ARYA Atherosclerosis最新文献

{"title":"Mid-term follow-up of COVID-19 patients with permanent pacemaker implantation due to bradyarrhythmia at the acute phase of infection.","authors":"Javad Shahabi, Saeed Sadri, Fereshteh Sattar, Amirhossein Azhari","doi":"10.48305/arya.2024.42107.2920","DOIUrl":"10.48305/arya.2024.42107.2920","url":null,"abstract":"<p><strong>Background: </strong>Arrhythmia is one of the important cardiac manifestations of SARS-CoV-2 disease with possible mechanisms such as direct damage to the myocardium, hypoxia, myocardial damage, cytokine storm, and electrolyte imbalances. Bradyarrhythmia is a manifestation of conduction system involvement, which is associated with an unfavorable prognosis and sometimes requires treatments such as implanting a pacemaker. Whether bradycardia in the acute phase of the COVID pandemic is a transient complication of the virus or whether it will be permanent can affect the treatment approach.Is the effect of SARS-CoV-2 on the conduction system of the heart temporary or permanent, and in the one-year follow-up, how many patients will need a pacemaker?</p><p><strong>Methods: </strong>The study population was among patients with symptomatic bradyar-rhythmias who were referred to Chamran Heart Center, Isfahan, Iran, from the outbreak of SARS-CoV-2 (February 2020) until February 2022 and were diagnosed with COVID-19 based on the polymerase chain reaction (PCR) test. They underwent permanent pacemaker implantation and were monitored for 1 month and 12 months after device implantation.</p><p><strong>Results: </strong>The most common comorbid disease was hypertension. Systolic blood pressure and respiratory rate in hospitalized patients decreased significantly during discharge. Also, oxygen saturation and heart rate increased significantly during discharge (P < 0.001). In this study, high-degree atrioventricular block remained permanent in most patients and was not transient.</p><p><strong>Conclusion: </strong>Based on the experiences gained from this study, the implantation of a permanent pacemaker for the treatment of bradyarrhythmia should be done based on the existing guidelines, regardless of the status of COVID-19.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"7-14"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Cytochrome P450 2D6 (*4, *9, *10, *41) alleles in healthy population from north-west of Iran.","authors":"Elahe Bagherinia, Amir Dehghani, Naser Khalili, Hamid Soraya, Morteza Bagheri","doi":"10.48305/arya.2025.42811.2980","DOIUrl":"10.48305/arya.2025.42811.2980","url":null,"abstract":"<p><strong>Background: </strong>The CYP2D6 gene locus is complex and highly polymorphic. Given the clinical importance of the CYP2D6 enzyme in liver xenobiotic metabolism, genotyping its significant alleles among different ethnic groups is essential for evaluating the efficacy of certain drugs. In this study, we assessed the frequency of the <i>CYP2D6*4, *9, *10, and *41</i> alleles in a healthy population from northwestern Iran.</p><p><strong>Methods: </strong>Fifty unrelated healthy individuals from West Azerbaijan Province, Iran, were studied using PCR-RFLP and ARMS-PCR techniques.</p><p><strong>Results: </strong><i>CYP2D6*9</i> (rs5030656) allele was not detected. The frequency (%) of <i>CYP2D6*4</i> (rs3892097), <i>CYP2D6*10</i> (rs1065852) and <i>CYP2D6*41</i> (rs28371725) alleles were 10%, 13% and 8%, respectively.</p><p><strong>Conclusion: </strong>Our findings indicate that the frequencies of \"non-functional\" and \"reduced function\" alleles are relatively high in this population. Determining Cytochrome P450 2D6 allele variations can contribute to risk assessment and patient management regarding adverse or poor drug responses, ultimately aiding in the prevention of increased mortality risks among different populations.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"33-42"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the power of obesity indices to predict cardiovascular diseases at different ages: An application of conditional time-dependent ROC curve in Healthy Heart Cohort of Yazd, Iran.","authors":"Mohammad Hashem Khademi Kolah Loui, Sara Jambarsang, Seyedeh Mahideh Namayandeh, Seyyed Mohammad Tabatabaei, Abdollah Hozhabrnia, Reyhane Sefidkar","doi":"10.48305/arya.2025.42469.2938","DOIUrl":"10.48305/arya.2025.42469.2938","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to estimate the power of anthropometric markers to predict 10-year CVD across different age groups in the Yazd Healthy Heart cohort.</p><p><strong>Methods: </strong>A total of 1,623 individuals aged 20 to 74, who were free of CVD, participated in the study. A conditional time-dependent receiver operating characteristic (ROC) curve was used to estimate the predictive power of anthropometric indices, including the Abdominal Volume Index (AVI), Body Adiposity Index (BAI), and Waist-to-Height Ratio (WHtR), adjusted for age and sex.</p><p><strong>Results: </strong>Of the 1,623 participants, 818 were males (50.40%) and 805 were females (49.60%). The Area Under the Curve (AUC) for the BAI ranged from 0.50 to 0.70 for males aged 40 to 70 years. In females, the BAI biomarker demonstrated considerable to excellent predictive power (AUC > 0.8) for individuals aged 20 to approximately 33 years. For males, AVI and WHtR showed fair to considerable predictive power in participants aged 20 to 30 years. In the age group of 30 to approximately 68 years, the predictive power varied from poor to ineffective, except for individuals close to 50 years old. In females, the predictive power of the AVI and WHtR biomarkers ranged from fair to considerable for those aged 20 to around 33 years.</p><p><strong>Conclusion: </strong>This study found that AVI and WHtR can fairly predict 10-year CVD risk in young individuals of both sexes, while the BAI was specifically applicable for predicting risk in young women. These markers are valuable and affordable tools for youth CVD screening.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"36-43"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of novel ultrathin, biodegradable polymer tetriflex (sirolimus-eluting stent) optimization using intravascular ultrasound (IVUS) in short coronary lesion (≤ 20mm) vs. long coronary lesion (≥ 20mm): Tetriflex IVUS study.","authors":"Najeeb Ullah Sofi, Mohit Sachan, Santosh Kumar Sinha, Mukesh J Jha, Umeshwar Pandey, Mahmodullah Razi, Awadesh K Sharma, Puneet Aggarwal, Praveen Shukla, Rakesh Varma","doi":"10.48305/arya.2024.41978.2912","DOIUrl":"10.48305/arya.2024.41978.2912","url":null,"abstract":"<p><strong>Background: </strong>Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) is useful for stent optimization. Outcomes of the ultrathin Supralimus Tetriflex stent (Sahajanand Medical Technologies Pvt. Ltd., India) using IVUS were evaluated among patients with short (≤ 20 mm) versus long lesions (≥ 20 mm).</p><p><strong>Methods: </strong>A total of 207 patients underwent PCI, and IVUS was performed post-deployment. The primary outcome was optimal stent deployment, defined as (a) mean surface area (MSA) >5.0 mm²; (b) plaque burden <50%; (c) complete apposition; and (d) no edge dissection. Secondary outcomes were target lesion failure (TLF)-a composite of cardiac death, target vessel myocardial infarction (TVMI), and target lesion revascularization (TLR)-stent thrombosis, and major adverse cardiovascular events (MACE; a composite of death, MI, stent thrombosis, and repeat revascularization).</p><p><strong>Results: </strong>Suboptimal deployment was significantly more frequent among patients with longer lesions (30.1% vs. 23.3%; p=0.03) due to higher rates of malapposition (17.3% vs. 10.6%) and MSA <5 mm² (9.6% vs. 7.7%). Following post-dilatation, suboptimal deployment was observed in 7.6% and 5.8% of patients, respectively. Residual plaque burden was 4.5% and 5.7%, respectively. The MSA in both groups was 6.3 mm² and 6.5 mm². Minimum and mean stent expansions were 82.1% versus 81.7% and 106.3% versus 109.8%, respectively, with no significant differences. TLF and stent thrombosis were observed in 0.9% versus 0.9% and 2.9% versus 3.8% of patients, respectively, with no significant differences. However, MACE was significantly higher (10.5% vs. 8.7%; p=0.05) among patients with longer lesions.</p><p><strong>Conclusion: </strong>Supralimus Tetriflex stent has very good optimal deployment based on angiogram and becomes better with IVUS imaging, making it safe among long lesions (≥ 20mm).</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"22-35"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surprising palpitation: An unexpected diagnosis of sarcoidosis.","authors":"Hoda Raffiei Jelodar, Roxana Sadeghi, Reza Hamneshin Behbahani, Kimia Karimi Toudeshki","doi":"10.48305/arya.2024.42684.2968","DOIUrl":"10.48305/arya.2024.42684.2968","url":null,"abstract":"<p><p>Sarcoidosis is a challenging disease characterized by the formation of granulomas in multiple organs. It presents with a variety of clinical symptoms, making diagnosis difficult for physicians. Myocardial involvement in sarcoidosis is rare, but it worsens prognosis and can lead to mortality. Physicians face challenges in diagnosing cardiac sarcoidosis due to its wide range of symptoms. Cardiac sarcoidosis that affects only the heart without involvement of other organs is extremely uncommon. In this case, we examine the scenario of a middle-aged man who experienced palpitations and was diagnosed with ventricular tachycardia. He remained in stable condition without any other clinical signs suggestive of sarcoidosis. This case highlights the importance of considering sarcoidosis as a potential diagnosis in patients presenting with palpitations and ventricular tachycardia on electrocardiogram, particularly when these symptoms are accompanied by sudden new-onset systolic dysfunction despite normal coronary arteries.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"3-9"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexities of AVNRT ablation and its impact on electrophysiological features: A comprehensive review in children?","authors":"Mohammad Rafie Khorgami, Feisal Rahimpour, Davood Ramezani Nezhad","doi":"10.48305/arya.2024.42551.2948","DOIUrl":"10.48305/arya.2024.42551.2948","url":null,"abstract":"<p><strong>Background: </strong>Paroxysmal Supraventricular Tachycardia (PSVT) is a broad term referring to any rapid heart rhythm originating above the heart's ventricles. Atrioventricular Nodal Reentrant Tachycardia (AVNRT) is a specific type of PSVT characterized by abnormal circuits or pathways within the atrioventricular (AV) node, a crucial component of the heart's electrical conduction system. AVNRT can cause rapid heartbeats due to abnormal electrical impulses circulating within the AV node. This study aimed to explore the association between the QT, PR, and QRS intervals before and after RF ablation.</p><p><strong>Methods: </strong>In this cross-sectional study, 115 children with recurrent cardiac arrhythmias were screened and included between 2010 and 2023. The management of arrhythmias followed established guidelines and consensus statements.</p><p><strong>Results: </strong>The mean age of the 115 children was 9.91 ± 3.30 years, and 52.2% were female. Statistical analysis revealed a significant difference in cycle length (p=0.001), ventricular drive cycle length (p=0.001), atrioventricular Wenckebach (p=0.002), and antegrade effective refractory period of the AV node (p=0.013) before and after ablation.</p><p><strong>Conclusion: </strong>Supraventricular arrhythmias in children present complex cases that require individualized treatment approaches. Assessing the QT, PR, and QRS intervals before and after RF ablation provides a valuable tool for evaluating the success of these procedures, particularly in cases involving AVNRT.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"28-32"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular function and arterial stiffness in multisystem inflammatory syndrome in children with Covid-19.","authors":"Alireza Ahmadi, Mohammad Reza Sabri, Mehdi Ghaderian, Bahar Dehghan, Chehreh Mahdavi, Davood Ramezaninezhad, Zahra Pourmoghaddas, Mohammad Reza Maracy, Pejman Nemat Gorgani, Behzad Ghazanfari","doi":"10.48305/arya.2025.43214.3008","DOIUrl":"10.48305/arya.2025.43214.3008","url":null,"abstract":"<p><strong>Background: </strong>Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, potentially caused by endothelial dysfunction and arterial stiffness.</p><p><strong>Methods: </strong>This study aimed to investigate the cardiovascular health of children with MIS-C compared to healthy controls. Fifty-nine children with MIS-C and fifty-nine healthy individuals were included in this cohort study. Non-invasive techniques were employed to measure the brachial artery's flow-mediated dilation (FMD), aortic distensibility (AD), and aortic strain (AS).</p><p><strong>Results: </strong>The MIS-C group demonstrated significantly higher systolic blood pressure (P = 0.012), with a mean of 100.2 (10.1) mmHg compared to 95.3 (9.6) mmHg in the healthy group. The relative risk (RR) for elevated pulse pressure in the MIS-C group was borderline higher than in the healthy group (RR 95% CI: 1.06 [1.01-1.14]; P = 0.046). However, FMD, AS, and AD values were lower in the MIS-C group, with means of 13.6 (8.9), 10.4 (4.1), and 15.5 (2.7), respectively, although no significant differences were observed (P > 0.05).</p><p><strong>Conclusion: </strong>Children with MIS-C exhibited higher pulse pressure, indicating potential arterial stiffness. They also showed lower FMD, suggesting endothelial dysfunction. FMD appears to be a more reliable indicator of endothelial dysfunction in MIS-C patients compared to aortic strain. These findings underscore the importance of early assessment and monitoring of cardiovascular complications in MIS-C patients. Endothelial dysfunction and arterial stiffness are well-established risk factors for future cardiovascular events.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"54-62"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study.","authors":"Soodeh Jahangiri, Seyed Arad Mosalamiaghili, Reza Heydarzadeh, Mohammadali Yousefzadeh, Reza Golchin Vafa, Hooyar Zarifkar, Kasra Assadian, Sina Sohrabizadeh, Hourshad Zarifkar, Mehrdad Sadeghi, Nazanin Hosseini, Mohammad Montaseri, Seyed Ali Hosseini, Javad Kojuri","doi":"10.48305/arya.2025.42573.2960","DOIUrl":"10.48305/arya.2025.42573.2960","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, Metabolic Score for Insulin Resistance (METS-IR), triglyceride-glucose (TyG) index, and triglyceride-glucose body mass index (TyG-BMI) have been associated with the occurrence and severity of coronary artery disease (CAD), although evidence remains limited.</p><p><strong>Methods: </strong>A total of 1,017 patients undergoing coronary angiography for the first time were included. Insulin resistance (IR) indices were calculated based on patients' laboratory data. Significant CAD was defined as more than 50% stenosis observed in coronary angiography¹.</p><p><strong>Results: </strong>A positive correlation was found between CAD and the TyG index (ρ = 0.083, p = 0.008). Patients with CAD had a significantly elevated TyG index (9.02 ± 0.62) compared to those with single-vessel disease (SVD) (8.87 ± 0.59) (p = 0.012). A strong association was observed between CAD and the TG/HDL-C ratio (ρ = 0.114, p < 0.001). Patients with multi-vessel disease exhibited a considerably higher index (4.47 ± 2.46) compared to those with SVD (3.77 ± 2.45) (p = 0.003). The TyG index cut-off was 9.22 (27.5% sensitivity, 79.3% specificity, 82.2% positive predictive value (PPV), and 23.89% negative predictive value (NPV)), while the TG/HDL-C ratio cut-off was 3.6 (44% sensitivity, 65.2% specificity, 81.5% PPV, and 25.5% NPV).</p><p><strong>Conclusion: </strong>Our findings indicate that the TG/HDL-C ratio, with a cut-off point of 3.6, and the TyG index, with a threshold of 9.22, are associated with the presence of CAD. (ClinicalTrials.gov registration number: NCT06237244).</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"44-53"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early experience of transcatheter aortic valve implantation (TAVI) procedure in Isfahan, Iran.","authors":"Amir Aris, Asieh Mansouri, Houman Dehghan, Faezeh Tabesh, Mohammad Amini, Alireza Khosravi Farsani","doi":"10.48305/arya.2025.43010.2995","DOIUrl":"10.48305/arya.2025.43010.2995","url":null,"abstract":"<p><strong>Background: </strong>Valve replacement is an optional treatment for patients with severe aortic stenosis (AS) and is associated with a better prognosis and improved quality of life. However, surgical valve replacement may result in severe complications, especially in the elderly. Transcatheter aortic valve replacement (TAVR) for treating symptomatic aortic stenosis has expanded exponentially, becoming a therapeutic option for intermediate- and high-risk patients. To thoroughly examine and monitor its practices and improve outcomes, our TAVI center in Isfahan established a detailed registry as the primary center for the TAVI procedure.</p><p><strong>Methods: </strong>This prospective study was conducted among all patients who underwent the TAVR procedure from September 2022 to December 2023 in Isfahan. Baseline characteristics (demographic, clinical, and procedural), 30-day outcomes, and one-year mortality data were collected.</p><p><strong>Results: </strong>A total of 50 patients underwent the TAVI procedure in Isfahan during our registry. Of these, 56% were male, and the mean age was 77.8 ± 6.7 years. The mean calculated STS score was 5.6. Cardiac death occurred in 4 patients (8%), one (2%) experienced a major vascular complication, 5 (10%) required new pacemaker implantation, and acute kidney injury was observed in 14%. Fever/sepsis occurred in 16%, cardiac tamponade in 6%, one patient (2%) had moderate AI, two patients experienced coronary obstructions, and one suffered a major cerebrovascular accident. Additionally, 4 patients (8%) developed atrial fibrillation, 1 (2%) had ventricular tachycardia, and 6 (12%) experienced AV block.</p><p><strong>Conclusion: </strong>We have shown good both 30-days outcome and one year mortality in our registry that could be a proper option in treating severe AS with comorbidities instead of surgical aortic valve replacement.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"18-27"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of abdominal obesity with the incidence of in-stent restenosis and thrombosis.","authors":"","doi":"10.48305/arya.2025.43542.3033","DOIUrl":"10.48305/arya.2025.43542.3033","url":null,"abstract":"<p><strong>Background: </strong>Given the association between obesity and increased risks of cardiovascular diseases, the acceleration of atherosclerosis, and the significance of patient outcomes after percutaneous coronary intervention (PCI), this study aimed to investigate the relationship between abdominal obesity and the incidence of in-stent restenosis (ISR) or stent thrombosis (ST) following PCI.</p><p><strong>Methods: </strong>This cross-sectional study included 5,980 patients who underwent angioplasty at Chamran Specialty Heart Hospital from March 2023 to February 2025. Of this population, 105 patients who developed ISR or ST and returned to the hospital were evaluated. Their demographic and clinical characteristics were recorded, and waist circumference was measured to assess abdominal obesity.</p><p><strong>Results: </strong>The findings revealed that ISR and ST occurred in 66 (86.8%) and 10 (13.2%) cases, respectively, among patients with abdominal obesity, whereas in patients without abdominal obesity, these complications were observed in 25 (86.2%) and 4 (13.8%) cases, respectively (P > 0.050). Additionally, the incidence of ISR or ST was reported to occur over a longer period in patients without abdominal obesity, whereas it was observed within a shorter timeframe after PCI in patients with abdominal obesity (P < 0.05).</p><p><strong>Conclusion: </strong>According to the results of this study, the prevalence of abdominal obesity was higher in patients with complications of ISR or ST after PCI. Also the incidence of ISR or ST occurred in a longer period of time in patients without abdominal obesity after PCI and in a shorter period of time after PCI in patients with abdominal obesity.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"43-50"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}