ARYA Atherosclerosis最新文献

{"title":"Impact of Smoking Status on Major Adverse Cardiovascular Events in STEMI Patients: A Retrospective Cohort Study in Western Iran.","authors":"Parisa Janjani, Nahid Salehi, Sayeh Motevaseli, Atiyeh Asadmobini","doi":"10.48305/arya.2026.45612.3094","DOIUrl":"10.48305/arya.2026.45612.3094","url":null,"abstract":"<p><strong>Background: </strong>ST-elevation myocardial infarction (STEMI) remains a major cause of mortality worldwide. Whether smoking status and cumulative exposure influence prognosis in the contemporary era of timely reperfusion and intensive secondary prevention remains uncertain, particularly in populations with very high smoking rates. This study aimed to evaluate the association between smoking status and major adverse cardiovascular events (MACE) among patients with STEMI in western Iran.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving 645 consecutive patients with STEMI at a tertiary center in Western Iran. Patients were stratified by smoking status: never-smokers (n = 356), moderate smokers (<15 pack-years, n = 124), and heavy smokers (≥15 pack-years, n = 165). Outcomes included 1-year all-cause mortality and MACE over 365 days. Cox regression models adjusted for confounders were used to estimate hazard ratio with 95% confidence intervals (HR, 95% CI).</p><p><strong>Results: </strong>In crude analyses, heavy smokers had lower 1-year mortality (HR = 0.44, 95% CI: 0.22-0.87) and MACE (HR = 0.60, 95% CI: 0.40-0.91) compared to never-smokers. After full adjustment, these associations became non-significant (mortality HR = 0.92, 95% CI: 0.28-3.02; MACE HR = 1.51, 95% CI: 0.81-2.81). Never-smokers were older, more likely female, and had higher comorbidity rates, explaining crude differences. Socioeconomic factors, particularly education, influenced outcomes.</p><p><strong>Conclusion: </strong>The smoker's paradox is driven by confounders, not a protective effect of smoking. Smoking cessation and addressing socioeconomic disparities are critical for improving STEMI outcomes in high-risk populations.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 3","pages":"27-35"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a comprehensive home-based cardiac rehabilitation intervention on the health promotion of patients with coronary artery disease: A randomized double-blind clinical trial.","authors":"Zahra Teimouri-Jervekani, Niloufar Ebadi, Marjan Jamalian, Fereshte Rastegarnasab, Safoura Yazdekhasti, Hamidreza Roohafza, Hassan Okati Aliabad, Alireza Ansari Moghaddam, Masoumeh Sadeghi","doi":"10.48305/arya.2026.45704.3108","DOIUrl":"10.48305/arya.2026.45704.3108","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the efficacy of a comprehensive home-based cardiac rehabilitation (HBCR) program in promoting health outcomes among Iranian patients with coronary artery disease (CAD).</p><p><strong>Methods: </strong>This randomized, double-blind, clinical trial was conducted on 259 patients with CAD. Participants were allocated to receive either usual care or the HBCR program. Anthropometric indices, lipid profiles, and cardiovascular events were evaluated at baseline and during the follow-up periods.</p><p><strong>Results: </strong>Changes in serum low-density lipoprotein cholesterol (LDL-C) and arterial blood pressure did not differ significantly between the groups. Body mass index (BMI) was significantly reduced in the HBCR group compared to the control group (P = 0.004). At the study endpoint, hip circumference also demonstrated a more favorable status in the HBCR group (P = 0.002). High-density lipoprotein cholesterol (HDL-C) serum levels improved more prominently in the HBCR group (P = 0.030). Triglyceride (TG) levels showed a similar pattern in both groups, but the overall increase after 12 months was significantly higher in the control group (P = 0.019). Serum total cholesterol (TC) continuously increased in the control group, whereas it decreased in the HBCR group at 12 months, remaining significantly lower than in the control group overall (P = 0.003). Regarding cardiovascular events, mortality was significantly higher in the control group after 18 months (P = 0.007). Additionally, the rate of return to work after 6 months was significantly higher in the HBCR group (P = 0.020).</p><p><strong>Conclusion: </strong>This study demonstrated that a home-based cardiac rehabilitation program is an effective intervention for patients with CAD, leading to superior clinical outcomes.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 3","pages":"67-74"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular stenting for coarctation of the aorta in Infants and young children in southeast Iran: A retrospective study.","authors":"Fatemeh Doost-Mohammadi, Reza Derakhshan","doi":"10.48305/arya.2026.45312.3062","DOIUrl":"10.48305/arya.2026.45312.3062","url":null,"abstract":"<p><strong>Background: </strong>Coarctation of the aorta (CoA) in infants and young children is typically treated with high-risk open-heart surgery. Endovascular stenting provides a less invasive alternative; however, its safety and efficacy remain underexplored. This study aimed to evaluate procedural success, complications, and four-year outcomes of stenting for CoA.</p><p><strong>Methods: </strong>A retrospective review included 30 infants and young children (28 days to 3 years of age, weight >2.5 kg) with CoA who underwent endovascular stenting in Kerman and Sistan-Baluchestan, Iran, from 2024 to 2025. Patients with complex heart defects requiring immediate surgery or weighing <2.5 kg were excluded. Diagnostics utilized echocardiography, femoral angiography (for gradient assessment), and CT angiography. Outcomes included reduction in gradient, <i>minor complications</i> (<i>hematoma, transient arrhythmia</i>, localized bleeding, and bruising), major complications (stent thrombosis, vascular rupture, stent migration, vascular injury, sepsis, and mortality), and stent patency.</p><p><strong>Results: </strong>Procedural success was achieved in 27 out of 30 patients (90%, 95% CI: 73.5-97.9%). The mean gradient was reduced by 89% (from 45 ± 10 mmHg to 5 ± 3 mmHg, p<0.001). Minor complications occurred in 3 of 30 patients (10%; 95% CI: 2.1-26.5%), including 2 hematomas and 1 transient arrhythmia; no major complications or mortality were reported. Four-year stent patency was 90% (95% CI: 73.5-97.9%); 3 out of 30 patients (10%) required re-dilation at 2.5 years due to growth. Cox regression analysis found no predictors for re-intervention (p>0.05).</p><p><strong>Conclusion: </strong>Endovascular stenting seems to be a safe and effective alternative for CoA in infants and young children. Larger prospective studies are necessary.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 2","pages":"35-46"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13283337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of whey protein-based beverage formulation on the expression of genes related to lipid metabolisms, muscle function, and oxidative stress in trained mice.","authors":"Alieh Abdolrezaie, Hashem Nayeri, Ali Mohammad Ahadi, Ali Nasirpour, Ahmad Bagheri Moghadam","doi":"10.48305/arya.2025.43538.3039","DOIUrl":"10.48305/arya.2025.43538.3039","url":null,"abstract":"<p><strong>Background: </strong>The expression of metabolic genes can be changed by the simultaneous effect of endurance exercise and nutrition. The aim of this study was to verify the effects of endurance exercise and whey protein consumption on the expression of Fibronectin type III domain-containing protein 5 (<i>FNDC5</i>), Paraoxonase-1 (<i>PON1</i>), and proliferator-activated receptor alpha (<i>PPARα</i>) genes in muscle.</p><p><strong>Methods: </strong>A total of twenty BalB/C male mice were accidentally selected and subsequently divided into four groups, with each group consisting of five mice. The groups were as follows: placebo, exercised, whey-supplemented, and exercise plus whey-supplemented. In the groups involving exercise, the animals underwent treadmill exercise three times per week. The expression of <i>FNDC5</i>, <i>PON1</i>, and <i>PPARα</i> genes was analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Finally, GraphPad Prism 9.0 software was used to statistically evaluate changes in gene expression, and one-way analysis of variance (ANOVA) at the p<0.05 level and Tukey's multiple comparison test.</p><p><strong>Results: </strong><i>FNDC5</i> gene expression in muscle increased in the groups that were supplemented with whey or exercised, compared to the placebo group. Investigations did not show a significant difference in <i>FNDC5</i> expression in the liver between the whey-supplemented, exercise plus whey-supplemented, and placebo groups. In both liver and muscle tissue, whey protein increased the expression of PON1 (P = 0.001) regardless of exercise. <i>PPARα</i> expression also increased in muscle tissue. Additionally, the expression of <i>PON1</i> in muscle was higher in the whey-supplemented group compared to the exercise and placebo groups.</p><p><strong>Conclusion: </strong>The consumption of whey protein and its interaction with exercise can significantly contribute to the modification of energy and lipid metabolism, muscle function, and oxidative stress through increased metabolic gene transcription.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 2","pages":"17-25"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13283339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A roy adaptation model-based care program and its impact on quality of life in patients with acute coronary syndrome: A randomized controlled trial.","authors":"Miaad Mirzapour, Mohsen Shahriari, Sima Babaei","doi":"10.48305/arya.2025.45561.3089","DOIUrl":"10.48305/arya.2025.45561.3089","url":null,"abstract":"<p><strong>Background: </strong>Acute coronary syndrome (ACS), a clinical manifestation of chronic coronary artery disease, is often associated with multiple complications, recurrent hospitalizations, and diminished quality of life. Evaluating quality of life is a key outcome for determining the effectiveness of clinical and educational interventions. This study examined the impact of a care program grounded in the Roy Adaptation Model (RAM) on the quality of life of patients with ACS.</p><p><strong>Methods: </strong>In this randomized controlled trial, 76 patients with ACS were randomly assigned to either the intervention or control group. Data collection took place from July to December 2024. Participants in the intervention arm received a twoweek educational care program grounded in the Roy Adaptation Model, delivered through inperson sessions and supplemented with an instructional booklet. Data were gathered using a demographic survey, the SF36 qualityoflife instrument, and the Roy Adaptation Model assessment form, which were administered at baseline and at one and three months following the intervention.</p><p><strong>Results: </strong>Independent ttests revealed no significant preintervention differences in physical, mental, or overall qualityoflife scores between the groups. Following the intervention, the intervention group demonstrated significant improvements. Repeatedmeasures ANOVA confirmed significant main effects of time and timebygroup interaction. Subscale analysis demonstrated significant improvements in seven of the eight SF36 domains in the intervention group. In contrast, the control group exhibited a significant improvement only in general health.</p><p><strong>Conclusion: </strong>The Roy Adaptation Model provides an effective framework for fostering adaptation and enhancing quality of life in cardiac patients.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 2","pages":"5-16"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the bifurcation angle and the angle of the origin of the left anterior descending with the severity of coronary artery disease.","authors":"Maryam Moradi, Saeid Zeidy, Asieh Maghami-Mehr, Fatemeh Poursabagh","doi":"10.48305/arya.2025.45215.3052","DOIUrl":"10.48305/arya.2025.45215.3052","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the association between the bifurcation angle and the angle of the origin of the left anterior descending (LAD) coronary artery with the degree of proximal LAD (pLAD) stenosis.</p><p><strong>Methods: </strong>This study was cross-sectional and addressed 578 patients suspected of coronary artery disease (CAD) who underwent coronary computed tomography angiography (CCTA) because of angina pectoris symptoms at Shahid Chamran Hospital, Isfahan. PLAD stenosis as well as the left main (LM)-LAD and the LAD-left circumflex artery (LCX) (bifurcation) angles were assessed and recorded on CCTA images. Then, one-way analysis of variance (ANOVA) or chi-squared tests were used. ROC analysis was used to evaluate the diagnostic value of each of the two angles in identifying pLAD stenosis.</p><p><strong>Results: </strong>Using a cut-off value of 23º for the LM-LAD angle, the sensitivity and specificity for predicting pLAD stenosis <50% were 63.70% and 47.67%, respectively. In addition, using a cut-off value of 30º for the LM-LAD angle, the sensitivity and specificity for predicting pLAD stenosis ≥50% were 52.24% and 68.77%, respectively (P value<0.05). Moreover, for predicting pLAD stenosis <50%, a 49º cut-off for the LAD-LCX angle demonstrated a sensitivity and specificity of 61.64% and 56.99%, respectively. Furthermore, for predicting pLAD stenosis ≥50%, a 50º cut-off for the LAD-LCX angle yielded a sensitivity and specificity of 70.15% and 58.63%, respectively (P value<0.05).</p><p><strong>Conclusion: </strong>The findings of this study showed that the LAD-LCX and LM-LAD angles had a direct and significant association with the severity of pLAD stenosis, such that wider angles were associated with greater pLAD stenosis.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 1","pages":"41-47"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project.","authors":"Mohammadtaghi Sarebanhassanabadi, Mahdieh Mousavirad, Lida Hosseini, Pedro Marques-Vidal, Alexander Kraemer, Seyedeh Mahdieh Namayandeh, Hamideh Mihanpour, Sima Mozafari","doi":"10.48305/arya.2025.45949.3127","DOIUrl":"10.48305/arya.2025.45949.3127","url":null,"abstract":"<p><strong>Background: </strong>The incidence of coronary artery disease (CAD) is influenced by several risk factors, including hypertension. Although the association between hypertension and CAD has been investigated in Western countries, limited research has been conducted in Asia and the Middle East. We investigated the association between hypertension and the 10year risk of CAD in the adult population.</p><p><strong>Methods: </strong>In this cohort study, 2,000 participants aged 20 to 74 years in the Yazd Healthy Heart Project were enrolled in 2005-2006 and followed up to 2015-2016. Participants with a history of CAD were excluded. At baseline, data on demographic characteristics, anthropometric measurements, biochemical blood tests, and lifestyle factors were collected. The association between hypertension and approximately 10year CAD risk was assessed using the Cox regression model.</p><p><strong>Results: </strong>The baseline prevalence of hypertension among adults was 36.1%. During the tenyear followup, CAD incidence was 16.8% in men, 12.0% in women, and 14.5% in the total population. After adjusting for potential confounders, hypertension increased the risk of CAD in men (HR = 1.64; 95% CI: 1.09-2.46), women (HR = 2.16; 95% CI: 1.15-4.05), and the whole sample (HR = 1.73; 95% CI: 1.23-2.43). This association was similar in men and women (p for interaction ≥0.05).</p><p><strong>Conclusion: </strong>This study demonstrated a significant association between hypertension and CAD risk, highlighting the need for targeted interventions in populations with hypertension to reduce CAD risk.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 2","pages":"26-34"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13283338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrograde transcatheter closure of perimembranous and muscular ventricular septal defects in pediatric and adult patients: 12month outcomes in a case series of 60 patients from Iran.","authors":"Fatemeh Doost-Mohammadi, Alireza Amirbeigi, Reza Derakhshan","doi":"10.48305/arya.2026.45972.3133","DOIUrl":"10.48305/arya.2026.45972.3133","url":null,"abstract":"<p><strong>Background: </strong>Conventional antegrade transcatheter closure of ventricular septal defects (VSDs) requires prolonged fluoroscopy and risks right-heart complications. This study evaluated the safety, efficacy, and 12-month outcomes of the retrograde approach using direct left ventricular access in pediatric and adult patients.</p><p><strong>Methods: </strong>Between January 2022 and June 2024, 60 consecutive Iranian patients (median age 10 years, range 1-40 years) with perimembranous (n = 48) or muscular (n = 12) VSDs underwent retrograde transcatheter closure using LifeTech occluders via bilateral femoral arterial access and left-sided transthoracic echocardiography at two centers in Kerman, Iran.</p><p><strong>Results: </strong>Technical success was 100%, with 95% achieved on the first attempt. Median defect size was 6.2 mm (range 2.8-11 mm). The Qp/Qs ratio decreased from 2.2 ± 0.5 to 1.1 ± 0.2 (P < 0.001), and ejection fraction increased from 58.5 ± 7.2% to 62.2 ± 6.5% (P < 0.05). Mean fluoroscopy time was 13.3 ± 4.1 minutes, radiation dose was 2.8 ± 1.1 mGy, and hospital stay was 1.2 ± 0.5 days. Minor complications occurred in five patients (8.3%; all Clavien-Dindo Grade I) and resolved without sequelae. At 12-month follow-up with cardiac CT or MRI in all patients, no device migration, embolization, aortic erosion, or significant residual shunt was observed.</p><p><strong>Conclusion: </strong>Retrograde transcatheter VSD closure appears to be safe and effective, and it may be reducing radiation exposure safe and highly effective, significantly reducing radiation exposure, making it a potential attractive alternative to conventional techniques in children and pediatric and adult patients.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 3","pages":"1-12"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-promoting lifestyle in cardiac patients: The mediating role of cognitive flexibility in the relationship between intimate relationships and distress tolerance.","authors":"Maedeh Mirzaei Malati, Majid Baradaran, Leila Moghtader","doi":"10.48305/arya.2025.45677.3105","DOIUrl":"10.48305/arya.2025.45677.3105","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to determine the predictive model of health-promoting lifestyle in cardiovascular patients based on intimate relationships and distress tolerance, mediated by cognitive flexibility.</p><p><strong>Methods: </strong>The research design was a cross-sectional correlational study using structural equation modeling. The statistical population included cardiovascular patients in 2025 who referred to three specialized cardiology clinics for outpatient examination. A total of 265 individuals were selected as the sample using convenience sampling. Standard questionnaires for health-promoting behaviors (Walker et al.), social intimacy (Miller and Lefcourt), distress tolerance (Simons and Gaher), and cognitive flexibility (Dennis and Vander Wal) were used. Statistical data analysis was performed using the Pearson correlation coefficient and path analysis with bootstrap testing, employing AMOS 24 and SPSS 26 software.</p><p><strong>Results: </strong>The results of path analysis and bootstrap testing showed that the proposed model had a good statistical fit (χ²/df = 2.94, RMSEA = 0.071, CFI = 0.939, GFI = 0.990). The indirect effect of intimate relationships on health-promoting lifestyle through cognitive flexibility (β = 0.1148, p = 0.001) and the indirect effect of distress tolerance on health-promoting lifestyle through cognitive flexibility (β = 0.0924, p = 0.001) were confirmed.</p><p><strong>Conclusion: </strong>The structural model, with good fit, explained the mediating role of cognitive flexibility in the relationship between intimate relationships and distress tolerance with health-promoting lifestyle in cardiovascular patients. These findings provide an operational framework for psychotherapy interventions based on strengthening distress tolerance and interpersonal relationships to improve cardiovascular health.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 1","pages":"7-17"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use and the cost of inpatient diagnostic and therapeutic procedures for cardiovascular diseases in public hospitals of Isfahan, Iran.","authors":"Reza Rezayatmand, Davood Nasiri, Alireza Khosravi Farsani, Farzaneh Mohammadi-Sefiddashti","doi":"10.48305/arya.2025.45299.3061","DOIUrl":"10.48305/arya.2025.45299.3061","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) are the most important cause of mortality and disability worldwide, causing substantial personal, social, and economic problems. This study determined the use and Cost of inpatient diagnostic and therapeutic CVD procedures in Isfahan from 2019 to 2021.</p><p><strong>Methods: </strong>This descriptive study covered a three-year period (2019-2021). Data were gathered from the Health Information System of two public hospitals that carried out these procedures (Chamran and Khorshid hospitals) in Isfahan, Iran. A list of procedures was carefully chosen according to experts' opinions, for which the use and cost of these procedures were extracted.</p><p><strong>Results: </strong>Coronary angiography demonstrated the highest annual average use (47.65%), while mitral valve repair showed the lowest (0.06%). The highest annual average total cost was seen in angioplasty (617,425,750,917 IRR), while the lowest was seen in mitral valve repair (2,375,305,232 IRR). Regarding cost per procedure, VSD surgery (409,107,479 IRR) had the highest annual average cost, while the lowest was seen in coronary angiography (56,340,938 IRR). A consistent upward trend in cost per procedure (in IRR) was observed across all procedures during the study period.</p><p><strong>Conclusion: </strong>The majority of cardiovascular procedure costs are attributable to diagnosing and treating ischemic heart disease (IHD). Consequently, the increasing prevalence of CVDs particularly IHD coupled with the use of advanced technologies, imposes a significant financial burden on the healthcare system. This underscores the critical need for policy actions focused on lifestyle modification and primary prevention. Such measures are essential to curb rising costs and ensure healthcare system sustainability.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"22 1","pages":"18-26"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}