European Journal of Translational Myology最新文献

{"title":"OZOILE^®: evaluating its impact and future applications in inflammatory dermatological treatments.","authors":"Fabiola Cassaro, Deborah Basilotta, Monica Currò, Pietro Impellizzeri, Carmelo Romeo, Salvatore Arena","doi":"10.4081/ejtm.2024.13071","DOIUrl":"10.4081/ejtm.2024.13071","url":null,"abstract":"<p><p>Dear Editor, I would like to express my sincere appreciation for the publication and detailed discussion of therapies for dermatological and inflammatory conditions, as exemplified in the recent article \"Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment, and pain management using Ozoile as a hydrogel and cream formulation\" by Vincenzo Francavilla et al. This insightful study has provided a comprehensive overview of the management of onychocryptosis, a common and often distressing condition, and has highlighted the innovative use of OZOILE® in a clinical setting.1 [...].</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D receptor gene polymorphisms in patients with relapsing multiple sclerosis.","authors":"Maryam Milanifard, Soraya Mehrabi, Reza Ahadi, Mohsen Nabiuni, Samaneh Azimi Souteh, Mohammad Taghi Joghataei","doi":"10.4081/ejtm.2024.12993","DOIUrl":"10.4081/ejtm.2024.12993","url":null,"abstract":"<p><p>The relationship between the Vitamin D Receptor (VDR) gene and many pathogenic pathways in Relapsing-Remitting Multiple Sclerosis (RRMS) remains unclear. Given the significance of the topic, we conducted this study to explore the correlation between vitamin D receptor gene polymorphisms and clinical and inflammatory factors in patients suffering from relapsing-remitting multiple sclerosis. The current research is a case/control study conducted based on the Helsinki Ethical Principles. RRMS disease was confirmed based on history, clinical symptoms, radiological signs and neurologist diagnosis. The research population consisted of healthy people and patients with RRMS who were referred to Hazrat Rasool Akram Hospital between 2021 and 2023. For each person participating in the study (RRMS patient and healthy), five milliliters of peripheral blood containing the anticoagulant EDTA was collected. Polymerase chain reaction was performed using two specific and appropriate oligonucleotide primers. The restriction fragment length polymorphism technique was used, one of the standard methods for identifying polymorphisms. Statistical analysis was performed using SPSS software version 23. The odds ratio and 95% confidence limits were calculated. The SNP Analyzer software was used to analyze the allele frequency of each polymorphism in healthy and RRMS individuals and compare the values. Prism version 5 software was used to draw diagrams. In the present study, a statistically significant difference was observed between the percentage of FokI genotypes in RRMS patients and healthy individuals. FokI polymorphism showed a significantly increased risk with an odds ratio of 7.28 in patients with the FF genotype compared to healthy individuals. ApaI, TaqI, and BsmI were not significantly different between the two groups. Based on the findings of the present study, FokI polymorphism showed a significant risk increase in RRMS patients with FF genotype compared to healthy individuals.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New horizons for adolescent idiopathic scoliosis treatment through PosturalSpine^® D'Amanti Method.","authors":"Francesca Campoli, Maria Chiara Parisi, Antonino Zoffoli, Donatella Di Corrado, Vincenzo Francavilla, Elvira Padua, Giuseppe Messina","doi":"10.4081/ejtm.2025.13313","DOIUrl":"10.4081/ejtm.2025.13313","url":null,"abstract":"<p><p>The aim of the study is to compare improvement outcomes in patients (aged between 8 and 18 years old) with idiopathic scoliosis treated with a traditional technique with those treated with an innovative method. The study included 17 participants allocated into two groups: experimental (n=8) and control (n=9) groups. The first group was treated with a new method with PosturalSpine® D'Amanti method, twice a week for 30 min per session while the second group was treated with kinesitherapy and traditional tools three times week for 45 min per session. The two groups are similar in the anthropometric characteristics, in baseline Risser index and in the Cobb angles average and no statistically significant differences were found between the two groups. After one year of motor intervention, both treatment groups showed improvements in the progression of scoliotic curves and the PosturalSpine® group showed a significantly higher improvement than the control group. Our results therefore suggest that this new specific method with PosturalSpine® D'Amanti method could play a significant role in improving adolescent idiopathic scoliosis compared to traditional exercises.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxy-inflammation in hyperbaric oxygen therapy applications.","authors":"Gerardo Bosco, Andrea Brizzolari, Matteo Paganini, Enrico Camporesi, Alessandra Vezzoli, Simona Mrakic-Sposta","doi":"10.4081/ejtm.2025.12783","DOIUrl":"10.4081/ejtm.2025.12783","url":null,"abstract":"<p><p>Hyperbaric Oxygen Therapy (HBOT) is a non-invasive method of O2 delivery that induces systemic hyperoxia. Hyperbaric chamber consists of a pressure vessel and a compressed breathing gas supply, which can regulate internal pressure. The chamber delivers 100% O2 to patients according to predetermined protocols and is monitored by trained personnel. HBOT relies on increasing the inspired O2 fraction (fiO2) and elevating the partial pressure of O2 (pO2). O2 is typically administered at pressures between 1.5 and 3.0 ATA for 60 to 120 minutes, depending on the clinical presentation. Currently, there are 15 indications for HBOT approved by the Undersea and Hyperbaric Medicine Society, categorized into three groups: emergency medicine, wound healing acceleration, and antimicrobial effects. The present narrative review aims to elucidate the mechanisms action underlying HBOT, particularly oxy-inflammation, in various pathologies within these categories.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neurophysiological and genetic assessment of a case of rapidly progressive scoliosis.","authors":"Maria Chiara Maccarone, Matilde Paramento, Edoardo Passarotto, Paola Contessa, Maria Rubega, Emanuela Formaggio, Stefano Masiero","doi":"10.4081/ejtm.2024.13249","DOIUrl":"10.4081/ejtm.2024.13249","url":null,"abstract":"<p><p>Scoliosis is a three-dimensional spinal deformity characterized by a lateral deviation of at least 10° Cobb, categorized into idiopathic and non-idiopathic forms, caused by identifiable factors like congenital abnormalities, neuromuscular conditions, or genetic syndromes. This case report discusses a 15-year-old girl with growth delay and Growth Hormone (GH) deficiency who experienced rapid scoliosis progression. Initial evaluations were normal, and Electroencephalography (EEG) showed nonspecific alterations, but further assessment revealed a MYH3 gene variant associated with scoliosis, short stature, and distinct facial features. Treatment with a Lyon ARTbrace and tailored exercises stopped curve progression. This case highlights the need for thorough evaluations in atypical AIS cases to uncover potential causes.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardised indexes reduce the variability of masticatory muscles electromyographic values.","authors":"Riccardo Rosati, Daniela Carmagnola, Gaia Pellegrini, Dolaji Henin, Massimiliano Vella, Claudia Dellavia","doi":"10.4081/ejtm.2025.13420","DOIUrl":"10.4081/ejtm.2025.13420","url":null,"abstract":"<p><p>In dentistry, Surface Electromyography (sEMG) is currently used in both clinical and research fields to study the electrical activity of the masticatory muscles, such as the anterior Temporals and Masseters, which are easily accessible. Due to biological and technical factors that can alter the capture of the sEMG signal, comparing recordings obtained from the same subject at different days, with electrode replacement, can be challenging, thus complicating inter- and intra-subject sEMG comparisons. In the present study, sEMG activity of the masticatory muscles during maximum teeth clenching was simultaneously recorded using two different electrode configurations (A and B) to simulate different electrodes positioning as may occur between appointments. Raw sEMG signals and standardised indexes based on acquisitions from configurations A and B were compared. The position of the electrodes significantly affected the sEMG raw potentials of the masticatory muscles during maximum teeth clenching, while standardised indexes were not influenced by electrode positioning.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ejtm3 experiences after ChatGPT and other AI approaches: values, risks, countermeasures.","authors":"Giorgio Fanò-Illic, Daniele Coraci, Maria Chiara Maccarone, Stefano Masiero, Marco Quadrelli, Aldo Morra, Barbara Ravara, Amber Pond, Riccardo Forni, Paolo Gargiulo","doi":"10.4081/ejtm.2025.13670","DOIUrl":"10.4081/ejtm.2025.13670","url":null,"abstract":"<p><p>We invariably hear that Artificial Intelligence (AI), a rapidly evolving technology, does not just creatively assemble known knowledge. We are told that AI learns, processes and creates, starting from fixed points to arrive at innovative solutions. In the case of scientific work, AI can generate data without ever having entered a laboratory, (i.e., blatantly plagiarizing the existing literature, a despicable old trick). How does an editor of a scientific journal recognize when she or he is faced with something like this? The solution is for editors and referees to rigorously evaluate the track records of submitting authors and what they are doing. For example, false color evaluations of 2D and 3D CT and MRI images have been used to validate functional electrical stimulation for degenerated denervated muscle and a home Full-Body In-Bed Gym program. These have been recently published in Ejtm and other journals. The editors and referees of Ejtm can exclude the possibility that the images were invented by ChatGPT. Why? Because they know the researchers: Marco Quadrelli, Aldo Morra, Daniele Coraci, Paolo Gargiulo and their collaborators as well! Artificial intelligence is not banned by the EJTM, but when submitting their manuscripts to previous and to a new Thematic Section dedicated to Generative AI in Translational Mobility Medicine authors must openly declare whether they have used artificial intelligence, of what type and for what purposes. This will not avoid risks of plagiarism or worse, but it will better establish possible liabilities.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound <i>vs.</i> x-ray: a new way for clinicians to track scoliosis progression?","authors":"Samra Pjanić, Goran Talić, Nikola Jevtić, Filip Golić, Ivan Soldatović, Nachiappan Chockalingam","doi":"10.4081/ejtm.2025.13422","DOIUrl":"10.4081/ejtm.2025.13422","url":null,"abstract":"<p><p>This retrospective study, utilising prospectively collected data, investigates the use of spine ultrasound as an alternative method for assessing scoliosis, with the aim of reducing radiation exposure. We included 92 patients aged 10 to 16 years with suspected idiopathic scoliosis. Exclusion criteria were weight over 150 kg, metal implants, pre-existing conditions, secondary deformities, and cognitive impairments. Each patient underwent clinical assessment and full spine radiographs, followed by spine ultrasound using the Scolioscan® system. Unprocessed B-mode ultrasound images were analysed using automatic measurements. The correlation between Ultrasound Coronal Angle (UCA) and Radiographic Cobb Angle (RCA) was evaluated at initial and follow-up visits. Strong correlations were found between UCA and RCA, with correlation coefficients ranging from 0.786 to 0.903 (p<0.001). The regression formula showed good predictive accuracy for curve progression on follow-up radiographs. The best results were observed in females and in primary thoracic curves (r = 0.936, p<0.001). Although only four patients exhibited true progression (≥5° increase in Cobb angle), changes in scoliotic angles were effectively detected using ultrasound. This study confirms the feasibility of unprocessed spine ultrasound for scoliosis monitoring in clinical settings. Automatic measurements without 3D reconstruction make ultrasound a practical tool for tracking progression. The regression model shows potential for predicting curve progression, although further validation is needed. These findings suggest spine ultrasound could reduce the need for radiographs, benefiting patients by minimising radiation exposure while providing reliable monitoring of scoliosis progression and treatment outcomes.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous coronary intervention <i>versus</i> coronary artery bypass in treatment of non-ST-segment elevation acute syndromes: a systematic review and meta-analysis study.","authors":"Amirmohammad Khalifehsoltani, Enwa Felix Oghenemaro, Ahmed Hussein Zwamel, M M Rekha, Manish Srivastava, Reza Akhavan-Sigari","doi":"10.4081/ejtm.2024.12930","DOIUrl":"10.4081/ejtm.2024.12930","url":null,"abstract":"<p><p>The objective of this study is to compare the effectiveness and safety of Percutaneous Coronary Intervention (PCI) and Coronary Artery Bypass Grafting (CABG) in the treatment of Non-ST-Segment Elevation Acute Coronary Syndromes (NSTE-ACS). A literature search was conducted across PubMed, Scopus, and Web of Science, covering studies up to June 2024. Studies comparing PCI and CABG in patients with NSTE-ACS were included, focusing on clinical outcomes such as mortality, myocardial infarction, cerebrovascular accidents, and the need for repeat revascularization. Data extraction and quality assessment were performed. Statistical analysis was conducted using R software, with the Mantel-Haenszel method and random-effects model employed to pool effect sizes and assess heterogeneity. A total of 15 studies met the eligibility criteria, including 48,891 patients. The pooled risk ratio (RR) for mortality showed no significant difference between PCI and CABG (RR=1.09, 95% CI: 0.90-1.19, p=0.28). CABG was associated with a significantly lower risk of subsequent MI (RR=0.56, 95% CI: 0.38-0.61, p <0.01) and the need for repeat revascularization (RR=2.94, 95% CI: 2.30-3.76, p <0.01). Conversely, PCI had a lower associated risk of CVA (RR=0.58, 95% CI: 0.42-0.79, p <0.01). High heterogeneity was observed in mortality outcomes, indicating variability among studies. The findings suggest that while PCI and CABG have comparable mortality risks in NSTE-ACS patients, CABG offers superior protection against myocardial infarction and the need for repeat revascularization, whereas PCI is associated with a lower risk of cerebrovascular accidents. These results underscore the importance of individualized patient assessment in choosing the optimal revascularization strategy, considering patient-specific risk factors and clinical profiles.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of the XXI Meeting of the Interuniversity Institute of Myology and preview of the XXII edition.","authors":"Anna Urciuolo, Fabio Penna","doi":"10.4081/ejtm.2025.13743","DOIUrl":"https://doi.org/10.4081/ejtm.2025.13743","url":null,"abstract":"<p><p>The 21st Annual Meeting of the Interuniversity Institute of Myology (IIM), held in Assisi, Italy, from September 4-7, 2024, gathered 123 experts, including basic and clinical myologists, pharmaceutical representatives, and patient organizations from Italy, Europe, Canada, and USA. The meeting fostered a proactive, collaborative and dynamic atmosphere, promoting scientific exchange and international partnerships focused on muscle research, from physiology to disease mechanisms, and eventually therapeutic approaches. The 21st IIM Meeting featured 6 main scientific sessions, showcasing 30 oral presentations and 45 always-on-display posters, all reporting original and unpublished research. The program was enriched by four keynote lectures from internationally renowned speakers and talks from delegates of the Société Française de Myologie, adding depth to the scientific discussions. As part of the IIM Meeting organization, this year there was also a free-access educational convention titled \"Physical exercise as prevention\". Leading IIM experts shared insights on exercise-based lifestyle interventions aimed at improving public health, with the participation of the Italian former boxer Roberto Cammarelle. The event drew a large in-person and online audience. This IIM Meeting edition strongly emphasized the involvement and growth of young researchers, with 50% of the attendees being <35, reinforcing IIM's commitment to fostering the next generation of myologists. Along this line, and to further support young researchers, awards for Best Talk, Best Poster Blitz, and Best Poster were presented. The winners joined the IIM Young Committee, contributing to the scientific organization of future IIM meetings together with the IIM Scientific Committee. The meeting was also integrated into the \"Advanced Myology Update 2024\" high-training course, organized by the University of Perugia in collaboration with IIM. The 11 trainees enrolled in the course participated in dedicated roundtables and exclusive lessons led by IIM's invited speakers. In this report are included the abstracts of both oral and poster presentations, with some being withheld for patent-related reasons. Through its annual congress and educational initiatives, IIM played a crucial role in shaping the future of myology research, fostering innovation, collaboration, and scientific excellence on an international scale. We invite you to save the date for the 22nd IIM meeting that will be held in the beautiful Assisi, September 11-14, 2025. We can't wait to welcome you!</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}