Journal of Taibah University Medical Sciences最新文献

{"title":"Evaluation of the effects of a dasatinib-containing, self-emulsifying, drug delivery system on HT29 and SW420 human colorectal carcinoma cells, and MCF7 human breast adenocarcinoma cells","authors":"","doi":"10.1016/j.jtumed.2024.07.002","DOIUrl":"10.1016/j.jtumed.2024.07.002","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000647/pdfft?md5=5b4386f108c575f1c129e8c366b55b07&pid=1-s2.0-S1658361224000647-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualization and establishment of value-based healthcare in Saudi Arabia: A scoping review","authors":"","doi":"10.1016/j.jtumed.2024.07.008","DOIUrl":"10.1016/j.jtumed.2024.07.008","url":null,"abstract":"<div><h3>Objectives</h3><p>Value-based healthcare (VBHC) represents a paradigm shift in healthcare delivery through optimizing patient outcomes relative to the costs of achieving those outcomes. This scoping review is aimed at revealing critical insights into the conceptualization and establishment of VBHC in the context of Saudi Arabia, a nation in a critical stage of healthcare transformation.</p></div><div><h3>Methods</h3><p>A scoping review was conducted by using online databases and official websites with a timeframe of 2017–2023. This review included 14 pieces of literature, comprising six research articles, six government documents, and two reports.</p></div><div><h3>Results</h3><p>The findings highlight increasing alignment with the definition of global VBHC principles, notably the emphasis on patient outcomes as a primary metric of healthcare value. Furthermore, financial reform has signaled a real move toward VBHC in the Kingdom, through a gradual shift from volume-based payments to value-based payments. However, the diverse interpretations and applications of VBHC across the examined literature indicate a promising stage of implementation characterized by evolving definitions and practices tailored to local needs and constraints.</p></div><div><h3>Conclusion</h3><p>This scoping review describes the current landscape of VBHC conceptualization and establishment, highlighting the substantial progress achieved and the future challenges.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000702/pdfft?md5=673e966d4a86bf0aeec940c7f5baea1a&pid=1-s2.0-S1658361224000702-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QSAR, molecular docking, and pharmacokinetic analysis of thiosemicarbazone-indole compounds targeting prostate cancer cells","authors":"","doi":"10.1016/j.jtumed.2024.07.004","DOIUrl":"10.1016/j.jtumed.2024.07.004","url":null,"abstract":"<div><h3>Objectives</h3><p>By 2030, prostate cancer is estimated to account for 1.7 million new cases and 499,000 deaths. The objectives of this research were to create a model revealing the activity of thiosemicarbazone-indole compounds as anticancer agents against the PC3 cell line; perform docking analysis between the compounds and the target enzyme; and predict the pharmacokinetics and drug-likeness of the compounds under investigation.</p></div><div><h3>Methods</h3><p>The quantitative structureactivity relationship (QSAR) method was used to build the model; molecular docking between the compounds and the target enzyme was performed; and the drug-likeness and pharmacokinetics of the inhibiting compounds was examined.</p></div><div><h3>Results</h3><p>The genetic function algorithm-multilinear regression approach was used for building the QSAR model. Build model 1 had the best performance, with R² (coefficient of determination) = 0.972517, R_adj (adjusted R-squared) = 0.964665, (CRp²) = 0.780922, and LOF (leave-one-out cross-validation) = 0.076524, demonstrated strongly indicated by the molecular descriptors. SHBd, SsCH3, JGI2, and RDF60P were highly dependent on proliferative activity. Compounds ID 7 and 22 had the potential to act as androgen receptor inhibitors, as suggested by molecular docking studies between the drugs and their target enzymes. Compounds ID 7 and 22 exhibited binding scores of −8.5 kcal/mol and −8.8 kcal/mol, respectively. The approved maximum medication molecules for oral bioavailability included the molecules with IDs 7 and 22.</p></div><div><h3>Conclusion</h3><p>This research provides valuable insights into the relationships among molecular descriptors, potential inhibitors, and pharmacokinetic properties in the treatment of PC3. These findings may contribute to the understanding and potential development of new therapeutic options for prostate cancer patients.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000660/pdfft?md5=5fff1200c5d74138c26f1ce6ab9b148e&pid=1-s2.0-S1658361224000660-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of non-communicable diseases in Health Council of Gulf Cooperation (GCC) countries","authors":"","doi":"10.1016/j.jtumed.2024.07.009","DOIUrl":"10.1016/j.jtumed.2024.07.009","url":null,"abstract":"<div><h3>Objectives</h3><p>This study was aimed at comparing deaths, years of potential life loss (YPLL), and economic loss due to nine non-communicable diseases (NCDs) among Health Council of Gulf Cooperation (GCC) countries.</p></div><div><h3>Methods</h3><p>The number of deaths and life expectancy by age and sex in each country, obtained from the 2019 World Health Organization database, were used to calculate YPLL by disease and sex. Economic loss was estimated by combining the annual income adjusted for the present value multiplied by the YPLL for each disease by sex and country.</p></div><div><h3>Results</h3><p>The nine NCDs were responsible for 152,854 deaths, 3 million YPLL, and 23.9 billion US$ economic loss in GCC countries. The most common cause of death was ischemic heart disease, which caused 82,232 deaths (54% of the total), 1.6 million YPLL (54% of the total), and a 12.8 billion US$ economic loss (53% of the total). The least common cause of death was lung cancer, which caused 1,960 deaths, 37,287 YPLL, and a 317.6 million US$ economic loss. KSA was the most affected country among all GCC countries in terms of deaths (68,027), YPLL (1.4 million), and economic loss (14.3 billion US$). Notably, KSA had 45%, 49%, and 60% of the entire region's deaths, YPLL, and economic loss, respectively. In contrast, Qatar was the least affected country in terms of deaths and YPLL, and Yemen was the least affected country in terms of economic loss.</p></div><div><h3>Conclusion</h3><p>The burden of NCDs in GCC countries in terms of deaths, YPLL, and economic loss is substantial. Policymakers should pay greater attention to detecting, preventing, and controlling these NCDs and their risk factors.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000714/pdfft?md5=b248622ea2ff7fa76393f2a2dd7f829c&pid=1-s2.0-S1658361224000714-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive study of CCN4, VCAM-1, MMP-3, and GM-CSF as reliable markers for disease activity in rheumatoid arthritis","authors":"","doi":"10.1016/j.jtumed.2024.08.001","DOIUrl":"10.1016/j.jtumed.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><p>The involvement of Wnt-1-induced secreted protein-1 (WISP1/CCN4) in several inflammatory reaction has recently been proposed. Nevertheless, this protein's involvement in rheumatoid arthritis (RA) remains debated. Associations between poorly diagnosed RA and several classical markers derived from demography and biochemistry have been reported.</p></div><div><h3>Aim</h3><p>We sought to investigate the reliability and effectiveness of serum concentrations of CCN4, vascular cell adhesion molecule-1 (VCAM-1), matrix melloprotenase-3 (MMP-3), and granulocyte-macrophage colony-stimulating factor (GM-CSF) in monitoring and predicting RA and bone damage, and their correlation with RA disease course.</p></div><div><h3>Methods</h3><p>The study analyzed 128 patients with RA, comprising 68 newly diagnosed and 60 previously diagnosed patients, as well as 60 controls. Biomarker levels were measured with enzyme linked immuno-sorbent assays. Routine laboratory parameters such as serological, clinical, biochemical, and hematological parameters were additionally measured. Demography, anthropometry, and clinical symptom data were collected through interviews and a questionnaire. The joint disease activity score 28 (DAS28) was used to determine disease activity.</p></div><div><h3>Results</h3><p>Concentrations of four biomarkers were significantly higher in the RA group than the healthy controls. Elevated biomarker concentrations were also observed in patients with high, rather than moderate or low, DAS28-ESR activity status, except for monocyte count, hematocrit (%), and urea level. Furthermore, CCN4 level positively correlated with VCAM-1, MMP-3, and GM-CSF levels, DA-S28-CRP and DAS28-ESR. The levels of three predictive markers, CCN4, VCAM-1, and MMP-3, were elevated in non-treated patients, whereas GM-CSF level showed no difference. The highest area under the curve was 73.3% for CCN4, with 93.3% sensitivity and 64.7% specificity.</p></div><div><h3>Conclusion</h3><p>Our data suggest that CCN4 can be reliably used to indicate activity and therapeutic response associated with RA, thus facilitating earlier RA diagnosis.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000738/pdfft?md5=0fae54684f8496a974e5390a1e0703ab&pid=1-s2.0-S1658361224000738-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142039672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic properties of Pelargonium graveolens leaf extract and its green-synthesized gold nanoparticles (in vitro study)","authors":"","doi":"10.1016/j.jtumed.2024.08.002","DOIUrl":"10.1016/j.jtumed.2024.08.002","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S165836122400074X/pdfft?md5=3a054e23ef9c2a659cc4920b064a0745&pid=1-s2.0-S165836122400074X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of 3D-printed teeth in dental education: A narrative review","authors":"","doi":"10.1016/j.jtumed.2024.07.005","DOIUrl":"10.1016/j.jtumed.2024.07.005","url":null,"abstract":"<div><h3>Background</h3><p>The contemporary era of education prompts the need for innovation that facilitates the comprehensible and immersive learning of students. Three-dimensional (3D) printing or additive manufacturing in the form of 3D-printed teeth provides an attractive alternative to extracted teeth and standard dental models, as they provide educational equality and realistic simulation of natural teeth.</p></div><div><h3>Aim</h3><p>This review article summarises the literature that has proven the role and effectiveness of 3D-printed teeth in dental education.</p></div><div><h3>Method</h3><p>This review article follows the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines. Two electronic research databases, PubMed and Google Scholar, were used to search for relevant studies. Studies discussing the applications of 3D-printed teeth in dental education were included.</p></div><div><h3>Results</h3><p>The positive and highly valuable role of 3D-printed teeth in dental education has been validated because of their feasible nature. Improvements in dental students’ confidence, clinical skills, and learning experiences have also been proven.</p></div><div><h3>Conclusion</h3><p>3D-printed teeth can serve as a convenient and accessible alternative to extracted and standard dental models for dental education.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000672/pdfft?md5=8a1c47a3e60d26702a45c21b22509db0&pid=1-s2.0-S1658361224000672-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of surgical management of ankle fractures in patients with diabetes","authors":"","doi":"10.1016/j.jtumed.2024.07.003","DOIUrl":"10.1016/j.jtumed.2024.07.003","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000659/pdfft?md5=5cad6c033ef8bfb0187f564ff9770181&pid=1-s2.0-S1658361224000659-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dampened inflammatory response in oral ulcer after topical therapy of adipose mesenchymal stem cell secretome","authors":"","doi":"10.1016/j.jtumed.2024.07.006","DOIUrl":"10.1016/j.jtumed.2024.07.006","url":null,"abstract":"<div><h3>Objectives</h3><p>Research has demonstrated that modulating inflammation can significantly accelerate the healing of oral ulcers. Our study focused on the adipose mesenchymal stem cell secretome (AdMSCS), which is rich in immunoregulatory molecules capable of dampening the immune response and interfering with inflammatory pathways. We assessed both inflammatory pathway expression and macrophage phenotypes at the sites of oral ulcers.</p></div><div><h3>Methods</h3><p>We induced oral ulcers in the inferior fornix mucosa of 20 healthy male Wistar rats (<em>Rattus norvegicus</em>). These subjects were treated topically with adipose MSC metabolite (AdMSCM) oral gel three times daily, for durations of 3 and 7 days. We performed immunohistochemical analyses to evaluate the expression of Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65 at the ulcer sites. Additionally, we assessed macrophage polarization by examining the ratio of M2/M1 macrophages, identified through CD68⁺Φ (M1) and CD163⁺Φ (M2) cells. Data were analyzed using one-way analysis of variance, followed by post-hoc Tukey's Honestly Significantly Difference test.</p></div><div><h3>Results</h3><p>Application of AdMSCM oral gel significantly reduced the expression of TLR4 and NF-κB p65. This treatment also enhanced macrophage polarization towards the anti-inflammatory M2 phenotype at the ulcer sites (<em>p</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>The topical application of AdMSCM oral gel effectively modulates the inflammatory response, enhancing healing processes in the oral ulcer rat model. This suggests its potential utility as a therapeutic agent in managing oral ulcers.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000684/pdfft?md5=7a0a20b143a48d4411087bd6bfa477ea&pid=1-s2.0-S1658361224000684-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of lycopene against celecoxib induced fat deposition and glycogen reduction in liver cells","authors":"","doi":"10.1016/j.jtumed.2024.07.007","DOIUrl":"10.1016/j.jtumed.2024.07.007","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000696/pdfft?md5=e9c050b09f8bab116e881bada0a353fa&pid=1-s2.0-S1658361224000696-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}