ARYA Atherosclerosis最新文献

{"title":"Correlation between transforming growth factor-β1 (TGF- β1) with premature atherosclerosis in type 1 diabetes.","authors":"Harjoedi Adji Tjahjono, Wisnu Barlianto, Dian Handayani, Handono Kalim","doi":"10.48305/arya.2024.11581.2125","DOIUrl":"10.48305/arya.2024.11581.2125","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes (T1D) carries a significant risk of atherosclerosis as the main driver for cardiovascular events. Atherosclerosis is initiated by the activation of the endothelium by various risk factors through the inflammation process. The anti-inflammatory cytokine TGF-β1 may inhibit the development of atherosclerosis.</p><p><strong>Methods: </strong>In a cross-sectional study, a total of 40 patients aged 14.5±3.16 years old with T1D and 40 healthy controls aged 14.7±0.99 years old were involved. Common carotid artery IMT (cIMT) was measured by real-time M-echocardiography mode (Affinity 50G Philips) and Flow Mediated Dilatation (FMD), using high-resolution ultrasonography and Doppler flow characteristics. The TGF-β1 level was measured by indirect ELISA at Saiful Anwar Hospital Laboratory.</p><p><strong>Results: </strong>There were no differences in age, gender, Body Mass Index (BMI), duration of diabetes, renal function, or nutritional status between the T1D and healthy groups (p>0.05). A significant difference in cIMT was observed between the T1D group and the healthy group (0.567 ± 0.87 mm vs. 0.387 ± 0.57 mm, p = 0.000), FMD (7.17 ± 3.98 mm vs. 11.22 ± 5.48 mm, p = 0.000), and the level of TGF-β1 cytokine (39.83±13.51 vs. 73.67±15.34 pg/ml, p = 0.000). A significantly negative correlation between TGF-β1 and cIMT (p = 0.000; r = -0.685) and a significantly positive correlation between TGF-β1 and FMD (p = 0.000; r = +0.55) were found.</p><p><strong>Conclusion: </strong>Atherosclerosis is an inflammatory disease accelerated by diabetes. The inflammation process is more prominent in T1D patients. T1D patients show a decreased level of TGF-β1, increased measurement of cIMT (>0.5 mm), and a decreased measurement of FMD.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 4","pages":"7-13"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of flow-mediated vasodilatation (FMD) and comparison with carotid intima-media thickness (CIMT) in children with cyanotic congenital heart disease.","authors":"Mehdi Ghaderian, Alireza Ahmadi, Narges Navabfar, Mohammad Reza Sabri, Bahar Dehghan, Chehreh Mahdavi","doi":"10.48305/arya.2023.42047.2917","DOIUrl":"10.48305/arya.2023.42047.2917","url":null,"abstract":"<p><strong>Background: </strong>There is a high mortality rate in cyanotic patients with congenital heart disease (CHD) due to cardiovascular complications. The cardiovascular prognosis is negatively affected by endothelium dysfunction, increased arterial stiffness, and impaired vascular system. This study aimed to determine carotid intimal mean thickness (CIMT) and flow-mediated dilatation (FMD) in a group of children with cyanotic CHD (CCHD).</p><p><strong>Methods: </strong>FMD and CIMT were evaluated for 45 children with CHKD and 38 patients who did not have CHKD over the period 2021 to 2022, as part of this case-control study. In terms of age and gender, the case group has been compared to controls.</p><p><strong>Results: </strong>Men accounted for 61.3% of the participants, with a mean standard deviation age of 7.8 5.39 years. In subjects with CCHD, CIMT increased non-significantly and FMD decreased significantly, but systolic blood pressure was significantly higher in patients than in the healthy group. (P=0.003).</p><p><strong>Conclusion: </strong>FMD was reduced in children with CCHD, but in controls, systolic blood pressure and CIMT were lower. The risk of developing atherosclerosis in CCHD patients may be increased by an increase in CIMT and systolic blood pressure.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 1","pages":"1-8"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of short-term consequences of atrial septal defect closure in adults referred to Shahid Chamran heart center in Isfahan.","authors":"Payam Ebrahimifar, Houman Dehghan, Alireza Khosravi Farsani","doi":"10.48305/arya.2024.31245","DOIUrl":"10.48305/arya.2024.31245","url":null,"abstract":"<p><strong>Background: </strong>Secundum Atrial Septal Defects (ASDs) are the most common type of atrial septal defects. Today, using different types of occluders, transcatheter closure is widely used to treat ASD and has replaced the surgical procedure in anatomically suitable patients. This study was performed to evaluate the short-term clinical outcomes of treatment of adult patients requiring an ASD device closure referred to Shahid Chamran Cardiovascular Center in Isfahan, Iran.</p><p><strong>Methods: </strong>All patients who underwent ASD treatment using transcatheter closure at Shahid Chamran Cardiovascular Center in 2020 and 2021 were recruited in this retrospective descriptive study. The characteristics of the treated lesion and the cardiovascular complications during treatment were recorded immediately and one month after treatment.</p><p><strong>Results: </strong>A total of 70 patients (47 females and 23 males) with a mean age of 39.81±12.56 years were investigated in this study. The number of difficult anomalies was 46 (65.7%), and the most common type was the deficient aortic rim. In terms of the incidence of vascular complications, hematoma, bleeding, and pseudoaneurysm were observed in 8 patients. The most common cardiac complication was atrial fibrillation, which occurred in 12 patients. No cardiovascular complications were observed during the one-month follow-up.</p><p><strong>Conclusion: </strong>The results of this single-institute study showed that ASD treatment by the transcatheter procedure using an ASO device at Shahid Chamran Cardiovascular Center was performed safely and successfully with very few complications. The short-term analysis of the outcomes indicated no major complications, deaths, or device malposition.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 4","pages":"32-37"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of using amplatzer ductal occluder type I and II for peri membranous ventricular septal defect closure: A systematic review.","authors":"Mehdi Ghaderian, Saba Ramezani, Samin Behdad, Mojgan Gharipour, Mehrnoush Dianatkhah, Silva Hovesepian, Negin Salemi","doi":"10.48305/arya.2024.42641.2962","DOIUrl":"10.48305/arya.2024.42641.2962","url":null,"abstract":"<p><strong>Background: </strong>Ventricular septal defect (VSD) is a common congenital heart defect that affects many individuals. Transcatheter closure has become a successful treatment method. However, certain devices used for closure can lead to life-threatening complications such as complete heart block. This systematic review aimed to assess the efficacy and safety of Amplatzer duct occluders (ADOs) types I and II for closing perimembranous VSDs (pmVSDs).</p><p><strong>Methods: </strong>This review followed the PRISMA 2020 guidelines and searched multiple databases for English articles on pmVSD closure using ADO I/II published up to 2022. Relevant keywords were used and the data were categorized to report the incidence of common complications.</p><p><strong>Results: </strong>The study, which involved 1,691 patients with primary pmVSD and ages ranging from 6 months to 15 years, found that ADO type I had a high success rate with low rates of complete heart block and other complications. ADO type II had a higher rate of severe complications, particularly complete heart block. The overall estimated success rate for device implantation was 97.3%, with only one procedure-related death. The occurrence of complete heart block was 2.3%, and residual shunts were the most frequent complication (4.8%).</p><p><strong>Conclusion: </strong>The findings of this systematic review provide valuable insights into the use of ADO types I and II for closing pmVSDs. Healthcare professionals should be aware of these findings and closely monitor patients who undergo ADO device closure for pmVSDs. Further research is recommended to determine the specific indications for using each type of Amplatzer device in the relevant population.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 6","pages":"54-64"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of chordal systolic anterior motion without hypertrophic cardiomyopathy misdiagnosed with acute coronary syndrome.","authors":"Mohammad Haji Aghajani, Fateme Omidi, Reza Hamneshin Behbahani, Moein Ebrahimi","doi":"10.48305/arya.2024.42681.2967","DOIUrl":"10.48305/arya.2024.42681.2967","url":null,"abstract":"<p><p>Chordal systolic anterior motion (SAM) refers to the anterior motion of the mitral valve towards the left ventricular outflow tract (LVOT) that occurs during systole. Chordal SAM is a potentially fatal condition. Chordal SAM is linked to an elevated risk of sudden death and can lead to significant obstruction of the left ventricular outflow tract (LVOT) and mitral regurgitation. It is crucial to acknowledge and consider this phenomenon when assessing individuals experiencing dyspnea and chest discomfort. By doing so, unnecessary therapies related to heart failure and heart attack might be avoided. Ensuring timely diagnosis is crucial in order to prevent unnecessary and potentially dangerous therapies that can aggravate LVOT obstruction and lead to hemodynamic instability. In this paper, we present a 47-year-old woman who experienced sudden chest pain and dyspnea. The patient had a history of hypertension and previous myocardial infarction. ST-elevation was observed in the first ECG. The primary treatment for acute coronary syndrome was initiated. Coronary angiography demonstrated that coronary vessels were not obstructed. The diagnosis of chordal SAM was initially overlooked during the echocardiography, but it was later identified during a subsequent echocardiography after cardiac catheterization. When using beta-blockers, her clinical condition improved.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 6","pages":"1-5"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and medication adherence in patients with ST- elevated myocardial infarction: Persian polypill study.","authors":"Elaheh Amirfar, Ehsan Shirvani, Shervin Ghaffari Hoseini, Marjan Mansourian, Shima Aminzadeh, Marjan Jamalian, Alireza Nateghi, Afshin Amirpour, Mohammad Kermani-Alghoreaishi, Zahra Teimouri-Jervekani, Jamshid Najafian, Hamid Sanei, Alireza Khosravi-Farsani, Kiyan Heshmt-Ghahdarijani, Mozhdeh Askari, Mohammadsadegh Sahebzadeh, Nizal Sarrafzadegan, Hamidreza Roohafza, Masoumeh Sadeghi","doi":"10.48305/arya.2025.43212.3007","DOIUrl":"10.48305/arya.2025.43212.3007","url":null,"abstract":"<p><strong>Background: </strong>Polypill or fixed-dose combination has been recognized as an effective secondary prevention strategy for patients with cardiovascular disease (CVD). This study aimed to evaluate the effectiveness of the polypill on one-year medication adherence, patient satisfaction, and lipid profile control in patients with ST-elevation myocardial infarction (STEMI).</p><p><strong>Methods: </strong>This was an open-label, multicentric, randomized clinical trial study of STEMI patients who were prescribed a polypill (Aspirin 81 mg, Atorvastatin 40 mg, Metoprolol Succinate 47.5 mg, and Valsartan 40 mg) versus usual care (continued with separate medications) for secondary prevention. The primary outcome was to compare one-year medication adherence between groups. Other outcomes included comparing patient satisfaction and lipid profile after 12 months of follow-up, as well as identifying predictor factors of medication adherence.</p><p><strong>Results: </strong>Of 624 STEMI participants, 289 patients were treated with the polypill (79.2% male; mean age 61.67 ± 8.54 years), and 335 patients received usual care (82.7% male; mean age 62.10 ± 9.63 years). After one-year follow-up, no significant differences were detected between groups regarding medication adherence (p-value = 0.351) and cholesterol levels (p-value = 0.808). The polypill strategy was associated with increased patient satisfaction and better control of LDL-C (p-value = 0.043) and HDL-C (p-value < 0.001). Patients with a history of chronic kidney disease (OR: 13.392; p-value = 0.001), cerebrovascular disease (OR: 4.577; p-value = 0.011), and higher waist circumference (OR: 1.01; p-value = 0.002) demonstrated a lower probability of medication adherence. In contrast, in-hospital complications such as arrhythmia (OR: 0.039; p-value = 0.010), bleeding (OR: 0.034; p-value = 0.007), and higher ejection fraction (OR: 0.965; p-value = 0.002) were associated with a higher probability of medication adherence.</p><p><strong>Conclusion: </strong>In STEMI patients, participants treated with polypills were more satisfied and showed better lipid profile control. However, a longer follow-up duration is needed to examine the effectiveness of the polypill on medication adherence in this subgroup.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 6","pages":"43-53"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ST-segment changes in lead aVR and angiographic findings, syntax score, short-term and intermediate outcomes in patients with acute coronary syndrome: A pilot study.","authors":"Afshin Amirpour, Hosein Masoumi, Masoumeh Sadeghi, Reihaneh Zavar, Bahar Darouei, Seyedeh Mahnaz Mirbod, Raza Amani-Beni","doi":"10.48305/arya.2024.42601.2954","DOIUrl":"10.48305/arya.2024.42601.2954","url":null,"abstract":"<p><strong>Background: </strong>In this study, we aimed to investigate the prognostic implications of lead aVR ST-segment elevation in an initial electrocardiogram (ECG) in patients diagnosed with acute coronary syndrome (ACS). Furthermore, we evaluated the association between electrocardiographic changes in lead aVR and objective measures such as angiographic findings and Syntax score.</p><p><strong>Methods: </strong>This retrospective cohort study, conducted as a pilot study, encompassing both a retrospective cross-sectional analysis and a longitudinal follow-up, took place at Chamran Hospital from November 2017 to October 2019. A 6-month follow-up was conducted via phone interviews to assess patient outcomes.</p><p><strong>Results: </strong>During the study period, there were 76 admissions with the final diagnosis of acute coronary syndrome and lead aVR ST-segment elevation on ECG. ARB intake and the severity of right coronary artery stenosis were significantly higher in patients with STE-aVR ≥1.5 mm. The clinical pathway analysis and 6-month follow-up outcomes concerning ST-segment changes in lead aVR did not reveal statistically significant differences in the distribution of various intervention strategies and clinical events. The overall ST-change was a significant risk factor for 6-month follow-up angiography (OR: 1.10; 95% CI: 1.002 to 1.213) and was also significantly associated with any stenosis in the RCA territory (OR: 1.10; 95% CI: 1.004 to 1.21). There was no significant association between ST-change and other follow-up hospital and angiography outcomes.</p><p><strong>Conclusion: </strong>The findings suggest that medication history, particularly with angiotensin receptor blockers, may shape the observed ST-segment changes in lead aVR. However, further investigation is needed to better understand the clinical implications of these trends.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 5","pages":"25-37"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of adherence to DASH diet components and reduction of heart failure risk in adults: A case-control study.","authors":"Abbas Abbasi, Davood Shafie, Reza Heidari Moghaddam, Masoumeh Sadeghi, Seyyed Morteza Safavi","doi":"10.48305/arya.2024.42670.2964","DOIUrl":"10.48305/arya.2024.42670.2964","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF), or congestive Heart failure (CHF), is a heart disorder with a number of symptoms caused by the heart's inability to pump blood. Our aim in conducting this study is to investigate the adherence to dietary approaches to stop hypertension (DASH) diet components and the risk of HF in Iranian adult women and men.</p><p><strong>Methods: </strong>In this hospital-based, case-control study, we included 340 participants (194 men and 146 women) aged 30-70 years who were recently (less than 6 months) diagnosed with HF. In this study, there were 169 participants in the control group and 171 participants in the case group. A semi-quantitative food frequency questionnaire (FFQ) with 148 items was used to assess food intake. Multiple logistic regression statistical tests were used to evaluate the relationship between DASH score and HF.</p><p><strong>Results: </strong>After adjusting for confounding variables, the data showed that adherence to the DASH diet was associated with a reduced risk of HF. Our data show that a significant relationship was found between the consumption of fruits (OR: 0.62; 95% CI: 0.53-0.68), vegetables (OR: 0.53; 95% CI: 0.28-0.81), legumes and nuts (OR: 0.75; 95% CI: 0.65-0.68), and heart failure, but no significant relationship was found with the other components of the DASH diet and heart failure.</p><p><strong>Conclusion: </strong>Findings suggest that there is an inverse relationship between adherence to the DASH-style diet and the likelihood of HF, and adherence to some components of the DASH diet was also effective in reducing the risk of HF. To obtain more complete results, it is necessary to conduct cohort studies and randomized clinical trials.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 4","pages":"38-46"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross- sectional study on the association between lifestyle factors and coronary artery stenosis severity among adults living in central Iran: A protocol for the Iranian- CARDIO study.","authors":"Maryam Motallaei, Mina Darand, Marzieh Taftian, Sara Beigrezaei, Faezeh Golvardi-Yazdi, Matin Mohyadini, Fatemeh Mirjalili, Zahra Darabi, Azam Ahmadi Vasmehjani, Seyedmostafa Seyedhosseini, Mohammad-Taghi Sareban-Hassanabadi, Sayyed Saeid Khayyatzadeh, Amin Salehi-Abargouei","doi":"10.48305/arya.2023.41026.2843","DOIUrl":"10.48305/arya.2023.41026.2843","url":null,"abstract":"<p><strong>Background: </strong>Although several studies have attempted to identify coronary artery disease (CAD) risk factors, few have explored the association between lifestyle-related factors and the severity of coronary artery stenosis. The present study was designed to assess the association between a combination of lifestyle, dietary, cardiometabolic, psychological, and mental factors, and CAD severity in adults undergoing angiography.</p><p><strong>Methods: </strong>This cross-sectional study aimed to recruit a total of 700 patients (aged 35 to 75 years) who met the inclusion criteria and were referred for angiography between July 2020 and November 2021 to Afshar Hospital, a central heart disease hospital in Yazd city, Iran. To assess the presence and intensity of CAD, we used the Gensini and SYNTAX scores. Biochemical factors were measured using standard kits from serum samples, and extra serum and whole blood samples were retained for further analyses. Data on general information, dietary food and supplement intake, eating habits, medicinal herbs consumption, psychological and mental state, sleep quality, and other variables were gathered by trained interviewers using specific questionnaires.</p><p><strong>Results: </strong>In total, 720 participants (444 males and 276 females) aged 56.57±9.78 years were included in the current study. Moderate to severe coronary artery stenosis was prevalent in 47.0% and 17.9% of participants based on Gensini and SYNTAX scores, respectively.</p><p><strong>Conclusion: </strong>The results of this study will enhance our understanding of the association between different risk factors and the severity of coronary artery stenosis.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 1","pages":"51-61"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is cardiac rehabilitation after pci as effective as cabg? The first experience from the eastern mediterranean region cardiac rehabilitation registry.","authors":"Masoumeh Sadeghi, Erfan Sheikhbahaei, Dominique Hansen, Razieh Hassannejad, Sina Rouhani, Mohammad Mahdi Hadavi, Safoura Yazdekhasti, Amir Behfar, Hamidreza Roohafza","doi":"10.48305/arya.2024.42234.2926","DOIUrl":"10.48305/arya.2024.42234.2926","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of cardiac rehabilitation (CR) programs following either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) has been separately studied. Few studies have compared the effects of similar CR programs between PCI and CABG. This study aimed to compare the effects of CR in patients recruited following either PCI or CABG on coronary heart disease risk factors, psychological variables, and functional capacity.</p><p><strong>Methods: </strong>For this retrospective study, the documents of the CR program registry of the Isfahan Cardiovascular Research Institute were reviewed from 2008 to 2021. Patients with ischemic heart disease undergoing PCI or CABG were enrolled in an 8-week exercise-based cardiac rehabilitation program. Demographics, smoking status, clinical data, echocardiographic parameters, laboratory data, functional capacity, and psychological status were assessed.</p><p><strong>Results: </strong>Patients who underwent CABG (n=557) were more likely to be referred to CR than those who underwent PCI (n=440). All variables changed significantly after the CR program compared to their baseline value in both the PCI and CABG groups. However, low-density lipoprotein and total cholesterol levels, peak systolic blood pressure, and resting and peak diastolic blood pressure did not change in any of the groups, and fasting blood sugar (p=0.01) and triglyceride (TG) (p=0.01) levels significantly decreased only in the PCI group. Between-group comparisons indicated that after adjustment, no significant difference was observed between the PCI and CABG groups except for TG, which was significantly reduced in the PCI group (p=0.01).</p><p><strong>Conclusion: </strong>The CR program was equally effective in patients who underwent either PCI or CABG.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 1","pages":"9-19"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}