European Journal of Translational Myology最新文献

{"title":"Clinical efficacy of ramp lesion treatment: a systematic review and meta analysis study.","authors":"Parsa Torkaman, Omid Elahifar, Mohsen Fathi, Hossein Hamdollahzadeh, Mohammadreza Sarshar, Kamal Arjmand, Ali Torkaman","doi":"10.4081/ejtm.2026.14704","DOIUrl":"10.4081/ejtm.2026.14704","url":null,"abstract":"<p><p>Ramp lesions, tears involving the peripheral attachment of the posterior horn of the medial meniscus, significantly impact knee stability and function, particularly in association with anterior cruciate ligament injuries. However, evidence regarding optimal treatment strategies remains inconclusive. This systematic review and meta-analysis aimed to evaluate and compare the clinical efficacy of various treatment modalities for ramp lesions. A comprehensive systematic search was conducted across major electronic databases, including PubMed, Scopus, and Web of Science, up to June 2025. Studies were included based on predefined eligibility criteria. Data extraction was performed and meta-analytic synthesis was conducted using random-effects models. A total of 17 studies met inclusion criteria. The pooled mean difference demonstrated significant improvements in both IKDC (MD=28.5 points; 95% CI: 27.9-29.2) and Lysholm scores (MD=28.5 points; 95% CI: 27.9-29.2). Subgroup analyses revealed notable effectiveness for AIR compared to CM and PM, with statistically significant subgroup differences (p<0.05). The overall treatment success rate was 87% (95% CI: 83-92%). Across techniques, patient-reported outcomes improved markedly (IKDC fixed-effect pooled Mean Difference [MD] 28.8 points, 95% CI 28.2-29.4; random-effects overall effect significant; I²=98%). In anterior vs posterior all-inside subgroups, IKDC showed no robust between-approach difference on the random-effects test (χ²=0.51, p=.48), with a small fixed-effect difference (χ²=4.34, p=.04). Lysholm scores also improved substantially (fixed-effect pooled MD 28.0 points, 95% CI 27.3-28.7), and the between-approach difference was significant, favoring the posterior subgroup on the fixed-effect model. The pooled clinical success proportion was 90% without a significant difference between approaches (p=.10). The findings indicate that surgical interventions, particularly All-inside repair has effectively improved knee function and patient-reported outcomes following ramp lesions compared to conservative management and partial meniscectomy. However, no.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does physical therapist contact matter? A randomised controlled trial comparing telerehabilitation and booklet-based exercise for knee osteoarthritis.","authors":"Petra Kotnik, Mohsen Hussein","doi":"10.4081/ejtm.2026.15253","DOIUrl":"10.4081/ejtm.2026.15253","url":null,"abstract":"<p><p>Telerehabilitation is increasingly used in knee osteoarthritis, but its effectiveness compared with structured home exercise and the role of physical therapist contact remain unclear. To address this, we aimed to investigate whether the clinical effectiveness of telerehabilitation for knee osteoarthritis is primarily attributable to the digital platform itself or to the extent and quality of physical therapist engagement within that platform. In this single-centre Randomised Controlled Trial (RCT), 118 patients with knee OA (Kellgren-Lawrence grade I-III) were allocated 1:1 to a 12-week telerehabilitation (TR; n=57) or booklet-based exercise programme (BB; n=61). Within the telerehabilitation group, participants were retrospectively stratified into those with Physical Therapist Contact (TR-C) and those without contact (TR-NC) for an exploratory analysis. Outcomes included knee pain (NRS, Numerical Rating Scale), Range Of Motion (ROM), WOMAC, physical activity (IPAQ), and health-related quality of life (SF-12). A post-hoc exploratory subgroup analysis was conducted and looked at the impact of a physical therapist with and without contact. A key component of the analysis was an exploratory subgroup comparison examining the role of physical therapist contact within the telerehabilitation group. Primary outcomes were analysed using mixed-model ANOVA, with exploratory subgroup comparisons. Both groups showed significant within-group improvements in pain, ROM, and WOMAC scores (all p ≤0.001), with no significant group × time interactions (p >0.05). Exploratory analysis identified significant differences based on physical therapist contact, with greater improvements in pain (p=0.009), knee flexion (p=0.041), and WOMAC Pain (p=0.047) among participants who engaged with the physical therapist. Participants without contact showed the smallest improvements. When stratified by physical therapist contact, participants receiving contact demonstrated greater improvements than those without contact, who showed the smallest gains. Telerehabilitation and booklet-based exercise programme provide comparable clinical outcomes at the group level. However, physical therapist engagement appears to be a key determinant of treatment response. These findings suggest that the effectiveness of TR depends more on clinical interaction than on digital delivery alone. Physical therapist contact may represent an important component influencing the effectiveness of telerehabilitation. It remains unclear whether telerehabilitation effectiveness stems from the digital platform, exercise content, or physical therapist guidance.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and critical thresholds for glucocorticoid-induced ocular adverse reactions in children: implications for muscle and neuromuscular disease management.","authors":"You Li, Tingxin Cui, Zhilang Lin, Lanqin Zhao, Yunxi Lai, Dongyuan Yun, Zikai Lin, Mingyuan Li, Yunjian Huang, Shiyuan Chen, Dongni Wang, Yuanquan Qiu, Yuanyuan Xu, Yahan Yang, Duoru Lin, Xiaoyun Jiang, Haotian Lin","doi":"10.4081/ejtm.2026.15147","DOIUrl":"10.4081/ejtm.2026.15147","url":null,"abstract":"<p><p>Systemic Glucocorticoid (GC) therapy is integral to managing various paediatric conditions, including inflammatory muscle and neuromuscular diseases. However, prolonged GC use in children poses a significant risk for severe ocular Adverse Drug Reactions (ADRs), notably Posterior Subcapsular Cataract (PSCC) and Steroid-Induced Ocular Hypertension (SIOH). These ADRs can lead to irreversible visual impairment, creating a substantial burden, particularly for paediatric patients already managing chronic conditions. Identifying specific risk factors and precise exposure thresholds is crucial for optimizing GC treatment and guiding timely ophthalmic monitoring. This retrospective case-control study analyzed data from 305 children with kidney disease, who received oral or intravenous GCs between December 2020 and December 2022. Participants were grouped into PSCC, SIOH, or control (no ocular ADRs). Logistic regression assessed risk factors, and Receiver Operating Characteristic (ROC) analysis determined critical thresholds for cumulative dose and duration. Results indicated seven significant risk factors for PSCC: younger age, longer GC duration, hypertension, growth retardation, vitamin D deficiency, immunosuppressant use, and oral methylprednisolone. Critical thresholds for cataract onset were identified as GC treatment duration >5.6 months or a cumulative dose >5,888 mg. For SIOH, higher daily GC dosage (>0.59 mg/kg/day), oral methylprednisolone, and growth retardation were significant risk factors. These findings elucidate key risk factors and establish quantitative GC exposure thresholds for ocular ADRs in children. They provide evidence-based guidance for ophthalmic screening and intervention timing, particularly relevant for paediatric patients with muscle and neuromuscular diseases requiring long-term GC therapy. Proactive monitoring and tailored GC management are essential to mitigate vision-threatening complications and improve long-term patient outcomes.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148035665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many excellent and one bad news regarding the European Journal of Translational Myology and the 2027 Padua Days on Muscle and Mobility Medicine.","authors":"Ugo Carraro","doi":"10.4081/ejtm.2026.15878","DOIUrl":"10.4081/ejtm.2026.15878","url":null,"abstract":"<p><p>Recently, both Clarivate and Scopus announced improved metrics for the European Journal of Translational Myology (EJTM), bringing its Impact Factor to 2.0 and its CiteScore to 4.1. I am proud of these achievements and share the credit with the entire PAGEpress staff. Furthermore, many organizers and moderators for the \"Padua Days on Muscle and Mobility Medicine\" 2027 (2027 Pd3m) have accepted their roles and proposed improvements for the event, which will take place at the Euganean Thermal Baths (Padua, Italy) from March 9 to 12, 2027. The program remains open to numerous additional speakers. On the downside, rising operating costs are affecting both digital publishing and event organization; it is hoped that these increases will not negatively impact the submission of contributions to the EJTM and the 2027 Pd3m conference. Those interested can find further information and forms for active participation (registration, accommodation, abstract template, and participation details) at the following address: www.paduamuscledays.it. Undoubtedly, the 2027 Pd3m promises to be an engaging event, on par with all previous editions of the \"Padua Days on Muscle and Mobility Medicine.\"</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term blood pressure variability after continuous versus interval aerobic training combined with resistance exercise in ischemic heart disease: a pilot study.","authors":"Matteo Vitarelli, Camilla Calandri, Giuseppe Caminiti, Maurizio Volterrani, Ferdinando Iellamo, Marco Alfonso Perrone, Domenico Mario Giamundo, Giuseppe Marazzi, Bruno Ruscello, Elvira Padua, Antonell Antelmi, Valentina Morsella","doi":"10.4081/ejtm.2026.14885","DOIUrl":"10.4081/ejtm.2026.14885","url":null,"abstract":"<p><p>Arterial hypertension and increased Blood Pressure Variability (BPV) are major prognostic determinants in patients with Ischemic Heart Disease (IHD). This randomized pilot study compared the effects of Continuous Combined Training (CCT; moderate-intensity continuous aerobic exercise plus resistance training) and Interval Combined Training (ICT; high-intensity interval aerobic exercise plus resistance training) on BPV and Blood Pressure (BP) parameters. Thirty-six clinically stable patients with IHD and hypertension were randomized to CCT or ICT for 12 weeks. Between-group changes in the study outcome were analysed by ANCOVA. Short-term systolic BPV significantly decreased in the CCT group but remained unchanged in the ICT group: [adjusted between-group difference -2.1 mmHg (95% CI: -3.2 to -1.4; p = 0.036). Resting systolic BP decreased similarly in both groups, whereas no significant changes were observed in 24-hour BP values. Peak oxygen uptake improved in both groups with a greater increase in the ICT group [adjusted between-groups difference +1.7 mL·kg-¹·min-¹ (95% CI: 0.7 to 2.2; p = 0.044). These findings suggest that, in patients with IHD, continuous combined training may be more effective than interval combined training in reducing short-term BPV, whereas interval training may confer greater improvements in aerobic capacity. Further adequately powered studies are warranted to confirm these results.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of <i>SP1</i> (<i>rs1800012</i>) in anterior cruciate ligament injuries: updated meta-analysis.","authors":"Abdulrahman Bani Kahled, Esra Barodi, Sajeda Darajah, Mohammed Oqlat, Eman Shamekh, Mohammad Jawarneh, Abdelrahim Alqudah","doi":"10.4081/ejtm.2026.14683","DOIUrl":"10.4081/ejtm.2026.14683","url":null,"abstract":"<p><p>The Anterior Cruciate Ligament (ACL) is vital for knee stability, and its rupture is a major orthopedic concern with significant health and economic impacts. Evidence suggests a substantial hereditary component in ACL injury susceptibility, with the COL1A1 rs1800012 (SP1) polymorphism frequently studied but with inconsistent results. To clarify the association between the rs1800012 in COL1A1 and ACL injury risk, this meta-analysis synthesized data from case-control and cohort studies focusing exclusively on ACL injuries. Systematic searches of PubMed, Embase, Web of Science, and Scopus identified studies up to June 2025. Eligible studies included individuals diagnosed with ACL injuries and healthy controls, reporting genotype frequencies for rs1800012. Pooled Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated for various genetic models using random-effects meta-analysis. Study quality was assessed via the Newcastle-Ottawa Scale, and publication bias and heterogeneity were evaluated. Nine studies (1,171 cases, 2,005 controls) were included. The TT genotype was significantly protective under the recessive model (TT vs. TG+GG: OR = 0.49, 95% CI: 0.25-0.97, p = 0.041), and also in direct genotype comparisons (TT vs. TG: OR = 0.41, 95% CI: 0.21-0.80, p = 0.009). Conversely, the TG genotype increased ACL injuries risk under the overdominant model (TG vs. TT+GG: OR = 1.28, 95% CI: 1.07-1.52, p = 0.006) and when compared to GG (TG vs. GG: OR = 1.24, 95% CI: 1.05-1.48, p = 0.014). No significant associations were observed under the allele contrast (T vs. G: OR = 1.04, 95% CI: 0.90- 1.21, p = 0.61) or dominant models (TT+TG vs. GG: OR = 1.15, 95% CI: 0.97-1.37, p = 0.10). Heterogeneity was consistently low, and sensitivity analyses confirmed the robustness of these findings. No evidence of publication bias was detected. This meta-analysis demonstrates genotype-specific effects of rs1800012 on ACL injuries risk: the TT genotype is protective, while the TG genotype confers increased risk.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength in young recreational skiers: Is it related to the risk of falling?","authors":"Verena Menz, Marc Philippe, Elena Pocecco, Johannes Burtscher, Barbara Strasser, Gerhard Ruedl, Martin Kopp, Martin Burtscher","doi":"10.4081/ejtm.2026.14764","DOIUrl":"10.4081/ejtm.2026.14764","url":null,"abstract":"<p><p>Handgrip Strength (HGS) is correlated with general health and fitness throughout the lifespan. However, the relationship between HGS and the frequency of sports accidents is not well understood. The aim of the present survey was twofold. Firstly, to collect HGS data from young skiers and compare them with existing normative values; secondly, to investigate whether the frequency of falls during a day of skiing is correlated with HGS. Data on HGS and falls were collected from 251 recreational downhill skiers, aged 6-25 years, on the day of recording. The results demonstrate the representative progression of HGS in boys and girls during growth and early adulthood. Additionally, the findings indicate that in young female skiers up to the age of 25 years, HGS is negatively correlated with the frequency of falls, which may be related to the generally lower muscle strength in females. Regular physical activity, including muscle strengthening and balance exercises, is crucial for preventing falls in skiers.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance and virulence gene patterns of <i>Staphylococcus aureus</i> in infectious mastitis: implications for inflammatory myopathies of the lactating breast.","authors":"Xu Li-Dong, Shi Feng, Ye De-Liang, Dong Li-Qian, Wu Ya-Ni","doi":"10.4081/ejtm.2025.14261","DOIUrl":"10.4081/ejtm.2025.14261","url":null,"abstract":"<p><p>With the present work, we aimed to investigate antimicrobial resistance and virulence gene patterns of Staphylococcus aureus in lactating patients with infectious mastitis and evaluate their potential impact on inflammatory myopathies of the lactating breast. Between January 2021 and April 2024, 158 lactating patients with culture-confirmed infectious mastitis were treated at Hangzhou Linping District Maternal and Child Health Hospital. Among these, 119 isolates were identified as S. aureus (82 MRSA, 37 MSSA). Antimicrobial susceptibility and virulence genes were analyzed. Muscle involvement was inferred indirectly from clinical presentation, including marked local induration, tenderness extending to deeper breast tissue, and reduced breast mobility. No imaging or biopsy was performed to confirm myopathic changes directly. S. aureus was the predominant pathogen. Both MRSA and MSSA showed high resistance to penicillin G, erythromycin, and Clindamycin, while all isolates were susceptible to nitrofurantoin, linezolid, vancomycin, and rifampicin. MRSA exhibited higher resistance than MSSA (p<0.05). Frequent resistance genes included aac(6')/aph(2''), blaZ, mecA, aph(3')-III, and qacA/B. Virulence genes hla, clfA, clfB, and fnbA were common; pvl was less frequent in MRSA (p<0.05). MRSA infections were associated with stronger local inflammation and increased clinical markers possibly related to muscle involvement, raising the possibility of an association with myopathic changes in lactating breast tissue. S. aureus, particularly MRSA, is the main pathogen in lactating mastitis. Specific virulence genes may influence the severity of local inflammation and myopathic changes, highlighting implications for inflammatory myopathies in the lactating breast.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin and exercise activate renal anti-aging pathways and enhance survival in young mice: a translational insight into muscle-kidney crosstalk.","authors":"Zahra Sadat Aghili, Mansour Homayoun, Hossein Rezazadeh, Saeed Zamani","doi":"10.4081/ejtm.2025.14214","DOIUrl":"10.4081/ejtm.2025.14214","url":null,"abstract":"<p><p>Irisin, a myokine released by skeletal muscle during physical activity, has emerged as a key regulator of energy metabolism, cellular stress responses, and longevity pathways. While previous studies have focused on aged animal-models or pathological states, the long-term impact of early-life interventions on molecular aging pathways remains poorly understood. This study investigated whether early-life irisin administration and physical exercise could modulate the renal-expression of Klotho and HSP70-two hallmark genes of cellular protection and anti-aging in young adult NMRI mice. Animals underwent 8 weeks of resistance training, endurance training, or irisin injection. Plasma irisin was quantified via ELISA, and renal Klotho and HSP70 expression levels were assessed using qPCR and Western-blotting. All interventions significantly increased circulating irisin and upregulated Klotho and HSP70 at both transcriptional and protein levels, with resistance training inducing the most pronounced effects. A 20-month survival analysis showed a trend toward improved longevity in all intervention groups. These findings suggest that early-life exercise and irisin exposure may activate renoprotective and longevity-associated pathways before the onset of molecular aging, supporting their potential as preventive strategies in translational geroscience.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the effects of dapagliflozin on cardiac myocyte injury markers and left ventricular diastolic function in heart failure patients with preserved ejection fraction after percutaneous coronary intervention.","authors":"Wang Lei, Hu Min, Chen Yue, Zhang Gejun, Wei Chao, Liu Qian","doi":"10.4081/ejtm.2025.14272","DOIUrl":"10.4081/ejtm.2025.14272","url":null,"abstract":"<p><p>The objective of this study was to analyze the effects of Dapagliflozin on cardiac myocyte injury markers and left ventricular diastolic function in patients with Heart Failure with Preserved Ejection Fraction (HF-PEF) after Percutaneous Coronary Intervention (PCI). The study included 120 HF-PEF patients post-PCI treated at our hospital between May 2021 and May 2024. Patients were divided into two groups: conventional therapy (n=49) and Dapagliflozin plus conventional therapy (n=71). Serum Cardiac Troponin I (cTnI) and Serum Amyloid A (SAA) were measured. Left ventricular function was assessed by Ejection Fraction (EF) and the E/e' ratio. The incidence of Major Adverse Cardiovascular Events (MACE) was also recorded. After treatment, the Dapagliflozin group showed significantly lower cTnI and SAA levels compared to the conventional group (p<0.05). EF was higher and E/e' ratio was lower in the Dapagliflozin group (p<0.05). The incidence of MACE was reduced to 1.41% versus 12.24% in the conventional group (p<0.05). In conclusion, Dapagliflozin effectively reduces cardiac myocyte injury markers, improves left ventricular diastolic function, and lowers the incidence of MACE in HF-PEF patients after PCI, demonstrating significant translational benefits for cardiac muscle function.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}