FatemaAlZahraa Ahmad, Shahira Mostafa, Eman A Maher, Mostafa Ezzat, Aliaa Ali Tawfeek
{"title":"Ultrasonography versus electrodiagnosis of median nerve before and after open carpal tunnel release surgery: which can better diagnose, predict and assess postoperative improvement?","authors":"FatemaAlZahraa Ahmad, Shahira Mostafa, Eman A Maher, Mostafa Ezzat, Aliaa Ali Tawfeek","doi":"10.4081/ejtm.2026.15547","DOIUrl":"10.4081/ejtm.2026.15547","url":null,"abstract":"<p><p>Diagnosis of Carpal Tunnel Syndrome (CTS) relies on a structured clinical approach with Electrodiagnostic Studies (EDX) accepted as the gold standard in the diagnosis. Yet, Ultrasound (US) has emerged as a non-invasive alternative especially in assessing morphological changes. And so, to accurately diagnose CTS by a valid non-painful simple tool, objectively assess postoperative improvement and finally to predict postoperative clinical outcome from preoperative data; clinical, EDX, and US data were collected, compared and correlated pre- and 1 month postoperative. While US achieved diagnostic accuracy of 80% in CTS diagnosis, particularly Wrist Cross-Sectional Area (wCSA) and Wrist-Forearm Ratio (WFR), it remains less sensitive than EDX. The diagnosis of CTS using wCSA/WFR achieved a sensitivity of 80.0%/80.0% and a specificity of 100%/85.7%, at a cutoff score of 12.5mm2/2.1 or above. In addition, linear regression analysis showed that only compound motor action potential (CMAP) amplitude could predict postoperative clinical improvement. Sensitivity of EDX (93.33%) overcome that of the US in detection of postoperative improvement. US is less sensitive than EDX in diagnosing CTS, assessment and prediction of postoperative clinical outcome.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bastien A Valencia-Sanchez, Myriam Loyo, Stephen Hadford, Dane J Genther, Hana Rosen, Matthew Miller, Michelle H Cameron, Patrick Byrne
{"title":"Protocol for randomized controlled trial of brief intraoperative electrical stimulation across cross-face nerve grafts in patients with facial paralysis.","authors":"Bastien A Valencia-Sanchez, Myriam Loyo, Stephen Hadford, Dane J Genther, Hana Rosen, Matthew Miller, Michelle H Cameron, Patrick Byrne","doi":"10.4081/ejtm.2026.14137","DOIUrl":"10.4081/ejtm.2026.14137","url":null,"abstract":"<p><p>Brief Intraoperative Electrical Stimulation (BIES) can enhance axonal regeneration across axotomy sites. Cross-Face Nerve Grafts (CFNG) are typically performed in two stages, with a 6-12-month interval to allow for axonal growth. This provides an opportunity to assess axonal regeneration via biopsy. We describe a protocol to evaluate the effects of a 10-minute BIES on axonal regeneration across CFNG. This is a protocol for a multicenter, double-blind, randomized controlled trial in patients with unilateral facial paralysis undergoing two-stage CFNG. After nerve coaptation, the intervention group will receive 10 minutes of BIES (biphasic current, 2mA amplitude, 100 μsec pulse duration, 16 Hertz) applied proximal to the donor facial to sural nerve coaptation. Controls will undergo standard surgery without stimulation. The primary outcome is the histological count of regenerated myelinated axons from a biopsy obtained during the second stage surgery. Secondary outcomes include patient reported quality of life and objective facial reanimation based on photo analysis. We aim to recruit 20 participants. This protocol evaluates the impact of BIES on histological, patient reported, and objective facial reanimation outcomes in CFNG.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mapping the literature about brain-computer interface in rehabilitation: a graph-theory-based PCA framework for semantic space analysis.","authors":"Daniele Coraci, Gianluca Regazzo, Stefano Masiero","doi":"10.4081/ejtm.2026.15674","DOIUrl":"10.4081/ejtm.2026.15674","url":null,"abstract":"<p><p>Brain-Computer Interfaces (BCIs) are increasingly used in neurorehabilitation, but the rapid expansion of scientific literature complicates the identification of clinically relevant studies. This study investigated whether expert-defined relevance within BCI rehabilitation literature emerges as a structural property of semantic networks through the integration of graph theory and Principal Component Analysis (PCA). A Lexical Network Analysis Based on Graph Theory (LENGTH) was applied to randomized controlled trials indexed in PubMed over the last decade using the query \"brain computer interface\" AND rehabilitation. Titles and abstracts were analyzed to construct a semantic network linking articles and lexical terms. Multiple graph-theoretical metrics were calculated and residualized against weighted degree to minimize document-size bias. PCA was subsequently applied to the residualized metrics. Forty-eight studies were included. The network showed a compact and highly interconnected structure, centered on motor and functional recovery concepts. PCA identified two principal components explaining of total variance. Relevant articles tended to occupy regions characterized by higher semantic integration and lower hierarchical influence. Although no clear categorical separation emerged, a consistent positional tendency was observed. These findings suggest that relevance may be represented as a topological property within a multidimensional semantic landscape, supporting the use of semantic-network approaches for literature screening and evidence synthesis.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Grossi, Andrea Fabris, Francesca Campoli, Lucio Caprioli, Matteo Vitarelli, Donatella Di Corrado, Claudio Messina, Domenico Cherubini, Robert Nowak, Elvira Padua, Giuseppe Messina, Bruno Ruscello
{"title":"Preliminary pre-post changes in neuromuscular performance after application of a wearable photobiomodulation device in young tennis athletes.","authors":"Alberto Grossi, Andrea Fabris, Francesca Campoli, Lucio Caprioli, Matteo Vitarelli, Donatella Di Corrado, Claudio Messina, Domenico Cherubini, Robert Nowak, Elvira Padua, Giuseppe Messina, Bruno Ruscello","doi":"10.4081/ejtm.2026.16043","DOIUrl":"10.4081/ejtm.2026.16043","url":null,"abstract":"<p><p>Athletes require effective recovery strategies to sustain performance, particularly in high-demand sports. Photobiomodulation (PBM) has emerged as a non-invasive approach capable of supporting muscle function without reported adverse effects. Wearable nanotechnology-based devices, such as Taopatch®, allow continuous and localized PBM delivery, representing a potential tool for sports applications. This pilot study investigated the acute effects of Taopatch® on neuromuscular performance in 28 young tennis players (11 females, 17 males; age 14.41 ± 2.60 years). Participants completed Squat Jump (SJ), Counter Movement Jump (CMJ), stiffness, and reaction time assessments before (T1) and after a 15-minute application period (T2). Taopatch® application was associated with pre-post increases in SJ flight time (unadjusted p=0.042) and maximal pre-take-off velocity (Vmax; unadjusted p=0.012), while CMJ concentric work also increased (unadjusted p=0.014). Several effects remained significant after Benjamini-Hochberg false discovery rate correction, whereas none remained significant after the more conservative Holm-Bonferroni correction. Stiffness responses varied among subgroups, while reaction time remained unchanged. These preliminary findings suggest a potential association between Taopatch® application and acute changes neuromuscular performance. However, the statistical evidence was sensitive to the multiple-comparison correction applied, and controlled studies are required to confirm these exploratory observations.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From uterine mechanics to motor control: a personal perspective on biomechanics across scales.","authors":"Joseph Mizrahi","doi":"10.4081/ejtm.2026.15707","DOIUrl":"10.4081/ejtm.2026.15707","url":null,"abstract":"<p><p>This paper offers a personal perspective on a lifetime of research in biomechanics, organized around the mechanical principles that connect muscle, joint, tissue, limb, and whole-body function. The narrative begins with uterine biomechanics during labor, where in-vivo strain measurements and shell modeling were used to examine contraction patterns, deformation, pacemaker activity, and the transition from near-isotropic to anisotropic behavior. It then turns to joint mechanics, including hip incongruity, acetabular contact pressure, implant fixation, knee arthroplasty, and the gliding index, followed by studies of rehabilitation biomechanics at the Loewenstein Rehabilitation Center. These sections examine gait recovery, stepping and jumping, postural control, bilateral force-platform measurements, and mathematical modeling of body sway across neurological, orthopedic and amputee populations. Subsequent sections address articular cartilage mechanics and cartilage tissue engineering, surgical modifications of the musculoskeletal system, impact loading and fatigue in running, mechanical impedance as a task-dependent expression of motor control, and Functional Electrical Stimulation (FES) for rehabilitation. The FES work includes muscle recruitment, fatigue monitoring using ³¹P magnetic resonance spectroscopy, fatigue modeling, EMG-based monitoring, hybrid activation and bioelectric field modeling. The final sections consider bone quality, osteoporosis, metastatic weakening, vertebral fragility, and biomechanical indeterminacy. Across these topics, the central theme is that biomechanics is most powerful when experiment, modeling, and clinical observation are integrated. The concluding section reflects on how indeterminacy, redundancy, adaptation, and structure-function relations unify seemingly diverse problems in biomechanics.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luigi Meccariello, Predrag Grubor, Francesco Bosco, Claudio Domenico Cobisi, Lara Cristiano, Giuseppina Casolaro, Jacopo Conteduca, Giuseppe Rollo, Dimitra Melissaridou, Michele Mercurio, Lawrence Camarda, Fernando De Maio, Giuseppe Rovere
{"title":"Crack Dol<sup>®</sup> <i>vs.</i> cryotherapy in postoperative pain treatment after patellar fracture fixation.","authors":"Luigi Meccariello, Predrag Grubor, Francesco Bosco, Claudio Domenico Cobisi, Lara Cristiano, Giuseppina Casolaro, Jacopo Conteduca, Giuseppe Rollo, Dimitra Melissaridou, Michele Mercurio, Lawrence Camarda, Fernando De Maio, Giuseppe Rovere","doi":"10.4081/ejtm.2026.15868","DOIUrl":"10.4081/ejtm.2026.15868","url":null,"abstract":"<p><p>Postoperative pain following patellar fracture surgery may delay rehabilitation and impair functional recovery. While cryotherapy is commonly used, concerns exist regarding its effects on local blood flow. Alternative topical cooling formulations may offer analgesic benefits without prolonged vasoconstriction. In this study, we compared postoperative pain, functional recovery, quality of life, and rescue analgesic consumption among patients receiving traditional ice therapy, ice spray, or Crack Dol® Foam Spray following surgical fixation of patellar fractures. Ninety patients undergoing surgical fixation for patellar fracture were prospectively enrolled in this non-randomized comparative cohort study and allocated into three groups (n=30 each) based on patient preference and clinical contraindications: ice therapy, ice spray, and Crack Dol® Foam Spray. Pain intensity (Visual Analogue Scale, VAS), health-related quality of life (SF-12), knee function (KOOS), and rescue analgesic consumption were assessed during postoperative follow-up. Patients in the Crack Dol® Foam Spray group had significantly lower VAS scores at 7, 30, and 90 days compared with the ice and ice spray groups (p=0.012, p=0.006, and p=0.004, respectively). At 90 days, SF-12 Physical and Mental Component Scores were significantly higher in the Crack Dol® group (p=0.009 and p=0.014, respectively). KOOS total scores were also significantly higher at 30 and 90 days (p=0.018 and p=0.007, respectively). Rescue analgesic consumption was significantly lower in the Crack Dol® group (p=0.011). In this prospective, non-randomized comparative cohort study, the use of Crack Dol® Foam Spray was associated with lower postoperative pain scores, lower rescue analgesic consumption, and better patient-reported functional and quality-of-life outcomes compared with traditional ice therapy and ice spray. Given the non-randomized treatment allocation, these findings should be interpreted as associations rather than evidence of a causal treatment effect. Further randomized controlled trials are needed to confirm these preliminary findings.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender differences in self-efficacy and self-management behaviors among adults with type 2 diabetes: a systematic review and meta-analysis.","authors":"Mohsen Khosravi, Leila Gonabadi-Nezhad","doi":"10.4081/ejtm.2026.15650","DOIUrl":"10.4081/ejtm.2026.15650","url":null,"abstract":"<p><p>A systematic meta-analysis was conducted to examine gender differences in self-efficacy and self-management among adults with Type 2 Diabetes Mellitus (T2DM). Twenty studies (2000-2025) with gender-disaggregated data were analyzed according to PRISMA 2020 guidelines. The meta-analysis used standardized mean differences (Hedges' g; men minus women) and a multilevel random-effects model, with moderator and sensitivity analyses for behavioral domains, measurement types, regions, and study quality. The pooled effect size was small and positive (g = 0.37, 95% CI: -0.11 to 0.85), but the confidence interval included zero and heterogeneity was substantial (I² = 95.3%), indicating considerable between-study variability. Moderator analyses showed no significant differences by behavioral domain, measurement method, region, or publication year. Evidence of small-study effects and wide prediction intervals further reduced certainty in the findings. Domain-specific results (e.g., dietary self-management) were also positive but imprecise. Importantly, the certainty of evidence was rated low to very low due to imprecision, inconsistency, and potential publication bias, as assessed by the GRADE framework. Therefore, these findings should be interpreted as provisional and hypothesis-generating rather than definitive. In summary, gender differences in self-efficacy and self-management in T2DM are small, inconsistently estimated, and of low certainty, with a tendency to favor men. These results suggest that gender is not a robust determinant of diabetes self-management, and that contextual and psychosocial factors likely contribute to variability across studies. Interventions should aim to enhance self-efficacy for all individuals with T2DM using context-sensitive and gender-responsive approaches. Future research should use standardized measures, report gender-disaggregated data, and include broader geographic samples.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cannabidiol and skeletal muscle insulin resistance: translational implications for exercise and rehabilitation medicine.","authors":"Gergana Todorova, Tanya Gesheva, Anna Mihaylova","doi":"10.4081/ejtm.2026.15541","DOIUrl":"10.4081/ejtm.2026.15541","url":null,"abstract":"<p><p>Insulin Resistance (IR) is a central pathophysiological mechanism underlying obesity, type 2 diabetes mellitus, metabolic syndrome, and metabolic dysfunction-associated steatotic liver disease, with significant implications for skeletal muscle function, exercise capacity, and rehabilitation outcomes. Because skeletal muscle represents the primary site of insulin-stimulated glucose disposal, muscle insulin resistance is a key determinant of both metabolic health and physical performance. Cannabidiol (CBD), a non-intoxicating phytocannabinoid derived from Cannabis sativa, has attracted increasing scientific interest due to its anti-inflammatory, antioxidant, and pleiotropic signaling properties. This narrative review aims to examine the relationship between CBD and insulin resistance, with a particular focus on skeletal muscle biology and its relevance for exercise and rehabilitation medicine. A structured literature search was conducted using major biomedical databases, including PubMed, Scopus, and Web of Science, to identify relevant preclinical and clinical studies. Evidence was synthesized narratively, with emphasis on skeletal muscle insulin resistance, endocannabinoid system signaling, potential mechanisms of CBD action, and clinical outcomes. Preclinical data suggest that CBD may influence several pathways involved in skeletal muscle insulin resistance, including chronic low-grade inflammation, oxidative stress, lipotoxicity, and ceramide accumulation. However, current human studies remain limited and do not demonstrate consistent improvements in glycemic control or insulin sensitivity with CBD alone. Furthermore, evidence regarding its effects on muscle function, exercise performance, or rehabilitation outcomes is lacking. In conclusion, CBD represents a biologically plausible but clinically unproven modulator of skeletal muscle insulin resistance. At present, it should be considered an experimental adjunct rather than an established therapeutic strategy. Future research should focus on well-designed clinical trials integrating metabolic and functional endpoints to determine its potential role alongside exercise-based interventions in rehabilitation medicine.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond biomechanics: a narrative review on the cognitive, emotional, and metacognitive mechanisms of exercise in chronic pain.","authors":"Gianluca Regazzo, Daniele Coraci, Stefano Masiero","doi":"10.4081/ejtm.2026.15506","DOIUrl":"10.4081/ejtm.2026.15506","url":null,"abstract":"<p><p>Chronic pain is increasingly recognized as a multidimensional condition sustained by interacting cognitive, behavioral, emotional, attentional, and metacognitive processes. Within this framework, physical exercise has gained relevance as a non-pharmacological intervention that may influence psychological mechanisms involved in pain persistence and disability. This narrative review provides an updated synthesis of recent evidence on the effects and mechanisms of physical exercise on cognitive, behavioral, emotional, and metacognitive dimensions of chronic pain. A structured literature search was conducted across PubMed/MEDLINE, Scopus and Web of Science, focusing on peer-reviewed studies published between January 2016 and December 2025. Evidence was synthesized narratively across mechanistic domains, integrating findings from rehabilitation science and clinical psychology. The literature suggests that exercise may act as an active experiential intervention capable of targeting several psychosocial factors in chronic pain. Across studies, exercise was associated with reductions in catastrophizing and maladaptive pain beliefs, improvements in pain self-efficacy, and attenuation of kinesiophobia. Exercise may also modulate attentional bias and hypervigilance, and psychologically informed exercise approaches appear particularly relevant for metacognitive processes, including reduced rumination, increased decentering, and improved non-reactive awareness of bodily sensations. In parallel, exercise shows beneficial effects on emotional aspects of chronic pain, likely mediated by both neurobiological and psychosocial mechanisms pathways. Overall, physical exercise should be conceptualized as a comprehensive intervention capable of acting on cognitive, behavioral, emotional, and metacognitive processes that sustain chronic pain. Future research should clarify modality-specific mechanisms, identify moderators of response and incorporate process-based outcomes to support personalized exercise prescriptions.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nedelcho Tzachev, Jannis Papathanasiou, Radoslav Milev, Plamen Ivanov, Nikola Hariskov, Petko Ginev, Virna Maria Tsitou
{"title":"From destruction to restoration: total hip arthroplasty in advanced hip joint tuberculosis. A case report.","authors":"Nedelcho Tzachev, Jannis Papathanasiou, Radoslav Milev, Plamen Ivanov, Nikola Hariskov, Petko Ginev, Virna Maria Tsitou","doi":"10.4081/ejtm.2026.15594","DOIUrl":"10.4081/ejtm.2026.15594","url":null,"abstract":"<p><p>Hip Tuberculosis (HTB) is a severe form of extrapulmonary Tuberculosis (TB) that can lead to progressive joint destruction, functional impairment, and reduced Quality Of Life (QoL). Optimal management requires timely Antitubercular Therapy (ATT), appropriate surgical intervention, and structured rehabilitation. This case report aims to present a 57-year-old Bulgarian female with advanced HTB, persisting chronic pain, severe functional limitation, and marked restriction in Range Of Motion (ROM) and Muscle Strength (MS). Baseline assessment revealed a Harris Hip Score (HHS) of 56 and pain intensity of 7/10 on the Visual Analogue Scale (VAS). Microbiological confirmation of Mycobacterium tuberculosis was obtained via bone biopsy. Following completion of ATT and normalization of inflammatory markers, the patient underwent Total Hip Arthroplasty (THA) using an anterolateral approach. An individualized Exercise-Based Postoperative Rehabilitation Program (EBRP) was implemented. At 6- Hip Flexion (HF) improved from 25° to 55°, while hip abduction increased from 15° to 40°. MS improved from 2/5 to 4+/5 in key muscle groups (MG). Functional performance improved significantly, with HHS increasing from 56 to 81 (+44.6%), and pain decreasing from 7/10 to 2/10 (-71.4%). No postoperative complications or infection recurrence were observed. This case highlights the importance of appropriate timing of THA after successful infection control with ATT, combined with a structured EBRP. A multidisciplinary approach is essential to optimize functional recovery and minimize complications in patients with HTB.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}