ARYA Atherosclerosis最新文献

{"title":"Association between epicardial and pericadial fat thickness and coronary artery calcification severity in chronic kidney disease patients: A pilot study.","authors":"Roxana Sadeghi, Pedram Sadeghi, Niloufar Taherpour, Taraneh Faghihi Langroudi, Shiva Samavat, Mohammad Haji Aghajani, Mohammad Parsa Mahjoob, Mehrdad Jafari Fesharaki","doi":"10.48305/arya.2025.43184.3005","DOIUrl":"10.48305/arya.2025.43184.3005","url":null,"abstract":"<p><strong>Background: </strong>This study aims to investigate the association between Coronary Artery Calcium (CAC) score and epicardial fat thickness (EFT) and pericardial fat thickness as indicators of inflammation in patients with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>This cross-sectional study measured patients' CAC scores using dual-source cardiac CT, quantified with Agatston's score and dedicated Ca-Scoring software. Epicardial and pericardial fat thicknesses were assessed via echocardiography.</p><p><strong>Results: </strong>Thirty-one CKD patients participated in the study, with an average age of 54.45 ± 15.12 years. Of these, 22 were male (70.97%) and 9 were female (29.03%). Fifteen CKD patients (48.39%) had moderate to severe CAC scores. Patients with CKD exhibiting severe coronary calcification were found to be older (P = 0.003). A significant positive correlation was observed between epicardial fat thickness (r = 0.58, P < 0.001) and pericardial fat thickness (r = 0.56, P = 0.001) with CAC score. Multivariable analysis revealed that for each one-unit increase in EFT, the odds of having a moderate to severe CAC score were 2.88 times greater than those of a normal score (OR = 2.88, 95% CI = 1.04-7.96, P = 0.041). Similarly, a one-unit increase in pericardial fat thickness was associated with 1.51 times higher odds of a moderate to severe CAC score compared to a normal score (OR = 1.51, 95% CI = 0.93-2.46, P = 0.093).</p><p><strong>Conclusion: </strong>The insights gained from this study advocate for a holistic approach to assessing cardiac function in patients with coronary calcification. By integrating echocardiographic analysis with traditional risk factor assessment, healthcare providers can gain a more comprehensive understanding of cardiovascular health, ultimately leading to better-targeted therapies to improve CKD patient outcomes.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"38-48"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Cytochrome P450 2D6 (*4, *9, *10, *41) alleles in healthy population from north-west of Iran.","authors":"Elahe Bagherinia, Amir Dehghani, Naser Khalili, Hamid Soraya, Morteza Bagheri","doi":"10.48305/arya.2025.42811.2980","DOIUrl":"10.48305/arya.2025.42811.2980","url":null,"abstract":"<p><strong>Background: </strong>The CYP2D6 gene locus is complex and highly polymorphic. Given the clinical importance of the CYP2D6 enzyme in liver xenobiotic metabolism, genotyping its significant alleles among different ethnic groups is essential for evaluating the efficacy of certain drugs. In this study, we assessed the frequency of the <i>CYP2D6*4, *9, *10, and *41</i> alleles in a healthy population from northwestern Iran.</p><p><strong>Methods: </strong>Fifty unrelated healthy individuals from West Azerbaijan Province, Iran, were studied using PCR-RFLP and ARMS-PCR techniques.</p><p><strong>Results: </strong><i>CYP2D6*9</i> (rs5030656) allele was not detected. The frequency (%) of <i>CYP2D6*4</i> (rs3892097), <i>CYP2D6*10</i> (rs1065852) and <i>CYP2D6*41</i> (rs28371725) alleles were 10%, 13% and 8%, respectively.</p><p><strong>Conclusion: </strong>Our findings indicate that the frequencies of \"non-functional\" and \"reduced function\" alleles are relatively high in this population. Determining Cytochrome P450 2D6 allele variations can contribute to risk assessment and patient management regarding adverse or poor drug responses, ultimately aiding in the prevention of increased mortality risks among different populations.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"33-42"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the power of obesity indices to predict cardiovascular diseases at different ages: An application of conditional time-dependent ROC curve in Healthy Heart Cohort of Yazd, Iran.","authors":"Mohammad Hashem Khademi Kolah Loui, Sara Jambarsang, Seyedeh Mahideh Namayandeh, Seyyed Mohammad Tabatabaei, Abdollah Hozhabrnia, Reyhane Sefidkar","doi":"10.48305/arya.2025.42469.2938","DOIUrl":"10.48305/arya.2025.42469.2938","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to estimate the power of anthropometric markers to predict 10-year CVD across different age groups in the Yazd Healthy Heart cohort.</p><p><strong>Methods: </strong>A total of 1,623 individuals aged 20 to 74, who were free of CVD, participated in the study. A conditional time-dependent receiver operating characteristic (ROC) curve was used to estimate the predictive power of anthropometric indices, including the Abdominal Volume Index (AVI), Body Adiposity Index (BAI), and Waist-to-Height Ratio (WHtR), adjusted for age and sex.</p><p><strong>Results: </strong>Of the 1,623 participants, 818 were males (50.40%) and 805 were females (49.60%). The Area Under the Curve (AUC) for the BAI ranged from 0.50 to 0.70 for males aged 40 to 70 years. In females, the BAI biomarker demonstrated considerable to excellent predictive power (AUC > 0.8) for individuals aged 20 to approximately 33 years. For males, AVI and WHtR showed fair to considerable predictive power in participants aged 20 to 30 years. In the age group of 30 to approximately 68 years, the predictive power varied from poor to ineffective, except for individuals close to 50 years old. In females, the predictive power of the AVI and WHtR biomarkers ranged from fair to considerable for those aged 20 to around 33 years.</p><p><strong>Conclusion: </strong>This study found that AVI and WHtR can fairly predict 10-year CVD risk in young individuals of both sexes, while the BAI was specifically applicable for predicting risk in young women. These markers are valuable and affordable tools for youth CVD screening.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"36-43"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of novel ultrathin, biodegradable polymer tetriflex (sirolimus-eluting stent) optimization using intravascular ultrasound (IVUS) in short coronary lesion (≤ 20mm) vs. long coronary lesion (≥ 20mm): Tetriflex IVUS study.","authors":"Najeeb Ullah Sofi, Mohit Sachan, Santosh Kumar Sinha, Mukesh J Jha, Umeshwar Pandey, Mahmodullah Razi, Awadesh K Sharma, Puneet Aggarwal, Praveen Shukla, Rakesh Varma","doi":"10.48305/arya.2024.41978.2912","DOIUrl":"10.48305/arya.2024.41978.2912","url":null,"abstract":"<p><strong>Background: </strong>Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) is useful for stent optimization. Outcomes of the ultrathin Supralimus Tetriflex stent (Sahajanand Medical Technologies Pvt. Ltd., India) using IVUS were evaluated among patients with short (≤ 20 mm) versus long lesions (≥ 20 mm).</p><p><strong>Methods: </strong>A total of 207 patients underwent PCI, and IVUS was performed post-deployment. The primary outcome was optimal stent deployment, defined as (a) mean surface area (MSA) >5.0 mm²; (b) plaque burden <50%; (c) complete apposition; and (d) no edge dissection. Secondary outcomes were target lesion failure (TLF)-a composite of cardiac death, target vessel myocardial infarction (TVMI), and target lesion revascularization (TLR)-stent thrombosis, and major adverse cardiovascular events (MACE; a composite of death, MI, stent thrombosis, and repeat revascularization).</p><p><strong>Results: </strong>Suboptimal deployment was significantly more frequent among patients with longer lesions (30.1% vs. 23.3%; p=0.03) due to higher rates of malapposition (17.3% vs. 10.6%) and MSA <5 mm² (9.6% vs. 7.7%). Following post-dilatation, suboptimal deployment was observed in 7.6% and 5.8% of patients, respectively. Residual plaque burden was 4.5% and 5.7%, respectively. The MSA in both groups was 6.3 mm² and 6.5 mm². Minimum and mean stent expansions were 82.1% versus 81.7% and 106.3% versus 109.8%, respectively, with no significant differences. TLF and stent thrombosis were observed in 0.9% versus 0.9% and 2.9% versus 3.8% of patients, respectively, with no significant differences. However, MACE was significantly higher (10.5% vs. 8.7%; p=0.05) among patients with longer lesions.</p><p><strong>Conclusion: </strong>Supralimus Tetriflex stent has very good optimal deployment based on angiogram and becomes better with IVUS imaging, making it safe among long lesions (≥ 20mm).</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"22-35"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surprising palpitation: An unexpected diagnosis of sarcoidosis.","authors":"Hoda Raffiei Jelodar, Roxana Sadeghi, Reza Hamneshin Behbahani, Kimia Karimi Toudeshki","doi":"10.48305/arya.2024.42684.2968","DOIUrl":"10.48305/arya.2024.42684.2968","url":null,"abstract":"<p><p>Sarcoidosis is a challenging disease characterized by the formation of granulomas in multiple organs. It presents with a variety of clinical symptoms, making diagnosis difficult for physicians. Myocardial involvement in sarcoidosis is rare, but it worsens prognosis and can lead to mortality. Physicians face challenges in diagnosing cardiac sarcoidosis due to its wide range of symptoms. Cardiac sarcoidosis that affects only the heart without involvement of other organs is extremely uncommon. In this case, we examine the scenario of a middle-aged man who experienced palpitations and was diagnosed with ventricular tachycardia. He remained in stable condition without any other clinical signs suggestive of sarcoidosis. This case highlights the importance of considering sarcoidosis as a potential diagnosis in patients presenting with palpitations and ventricular tachycardia on electrocardiogram, particularly when these symptoms are accompanied by sudden new-onset systolic dysfunction despite normal coronary arteries.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"3-9"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized dissection of ascending aorta and arch rupture due to fire suppressant blast: A rare mechanism of injury successfully managed by urgent surgical intervention.","authors":"Robert Grant, Anand Iyer, Pouya Nezafati","doi":"10.48305/arya.2025.43477.3029","DOIUrl":"10.48305/arya.2025.43477.3029","url":null,"abstract":"<p><strong>Background: </strong>Traumatic aortic injuries are predominantly caused by high-impact motor vehicle collisions, often due to sudden deceleration. This report presents a rare case of localized dissection and partial aortic arch rupture resulting from a fire suppressant explosion.</p><p><strong>Case presentation: </strong>A 36-year-old male was transferred following a fire suppressant explosion at a copper smelter. He presented with central chest pain and stable hemodynamics, with no signs of external chest trauma. Computed tomography (CT) imaging revealed a localized dissection of the ascending aorta and a partial rupture of the aortic arch, in addition to fractures in the hand and foot caused by suppressant debris. The patient subsequently became hemodynamically unstable and required urgent surgical intervention. He underwent ascending aortic and aortic arch repairs. Postoperatively, his course was complicated by a pulmonary embolism, which was managed medically. He was eventually discharged after recovering from his injuries.</p><p><strong>Conclusion: </strong>Aortic injuries resulting from small-scale blasts can occur. Successful management relies on a high index of suspicion and timely surgical intervention.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"1-4"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lavender aromatherapy and acetaminophen as preemptive on comfort and Nitroglycerin-induced headache in acute coronary syndrome.","authors":"Roghayeh Ezati-Soleiman, Arezou Karampourian, Mahnaz Khatiban, Leili Tapak, Mohammad-Hossein Sayadi","doi":"10.48305/arya.2025.42978.2992","DOIUrl":"10.48305/arya.2025.42978.2992","url":null,"abstract":"<p><strong>Background: </strong>Nitroglycerin (NTG) improves cardiac ischemia, but one of its side effects is headache. This study aimed to compare the effects of lavender aromatherapy and acetaminophen as preemptive interventions on comfort and NTG-induced headache in patients with acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>This three-arm randomized clinical trial was conducted on 90 patients divided into three groups of 30. In the acetaminophen group, patients were given 500 mg of oral acetaminophen approximately 15 minutes before IV nitroglycerin infusion. In the lavender group, 15 minutes before nitroglycerin IV infusion, cotton gauze soaked in three drops of 2% lavender essential oil was used. In the control group, patients received routine care for the treatment of NTG-induced headaches. The severity of patients' headaches was evaluated using the visual analog scale (VAS) at 5, 10, 15, and 60 minutes after starting nitroglycerin infusion.</p><p><strong>Results: </strong>The mean headache intensity at the 60th minute in the lavender and control groups was 1.37 ± 1.10 and 2.50 ± 2.43, respectively, while no headaches were reported in the acetaminophen group. The highest mean pain severity recorded at different times was 2.12 ± 0.86 in the control group. Headache severity varied across the intervention minutes among the three groups (p < 0.001). Additionally, post-intervention comfort was significantly higher in the acetaminophen and lavender groups compared to the control group (p < 0.001), with a significant difference observed between the groups (p < 0.001).</p><p><strong>Conclusion: </strong>The results of this study suggest that acetaminophen can be used as a preemptive agent to reduce NTG-induced headaches and improve the comfort of ACS patients.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"28-37"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights into nonbacterial thrombotic endocarditis in cancer patients: A case-based systematic review.","authors":"Ali Torkan, Houman Dehghan, Marzieh Tajmirriahi, Reihaneh Zavar","doi":"10.48305/arya.2025.45107.3045","DOIUrl":"10.48305/arya.2025.45107.3045","url":null,"abstract":"<p><strong>Background: </strong>Nonbacterial thrombotic endocarditis (NBTE) is a rare yet critical complication in cancer patients, with high embolic risk and poor prognoses. This systematic review investigates the clinical presentation, valve involvement, embolic risk, vegetation management, and prognostic variability across cancer types in NBTE cases.</p><p><strong>Methods: </strong>Adhering to PRISMA guidelines, we conducted a comprehensive literature search in PubMed, Scopus, and Embase for studies from 2000 to September 2024. Extracted data included demographics; cancer type and site; NBTE diagnosis timing; valve characteristics; embolic events; and patient outcomes. Chi-square and regression analyses evaluated associations among clinical variables and outcomes. Quality was appraised using the Joanna Briggs Institute tool.</p><p><strong>Results: </strong>From 38 studies comprising 40 cases, the mean patient age was 50.5 years (±12.5), with equal gender distribution (20 males, 20 females). Pancreatic adenocarcinoma (17.5%) and lung adenocarcinoma (15.0%) were most frequently associated with NBTE. Mortality rates varied significantly by cancer type, with gastrointestinal and urogenital cancers showing the highest rates. A significant association was found between cancer type and vegetation management strategy (χ² = 24.41, p = 0.018). Further correlations indicated that longer cancer histories necessitated more invasive management, and concurrent embolic events correlated with poorer prognoses. Quality assessment reinforced the findings' reliability (65% high quality).</p><p><strong>Conclusion: </strong>NBTE in cancer patients shows distinct clinical and prognostic patterns, with cancer type impacting both management and outcomes. These insights highlight the importance of tailored management approaches and provide a basis for future research to enhance care and prognostic assessments in NBTE cases within oncology.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"55-78"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid dysfunction in heart failure with preserved ejection fraction: A systematic review and meta-analysis.","authors":"Maryam Heidarpour, Mania Banar, Amir Parsa Abhari, Sadegh Mazaheri-Tehrani, Ziba Farajzadegan, Mohammad Fakhrolmobasheri, Parastesh Rezvanian, Davood Shafie","doi":"10.48305/arya.2025.45322.3064","DOIUrl":"10.48305/arya.2025.45322.3064","url":null,"abstract":"<p><strong>Background: </strong>Despite controversial findings regarding the association between thyroid hormones and heart failure with preserved ejection fraction (HFpEF), thyroid dysfunction is widely assumed to be independently associated with this condition. Herein, we sought to systematically review the existing literature and estimate the prevalence of thyroid dysfunction in patients with HFpEF.</p><p><strong>Methods: </strong>We conducted a comprehensive search in PubMed, Scopus, Web of Science, Embase, and ProQuest up to the end of November 2024. Observational studies assessing thyroid dysfunction prevalence in patients with HFpEF were included in this study. The prevalence of overt thyroid dysfunction, low T3 syndrome, and subclinical hypothyroidism (SCH) was pooled using a random-effects model. Duval and Tweedie's Trim and Fill test, funnel plot, and Egger's test were utilized for publication bias assessment. All analyses were conducted with R Version 4.5.1 and Comprehensive Meta-Analysis Version 3 software.</p><p><strong>Results: </strong>Fourteen studies involving 3,931 subjects with HFpEF were included in this analysis. The pooled prevalence of overt thyroid dysfunction, based on six studies, was 15% (95% CI: 7%-29%). The pooled prevalence of low T3 syndrome was 22% (95% CI: 20%-25%), and for SCH, it was 15% (95% CI: 1%-68%).</p><p><strong>Conclusion: </strong>Despite heterogeneity among the included studies, our findings suggest that thyroid dysfunction is relatively common in patients with HFpEF and may be associated with more severe symptoms and worse outcomes.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 6","pages":"80-98"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-month survival and predictors of mortality after ischemic stroke: A prospective cohort study in Iran.","authors":"Zohre Foroozanfar, Mahboubeh Parsaeian, Siamak Abdi, Masoud Mehrpour, Mohamadreza Gheini, Rana Mashakhi Sarbangoli, Akram Yazdani, Mohsen Mohammadi, Akbar Fotouhi","doi":"10.48305/arya.2025.45310.3060","DOIUrl":"10.48305/arya.2025.45310.3060","url":null,"abstract":"<p><strong>Background: </strong>The burden of stroke can be reduced by controlling its mortality risk factors. We aimed to identify the predictors of mortality within six months after ischemic stroke.</p><p><strong>Methods: </strong>This prospective cohort study was performed on 703 ischemic stroke patients in Tehran, Iran, during 2018-2019. Data on demographic and clinical characteristics were collected through interviews and hospital records. The patients' survival status was followed up by telephone interviews at 28 days, 3 months, and 6 months after stroke. Cox proportional hazard model and extended Cox model were used to determine the predictors of mortality after stroke.</p><p><strong>Results: </strong>The 6-month mortality rate was 19.50% (95% CI: 16.70-22.67). Age (HR=1.01; 95% CI: 1.001-1.03), higher educational levels (HR=1.05; 95% CI: 1.01-1.10), and blood sugar levels on admission (HR=1.04; 95% CI: 1.01-1.08) were significantly associated with an increase in 6-month mortality. However, alcohol consumption (HR=0.09; 95% CI: 0.02-0.38), alteplase administration (HR=0.65; 95% CI: 0.43-0.98), and higher hemoglobin values (HR=0.80; 95% CI: 0.72-0.88) were associated with a decrease in 6-month mortality. The hazard ratio of death for diastolic blood pressure, socioeconomic status, cholesterol levels, and stroke severity varied over time.</p><p><strong>Conclusion: </strong>Some characteristics significantly increased or decreased the risk of mortality after stroke. Additionally, the effect of some variables changed over time, suggesting that stroke prognosis may be associated with dynamic risk factors. Identifying and addressing these factors can inform targeted strategies to improve post-stroke survival outcomes.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 6","pages":"51-60"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}