European Journal of Translational Myology最新文献

{"title":"Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review.","authors":"Francisco Aguirre, Mayalen Valero-Breton, Daniel Cabrera, Luis Peñailillo, María Carolina Otero, Claudia Fredes, Claudio Cabello-Verrugio","doi":"10.4081/ejtm.2025.13365","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13365","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by altered liver function due to fatty accumulation, which can lead to liver inflammation and, in advanced stages, liver carcinoma. MASLD is closely linked to several metabolic alterations, such as obesity and insulin resistance, which directly affect skeletal muscles and contribute to the development of sarcopenia. Sarcopenia is the loss of muscle mass and strength, leading to decreased physical performance in severe stages. Skeletal muscles secrete molecules known as myokines under various conditions, such as exercise or diseases like MASLD. These myokines modulate communication between the skeletal muscle and other tissues. These myokines regulate muscle mass and, in pathological conditions, contribute to the development of sarcopenia. Emerging evidence highlights the crucial role of myokines in regulating skeletal muscle metabolism and function in MASLD. Myokines influence muscle metabolism, inflammation, and insulin sensitivity, offering potential therapeutic targets for managing muscle atrophy and sarcopenia in the context of MASLD. Understanding the interaction between myokines and skeletal muscle may lead to novel interventions to mitigate MASLD progression and sarcopenia. This review examines the mechanisms by which myokines regulate skeletal muscle metabolism and function in the context of MASLD.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative response of rat skeletal muscle to the implantation of a collagen-based bone graft substitute: an <i>in vivo</i> study.","authors":"Fernando Leiva-Cepas, Maria Jesus Gil-Belmonte, Ignacio Jimena, Maria Angeles Peña-Toledo, Rafael Villalba, Jose Peña-Amaro","doi":"10.4081/ejtm.2025.13574","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13574","url":null,"abstract":"<p><p>The application of implantable biomaterials in reconstructive grafting is a common practice in surgical fields such as orthopedics, maxillary and plastic surgery. This study explores the regenerative response of skeletal muscle to a porous bovine collagen-based matrix (Osteovit®) in a volumetric muscle loss injury model. Forty male Wistar rats were divided into four groups. Normal control underwent no procedure and regenerative control had mepivacaine injected in the tibialis anterior muscle to provoke a standard regenerative response. In the other two groups, a volumetric defect was created in the tibialis anterior muscle; the fibrosis control had no treatment, while the collagen-scaffolding group had a bone substitution matrix implanted. Animals were sacrificed at 21, 28, and 60 days post-procedure for histological, histochemical, immunohistochemical and histomorphometry analysis to evaluate muscle architecture and myogenic regenerative response. Significant changes in tissue architecture among groups, with a notable emphasis on the integration of the collagen scaffold, were demonstrated. This was also confirmed at the histomorphometry analysis, which found differences at the cross-sectional area, minor diameter and form factor values between groups The bone substitution matrix did not inhibit regeneration but promoted an abnormal one. This can be explained by the excessive formation of connective tissue, which led to the genesis of intramuscular tendons that may have interfered with the normal development of regenerative muscle fibers. The findings highlight the need for further investigation into the cellular mechanisms underlying skeletal muscle regeneration in response to implantable biomaterials.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic strategy with indirect spinal manipulations in C2-C3 segments for long-term treatment of cervicogenic headache.","authors":"Marieta Karadjova, Teodor Angelov, Julia Petrova, Fabio Antonaci","doi":"10.4081/ejtm.2025.13845","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13845","url":null,"abstract":"<p><p>Cervicogenic Headache (CGH) is a secondary type headache, associated with dysfunction in upper cervical segments (C1-C2-C3) and manifested by specific clinical features. It is unilateral, starting from one side of the posterior head and neck, migrating to the front, sometimes associated with ipsilateral arm discomfort and, in addition, neuralgia with ipsilateral conjunctival inection. Our research is based on 29 patients (with average age of 49.78 years ± 10.41 (34-73)) with headache: 19 females and 10 males. We examined the active range of motion (AROM). We used palpatory maneuvers, finding local symptoms (facet joints' tenderness) and symptoms in the segmental territory - cellulalgia in the supraorbital and submandibular region (found by the pinch-roll test - PR-SO and PR-SM). The clinical examination before and immediately after the indirect high velocity low amplitude (HVLA) manipulations, as well as at the end of treatment, showed a significant reduction in the Visual Analogue Scale (VAS) score, in local symptoms and especially in measurable indicators - skin fold (PR-SO and PR-SM) in mm. (p<0.01 and p<0.001). Our study shows that indirect HVLA-spine manipulations have an invariable place in the treatment of cervicogenic headache.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentric macro EMG role in electrodiagnostic evaluation of inflammatory myopathies.","authors":"Eman ElZamarany, Ayat Allah Farouk, Lamia Afifi, Sandra Ahmed, Eman Ashraf, Eman Attia, Marwa Shalaby","doi":"10.4081/ejtm.2025.13833","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13833","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory myopathies (IM) encompass a diverse group of systemic autoimmune muscle disorders, not easy to diagnose. Concentric-macro EMG is supposed to reflect electrical activity of the entire motor unit. It could help in electrophysiological characterization of inflammatory myopathies and recognizing earlier myopathic changes.</p><p><strong>Results: </strong>Conventional EMG in our IM patients showed myopathic changes in all the cases, so it could be a golden tool for diagnosis. The degree of abnormalities was variable in different muscles in concentric macro EMG. Myopathic changes using concentric macro EMG was not so advanced as those seen in chronic stable relapsing phase.</p><p><strong>Conclusion: </strong>Pooling up the results of the conventional EMG and Con-Mac will give optimal results for diagnosis and could help in follow up of patients with IM.</p><p><strong>Key words: </strong>inflammatory myopathies; Concentric macro EMG.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of moderate physical training program in post-myocardial infarction patients with arterial hypertension.","authors":"David M Aronov, Marina G Bubnova, Nadezhda P Lyamina, H Fred Downey, Eugenia B Manukhina, Svetlana Lyamina","doi":"10.4081/ejtm.2025.13943","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13943","url":null,"abstract":"<p><p>The clinical effectiveness of physical training in a cardiac rehabilitation program (CRP) was assessed in hypertensive (AH), post-myocardial infarction (MI) patients. 206 patients were randomized into a physically trained group (PhTG, n=102) and an untrained, control group (CG, n=104). All patients received standard drug therapy. PhTG patients performed mild callisthenic exercises and moderately intensive bicycle exercise three times/week for one year. Compared to control patients, PhTG patients had significant changes in exercise capacity (duration +38%, p<0.001; total work +63.6%, p<0.001); rate-pressure product (-8.2%, p<0.01); left ventricular ejection fraction (+7.6%, p<0.001); left ventricular stroke volume (+5.1%, p<0.01). Resting BP decreased in PhTG patients (systolic BP, -3.1%, p<0.05; diastolic BP, -3.5%, p<0.001), but increased in CG patients (systolic BP, +3.1%, p<0.05; diastolic BP +3.4%, p<0.05). PhTG patients had fewer myocardial ischemic episodes, including painless ischemia during exercise, fewer angina attacks, less nitroglycerin consumption, improved quality of life, fewer cardiovascular events (-50%, p<0.05), and days of absence from work (-43.2%, p <0.05). Thus, supplementing a CRP with moderate exercise improved BP, work capacity, cardiac function, and quality of life in hypertensive, post-MI patients.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma and salivary irisin response to moderate load/high volume resistance exercise in young, resistance-trained men.","authors":"Luigi Marano, Sara Missaglia, Eleonora Martegani, Andrea Bonanomi, Chiara Tremolada, Daniela Tavian, Ferdinando Cereda","doi":"10.4081/ejtm.2025.13957","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13957","url":null,"abstract":"<p><p>Irisin's response to Resistance Exercise (RE) remains unclear. We investigated plasma and salivary irisin levels following acute moderate load/high volume (ML/HV) RE and explored correlations with muscle damage markers. Eight healthy, resistance-trained young males (23.9 ± 3 yrs) completed one ML/HV RE session (full-body, 30 sets to failure, 70% 1RM). Plasma/saliva irisin, plasma Creatine Kinase (CK), and Visual Analogue Scale (VAS) for muscle soreness were assessed at baseline, 15 min, 24h, and 48h post-exercise. Plasma irisin increased significantly by ~9% (p=0.01) and salivary irisin by ~4% (p=0.02) at 15 min post-exercise, returning towards baseline by 24h. A strong correlation (rho=0.8, p=0.03) existed between percentage changes in plasma and salivary irisin at 15 min. CK and VAS peaked at 24h (p<0.001; p=0.02 vs 48h, respectively), but showed no significant correlation with irisin changes. Acute ML/HV RE elicits a transient increase in plasma and salivary irisin. Saliva may be a useful non-invasive proxy for irisin changes post-RE. This acute irisin response appears independent of EIMD markers in this population. Findings require confirmation in larger studies.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensation for balance disorders: analysis of this multifactorial process.","authors":"Philippe Perrin, Art Mallinson, Neil Longridge, Enrico Armato, Mans Magnusson, Georges Dumas, Nicolas Perrin, Pierre Denise, Paolo Gargiulo, Hannes Petersen, Christian Beyaert","doi":"10.4081/ejtm.2025.13816","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13816","url":null,"abstract":"<p><p>The European Society for Clinical Evaluation of Balance Disorders (ESCEBD), based in Nancy, France, has been meeting yearly since 2005 to discuss equilibrium-related themes that are not yet clearly defined or standardized. One of our latest discussions was with regard to outlining strategies of internal and external compensation that may be used to cope with balance disorders. A Committee was elected to discuss the mechanisms of compensation that may be involved in coping with balance system disorders. Compensation, referring to the immediate or short-term adaptive mechanisms that are used to counterbalance the effects of deficiencies that disrupt balance maintenance, can include alternative strategies, resources, or environmental supports to overcome deficits or challenges associated with a deficiency. The strategies can be internal (i.e. utilizing the individual's own multi-sensory neural integration, motor, and cognitive resources) or external (i.e. modifying the environment, or using assistive or adaptive devices) to reduce fall hazard and enhance safety. This report focuses principally on internal compensation, generated by sensorimotor processes of the central nervous system (CNS) in response to impairment of either sensory information (e.g. vestibular pathologies), the musculoskeletal system (e.g. lower limb amputation and myopathies) or the CNS itself (e.g. upper motor neuron syndrome). The multifactorial process of compensation may explain the limitations encountered by the CNS in compensating for complex bodily impairments and may also limit our understanding of how the CNS adapts to balance disorders. Newly developed devices, such as wearable sensory substitution devices, are on the horizon as possible tools.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a multidimensional robotic rehabilitation approach feasible in Guillain-Barrè syndrome? Report from a clinical case.","authors":"Caterina Tramonti, Benedetta Gnetti, Paola Gemignani, Stefania Callegari, Marco Germanotta, Francesca Cecchi, Irene Giovanna Aprile, Pietro Balbi","doi":"10.4081/ejtm.2025.12758","DOIUrl":"https://doi.org/10.4081/ejtm.2025.12758","url":null,"abstract":"<p><p>We describe the case of a 54-year-old patient, who was admitted to our Rehabilitation Unit with diagnosis of  Guillain-Barré Syndrome (GBS). Neurophysiological investigation revealed an axonal polyneuropathy, with impairment of the motor component and preserved sensory function. Despite rapid diagnosis, therapeutic treatment and customized progressive rehabilitation program, nine months after the onset of the disease he presented severe motor sequelae and functional impairment. Patient's hospitalization lasted about two months, while he performed a conventional rehabilitation training. Besides, he underwent a 4-week comprehensive rehabilitation treatment, including both conventional and robotic multidimensional trainings, for 5 1-h sessions per week. Despite the residual global impairment, this treatment, specifically tailored on patient's skills and progress, promoted improvements in functional abilities such as motricity, trunk control, and activities of daily living. Therefore, this case report evidenced the feasibility and efficacy of a multidimensional robotic therapeutic approach along with conventional treatment in the post-acute phase of GBS.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction. <i>Hungry runners - low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review</i>.","authors":"The Publisher","doi":"10.4081/ejtm.2025.13900","DOIUrl":"10.4081/ejtm.2025.13900","url":null,"abstract":"<p><p>In the paper titled \"Hungry runners - low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review\", published in vol. 33, issue 2 of 2023, Supplementary Table 1 was mistakenly mentioned as Table 1. The correct supplementary file is now available. Reference Cupka M, Sedliak M. Hungry runners - low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review. Eur J Translat Myol 2023;33:11104 doi: 10.4081/ejtm.2023.11104.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of the XXI Meeting of the Interuniversity Institute of Myology and preview of the XXII edition.","authors":"Anna Urciuolo, Fabio Penna","doi":"10.4081/ejtm.2025.13743","DOIUrl":"10.4081/ejtm.2025.13743","url":null,"abstract":"<p><p>The 21st Annual Meeting of the Interuniversity Institute of Myology (IIM), held in Assisi, Italy, from September 4-7, 2024, gathered 123 experts, including basic and clinical myologists, pharmaceutical representatives, and patient organizations from Italy, Europe, Canada, and USA. The meeting fostered a proactive, collaborative and dynamic atmosphere, promoting scientific exchange and international partnerships focused on muscle research, from physiology to disease mechanisms, and eventually therapeutic approaches. The 21st IIM Meeting featured 6 main scientific sessions, showcasing 30 oral presentations and 45 always-on-display posters, all reporting original and unpublished research. The program was enriched by four keynote lectures from internationally renowned speakers and talks from delegates of the Société Française de Myologie, adding depth to the scientific discussions. As part of the IIM Meeting organization, this year there was also a free-access educational convention titled \"Physical exercise as prevention\". Leading IIM experts shared insights on exercise-based lifestyle interventions aimed at improving public health, with the participation of the Italian former boxer Roberto Cammarelle. The event drew a large in-person and online audience. This IIM Meeting edition strongly emphasized the involvement and growth of young researchers, with 50% of the attendees being <35, reinforcing IIM's commitment to fostering the next generation of myologists. Along this line, and to further support young researchers, awards for Best Talk, Best Poster Blitz, and Best Poster were presented. The winners joined the IIM Young Committee, contributing to the scientific organization of future IIM meetings together with the IIM Scientific Committee. The meeting was also integrated into the \"Advanced Myology Update 2024\" high-training course, organized by the University of Perugia in collaboration with IIM. The 11 trainees enrolled in the course participated in dedicated roundtables and exclusive lessons led by IIM's invited speakers. In this report are included the abstracts of both oral and poster presentations, with some being withheld for patent-related reasons. Through its annual congress and educational initiatives, IIM played a crucial role in shaping the future of myology research, fostering innovation, collaboration, and scientific excellence on an international scale. We invite you to save the date for the 22nd IIM meeting that will be held in the beautiful Assisi, September 11-14, 2025. We can't wait to welcome you!</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}