ARYA Atherosclerosis最新文献

{"title":"Severe pulmonary hypertension associated with unilateral pulmonary artery hypoplasia: A case report.","authors":"Mohammadreza Malakoutikhah, Forough Kalantari, Alireza Nematollahi, Hazhir Moradi, Elham Kalantari","doi":"10.48305/arya.2025.45447.3076","DOIUrl":"10.48305/arya.2025.45447.3076","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension (PH), defined as mean pulmonary arterial pressure >20 mmHg, has diverse etiologies and high morbidity and mortality, necessitating early, accurate diagnosis.</p><p><strong>Methods: </strong>A 42-year-old woman, misdiagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) and treated with anticoagulation for four years, had a rare congenital vascular anomaly. She presented with cough, hemoptysis (~200 mL of fresh blood two hours before admission), progressive dyspnea, and chest discomfort. Examination revealed a loud P2, suggesting right ventricular strain. Echocardiography showed elevated pulmonary artery pressure with right ventricular dysfunction. Chest CT angiography revealed abnormal vascular anatomy; pulmonary angiography confirmed unilateral pulmonary artery hypoplasia (UPAH) as the cause of PH. Anticoagulation was stopped, and embolization was performed successfully. At the two-month follow-up, symptoms had resolved and hemoptysis had not recurred.</p><p><strong>Results: </strong>UPAH is a rare congenital cause of PH that can mimic CTEPH, leading to misdiagnosis and inappropriate prolonged anticoagulation. Symptoms often overlap with common conditions such as pulmonary thromboembolism. In this case, lack of treatment response prompted reevaluation. Careful reassessment of prior imaging, history, and rare differential diagnoses was essential. This case highlights the importance of reconsidering the diagnosis when the course deviates from expectations and the need for individualized management in uncommon PH etiologies.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 6","pages":"1-7"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the association of ischemic ECG changes and CBC parameters in normal population.","authors":"Mahdiyeh Yaghooti-Khorasani, Naiemeh Varasteh, Hossein Hatamzadeh, Sara Saffar Soflaei, Susan Darroudi, Toktam Sahranavard, Maryam Allahyari, Ehsan Mosa Farkhani, Alireza Heidari-Bakavoli, Hedieh Alimi, Azadeh Izadi-Moud, Fahime Hosseinzadeh, Gordon A Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan, Mohsen Moohebati","doi":"10.48305/arya.2025.43555.3038","DOIUrl":"10.48305/arya.2025.43555.3038","url":null,"abstract":"<p><strong>Background: </strong>Finding the relation between complete blood count (CBC) parameters and ischemic electrocardiogram (ECG) changes among a large normal population, for the first time.</p><p><strong>Methods: </strong>Participants of the first phase of the MASHAD cohort study were enrolled in this cross-sectional study. Twelve-lead ECGs were taken from participants. According to the Minnesota codes, we divided the ischemic ECG changes into major and minor. Major ischemic changes included major Q-wave changes, minor Q-wave plus ST-T changes, and major isolated ST-T changes. Minor changes included minor isolated Q/QS waves, minor ST/T changes, and ST-segment elevation. The mean of the CBC parameters was compared between individuals with and without ischemic changes. The backward stepwise logistic regression model was implemented to estimate the odds ratios of ECG changes and eliminate confounders. Data were analyzed using SPSS version 20, with significance set at p < 0.05.</p><p><strong>Results: </strong>Among 9,106 participants, 510 individuals (5.6%) had minor and major ischemic changes, with a preference for males. Major ischemic changes were not associated with CBC parameters. However, the odds of having minor ischemic changes increased 1.96-fold with increasing red blood cell (RBC) count (OR = 1.96 [1.31-2.94], p = 0.001); though, they decreased by 0.18 units with increasing hemoglobin (OR = 0.81 [0.73-0.92], p = 0.001). Additionally, high mean corpuscular volume (MCV) increased the odds of minor ischemic changes (OR = 1.05 [1.01-1.08], p = 0.004).</p><p><strong>Conclusion: </strong>Among Mashhad's normal population, major ischemic changes were not associated with CBC parameters. Also, minor and major ischemic changes were positively associated with WBC count.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 4","pages":"15-25"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexities of AVNRT ablation and its impact on electrophysiological features: A comprehensive review in children?","authors":"Mohammad Rafie Khorgami, Feisal Rahimpour, Davood Ramezani Nezhad","doi":"10.48305/arya.2024.42551.2948","DOIUrl":"10.48305/arya.2024.42551.2948","url":null,"abstract":"<p><strong>Background: </strong>Paroxysmal Supraventricular Tachycardia (PSVT) is a broad term referring to any rapid heart rhythm originating above the heart's ventricles. Atrioventricular Nodal Reentrant Tachycardia (AVNRT) is a specific type of PSVT characterized by abnormal circuits or pathways within the atrioventricular (AV) node, a crucial component of the heart's electrical conduction system. AVNRT can cause rapid heartbeats due to abnormal electrical impulses circulating within the AV node. This study aimed to explore the association between the QT, PR, and QRS intervals before and after RF ablation.</p><p><strong>Methods: </strong>In this cross-sectional study, 115 children with recurrent cardiac arrhythmias were screened and included between 2010 and 2023. The management of arrhythmias followed established guidelines and consensus statements.</p><p><strong>Results: </strong>The mean age of the 115 children was 9.91 ± 3.30 years, and 52.2% were female. Statistical analysis revealed a significant difference in cycle length (p=0.001), ventricular drive cycle length (p=0.001), atrioventricular Wenckebach (p=0.002), and antegrade effective refractory period of the AV node (p=0.013) before and after ablation.</p><p><strong>Conclusion: </strong>Supraventricular arrhythmias in children present complex cases that require individualized treatment approaches. Assessing the QT, PR, and QRS intervals before and after RF ablation provides a valuable tool for evaluating the success of these procedures, particularly in cases involving AVNRT.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 2","pages":"28-32"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular function and arterial stiffness in multisystem inflammatory syndrome in children with Covid-19.","authors":"Alireza Ahmadi, Mohammad Reza Sabri, Mehdi Ghaderian, Bahar Dehghan, Chehreh Mahdavi, Davood Ramezaninezhad, Zahra Pourmoghaddas, Mohammad Reza Maracy, Pejman Nemat Gorgani, Behzad Ghazanfari","doi":"10.48305/arya.2025.43214.3008","DOIUrl":"10.48305/arya.2025.43214.3008","url":null,"abstract":"<p><strong>Background: </strong>Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, potentially caused by endothelial dysfunction and arterial stiffness.</p><p><strong>Methods: </strong>This study aimed to investigate the cardiovascular health of children with MIS-C compared to healthy controls. Fifty-nine children with MIS-C and fifty-nine healthy individuals were included in this cohort study. Non-invasive techniques were employed to measure the brachial artery's flow-mediated dilation (FMD), aortic distensibility (AD), and aortic strain (AS).</p><p><strong>Results: </strong>The MIS-C group demonstrated significantly higher systolic blood pressure (P = 0.012), with a mean of 100.2 (10.1) mmHg compared to 95.3 (9.6) mmHg in the healthy group. The relative risk (RR) for elevated pulse pressure in the MIS-C group was borderline higher than in the healthy group (RR 95% CI: 1.06 [1.01-1.14]; P = 0.046). However, FMD, AS, and AD values were lower in the MIS-C group, with means of 13.6 (8.9), 10.4 (4.1), and 15.5 (2.7), respectively, although no significant differences were observed (P > 0.05).</p><p><strong>Conclusion: </strong>Children with MIS-C exhibited higher pulse pressure, indicating potential arterial stiffness. They also showed lower FMD, suggesting endothelial dysfunction. FMD appears to be a more reliable indicator of endothelial dysfunction in MIS-C patients compared to aortic strain. These findings underscore the importance of early assessment and monitoring of cardiovascular complications in MIS-C patients. Endothelial dysfunction and arterial stiffness are well-established risk factors for future cardiovascular events.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 1","pages":"54-62"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of C1q/TNF-related protein-1 (CTRP1) and CTRP3 in patients with coronary artery disease.","authors":"Gholamreza Namazi, Maryam Mehranian, Alireza Mafi, Razieh Salami, Fariba Raygan","doi":"10.48305/arya.2025.43204.3006","DOIUrl":"10.48305/arya.2025.43204.3006","url":null,"abstract":"<p><strong>Background: </strong>Research suggests that C1q/TNF-related proteins (CTRPs) play a role in inflammation and may impact coronary artery disease (CAD). This study aimed to measure their levels in CAD patients and assess their correlation with disease severity.</p><p><strong>Methods: </strong>This study involved 88 individuals (50 men and 38 women) who underwent coronary angiography. Among them, 47 patients had significant coronary obstruction and were selected as the case group, and 41 individuals without significant obstruction were considered as the control group. Serum levels of CTRP1 and CTRP3 were quantified using the ELISA method, whereas other parameters were assessed by standard laboratory techniques. Multiple logistic regression analysis was used to examine the association between CTRP1 and CTRP3 levels with CAD.</p><p><strong>Results: </strong>The mean age of CAD patients was 62.1 ± 11.5 years. Thirty-one patients were male and sixteen were female. The control group comprised nineteen men and twenty-two women, with a mean age of 62.3 ± 12.7 years. The concentrations of CTRP1 and CTRP3 proteins were significantly higher in individuals with CAD relative to controls. Except for serum HDL levels, which were lower in the CAD group than in the control group, there were no significant differences in the demographic or clinical features between the studied groups. A direct and significant association was discovered between the amounts of assessed adipokines and the severity of CAD.</p><p><strong>Conclusion: </strong>A greater concentration of both CTRP1 and CTRP3 was strongly associated with the presence and severity of CAD, indicating that these adipocytokines may serve as markers for CAD.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 5","pages":"34-41"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to avoid oversizing Perceval sutureless aortic valve: Technique.","authors":"Pouya Nezafati, Sumit Yadav","doi":"10.48305/arya.2025.43498.3031","DOIUrl":"10.48305/arya.2025.43498.3031","url":null,"abstract":"<p><p>Aortic valve replacement surgery technique has been revolutionised with the introduction of sutureless valves. Perceval sutureless aortic valve (PSV) is one of the most widely used examples. However, oversizing the PSV has been reported to be an issue. After a case of PSV stent recoil in our institution, a new technique was developed, where only the white obturator is used to size the valve. Recently, this technique was also mentioned by different authors. With this technique, we achieved low rates of paravalvular leaks and pacemaker implantation, with good transvalvular gradients. Therefore, we recommend this technique over the manufacturer's instructions.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 5","pages":"1-3"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between egg consumption and major and minor ischemia changes on electrocardiogram: A population-based study.","authors":"Najmeh Seifi, Sara Saffar Soflaei, Muhammad Islampanah, Hossein Hatamzadeh, Bahareh Payami, Mahsa Ammarlou, Farnaz Farrokhzadeh, Habibollah Esmaily, Sara Yousefian, Helia Rezaeifard, Gordon A Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan","doi":"10.48305/arya.2025.43549.3036","DOIUrl":"10.48305/arya.2025.43549.3036","url":null,"abstract":"<p><strong>Background: </strong>Eggs, while nutrient-rich, have high cholesterol content. The link between egg consumption and cardiovascular disease (CVD) remains debated. This study investigates how egg intake correlates with minor and major electrocardiogram (ECG) abnormalities, which serve as potential indicators of CVD.</p><p><strong>Methods: </strong>In this cross-sectional study, a total of 5,928 participants without cardiovascular disease (CVD), aged between 35 and 65 years, were included. Dietary egg consumption was evaluated using a validated food frequency questionnaire. The Minnesota coding system was employed to identify minor and major ischemic abnormalities on ECG. Odds ratios (ORs) for major and minor ischemic patterns across different egg consumption categories were calculated using multivariable logistic regression.</p><p><strong>Results: </strong>Using several statistical models, this study showed that higher egg consumption was associated with lower odds of isolated major ECG abnormalities in men, but not in women. In the fully adjusted model, consuming more than four eggs per week, compared to the lowest category (<1/week), was correlated with a 40% decrease in the odds of major ischemic changes on ECG in men (OR: 0.60, 95% CI: 0.39-0.93). Regarding minor ischemic abnormalities, there was no significant association with egg consumption in either women or men.</p><p><strong>Conclusion: </strong>Our findings suggest a gender-specific effect of egg consumption on the presence of major ischemic changes on ECG. Further research is warranted to explore the underlying mechanisms and to inform tailored dietary guidelines for different populations.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"5-15"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure is the most negative consequence of CABG surgery (importance of exercise rehabilitation approach).","authors":"Sara Zare Karizak","doi":"10.48305/arya.2025.42587.2953","DOIUrl":"10.48305/arya.2025.42587.2953","url":null,"abstract":"<p><strong>Background: </strong>Statistics indicate that approximately 25,000 open-heart surgeries are performed annually in Iran, with coronary artery bypass grafting (CABG) surgeries accounting for 50-60% of these procedures. Although CABG offers numerous benefits to patients with coronary artery disease (CAD), some cases have reported negative consequences, such as heart failure (HF).</p><p><strong>Methods: </strong>This study explored several influential blood indices related to HF following CABG surgery using manuscripts extracted from PubMed, Scopus, and Google Scholar. The analysis focused on indicators that can exacerbate HF, including fibrotic factors such as catecholamines and the renin-angiotensin-aldosterone system (RAAS).Conversely, it also investigated anti-fibrotic factors, including adrenomedullin (ADM), the natriuretic peptide system (NPS), NP-converting enzymes, and NP receptors. Additionally, the study evaluated the impact of various exercise training programs on these variables.</p><p><strong>Results: </strong>Some fibrotic factors, such as catecholamines and the RAAS, contrast with anti-fibrosis factors, including NPs, their producing enzymes, receptors, production and excretion processes, ADM, and others. Research suggests these elements can be positively influenced by exercise rehabilitation.This study highlights the beneficial effects of exercise rehabilitation, specifically in reducing fibrotic factors and enhancing anti-fibrosis factors.</p><p><strong>Conclusion: </strong>All types of exercise training-including endurance, resistance, and combined training, in both continuous and interval modes with moderate and high intensity-can delay fibrotic pathways after surgery and prevent subsequent adverse structural (pathologic hypertrophy) and functional changes in the heart, such as HF.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 3","pages":"59-74"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between short-term PM2.5 exposure and the incidence of NSTEMI: A case-crossover study.","authors":"Shayan Pourghazi, Roxana Sadeghi, Niloufar Taherpour, Mohammad Haji Aghajani, Mohammad Parsa Mahjoob, Amir Heidari","doi":"10.48305/arya.2025.45152.3046","DOIUrl":"10.48305/arya.2025.45152.3046","url":null,"abstract":"<p><strong>Background: </strong>The incidence of acute myocardial infarction (AMI) is on the rise, partly due to exposure to particulate matter (PM). However, the nature of the events and individuals at higher risk is unclear. This study examines the relationship between air pollution exposure, specifically particles with a diameter <2.5 microns (PM2.5), and the occurrence of non-ST-segment elevation myocardial infarction (NSTEMI).</p><p><strong>Methods: </strong>In this case-crossover study, NSTEMI patients in Imam Hossein Hospital during 2021-2024 were considered. PM2.5 particle levels in Tehran during the 24 hours before NSTEMI admission and during three control periods (7, 14, and 21 days earlier) were recorded. Data were analyzed using Stata 17 and conditional logistic regression.</p><p><strong>Results: </strong>Of 4,686 patients, 216 (4.61%) experienced NSTEMI. The median PM2.5 level was 91.5 μg/m³ (interquartile range = 78-113). PM2.5 levels did not differ between risk and control times (P = 0.740). Median PM2.5 levels were highest in autumn, followed by winter, and lowest in spring (P < 0.001). PM2.5 levels were not strongly associated with the occurrence of NSTEMI (P = 0.268). Considering PM2.5 levels, the occurrence of NSTEMI during winter was 3.42-fold greater than in autumn (OR = 3.42, 95% CI = 1.07-10.59). A significant association between PM2.5 levels and NSTEMI was observed only in winter, where each 1 μg/m³ increase in PM2.5 was associated with slightly reduced odds of NSTEMI (OR = 0.98, 95% CI: 0.97-0.99).</p><p><strong>Conclusion: </strong>Exposure to PM2.5 was not related to the incidence of NSTEMI. Nevertheless, seasonal factors, particularly in autumn and winter, could be responsible for NSTEMI events.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 6","pages":"8-17"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12747305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate to severe aortic stenosis: Unraveling risk factors, clinical manifestations, and one-year cardiovascular outcomes.","authors":"Azam Soleimani, Nastaran Karimi, Marjan Jamalian, Zahra Soleimani","doi":"10.48305/arya.2025.42971.2993","DOIUrl":"10.48305/arya.2025.42971.2993","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis (AS), a progressively degenerative cardiac condition, poses a substantial burden on morbidity and mortality. This study responds to the scarcity of comprehensive data on moderate to severe AS, focusing on risk factors, clinical manifestations, and one-year outcomes.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted at Chamran Hospital (2021-2022) involving 97 patients with moderate-to-severe AS. Exclusion criteria included infiltrative diseases, radiotherapy history, cardiogenic shock, ejection fraction <20%, fever, sepsis, and active infections. Data were collected using a standardized checklist with three sections: baseline demographics and risk factors, echocardiographic parameters, and outcomes (in-hospital events, surgical aortic valve replacement [AVR], and one-year mortality).</p><p><strong>Results: </strong>Among the patients, 29 (29.9%) were classified as moderate AS and the remainder were severe AS. Severe AS patients exhibited higher systolic pulmonary artery pressure (sPAP) and higher prevalence of moderate to severe diastolic dysfunction and three-vessel disease (3VD). Echocardiographic parameters such as mean pressure gradient (MG), peak velocity (PV), and high sPAP were related to the severity of AS (moderate to severe) by odds ratios of 1.13, 6.09, and 1.15 folds, respectively.</p><p><strong>Conclusion: </strong>AS imposes a significant burden of cardiovascular risk on the population. Patients with severe AS showed higher prevalence of increased filling pressures, moderate to severe diastolic dysfunction, 3VD, and higher sPAP compared with the moderate group, with no difference in clinical presentation and one-year outcome.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"21 5","pages":"42-50"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}