European Journal of Translational Myology最新文献_第10页

Angiotensin-(1-7) improves skeletal muscle regeneration. 血管紧张素-（1-7）可改善骨骼肌再生。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-12-15 DOI: 10.4081/ejtm.2023.12037

Mayalen Valero-Breton, Franco Tacchi, Johanna Abrigo, Felipe Simon, Daniel Cabrera, Claudio Cabello-Verrugio

{"title":"Angiotensin-(1-7) improves skeletal muscle regeneration.","authors":"Mayalen Valero-Breton, Franco Tacchi, Johanna Abrigo, Felipe Simon, Daniel Cabrera, Claudio Cabello-Verrugio","doi":"10.4081/ejtm.2023.12037","DOIUrl":"10.4081/ejtm.2023.12037","url":null,"abstract":"Skeletal muscle possesses regenerative potential via satellite cells, compromised in muscular dystrophies leading to fibrosis and fat infiltration. Angiotensin II (Ang-II) is commonly associated with pathological states. In contrast, Angiotensin (1-7) [Ang-(1-7)] counters Ang-II, acting via the Mas receptor. While Ang-II affects skeletal muscle regeneration, the influence of Ang-(1-7) remains to be elucidated. Therefore, this study aims to investigate the role of Ang-(1-7) in skeletal muscle regeneration. C2C12 cells were differentiated in the absence or presence of 10 nM of Ang-(1-7). The diameter of myotubes and protein levels of myogenin and myosin heavy chain (MHC) were determined. C57BL/6 WT male mice 16-18 weeks old) were randomly assigned to injury-vehicle, injury-Ang-(1-7), and control groups. Ang-(1-7) was administered via osmotic pumps, and muscle injury was induced by injecting barium chloride to assess muscle regeneration through histological analyses. Moreover, embryonic myosin (eMHC) and myogenin protein levels were evaluated. C2C12 myotubes incubated with Ang-(1-7) showed larger diameters than the untreated group and increased myogenin and MHC protein levels during differentiation. Ang-(1-7) administration enhances regeneration by promoting a larger diameter of new muscle fibers. Furthermore, higher numbers of eMHC (+) fibers were observed in the injured-Ang-(1-7), which also had a larger diameter. Moreover, eMHC and myogenin protein levels were elevated, supporting enhanced regeneration due to Ang-(1-7) administration. Ang-(1-7) effectively promotes differentiation in vitroand improves muscle regeneration in the context of injuries, with potential implications for treating muscle-related disorders.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerobic training and vitamin E administration ameliorates cardiac apoptosis markers in rats exposed to methamphetamine. 有氧训练和维生素 E 可改善暴露于甲基苯丙胺的大鼠的心脏凋亡指标。

IF 2.2

European Journal of Translational Myology Pub Date : 2023-12-11 DOI: 10.4081/ejtm.2023.12112

Hamidreza Salimi, Amir Hossein Haghighi, Shima Ababzadeh, Hamid Marefati, Sadegh Abbasian, Amber L Pond, Paulo Gentil

{"title":"Aerobic training and vitamin E administration ameliorates cardiac apoptosis markers in rats exposed to methamphetamine.","authors":"Hamidreza Salimi, Amir Hossein Haghighi, Shima Ababzadeh, Hamid Marefati, Sadegh Abbasian, Amber L Pond, Paulo Gentil","doi":"10.4081/ejtm.2023.12112","DOIUrl":"10.4081/ejtm.2023.12112","url":null,"abstract":"Methamphetamine (MA) abuse is related to risks to the cardiovascular system. The present study aimed to compare the effects of moderate-intensity aerobic training (MIAT) and vitamin E (Vit.E) supplementation on markers of cardiac apoptosis following MA exposure. Fifty-four rats were randomly divided into six groups. CON group did not receive MA, while the others received MA alone or in combination with MIAT, Vit. E, MIAT+Vit E, or paraffin (PAR). These groups received MA incrementally for 23 consecutive days. Vit.E and MIAT+Vit.E groups received vitamin E three times a week for six weeks. MIAT and MIAT+Vit.E groups exercised for 25-40 min. Immunohistochemical and gene expression analyses were performed on the heart tissues. Bax and TGF-β expression was significantly higher, while Bcl-2 and VEGF expression was significantly lower in the MA and PAR groups than in the other groups (p < 0.05). Bcl-2 and VEGF expression was higher, and Bax and TGF-β expression was significantly lower in the MIAT and MIAT+Vit.E groups than in the other groups (p < 0.05). In Vit.E treated groups, Bax and TGF-β expression were lower, and VEGF was higher than that in the MA and PAR groups, but higher than those in the CON, MIAT and MIAT+Vit.E groups. MA increased the expression of Bax and TGF-β, and decreased the expression of Bcl-2 and VEGF, suggesting increased cardiac apoptosis. In contrast, MIAT and Vit.E decreased the expression of Bax and TGF-β, suggesting a reduction in cardiac apoptosis induced by MA.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study. 终生耐力运动能否通过对男性昼夜节律功能、肌肉表现和健康状况的有益影响来改善衰老?比较横断面研究方案。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-12-05 DOI: 10.4081/ejtm.2023.12012

Genc Berisha, Milan Sedliak, Michal Zeman, Dušan Hamar, Ján Cvečka, Veronika Tirpáková, Matej Vajda, Ľudmila Oreská, Alena Černáčková, Martin Čupka, Nejc Šarabon, Feliciano Protasi, Sandra Zampieri, Helmut Kern, Stefan Lofler, Antonio Musaro, Katarína Stebelová, Monika Okuliarová

{"title":"Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study.","authors":"Genc Berisha, Milan Sedliak, Michal Zeman, Dušan Hamar, Ján Cvečka, Veronika Tirpáková, Matej Vajda, Ľudmila Oreská, Alena Černáčková, Martin Čupka, Nejc Šarabon, Feliciano Protasi, Sandra Zampieri, Helmut Kern, Stefan Lofler, Antonio Musaro, Katarína Stebelová, Monika Okuliarová","doi":"10.4081/ejtm.2023.12012","DOIUrl":"10.4081/ejtm.2023.12012","url":null,"abstract":"A well-synchronized circadian system is a manifestation of an individual's health. A gradual weakening of the circadian timing function characterizes aging. Regular exercise has been suggested as a modality to improve many detrimental changes associated with aging. Therefore, we aim to examine the benefits and risks of lifelong endurance exercise on age-dependent changes in the circadian time-keeping function, the performance of the muscular system and health status. The study protocol has a comparative cross-sectional design, including groups of senior (65 to 75 years old, n=16) and young (20-30 years old, n=16) endurance runners and triathletes. Age-matched groups of young and elderly sedentary men are included as controls. The circadian function is evaluated mainly by measurement of urinary 6-sulphatoxymelatonin, a metabolite of the hormone melatonin shown to participate in the modulation of sleep cycles. The 6-sulphatoxymelatonin will be assessed in urine samples collected upon awakening in the morning and in the late evening, as a marker of melatonin production. In addition, sleep/activity rhythms and sleep quality will be measured by wrist actigraphy. Performance of the muscular system will be assessed by examination of muscular strength and quantifying of gene expression in the skeletal muscle tissue samples. Health status and age-induced reduction in immune function are to be analysed via the balance of pro- and anti-inflammatory immune markers in the plasma and skeletal muscle, body composition, bone density and physical fitness.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of radiopacity of cements used in implant-supported prosthesis by indirect digital radiography: an in-vitro study. 间接数字x线摄影评估种植体支撑假体中骨水泥的放射不透明度:一项体外研究。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-12-01 DOI: 10.4081/ejtm.2023.11940

Mahla Esfahanian, Amin Mahdavi Asl

{"title":"Evaluation of radiopacity of cements used in implant-supported prosthesis by indirect digital radiography: an in-vitro study.","authors":"Mahla Esfahanian, Amin Mahdavi Asl","doi":"10.4081/ejtm.2023.11940","DOIUrl":"10.4081/ejtm.2023.11940","url":null,"abstract":"In order to help dentists in choosing the right type of cement for implant-based prostheses, the radiopacity of commonly used cements available in the market was investigated by digital radiography with PSP sensor. In the present study, temporary cements of TempBond (Kerr, Germany), TempBond clear (Kerr, Germany), Dycal (Dentsply, USA) and permanent cements of Multilink N (Ivoclar, Brazil), Panavia F 2.0 (Kurrary, Japan), Fuji plus (GC, Japan), RelyX (3M, USA), Durelon (3M, USA) were used. Four pill-like samples with 0.5 mm and 1 mm thickness and 5 mm in diameter inside the silicon index as recommended by the manufacturer were prepared for each cement. Aluminum step wedge (99% aluminum alloy) was used as control. Using digital radiography, cement and aluminum step wedge samples were radiographed. The images of cement tablets were measured by digital radiography using DFW software to check their radiopacity values. Bonferroni test and Mann-Whitney U test were used for comparison of cements. The highest radiopacity between the group of 1 and 0.5 mm thickness was related to Glass ionomer Fujiplus GC (2407±45.99) and TempBond (137.21±22.46) cement, respectively. Whereas, the lowest radiopacity among the groups was related to Clear cement. The difference between the mean radiopacities among the studied groups was statistically significant (p<0.001). Based on the results, among the available cements, Glass ionomer Fujiplus GC and TempBond cement are the most efficient for 1 and 0.5 mm thickness, respectively, and Clear cement is the least efficient cement in both groups in terms of radiopacity.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138483203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability and clinical applicability of lower limp strength using an enhanced paper grip strength. 可靠性和临床适用性较低的跛行强度使用增强纸握力。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-12-01 DOI: 10.4081/ejtm.2023.11841

Maria Tsekoura, Melina Pantou, Konstantinos Fousekis, Evdokia Billis, John Gliatis, Elias Tsepis

{"title":"Reliability and clinical applicability of lower limp strength using an enhanced paper grip strength.","authors":"Maria Tsekoura, Melina Pantou, Konstantinos Fousekis, Evdokia Billis, John Gliatis, Elias Tsepis","doi":"10.4081/ejtm.2023.11841","DOIUrl":"10.4081/ejtm.2023.11841","url":null,"abstract":"The enhanced paper grip test (EGPT) quantitatively assesses lower limb strength. EGPT assesses the hallux grip force by reacting a pulling force derived from a card, being positioned underneath the participant's hallux. This study aimed to investigate the repeatability and clinical applicability of the EPGT for assessing foot muscle strength. EPGT force was measured using a dynamometer. The reliability of the measurement of EPGT force was assessed by having two examiners performing the test on the same group of healthy adults. Clinical applicability was assessed in community-dwelling adults of both genders. EPGT force was recorded for both feet using the same standardised protocol for all participants. Regarding reliability, 20 healthy adults aged 23.04±5.5 years participated in the present study. The EGPT demonstrated good to excellent test-retest (ICC1,2 0.8 to 0.86) and interrater reliability (ICC1,2 0.82 to 0.88). A convenience sample of 15 community-dwelling adults (71.6±7.8 years, 68.5% women) was recruited for clinical applicability testing. All participants performed the test with mean score 15±5.7 N. EPGT is a reliable measurement of the hallux grip force strength and can be used for clinical and research purposes.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138483204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Report and Abstracts of the 15th Congress of the Mediterranean Forum of Physical and Rehabilitation Medicine: Rome, July 6-8, 2023. 第15届地中海物理和康复医学论坛大会报告和摘要:罗马，2023年7月6日至8日。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-12-01 DOI: 10.4081/ejtm.2023.12116

Nicola Manocchio, Isabella Iovene, Antonio Santoro, Maria Chiara Maccarone, Calogero Foti

{"title":"Report and Abstracts of the 15th Congress of the Mediterranean Forum of Physical and Rehabilitation Medicine: Rome, July 6-8, 2023.","authors":"Nicola Manocchio, Isabella Iovene, Antonio Santoro, Maria Chiara Maccarone, Calogero Foti","doi":"10.4081/ejtm.2023.12116","DOIUrl":"10.4081/ejtm.2023.12116","url":null,"abstract":"The 15th Mediterranean Forum of Physical and Rehabilitation Medicine (MFPRM) Congress, held in Rome from 6 to 8 July 2023, brought together over 600 PRM specialists and residents from 51 countries and 5 continents to share knowledge, perspectives, and research findings. The Congress focused on the theme \"Beyond COVID,\" highlighting the resilience and adaptability of PRM in the face of the pandemic. Presentations showcased the latest advancements in PRM across various subspecialties, including orthopedics and sports re-education, neurological disorders, pharmacotherapy and pain, pediatrics disorders, musculoskeletal disease, ergonomics and robotics, spasticity management, ICF and evaluation scales, spinal cord injury, musculoskeletal ultrasounds, rehabilitation of patients with cancers disease, post COVID-19 re-education, cardio-respiratory and urogynecological disorders, and traumatic brain injury. The congress successfully served as a platform for knowledge exchange, collaboration, and innovation in PRM, highlighting the importance of international cooperation and the resilience of PRM in adapting to emerging challenges.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of adding glucosamine or glucosamine combined with chondroitin to exercise on pain and physical function in adults with knee osteoarthritis: a systematic review and meta-analysis. 添加葡萄糖胺或葡萄糖胺联合软骨素运动对成人膝关节骨关节炎患者疼痛和身体功能的影响:一项系统回顾和荟萃分析。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-11-23 DOI: 10.4081/ejtm.2023.12013

Tina Čeh, Nejc Šarabon

{"title":"Effects of adding glucosamine or glucosamine combined with chondroitin to exercise on pain and physical function in adults with knee osteoarthritis: a systematic review and meta-analysis.","authors":"Tina Čeh, Nejc Šarabon","doi":"10.4081/ejtm.2023.12013","DOIUrl":"10.4081/ejtm.2023.12013","url":null,"abstract":"It is well known that different types of exercise significantly improve physical function and relieve pain in knee osteoarthritis (KOA) patients. The aim of this study was to investigate the added effects of glucosamine or glucosamine and chondroitin supplementation in combination with an exercise program in the management of KOA. The randomized controlled trials on adding glucosamine (G) or G combined with chondroitin (C) to an exercise program in the treatment of KOA were searched in the PubMed, Cochrane Central Register of Controlled Trials, PEDro, and Web of Science online databases. The Pedro scale tool was used to assess quality of literature. A meta-analysis was performed using the Review Manager 5.4 software. In total, 6 studies (including 297 participants) were included for the final meta-analysis. According to the PEDro scale, the average quality of the studies was rated as good (mean = 8.2 (2)). The results showed that the effect of G, or G and C, in combination with exercise is not significant, as indicated by the assessed knee pain (WOMAC pain: SMD -0.18, 95% CI -0.47 to 0.11, p = 0.23; and VAS pain: SMD -0.34, 95% CI -0.85 to 0.17, p = 0.20) and physical function (SMD -0.13, 95% CI -0.95 to 0.69, p = 0.76). Adding glucosamine alone or a combination of glucosamine and chondroitin to exercise, has no effect on knee pain and physical function compared with exercise alone in KOA patients. Keywords: treatment, dietary supplement, physical activity, older adults.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors associated with implant sites prepared by orthodontic treatment: a systematic review. 正畸治疗预备种植体部位相关的危险因素:系统回顾。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-11-21 DOI: 10.4081/ejtm.2023.11727

Mohsen Taban, Arezousadat Fatemi, Milad Soleimani, Seyed Masoud Sajedi, Berahman Sabzevari

{"title":"Risk factors associated with implant sites prepared by orthodontic treatment: a systematic review.","authors":"Mohsen Taban, Arezousadat Fatemi, Milad Soleimani, Seyed Masoud Sajedi, Berahman Sabzevari","doi":"10.4081/ejtm.2023.11727","DOIUrl":"10.4081/ejtm.2023.11727","url":null,"abstract":"The patient's health and quality of life would probably be improved with dental implant. This study aimed to evaluate the risk factors associated with dental implants place by orthodontic treatment. In this study, information on risk factors associated with implants of sites prepared, radiology stereotypes and hospitalized were obtined from databases such as Scopus, Google scholar and PubMed, and 58 articles were included for this purpose. After analyzing the articles, 24 articles were not accepted and 34 articles were accepted, then, 16 articles were miscarriage and 18 articles were scientific sources. The results showed that orthodontic treatment has a significant effect on a person's sense of beauty and would possibly increase self-confidence and quality of life. The stability of the implant in the healing phase depends on the quality and quantity of the bone. Also, the width of the bone is one of the important issues in creating a successful treatment. When an implant fails, problems and symptoms of failure usually occur within the first year after surgery. After one year, there is only about a 1% chance of failure, and on average only 1% of all implants fail each year.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital monitoring of weight-bearing improves success rates and reduces complications in lower extremity surgeries. 数字负重监测提高了下肢手术的成功率并减少了并发症。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-11-14 DOI: 10.4081/ejtm.2023.11974

Babak Otoukesh, Seyedeh Fariba Moshiri, Behrad Jahangiri, Kamal Mehraban Jafarlou, Shayan Amiri, Nadieh Baniasadi, Bahareh Heshmat Ghahderijani

{"title":"Digital monitoring of weight-bearing improves success rates and reduces complications in lower extremity surgeries.","authors":"Babak Otoukesh, Seyedeh Fariba Moshiri, Behrad Jahangiri, Kamal Mehraban Jafarlou, Shayan Amiri, Nadieh Baniasadi, Bahareh Heshmat Ghahderijani","doi":"10.4081/ejtm.2023.11974","DOIUrl":"10.4081/ejtm.2023.11974","url":null,"abstract":"The aim of this study is to develop a digital monitoring system to track weight and evaluate its impact on postoperative outcomes after lower extremity surgeries (LES). This parallel randomized controlled trial enrolled 266 patients who underwent LES (fracture or joint replacement) at our medical center between March 11, 2022, and January 10, 2023. Patients were randomly assigned to the intervention and control groups in a 1:1 ratio. The intervention group (n=116) used a cane and shoes equipped with a weight-bearing system after lower limb surgery, while the control group (n=116) used a simple cane and shoes without a weight-bearing system. The primary outcomes included callus formation, duration of union, and success rate of union in the two groups. The intervention group had a significantly higher rate of complete surgical success than the control group (93.9% vs. 79.3%, p=0.001). The intervention group also had a significantly lower risk of non-union than the control group (OR: 2.33, 95% CI: 1.14, 3.48, p=0.001). The mean duration of surgery until the time of union and the meantime of callus formation was significantly lower in the intervention group (p=0.01). The use of a digital monitoring system for weighing in LES significantly increased the success rate and reduced post-operative complications. Therefore, incorporating this system can enhance the rehabilitation process and prevent revision surgeries in patients with LES.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of molecular biophysical stimulation therapy in chronic musculoskeletal disorders: a narrative review. 分子生物物理刺激治疗慢性肌肉骨骼疾病的潜力：叙述性综述。

IF 1.8

European Journal of Translational Myology Pub Date : 2023-11-09 DOI: 10.4081/ejtm.2023.11894

Matej Žnidarič, Ziga Kozinc, Dominik Škrinjar

{"title":"Potential of molecular biophysical stimulation therapy in chronic musculoskeletal disorders: a narrative review.","authors":"Matej Žnidarič, Ziga Kozinc, Dominik Škrinjar","doi":"10.4081/ejtm.2023.11894","DOIUrl":"10.4081/ejtm.2023.11894","url":null,"abstract":"Current treatment of chronic musculoskeletal diseases does not give sufficient results despite the implementation of novel drugs and techniques in orthopaedics and physical therapy. For instance, osteoporosis treatment is currently mainly limited to drug application, while the goal of osteoarthritis treatment is to mitigate pain symptoms through physical therapy. The main therapeutic principle in the management of osteoporosis is not only to increase bone mass, but also to improve bone and the cartilage quality, which depends on the biomechanical balance. Therefore, there is a strong demand for advanced technologies that would safely and non-invasively accelerate cartilage regeneration and improve bone density. Ten years ago, a new state-of-the-art technology - \"Molecular biophysical stimulation therapy (MBST)\", specifically nuclear magnetic resonance therapy, emerged on the medical technology market and until now, it has shown successful results in the conservative treatment of musculoskeletal disorders, including back pain. The aim of this review is to provide an integrated, synthesized overview of the current evidence of efficacy of MBST for managing chronic musculoskeletal disorders.","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0