ARYA Atherosclerosis最新文献

{"title":"Clinical insights into nonbacterial thrombotic endocarditis in cancer patients: A case-based systematic review.","authors":"Ali Torkan, Houman Dehghan, Marzieh Tajmirriahi, Reihaneh Zavar","doi":"10.48305/arya.2025.45107.3045","DOIUrl":"10.48305/arya.2025.45107.3045","url":null,"abstract":"<p><strong>Background: </strong>Nonbacterial thrombotic endocarditis (NBTE) is a rare yet critical complication in cancer patients, with high embolic risk and poor prognoses. This systematic review investigates the clinical presentation, valve involvement, embolic risk, vegetation management, and prognostic variability across cancer types in NBTE cases.</p><p><strong>Methods: </strong>Adhering to PRISMA guidelines, we conducted a comprehensive literature search in PubMed, Scopus, and Embase for studies from 2000 to September 2024. Extracted data included demographics; cancer type and site; NBTE diagnosis timing; valve characteristics; embolic events; and patient outcomes. Chi-square and regression analyses evaluated associations among clinical variables and outcomes. Quality was appraised using the Joanna Briggs Institute tool.</p><p><strong>Results: </strong>From 38 studies comprising 40 cases, the mean patient age was 50.5 years (±12.5), with equal gender distribution (20 males, 20 females). Pancreatic adenocarcinoma (17.5%) and lung adenocarcinoma (15.0%) were most frequently associated with NBTE. Mortality rates varied significantly by cancer type, with gastrointestinal and urogenital cancers showing the highest rates. A significant association was found between cancer type and vegetation management strategy (χ² = 24.41, p = 0.018). Further correlations indicated that longer cancer histories necessitated more invasive management, and concurrent embolic events correlated with poorer prognoses. Quality assessment reinforced the findings' reliability (65% high quality).</p><p><strong>Conclusion: </strong>NBTE in cancer patients shows distinct clinical and prognostic patterns, with cancer type impacting both management and outcomes. These insights highlight the importance of tailored management approaches and provide a basis for future research to enhance care and prognostic assessments in NBTE cases within oncology.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"55-78"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexities of AVNRT ablation and its impact on electrophysiological features: A comprehensive review in children?","authors":"Mohammad Rafie Khorgami, Feisal Rahimpour, Davood Ramezani Nezhad","doi":"10.48305/arya.2024.42551.2948","DOIUrl":"10.48305/arya.2024.42551.2948","url":null,"abstract":"<p><strong>Background: </strong>Paroxysmal Supraventricular Tachycardia (PSVT) is a broad term referring to any rapid heart rhythm originating above the heart's ventricles. Atrioventricular Nodal Reentrant Tachycardia (AVNRT) is a specific type of PSVT characterized by abnormal circuits or pathways within the atrioventricular (AV) node, a crucial component of the heart's electrical conduction system. AVNRT can cause rapid heartbeats due to abnormal electrical impulses circulating within the AV node. This study aimed to explore the association between the QT, PR, and QRS intervals before and after RF ablation.</p><p><strong>Methods: </strong>In this cross-sectional study, 115 children with recurrent cardiac arrhythmias were screened and included between 2010 and 2023. The management of arrhythmias followed established guidelines and consensus statements.</p><p><strong>Results: </strong>The mean age of the 115 children was 9.91 ± 3.30 years, and 52.2% were female. Statistical analysis revealed a significant difference in cycle length (p=0.001), ventricular drive cycle length (p=0.001), atrioventricular Wenckebach (p=0.002), and antegrade effective refractory period of the AV node (p=0.013) before and after ablation.</p><p><strong>Conclusion: </strong>Supraventricular arrhythmias in children present complex cases that require individualized treatment approaches. Assessing the QT, PR, and QRS intervals before and after RF ablation provides a valuable tool for evaluating the success of these procedures, particularly in cases involving AVNRT.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"28-32"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the association of ischemic ECG changes and CBC parameters in normal population.","authors":"Mahdiyeh Yaghooti-Khorasani, Naiemeh Varasteh, Hossein Hatamzadeh, Sara Saffar Soflaei, Susan Darroudi, Toktam Sahranavard, Maryam Allahyari, Ehsan Mosa Farkhani, Alireza Heidari-Bakavoli, Hedieh Alimi, Azadeh Izadi-Moud, Fahime Hosseinzadeh, Gordon A Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan, Mohsen Moohebati","doi":"10.48305/arya.2025.43555.3038","DOIUrl":"10.48305/arya.2025.43555.3038","url":null,"abstract":"<p><strong>Background: </strong>Finding the relation between complete blood count (CBC) parameters and ischemic electrocardiogram (ECG) changes among a large normal population, for the first time.</p><p><strong>Methods: </strong>Participants of the first phase of the MASHAD cohort study were enrolled in this cross-sectional study. Twelve-lead ECGs were taken from participants. According to the Minnesota codes, we divided the ischemic ECG changes into major and minor. Major ischemic changes included major Q-wave changes, minor Q-wave plus ST-T changes, and major isolated ST-T changes. Minor changes included minor isolated Q/QS waves, minor ST/T changes, and ST-segment elevation. The mean of the CBC parameters was compared between individuals with and without ischemic changes. The backward stepwise logistic regression model was implemented to estimate the odds ratios of ECG changes and eliminate confounders. Data were analyzed using SPSS version 20, with significance set at p < 0.05.</p><p><strong>Results: </strong>Among 9,106 participants, 510 individuals (5.6%) had minor and major ischemic changes, with a preference for males. Major ischemic changes were not associated with CBC parameters. However, the odds of having minor ischemic changes increased 1.96-fold with increasing red blood cell (RBC) count (OR = 1.96 [1.31-2.94], p = 0.001); though, they decreased by 0.18 units with increasing hemoglobin (OR = 0.81 [0.73-0.92], p = 0.001). Additionally, high mean corpuscular volume (MCV) increased the odds of minor ischemic changes (OR = 1.05 [1.01-1.08], p = 0.004).</p><p><strong>Conclusion: </strong>Among Mashhad's normal population, major ischemic changes were not associated with CBC parameters. Also, minor and major ischemic changes were positively associated with WBC count.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"15-25"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular function and arterial stiffness in multisystem inflammatory syndrome in children with Covid-19.","authors":"Alireza Ahmadi, Mohammad Reza Sabri, Mehdi Ghaderian, Bahar Dehghan, Chehreh Mahdavi, Davood Ramezaninezhad, Zahra Pourmoghaddas, Mohammad Reza Maracy, Pejman Nemat Gorgani, Behzad Ghazanfari","doi":"10.48305/arya.2025.43214.3008","DOIUrl":"10.48305/arya.2025.43214.3008","url":null,"abstract":"<p><strong>Background: </strong>Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, potentially caused by endothelial dysfunction and arterial stiffness.</p><p><strong>Methods: </strong>This study aimed to investigate the cardiovascular health of children with MIS-C compared to healthy controls. Fifty-nine children with MIS-C and fifty-nine healthy individuals were included in this cohort study. Non-invasive techniques were employed to measure the brachial artery's flow-mediated dilation (FMD), aortic distensibility (AD), and aortic strain (AS).</p><p><strong>Results: </strong>The MIS-C group demonstrated significantly higher systolic blood pressure (P = 0.012), with a mean of 100.2 (10.1) mmHg compared to 95.3 (9.6) mmHg in the healthy group. The relative risk (RR) for elevated pulse pressure in the MIS-C group was borderline higher than in the healthy group (RR 95% CI: 1.06 [1.01-1.14]; P = 0.046). However, FMD, AS, and AD values were lower in the MIS-C group, with means of 13.6 (8.9), 10.4 (4.1), and 15.5 (2.7), respectively, although no significant differences were observed (P > 0.05).</p><p><strong>Conclusion: </strong>Children with MIS-C exhibited higher pulse pressure, indicating potential arterial stiffness. They also showed lower FMD, suggesting endothelial dysfunction. FMD appears to be a more reliable indicator of endothelial dysfunction in MIS-C patients compared to aortic strain. These findings underscore the importance of early assessment and monitoring of cardiovascular complications in MIS-C patients. Endothelial dysfunction and arterial stiffness are well-established risk factors for future cardiovascular events.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"54-62"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between egg consumption and major and minor ischemia changes on electrocardiogram: A population-based study.","authors":"Najmeh Seifi, Sara Saffar Soflaei, Muhammad Islampanah, Hossein Hatamzadeh, Bahareh Payami, Mahsa Ammarlou, Farnaz Farrokhzadeh, Habibollah Esmaily, Sara Yousefian, Helia Rezaeifard, Gordon A Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan","doi":"10.48305/arya.2025.43549.3036","DOIUrl":"10.48305/arya.2025.43549.3036","url":null,"abstract":"<p><strong>Background: </strong>Eggs, while nutrient-rich, have high cholesterol content. The link between egg consumption and cardiovascular disease (CVD) remains debated. This study investigates how egg intake correlates with minor and major electrocardiogram (ECG) abnormalities, which serve as potential indicators of CVD.</p><p><strong>Methods: </strong>In this cross-sectional study, a total of 5,928 participants without cardiovascular disease (CVD), aged between 35 and 65 years, were included. Dietary egg consumption was evaluated using a validated food frequency questionnaire. The Minnesota coding system was employed to identify minor and major ischemic abnormalities on ECG. Odds ratios (ORs) for major and minor ischemic patterns across different egg consumption categories were calculated using multivariable logistic regression.</p><p><strong>Results: </strong>Using several statistical models, this study showed that higher egg consumption was associated with lower odds of isolated major ECG abnormalities in men, but not in women. In the fully adjusted model, consuming more than four eggs per week, compared to the lowest category (<1/week), was correlated with a 40% decrease in the odds of major ischemic changes on ECG in men (OR: 0.60, 95% CI: 0.39-0.93). Regarding minor ischemic abnormalities, there was no significant association with egg consumption in either women or men.</p><p><strong>Conclusion: </strong>Our findings suggest a gender-specific effect of egg consumption on the presence of major ischemic changes on ECG. Further research is warranted to explore the underlying mechanisms and to inform tailored dietary guidelines for different populations.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"5-15"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure is the most negative consequence of CABG surgery (importance of exercise rehabilitation approach).","authors":"Sara Zare Karizak","doi":"10.48305/arya.2025.42587.2953","DOIUrl":"10.48305/arya.2025.42587.2953","url":null,"abstract":"<p><strong>Background: </strong>Statistics indicate that approximately 25,000 open-heart surgeries are performed annually in Iran, with coronary artery bypass grafting (CABG) surgeries accounting for 50-60% of these procedures. Although CABG offers numerous benefits to patients with coronary artery disease (CAD), some cases have reported negative consequences, such as heart failure (HF).</p><p><strong>Methods: </strong>This study explored several influential blood indices related to HF following CABG surgery using manuscripts extracted from PubMed, Scopus, and Google Scholar. The analysis focused on indicators that can exacerbate HF, including fibrotic factors such as catecholamines and the renin-angiotensin-aldosterone system (RAAS).Conversely, it also investigated anti-fibrotic factors, including adrenomedullin (ADM), the natriuretic peptide system (NPS), NP-converting enzymes, and NP receptors. Additionally, the study evaluated the impact of various exercise training programs on these variables.</p><p><strong>Results: </strong>Some fibrotic factors, such as catecholamines and the RAAS, contrast with anti-fibrosis factors, including NPs, their producing enzymes, receptors, production and excretion processes, ADM, and others. Research suggests these elements can be positively influenced by exercise rehabilitation.This study highlights the beneficial effects of exercise rehabilitation, specifically in reducing fibrotic factors and enhancing anti-fibrosis factors.</p><p><strong>Conclusion: </strong>All types of exercise training-including endurance, resistance, and combined training, in both continuous and interval modes with moderate and high intensity-can delay fibrotic pathways after surgery and prevent subsequent adverse structural (pathologic hypertrophy) and functional changes in the heart, such as HF.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"59-74"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of severity of pain in non-cardiac chest pain patients: A cross sectional study.","authors":"Hamidreza Roohafza, Danesh Heidari, Awat Feizi, Azam Khani, Kasra Shokri, Sara Bagherieh, Niloufar Yavari, Parsa Saneian, Ali Karami, Masoumeh Sadeghi","doi":"10.48305/arya.2025.43240.3010","DOIUrl":"10.48305/arya.2025.43240.3010","url":null,"abstract":"<p><strong>Background: </strong>This study aims to explore the psychosocial factors related to the severity of pain in patients with non-cardiac chest pain (NCCP), providing insights to support more comprehensive and targeted management strategies.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at two university-affiliated hospitals. Patients diagnosed with NCCP, based on physical examination and angiographic findings, completed questionnaires assessing type D personality, cardiac anxiety, fear of bodily sensations, somatization, depression, and pain severity. Univariate and multiple logistic regression analyses were conducted to identify factors influencing pain severity levels.</p><p><strong>Results: </strong>A total of 156 males and 204 females, with a mean age of 55.76 ± 12.83 years, were divided into low-pain (N = 182) and high-pain (N = 178) groups. Higher education and being female were significantly associated with greater pain severity. Depression, type D personality, somatization, and cardiac anxiety were significantly correlated with pain severity. Multiple logistic regression analysis indicated that self-rated health (OR,: 2.14; 95% CI. :1.18-3.90), depression (OR-11.15; 95% CI-:1.09-1.22), type D personality (OR-: 1.90; 95% CI-: 1.06- 3.41), somatization (OR-: 1.03; 95% CI-: 1.01-1.06), and fear of bodily sensation (OR-: 1.90; 95% CI-: 1.06-3.41), were all associated with pain severity.</p><p><strong>Conclusion: </strong>This study concluded that type D personality, fear of bodily sensations, depression, somatization, cardiac anxiety, and poor self-rated health were associated with increased NCCP severity. By controlling the disease and managing related pain earlier, more coherent treatment strategies can be implemented, ultimately improving patients' quality of life.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"49-58"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"rs17576 polymorphism of matrix metalloproteinase-9 in predicting coronary artery disease severity and its adverse outcome.","authors":"Hidayet Demir, Mehmet Altuğ Tunçer, Mehrdad Sheikhvatan, Sumaia M Abuqalben","doi":"10.48305/arya.2025.43384.3019","DOIUrl":"10.48305/arya.2025.43384.3019","url":null,"abstract":"<p><strong>Background: </strong>The role of matrix metalloproteinases in developing ischemic heart disease has been suggested. We investigated the effect of the <i>MMP-9</i> gene polymorphism rs17576 on the severity of coronary artery disease and outcomes in affected individuals.</p><p><strong>Methods: </strong>A total of 654 patients suspected of having coronary artery disease were assessed. Real-time PCR was performed for <i>MMP-9</i> (rs17576) genotyping, and ELISA was used to assess <i>MMP-9</i> plasma levels. The patients were followed up for one year.</p><p><strong>Results: </strong>Coronary angiography showed coronary artery involvement in 28% of patients. The frequencies of AA, AG, and GG genotypes of rs17576 in the group without coronary artery involvement were 5.5%, 31.4%, and 63.1%, respectively, while in those with coronary artery disease, the frequencies were 55.2%, 29.5%, and 15.3%, respectively, showing a significant difference (p < 0.001). The frequency of the major allele (G allele) in the normal group and the groups with single-, two-, and three-coronary involvement was 21.1%, 65.4%, 61.8%, and 85.0%, respectively, indicating a significant difference (p < 0.001). The mean serum level of <i>MMP-9</i> was 2,963 ± 1,077 pg/ml in the group with coronary artery disease and 2,145 ± 926 pg/ml in the group without coronary involvement, with a significant difference between the two groups (p = 0.008). The presence of the A allele of rs17576 was associated with an increased hazard of one-year mortality in the coronary artery disease group (HR = 5.764, p < 0.001).</p><p><strong>Conclusion: </strong>Tracking the rs17576 polymorphism of the <i>MMP-9</i> gene can predict coronary artery disease severity and its long-term poorer outcome.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"16-27"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of vascular adhesion molecule-1 in an ischemia-reperfusion cardia model.","authors":"Seyedamirhossein Zarei, Afshin Nazari, Farzaneh Chehelcheraghi, Mehdi Birjandi, Roxana Karbaschi","doi":"10.48305/arya.2025.43457.3025","DOIUrl":"10.48305/arya.2025.43457.3025","url":null,"abstract":"<p><strong>Background: </strong>Vascular adhesion molecule-1 (VCAM-1) is involved in promoting inflammation within blood vessels, activating endothelial cells, and is a key factor in the progression of diabetic vasculopathy in rats with diabetes, contributing to the underlying pathophysiological processes. This study focused on the expression level of VCAM-1 in diabetic rats subjected to a six-week schedule of aerobic training and valerian supplements.</p><p><strong>Methods: </strong>Fifty male Wistar rats' hearts were removed under deep anesthesia and were studied using Lutgendorf's apparatus. They were divided into five groups (10 each): Healthy control (C), Diabetic control (DC), Diabetic with valerian (DV), Diabetic with exercise (DE), and Diabetic with valerian and exercise (DVE). Diabetes was induced in the animals by administering a shot of STZ (50 mg/kg) in their abdominal area. Following confirmation of diabetes in the animals, moderate exercise five days a week, combined with intraperitoneal administration of 200 mg/kg/day of valerian, was maintained for six weeks. Heart tissue was obtained from diabetic cardiac ischemia-reperfusion model (CI/RM) injury (n=40) and control rats (n=10).</p><p><strong>Results: </strong>VCAM-1 expression and histological parameters were not observed when comparing experimental and control groups. However, the exercise/valerian treatment (E + V) notably reduced the irregularity in cardiac tissue and increased the size of cardiomyocytes.</p><p><strong>Conclusion: </strong>These findings suggest that E + V extract could diminish the levels of diabetic cardiac complications. Also, it had a dual effect: it corrected cardiac tissue abnormalities and increased the size of cardiomyocytes, enhancing the overall structure and function of the heart. More research is needed to understand non-pharmacological complementary treatments in this area.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"44-54"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public awareness and knowledge of stroke risk factors and symptoms in Saudi Arabia: A cross-sectional study.","authors":"Nouf Khaled A Alrawili, Sadeem N Alanazi, Shahad N Alanazi, Hind A Rikabi, Eman Mohamed Abdulkareem, Lina Eltaib","doi":"10.48305/arya.2025.43466.3027","DOIUrl":"10.48305/arya.2025.43466.3027","url":null,"abstract":"<p><p>Stroke is a critical global health issue characterized by sudden neurological dysfunction due to disrupted blood flow to the brain. This study aims to enhance understanding of stroke by examining its risk factors, symptoms, and prevention strategies. This was a cross-sectional study conducted in Saudi Arabia; the research involved a random sample of 442 participants over two months in 2024. The findings revealed that 63% of respondents were female, with the majority (64%) aged between 20-40 years, and 76% had university education. The overall knowledge level regarding stroke was moderate, at 62%. Of the 275 participants from the Northern Border Region, 60% demonstrated knowledge regarding risk factors, 58% regarding signs and symptoms, and 60% regarding treatment options. These results highlight a significant gap in knowledge among the Saudi public, particularly in understanding stroke's general aspects, risk factors, symptoms, and treatment options. The study emphasizes the importance of early recognition of stroke symptoms, summarized by the F.A.S.T. acronym, for timely medical intervention. It underscores the necessity for improved public education and awareness campaigns to enhance understanding and potentially reduce the impact of stroke in the community. A multifaceted approach integrating awareness, lifestyle modifications, and medical management is essential for effective stroke prevention and improved quality of life for individuals at risk.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"26-35"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}