ARYA Atherosclerosis最新文献

{"title":"ST-segment elevation differential diagnosis in a patient with ovarian cancer: A case report.","authors":"Faezeh Dehghani-Tafti, Mahmood Emami-Meybodi, Seyed Mostafa Seyed Hossieni Tezerjani, Roghayeh Pourkia","doi":"10.48305/arya.2026.45246.3056","DOIUrl":"10.48305/arya.2026.45246.3056","url":null,"abstract":"<p><p>Across the world the incidence of cancer is predicted to increase by 47% over the next 20 years. Increasingly, cardiologists will be faced with patients presenting with acute coronary syndromes, who are receiving active treatment for cancer. On the other hand, metastasis of malignant tumors to the heart is not usual but can present with various clinical features such as pericardial effusion, heart failure, arrhythmia, and myocardial infarction. Rarely, they may cause characteristic electrocardiographic changes, resembling ST-segment elevated myocardial infarction (STEMI). Decision making in this scenario is complex and requires detailed knowledge of the patient's cancer stage, response to cancer treatment, and overall prognosis. Proper diagnosis is critical in these patients to prevent unnecessary or even harmful interventions such as fibrinolytic therapy. We reported a 45-year-old woman with a history of ovarian carcinoma, who presented with atypical chest pain and ECG findings suggestive myocardial infarction. But after full investigation we realized these ECG changes were due to the myocardial invasion of the tumor not coronary atherosclerosis and obstruction.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 2","pages":"1-4"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13283341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escaping voluntary confinement: A framework to address Stockholm syndrome in cardiac nursing.","authors":"Mohammadreza Shafeie, Akbar Etebarian, Saeid Sharifi, Mashallah Valikhani Dehaqani","doi":"10.48305/arya.2026.45990.3134","DOIUrl":"10.48305/arya.2026.45990.3134","url":null,"abstract":"<p><strong>Background: </strong>Due to high burnout and intense emotional investment in patient outcomes, nurses may inadvertently become trapped in dysfunctional interpersonal dynamics at work, resembling Stockholm syndrome. Understanding and managing this phenomenon requires field research. This study explores intervention strategies to address organizational Stockholm syndrome among nursing staff in cardiac care hospitals in Isfahan.</p><p><strong>Methods: </strong>This sequential exploratory mixed-methods study comprised qualitative and quantitative phases. In Phase I, 21 cardiac nursing specialists were purposively recruited and interviewed using semi-structured, in-depth interviews. Data were analyzed using Braun and Clarke's thematic analysis, and trustworthiness was ensured according to Lincoln and Guba's criteria. In Phase II, the qualitative findings informed the development of a structured survey administered to 276 staff working in cardiovascular wards in Isfahan. Participants rated eight qualitatively derived strategic domains using a 5-point Likert scale. A hierarchical model was tested in AMOS 22 to examine the higher-order organization and conceptual coherence of the proposed framework.</p><p><strong>Results: </strong>The findings support a hierarchical framework for addressing organizational Stockholm syndrome among cardiac nurses, highlighting coordinated strategies across individual, interpersonal, and organizational domains. The three higher-order dimensions were Individual Empowerment (positive affect, psychological development, and self-belief), Interpersonal Development (social capital and communication climate), and Improving Organizational Climate (social hope and morale). The quantitative findings indicated acceptable hierarchical coherence among the domains, providing preliminary structural support for the proposed framework.</p><p><strong>Conclusion: </strong>The proposed tri-level framework offers a practical approach for hospital management to address organizational Stockholm syndrome by supporting empowerment initiatives, strengthening organizational voice, and enhancing transparency. Integrating these strategies may improve psychological safety, promote staff well-being, and ultimately contribute to better quality of patient care.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 1","pages":"69-81"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-term follow-up of COVID-19 patients with permanent pacemaker implantation due to bradyarrhythmia at the acute phase of infection.","authors":"Javad Shahabi, Saeed Sadri, Fereshteh Sattar, Amirhossein Azhari","doi":"10.48305/arya.2024.42107.2920","DOIUrl":"10.48305/arya.2024.42107.2920","url":null,"abstract":"<p><strong>Background: </strong>Arrhythmia is one of the important cardiac manifestations of SARS-CoV-2 disease with possible mechanisms such as direct damage to the myocardium, hypoxia, myocardial damage, cytokine storm, and electrolyte imbalances. Bradyarrhythmia is a manifestation of conduction system involvement, which is associated with an unfavorable prognosis and sometimes requires treatments such as implanting a pacemaker. Whether bradycardia in the acute phase of the COVID pandemic is a transient complication of the virus or whether it will be permanent can affect the treatment approach.Is the effect of SARS-CoV-2 on the conduction system of the heart temporary or permanent, and in the one-year follow-up, how many patients will need a pacemaker?</p><p><strong>Methods: </strong>The study population was among patients with symptomatic bradyar-rhythmias who were referred to Chamran Heart Center, Isfahan, Iran, from the outbreak of SARS-CoV-2 (February 2020) until February 2022 and were diagnosed with COVID-19 based on the polymerase chain reaction (PCR) test. They underwent permanent pacemaker implantation and were monitored for 1 month and 12 months after device implantation.</p><p><strong>Results: </strong>The most common comorbid disease was hypertension. Systolic blood pressure and respiratory rate in hospitalized patients decreased significantly during discharge. Also, oxygen saturation and heart rate increased significantly during discharge (P < 0.001). In this study, high-degree atrioventricular block remained permanent in most patients and was not transient.</p><p><strong>Conclusion: </strong>Based on the experiences gained from this study, the implantation of a permanent pacemaker for the treatment of bradyarrhythmia should be done based on the existing guidelines, regardless of the status of COVID-19.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"7-14"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing in hospital mortality prediction model tools for patients with acute myocardial infarction (STEMI) using Yazd cardiovascular disease registry, YCDR data.","authors":"Seyedeh Mahdieh Namayandeh, Mohsen Mohammadi, Masoud Mirzaei, Mohsen Askarishahi, Hamidreza Dehghani, Seyed Mahmoud Sadr Bafghi","doi":"10.48305/arya.2025.43144.3004","DOIUrl":"10.48305/arya.2025.43144.3004","url":null,"abstract":"<p><strong>Background: </strong>An acute ST-elevation myocardial infarction (STEMI) is a medical event characterized by transmural myocardial ischemia that leads to myocardial injury or necrosis. This study was undertaken to develop, evaluate, and compare models for assessing the risk of hospital mortality in patients with acute myocardial infarction.</p><p><strong>Methods: </strong>The study made use of data from the Yazd Cardiovascular Diseases Registry (YCDR), which is a cohort study of inpatient records of ischemic heart disease in Yazd province, Iran. A total of 1,861 patients who had experienced a STEMI were included in the analysis. Decision tree analysis was conducted using R software with the <i>rpart</i> package. Additionally, to analyze the data and adjust for any confounding variables, logistic regression was performed using the <i>glm2</i> package. To compare the effectiveness of the two models, accuracy measures were used, and the Receiver Operating Characteristic (ROC) curve was applied.</p><p><strong>Results: </strong>In this study, three clinical, laboratory, and clinical-laboratory models were created. In a clinical-laboratory model, variables such as blood sugar (BS), triglycerides, HDL cholesterol, peak myocardial band (MBpick), CVA history, and low ejection fraction (EF) were found to increase the risk of in-hospital mortality in patients with ST-elevation myocardial infarction (STEMI). Conversely, higher levels of hemoglobin, low HDL-C, and previous myocardial infarction (MI) were associated with a protective effect against the risk of in-hospital mortality from acute myocardial infarction.The performance of the models in terms of Receiver Operating Characteristic (ROC) curve was 86.5%, 79.5%, and 90.2% for logistic regression model in three different models: clinical, laboratory, and combined clinical-laboratory. The accuracy of these models was calculated to be 88.3%, 81.3%, and 93%, respectively. Important variables influencing the prediction of in-hospital mortality in STEMI patients included Killip class, triglycerides, blood sugar, creatinine levels, the need for treatment due to ventricular fibrillation or ventricular tachycardia (VF/VT), age, and hemoglobin (HB). In the ROC curve analysis of the decision tree algorithm across the clinical, laboratory, and combined clinical-laboratory models, the performance levels were 74.6%, 69.8%, and 81.7%, respectively. The accuracy of the decision tree was 93.0%, 92.5%, and 95.8%.</p><p><strong>Conclusion: </strong>The findings of this study indicated that the decision tree algorithm had higher accuracy across all three models: clinical, laboratory, and combined clinical-laboratory compared to logistic regression. However, logistic regression showed higher sensitivity and better ROC curve performance than the decision tree algorithm.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 5","pages":"21-33"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between diabetes and atherosclerosis: A review of pathophysiological mechanisms.","authors":"Mostafa Cheraghi, Arash Karimi, Mehrnoosh Sedighi, Solmaz Jabarzare","doi":"10.48305/arya.2025.43558.3037","DOIUrl":"10.48305/arya.2025.43558.3037","url":null,"abstract":"<p><p>Atherosclerosis, characterized by lipid accumulation in arterial walls, is a leading cause of cardiovascular morbidity and mortality, with increased prevalence among individuals with diabetes mellitus. Diabetes is a chronic condition marked by persistently high blood glucose levels, a condition that can potentially result in long-term complications, including heart, blood vessel, eye, kidney, and nerve damage. Diabetes, marked by chronic hyperglycemia, contributes to atherogenesis through mechanisms including endothelial dysfunction, oxidative stress, formation of advanced glycation end-products (AGEs), and chronic inflammation. This study provides a synopsis of the predominant characteristics of diabetes that may potentially impact the atherogenic process, including oxidative stress, altered protein kinase signaling, and the role of select microRNAs and epigenetic modifications. This review comprehensively examines literature from 1969 to 2025, focusing on the molecular and cellular pathways linking diabetes to atherosclerosis. Effective glycemic control and management of associated risk factors remain pivotal in mitigating atherosclerotic progression in diabetic patients. Understanding these interconnected mechanisms is essential for developing targeted therapies to reduce cardiovascular complications associated with diabetes.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 5","pages":"62-80"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cardiac rehabilitation program on work ability in patients following percutaneous coronary intervention (PCI): A retrospective cohort study.","authors":"Hanieh Najafloo, Salman Khazaei, Lobat Majidi, Azadeh Mozayani Monfared, Seyed Kianoosh Hosseini, Saeid Ghiasvandi","doi":"10.48305/arya.2025.45414.3070","DOIUrl":"10.48305/arya.2025.45414.3070","url":null,"abstract":"<p><strong>Background: </strong>Cardiac rehabilitation (CR) is a critical intervention for reducing complications after cardiovascular procedures such as percutaneous coronary intervention (PCI). One of the key outcomes used to evaluate the effectiveness of CR programs is improvement in patients' work ability. This study aimed to assess the impact of a structured CR program on work ability in patients undergoing PCI.</p><p><strong>Methods: </strong>A retrospective study was conducted, comparing 36 patients who participated in a structured CR program following PCI with 36 patients who did not receive rehabilitation. The CR program included educational and exercise components, delivered over four weeks with three sessions per week. Work ability was evaluated three months post-intervention using a standardized questionnaire. Statistical analyses, including independent t-tests and correlation assessments, were performed to examine the relationship between CR participation and work ability.</p><p><strong>Results: </strong>The two groups were comparable in terms of age, gender, and underlying medical conditions (p > 0.05). Notably, 80% of patients in the CR group demonstrated good to excellent work ability, compared with only 25% in the control group (p < 0.001). The mean work ability score was significantly higher in the CR group than in the control group (mean difference = 7.55, p < 0.001).</p><p><strong>Conclusion: </strong>Participation in a cardiac rehabilitation program significantly improves work ability in patients following PCI. These findings highlight the importance of integrating CR into post-PCI care. Future research should focus on randomized clinical trials incorporating diverse rehabilitation protocols and extended follow-up periods to further validate these results.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 6","pages":"69-79"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of crocin against contrast induced acute kidney injury following angiography: A randomized controlled clinical trial.","authors":"Arefe Khani, Javad Khalili Fard, Arash Amin, Nasrollah Moradifar, Mehdi Birjandi, Fatemeh Ahmadpour, Amin Rakhshan, Seyyed Mohammad Mousavinia, Forouzan Ahmadpour, Negin Monazzami Motlagh","doi":"10.48305/arya.2025.43490.3030","DOIUrl":"10.48305/arya.2025.43490.3030","url":null,"abstract":"<p><strong>Background: </strong>The use of contrast media in angiography has risen alongside the increasing incidence of cardiovascular diseases. Contrast agents cause acute kidney injury due to increased oxidative stress. Antioxidants such as crocin may help prevent contrast-induced acute kidney injury (CI-AKI).</p><p><strong>Methods: </strong>A randomized controlled clinical trial involved 60 patients over 18 years old undergoing Percutaneous Coronary Intervention (PCI). Standard hydration therapy was administered to the patients in both groups. The intervention group received 30 mg crocin three consecutive times. Oxidative stress levels and antioxidant system activity were measured, including malondialdehyde (MDA), reactive oxygen species (ROS), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD). The prevalence of CI-AKI was also examined by measuring serum creatinine (SCr), blood urea nitrogen (BUN), and the estimated glomerular filtration rate (eGFR).</p><p><strong>Results: </strong>The analysis found no statistically significant differences between the groups for the GPx, CAT, MDA, ROS, SOD, SCr, BUN, and eGFR indices (P > 0.05). The study found a significant decrease in the average SCr and BUN in the intervention group post-PCI (P < 0.05). There were two incidences of CIN in the control group and none in the intervention group; however, the two groups did not differ significantly (P = 0.492). Conclusion: Although oral administration of 30 mg of crocin did not lead to significant changes in oxidant biomarkers, the capacity of the antioxidant defense system tended to increase. Moreover, SCr, BUN, and the incidence of CI-AKI were lower in the intervention group.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 6","pages":"18-29"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation the effects of Rivaroxaban on oxidative stress and antioxidant capacity in patients heart failure.","authors":"Galia Dilanchian, Ziba Rezvani Sichani, Hashem Nayeri, Sedigheh Asgary","doi":"10.48305/arya.2025.43452.3024","DOIUrl":"10.48305/arya.2025.43452.3024","url":null,"abstract":"<p><strong>Background: </strong>Rivaroxaban, a direct Factor Xa inhibitor, primarily acts by disrupting the coagulation cascade. However, it may also influence oxidative stress. This effect likely stems from its ability to reduce thrombin-mediated reactive oxygen species (ROS) production and mitigate inflammation. The major aim of the present investigation was to assess the effects of Rivaroxaban on oxidative stress and antioxidant capacity in patients with heart failure.</p><p><strong>Methods: </strong>This study included 39 patients (17 males and 22 females, aged 30-95 years) with Stage B heart failure (HF) who had never previously received Rivaroxaban. Patients were enrolled from Chamran Cardiovascular Hospital in Isfahan after providing written informed consent, approved by the Falavarjan University Ethical Committee (IR.IAU.FALA.REC.1398.029). All patients had structural cardiac abnormalities, including reduced left ventricular ejection fraction (LVEF < 40%) or diastolic dysfunction, but no clinical symptoms of HF. Rivaroxaban (20 mg/day) was administered orally to all patients for two months using a pre-post design. Blood samples were collected before and after treatment to assess oxidative stress and antioxidant biomarkers, including total antioxidant capacity (TAC), malondialdehyde (MDA), homocysteine (Hcy), and the enzymatic activities of paraoxonase-1 (PON1) and arylesterase. TAC, MDA, and enzyme activities were measured spectrophotometrically, while homocysteine levels were determined using ELISA.</p><p><strong>Results: </strong>The results showed a significant reduction in MDA levels (P < 0.001), indicating reduced oxidative stress after Rivaroxaban treatment. However, no statistically significant changes were observed in other biomarkers, including homocysteine, arylesterase, paraoxonase, and TAC (P > 0.05).</p><p><strong>Conclusion: </strong>In conclusion, Rivaroxaban appears to effectively reduce oxidative stress, as evidenced by decreased MDA levels.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"36-43"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The thrill is vanished: Percutaneous exclusion of post trans radial arteriovenous fistula using stent graft through transbrachial approach.","authors":"Santosh Kumar Sinha, Mukesh Jitendra Jha, Umeshwar Pandey, Mahmodullah Razi, Awadesh Kumar Sharma","doi":"10.48305/arya.2025.43276.3011","DOIUrl":"10.48305/arya.2025.43276.3011","url":null,"abstract":"<p><p>Radial arteriovenous fistula (AVF) following radial intervention is exceedingly scarce. Here, we report a case of a 73-year-old man who was admitted with acute myocardial ischaemic syndrome and underwent transradial angioplasty of the proximal left anterior descending and circumflex artery. Fourteen months later, he presented with progressive swelling, dilated superficial veins, a palpable thrill, continuous bruit, and tingling at the local site. Doppler ultrasonography (DUS) diagnosed radial AVF with multiple fistulous communications draining into the cephalic vein, confirmed by contrast-enhanced computed tomography (CECT). Local compression using a prolonged compressive bandage (>12 hours) and a DUS probe was attempted but remained ineffectual. A 2.8 × 26 mm Graftmaster stent graft (Abbott Vascular, USA) was deployed into the radial artery across the fistula neck via a transbrachial approach, slowly expanded over 60 seconds at 12 atm pressure, and post-dilated with a 3 × 15 mm noncompliant balloon at 15 atm pressure. A post-procedure angiogram displayed complete closure of the fistula with restoration of palmar arch perfusion. This is the first reported case of successful exclusion of RAVF through transbrachial approach using a ever covered stent, and only the second case overall of percutaneous exclusion using a stent graft.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful percutaneous closure of a large ventricular septal defect (VSD) in a 9-month-old Infant: A case report.","authors":"Reza Derakhshan, Fatemeh Doost Mohammadi","doi":"10.48305/arya.2025.43587.3042","DOIUrl":"10.48305/arya.2025.43587.3042","url":null,"abstract":"<p><p>Ventricular septal defect (VSD) is a common congenital heart defect. In large VSDs with significant left-to-right shunting, percutaneous closure can be an effective alternative to surgical repair. In some cases, percutaneous closure of septal defects is a successful treatment. Our main objective in this case report is to discuss the transcatheter closure of ventricular septal defects in a low-birth-weight infant. We are presenting the case of a 9-month-old male infant who is experiencing failure to thrive (FTT) alongside a significant ventricular septal defect (VSD). The patient successfully underwent percutaneous closure of the VSD using an antegrade approach with a symmetric device. Follow-up evaluations after the procedure confirmed that the closure was effective, the device was in the correct position, and pulmonary hypertension had resolved. As far as we know, this case represents one of the youngest and lowest-weight infants reported in Iran for successful percutaneous VSD closure instead of open surgery.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 5","pages":"4-8"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}