European Journal of Translational Myology最新文献

{"title":"A study on the predictive value of CT plain scan of pericoronal fat thickness combined with clinical indicators for young patients with coronary atherosclerotic heart disease.","authors":"Aichao Ruan, Lihua Zhang, Yang Gu","doi":"10.4081/ejtm.2026.15842","DOIUrl":"10.4081/ejtm.2026.15842","url":null,"abstract":"<p><p>This study aimed to investigate whether chest CT scans could predict the incidence of atherosclerotic heart disease in patients aged ≤40 years. Convenience sampling was used to select 296 patients aged ≤ 40 years with Acute Coronary Syndrome (ACS), and their general information and CT data were collected. According to the results of coronary CTA, patients were divided into a diseased group (134) and an untreated group (162). Single and multiple logistic regression were used to analyze variables, and different variable combination models and single variable models were established to analyze the clinical value of different models. The results showed systolic blood pressure, diastolic blood pressure Thick1 and BMI. There is a statistically significant relationship between fasting blood glucose and the occurrence of coronary artery plaques. After single factor logistic regression analysis, multiple factor logistic analysis was carried out for indicators with P values less than 0.05. The results showed that gender (OR: 2.1, 95% CI: 1.031-4.292, p=0.04), systolic blood pressure (OR: 1.02, 95% CI: 1.01-1.036, p=0.000), diastolic blood pressure (OR: 1.04, 95% CI: 1.017-1.054, p=0.000), Chol (OR: 1.26, 95% CI: 1.056-1.495, p=0.01), TG (OR: 1.35, 95% CI: 1.09-1.678, p=0.01), FBG (OR: 1.11, 95% CI: 1.009-1.213, p=0.03), Thick1 (OR: 1.5, 95% CI: 1.337-1.682, p=0.000) and coronary atherosclerosis. The area under the curve of the prediction model based on the thickness of coronal fat (Thick1), as well as the area under the curve of the prediction model based on systolic blood pressure, diastolic blood pressure, and FBG, show that the effectiveness of the Thick1 model is much higher than that of the clinical indicator model. Chest CT scans hold clinical significance in predicting coronary atherosclerosis in patients aged ≤40 years with ACS.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific 3D-printed implants for reconstruction of elbow nonunion with bone defects: a case report and technical note.","authors":"Giacomo Mazzei, Jose Carlos Orihuela, Ignacio Maria Silva Rossi, Alberto Alvarez Jimenez, Luis Bahillo O'Mahoney, Francisco Castellano Torres, Giuseppe Rovere, Luigi Meccariello","doi":"10.4081/ejtm.2026.15922","DOIUrl":"10.4081/ejtm.2026.15922","url":null,"abstract":"<p><p>Distal humeral nonunion associated with extensive bone loss remains one of the most challenging reconstructive conditions in upper-extremity surgery. We present a technically demanding case treated using a patient-specific 3D-printed implant and discuss its potential advantages compared with alternative reconstructive strategies. This case report describes the management of a 59-year-old woman presenting with a hypertrophic distal humeral shaft nonunion three years after intramedullary nailing. Preoperative evaluation included bilateral Computed Tomography (CT) using a dedicated low-artifact acquisition protocol to enable contralateral humeral mirroring, three-dimensional virtual planning, and the design of a patient-specific implant. A custom-made Ti6Al4V implant featuring a cemented proximal stem, a porous metaphyseal interface, and a dual-flange distal fixation platform was manufactured based on the preoperative planning. Reconstruction was performed through a posterior approach with olecranon osteotomy using patient-specific cutting guides. Clinical and radiographic outcomes were prospectively assessed at 1, 3, 6, and 12 months postoperatively. Progressive improvements were observed in elbow motion, MEPS, TCI, and sleep quality (PSQI). By 12 months, the patient achieved near-complete ROM and excellent clinical scores, with radiographs showing full union and stable alignment. At 1 year, however, a fall resulted in proximal stem mobilization, while the distal fixation and porous interface remained stable. This case demonstrates that patient-specific reconstruction can achieve accurate anatomical restoration, stable fixation, and excellent functional recovery in selected patients with complex distal humeral nonunion and bone loss. It also highlights the potential advantages of customized implants, while emphasizing the importance of meticulous preoperative planning, complete implant fixation, and appropriate postoperative protection to minimize the risk of late mechanical failure. Although the present findings are encouraging, further clinical studies are required to establish the long-term effectiveness and broader applicability of this reconstructive strategy.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterolateral approach for total ankle arthroplasty, preliminary results of a less-invasive surgical pathway: an observational retrospective study.","authors":"Matteo Catananti, Giuseppe Rovere, Matteo D' Ambrosio, Marco Peruzzi, Vincenzo Di Sanzo, Fernando De Maio, Pasquale Farsetti, Natale Maria Gangemi","doi":"10.4081/ejtm.2026.15586","DOIUrl":"10.4081/ejtm.2026.15586","url":null,"abstract":"<p><p>Total Ankle Arthroplasty (TAA) has evolved into a reliable treatment option for end-stage ankle osteoarthritis; however, wound healing complications remain a significant concern, particularly with traditional anterior approaches. These complications are largely related to the vulnerability of the anterior soft-tissue envelope and may negatively affect early outcomes. The purpose of the present study was to evaluate the safety and early clinical outcomes of a curvilinear anterolateral approach for TAA, with particular focus on wound healing and soft-tissue complications. A retrospective observational study was conducted on 48 consecutive patients undergoing TAA between January 2023 and December 2025. A total of 49 ankle arthroplasties were performed using a curvilinear anterolateral approach. Patient demographics, comorbidities, and perioperative variables were recorded. Primary outcomes included wound-related complications and time to complete healing. Secondary outcomes included functional improvement assessed using the Foot and Ankle Outcome Score (FAOS). Three patients (6.1%) developed wound-related complications. Two patients (4.1%) experienced superficial wound dehiscence, which resolved with conservative treatment. One patient (2.0%) developed a deeper wound complication involving the soft tissues without prosthetic involvement; this case occurred in a high-risk patient with multiple comorbidities and was successfully managed with advanced wound care. No cases of deep prosthetic infection were observed. All remaining cases (93.9%) achieved uneventful wound healing within 12 to 21 days. Functional outcomes showed a significant improvement, with mean FAOS increasing from 40±5 preoperatively to 75±5 at final follow-up. The curvilinear anterolateral approach for TAA demonstrated a low rate of wound-related complications and consistent early functional improvement. By preserving the tibialis anterior tendon sheath and optimizing incision placement, this technique may reduce both vascular and mechanical risk factors associated with wound healing disorders. It represents a safe and reproducible alternative to traditional anterior and transfibular approaches, particularly in patients at increased risk for soft-tissue complications.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148398831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of 4.4 mL single-dose intra-articular cross-linked hyaluronic acid injection in patients with knee osteoarthritis.","authors":"Luigi Meccariello, Clemente Villani, Jacopo Conteduca, Giuseppina Casolaro, Lawrence Camarda, Giuseppe Rovere","doi":"10.4081/ejtm.2026.15626","DOIUrl":"10.4081/ejtm.2026.15626","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a degenerative joint disease with increasing prevalence due to population aging. Conservative management of knee OA has traditionally focused on pain control, with intra-articular injections widely used for targeted local therapy. This study evaluated the clinical efficacy of a single 4.4 mL intra-articular injection of cross-linked hyaluronic acid compared with hylastan SGL-80 (4 mL) in patients with knee OA. In this interventional cohort study, 120 patients with grade III knee OA (Outerbridge) were allocated to two groups: Group 1 (UP; n=60) received 4.4 mL cross-linked hyaluronic acid, and Group 2 (Normal; n=60) received hylastan SGL-80/4 mL. All patients followed a 15-day NSAID protocol before injection and had no prior knee injections within 6 months. Outcomes were assessed using VAS, KOOS, and SF-12 at baseline and up to 6 months. Analgesic use, complications, and VAS-KOOS correlations were evaluated. Both groups showed a low complication rate (5%). Pain reduction over 6 months was significantly greater in Group 1 (VAS 6.93 to 2.32) than in Group 2 (6.44 to 3.52; p=0.030). Group 1 demonstrated superior KOOS (p=0.017), SF-12 scores (p=0.021), and reduced anti-inflammatory drug use (p=0.026). VAS-KOOS correlation confirmed greater clinical improvement in Group 1 at 180 days (p=0.031). A single 4.4 mL intra-articular injection of cross-linked hyaluronic acid provides significant and sustained improvement in pain, function, and quality of life in patients with knee OA.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonography versus electrodiagnosis of median nerve before and after open carpal tunnel release surgery: which can better diagnose, predict and assess postoperative improvement?","authors":"FatemaAlZahraa Ahmad, Shahira Mostafa, Eman A Maher, Mostafa Ezzat, Aliaa Ali Tawfeek","doi":"10.4081/ejtm.2026.15547","DOIUrl":"10.4081/ejtm.2026.15547","url":null,"abstract":"<p><p>Diagnosis of Carpal Tunnel Syndrome (CTS) relies on a structured clinical approach with Electrodiagnostic Studies (EDX) accepted as the gold standard in the diagnosis. Yet, Ultrasound (US) has emerged as a non-invasive alternative especially in assessing morphological changes. And so, to accurately diagnose CTS by a valid non-painful simple tool, objectively assess postoperative improvement and finally to predict postoperative clinical outcome from preoperative data; clinical, EDX, and US data were collected, compared and correlated pre- and 1 month postoperative. While US achieved diagnostic accuracy of 80% in CTS diagnosis, particularly Wrist Cross-Sectional Area (wCSA) and Wrist-Forearm Ratio (WFR), it remains less sensitive than EDX. The diagnosis of CTS using wCSA/WFR achieved a sensitivity of 80.0%/80.0% and a specificity of 100%/85.7%, at a cutoff score of 12.5mm2/2.1 or above. In addition, linear regression analysis showed that only compound motor action potential (CMAP) amplitude could predict postoperative clinical improvement. Sensitivity of EDX (93.33%) overcome that of the US in detection of postoperative improvement. US is less sensitive than EDX in diagnosing CTS, assessment and prediction of postoperative clinical outcome.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for randomized controlled trial of brief intraoperative electrical stimulation across cross-face nerve grafts in patients with facial paralysis.","authors":"Bastien A Valencia-Sanchez, Myriam Loyo, Stephen Hadford, Dane J Genther, Hana Rosen, Matthew Miller, Michelle H Cameron, Patrick Byrne","doi":"10.4081/ejtm.2026.14137","DOIUrl":"10.4081/ejtm.2026.14137","url":null,"abstract":"<p><p>Brief Intraoperative Electrical Stimulation (BIES) can enhance axonal regeneration across axotomy sites. Cross-Face Nerve Grafts (CFNG) are typically performed in two stages, with a 6-12-month interval to allow for axonal growth. This provides an opportunity to assess axonal regeneration via biopsy. We describe a protocol to evaluate the effects of a 10-minute BIES on axonal regeneration across CFNG. This is a protocol for a multicenter, double-blind, randomized controlled trial in patients with unilateral facial paralysis undergoing two-stage CFNG. After nerve coaptation, the intervention group will receive 10 minutes of BIES (biphasic current, 2mA amplitude, 100 μsec pulse duration, 16 Hertz) applied proximal to the donor facial to sural nerve coaptation. Controls will undergo standard surgery without stimulation. The primary outcome is the histological count of regenerated myelinated axons from a biopsy obtained during the second stage surgery. Secondary outcomes include patient reported quality of life and objective facial reanimation based on photo analysis. We aim to recruit 20 participants. This protocol evaluates the impact of BIES on histological, patient reported, and objective facial reanimation outcomes in CFNG.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}