospitalized with pneumonia in July 2024. The respiratory symptoms resolved on piperacillin-tazobactam, however the patient reported chronic pain in his TKA on admission, and these symptoms persisted. In August 2024 the TKA was replaced, and <em>Francisella tularensis</em> was cultured from the periprosthetic tissue samples. Since tularaemia was not suspected, and the microbiological laboratory not alerted, two laboratory scientists were potentially exposed to <em>Francisella</em> bacteria. One of the two medical laboratory scientists received post-exposure antibiotic prophylaxis, neither developed infection.</div></div><div><h3>Conclusion</h3><div>We present the first reported case of periprosthetic joint associated <em>F. tularensis</em> infection in Denmark. Unexpected culture of <em>F. tularensis</em> may be accompanied by pathogen exposure of laboratory personnel that generate concern and anxiety. Most laboratory associated infections are caused by <em>F. tularensis</em> type A, thus guidelines taking subspecies virulence and infectivity into consideration may be relevant, especially in a European context.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02195"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of discordant Chikungunya manifestations in a married couple: From acute undifferentiated fever to fatal sepsis with purpura fulminans

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02182

Ditthawat Pathomchareansukchai , Navin Horthongkham , Pinyo Rattanaumpawan

引用次数: 0

An uncommon cause of osteomyelitis: Serratia fonticola A rare pathogen in human infections 一种罕见的引起骨髓炎的原因：fonticola沙雷菌一种在人类感染中罕见的病原体。

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2024.e02131

Sirine Ahmad , Mohammed Alsaeed

引用次数: 0

Acute gonococcal urethritis

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2024.e02130

H. Shatikkulamin , Chandana Shajil

引用次数: 0

A case of W. chitiniclastica bacteremia in a 38-year-old homeless male originating from a maggot-infested amputated foot

IF 1.1

IDCases Pub Date : 2025-01-01 DOI: 10.1016/j.idcr.2025.e02146

Ashlyn Lipnicky , Praveen Subramanian , Wissam El Atrouni

{"title":"A case of W. chitiniclastica bacteremia in a 38-year-old homeless male originating from a maggot-infested amputated foot","authors":"Ashlyn Lipnicky , Praveen Subramanian , Wissam El Atrouni","doi":"10.1016/j.idcr.2025.e02146","DOIUrl":"10.1016/j.idcr.2025.e02146","url":null,"abstract":"<div><div><em>Wohlfahrtiimonas</em> (<em>W.</em>) <em>chitiniclastica</em> was first isolated from the larval stage of the fly vector <em>Wohlfahrtia magnifica.</em> It is a gram-negative, non-motile, strictly aerobic rod that thrives in temperatures between 28º C and 37º C. Its strong chitinase activity aids in metamorphosis, which suggests a symbiotic relationship with the fly. Although rare, <em>W. chitiniclastica</em> has been implicated in human infections, like bacteremia and osteomyelitis, typically transmitted through fly larvae in skin wounds. Over the past decade, there have been 12 documented human infections, including five confirmed cases of bacteremia. We present a case involving a 38-year-old homeless male with <em>W. chitiniclastica</em> bacteremia secondary to maggot-infested wounds. The patient had a medical history of late latent syphilis and previous frostbite requiring right transmetatarsal amputation and presented with a stump infection on the right foot, featuring maggots. He was afebrile with stable signs and blood cultures revealed <em>W. chitiniclastica</em>. The pathogen was susceptible to various antibiotics, including cefepime, piperacillin/tazobactam, meropenem, trimethoprim-sulfamethoxazole, and levofloxacin. The patient was treated with piperacillin/tazobactam and later transitioned to oral trimethoprim-sulfamethoxazole but left against medical advice. This case underscores the intersection of infectious diseases and social inequalities, highlighting the need for clinicians to consider <em>W. chitiniclastica</em> in patients with poor hygiene, alcoholism, peripheral vascular disease, and open wounds. It also emphasizes the dual role of maggots in wound care, capable of both cleaning necrotic tissue and introducing pathogenic bacteria.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"39 ","pages":"Article e02146"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0