European Journal of Translational Myology最新文献

{"title":"Differences in physical function across dementia subtypes and cognitive decline: a cross-sectional study.","authors":"Kristina Batič, Žiga Kozinc, Polona Rus Prelog","doi":"10.4081/ejtm.2025.13726","DOIUrl":"10.4081/ejtm.2025.13726","url":null,"abstract":"<p><p>Cognitive impairment significantly affects physical function in dementia patients, but variations across dementia types and levels of cognitive decline remain unclear. This retrospective cross-sectional study included 874 patients (80.75 ± 8.00 years; 60.4% female) with different dementia types and cognitive impairment levels. Six physical function tests were administered: the De Morton Mobility Index (DEMMI), 6-minute walking test (6MTW), 10-meter walking test (10MWT), hand grip strength (HGS), 30-second chair stand (30sSTS), and the timed \"Up & Go\" test (TUG). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). The Mild Cognitive Impairment (MCI) group outperformed Alzheimer's Dementia (AD) and Vascular Dementia (VaD) on DEMMI, 30sSTS and HGS (p < 0.001, η² = 0.012 to 0.052). Differences in the 6MWT were significant in ANOVA but disappeared after adjusting for sex and age (p = 0.066). Severe cognitive impairment was linked to significantly lower physical performance across all measures (p < 0.001, η² = 0.037 to 0.064). Physical function profiles vary by dementia type and cognitive decline level, highlighting the need for targeted interventions to address specific physical challenges.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradigm shifts: how electrical stimulation opened up new avenues in science and medicine.","authors":"Stanley Salmons","doi":"10.4081/ejtm.2025.14058","DOIUrl":"10.4081/ejtm.2025.14058","url":null,"abstract":"<p><p>The discovery that skeletal muscle can respond adaptively to use, even to the extent of re-expressing its genome, overturned two paradigms and led to new insights into gene regulation and a variety of clinical applications.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a multidimensional robotic rehabilitation approach feasible in Guillain-Barrè syndrome? Report from a clinical case.","authors":"Caterina Tramonti, Benedetta Gnetti, Paola Gemignani, Stefania Callegari, Marco Germanotta, Francesca Cecchi, Irene Giovanna Aprile, Pietro Balbi","doi":"10.4081/ejtm.2025.12758","DOIUrl":"10.4081/ejtm.2025.12758","url":null,"abstract":"<p><p>We describe the case of a 54-year-old patient, who was admitted to our Rehabilitation Unit with diagnosis of Guillain-Barré Syndrome (GBS). Neurophysiological investigation revealed an axonal polyneuropathy, with impairment of the motor component and preserved sensory function. Despite rapid diagnosis, therapeutic treatment and customized progressive rehabilitation program, nine months after the onset of the disease he presented severe motor sequelae and functional impairment. Patient's hospitalization lasted about two months, while he performed a conventional rehabilitation training. Besides, he underwent a 4-week comprehensive rehabilitation treatment, including both conventional and robotic multidimensional trainings, for 5 1-h sessions per week. Despite the residual global impairment, this treatment, specifically tailored on patient's skills and progress, promoted improvements in functional abilities such as motricity, trunk control, and activities of daily living. Therefore, this case report evidenced the feasibility and efficacy of a multidimensional robotic therapeutic approach along with conventional treatment in the post-acute phase of GBS.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of moderate physical training program in post-myocardial infarction patients with arterial hypertension.","authors":"David M Aronov, Marina G Bubnova, Nadezhda P Lyamina, H Fred Downey, Eugenia B Manukhina, Svetlana Lyamina","doi":"10.4081/ejtm.2025.13943","DOIUrl":"10.4081/ejtm.2025.13943","url":null,"abstract":"<p><p>The clinical effectiveness of physical training in a Cardiac Rehabilitation Program (CRP) was assessed in hypertensive (Arterial Hypertension, AH), post-Myocardial Infarction (MI) patients. 206 patients were randomized into a physically trained group (PhTG, n=102) and an untrained, control group (CG, n=104). All patients received standard drug therapy. PhTG patients performed mild callisthenic exercises and moderately intensive bicycle exercise three times/week for one year. Compared to control patients, PhTG patients had significant changes in exercise capacity (duration +38%, p<0.001; total work +63.6%, p<0.001); rate-pressure product (-8.2%, p<0.01); left ventricular ejection fraction (+7.6%, p<0.001); left ventricular stroke volume (+5.1%, p<0.01). Resting BP decreased in PhTG patients (systolic BP, -3.1%, p<0.05; diastolic BP, -3.5%, p<0.001), but increased in CG patients (systolic BP, +3.1%, p<0.05; diastolic BP +3.4%, p<0.05). PhTG patients had fewer myocardial ischemic episodes, including painless ischemia during exercise, fewer angina attacks, less nitroglycerin consumption, improved quality of life, fewer cardiovascular events (-50%, p<0.05), and days of absence from work (-43.2%, p<0.05). Thus, supplementing a CRP with moderate exercise improved BP, work capacity, cardiac function, and quality of life in hypertensive, post-MI patients.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What matters in rehabilitation: a mixed methods study of critical success factors from the perspectives of patients and healthcare professionals.","authors":"Špela Matko, Chiara Vetrano, Delia Cristea, Patricia Riedl, Ferdinand Prüfer, Michael J Fischer, Bibiane Steinecker-Frohnwieser, Tanja Stamm, Vincent Grote","doi":"10.4081/ejtm.2025.14060","DOIUrl":"10.4081/ejtm.2025.14060","url":null,"abstract":"<p><p>The success of rehabilitation is usually assessed based on the results reported by patients and physicians. However, these assessments often vary and frequently fail to take psychosocial and contextual factors into account. This study investigated how Patient Researchers (PRs) and Healthcare Professional Researchers (HPRs) perceive rehabilitation outcomes and which Critical Success Factors (CSFs) they consider most influential. Using a participatory mixed-methods design, 90 anonymized patient records were evaluated and divided into groups based on good, poor, and conflicting outcomes. The participants - 3 PRs and 24 HPRs - assessed the success of rehabilitation and the potential significance of previously identified CSFs. In contrast to the HPRs, the PRs attributed greater influence to psychosocial factors. The HPRs generally provided a more accurate assessment of the outcome ratings in the patient records, correctly classifying 54.5% vs. 47.7%. Ultimately, the most important CSFs were incorporated into the Rehabilitation Expectation and Perception Scale (REPS), a screening instrument for identifying context-sensitive factors that influence rehabilitation success. This new approach supports personalized, context-sensitive rehabilitation planning, aiming to optimize treatment and facilitate a more nuanced assessment of rehabilitation success.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction. <i>Hungry runners - low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review</i>.","authors":"The Publisher","doi":"10.4081/ejtm.2025.13900","DOIUrl":"10.4081/ejtm.2025.13900","url":null,"abstract":"<p><p>In the paper titled \"Hungry runners - low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review\", published in vol. 33, issue 2 of 2023, Supplementary Table 1 was mistakenly mentioned as Table 1. The correct supplementary file is now available. Reference Cupka M, Sedliak M. Hungry runners - low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review. Eur J Translat Myol 2023;33:11104 doi: 10.4081/ejtm.2023.11104.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of the XXI Meeting of the Interuniversity Institute of Myology and preview of the XXII edition.","authors":"Anna Urciuolo, Fabio Penna","doi":"10.4081/ejtm.2025.13743","DOIUrl":"10.4081/ejtm.2025.13743","url":null,"abstract":"<p><p>The 21st Annual Meeting of the Interuniversity Institute of Myology (IIM), held in Assisi, Italy, from September 4-7, 2024, gathered 123 experts, including basic and clinical myologists, pharmaceutical representatives, and patient organizations from Italy, Europe, Canada, and USA. The meeting fostered a proactive, collaborative and dynamic atmosphere, promoting scientific exchange and international partnerships focused on muscle research, from physiology to disease mechanisms, and eventually therapeutic approaches. The 21st IIM Meeting featured 6 main scientific sessions, showcasing 30 oral presentations and 45 always-on-display posters, all reporting original and unpublished research. The program was enriched by four keynote lectures from internationally renowned speakers and talks from delegates of the Société Française de Myologie, adding depth to the scientific discussions. As part of the IIM Meeting organization, this year there was also a free-access educational convention titled \"Physical exercise as prevention\". Leading IIM experts shared insights on exercise-based lifestyle interventions aimed at improving public health, with the participation of the Italian former boxer Roberto Cammarelle. The event drew a large in-person and online audience. This IIM Meeting edition strongly emphasized the involvement and growth of young researchers, with 50% of the attendees being <35, reinforcing IIM's commitment to fostering the next generation of myologists. Along this line, and to further support young researchers, awards for Best Talk, Best Poster Blitz, and Best Poster were presented. The winners joined the IIM Young Committee, contributing to the scientific organization of future IIM meetings together with the IIM Scientific Committee. The meeting was also integrated into the \"Advanced Myology Update 2024\" high-training course, organized by the University of Perugia in collaboration with IIM. The 11 trainees enrolled in the course participated in dedicated roundtables and exclusive lessons led by IIM's invited speakers. In this report are included the abstracts of both oral and poster presentations, with some being withheld for patent-related reasons. Through its annual congress and educational initiatives, IIM played a crucial role in shaping the future of myology research, fostering innovation, collaboration, and scientific excellence on an international scale. We invite you to save the date for the 22nd IIM meeting that will be held in the beautiful Assisi, September 11-14, 2025. We can't wait to welcome you!</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and morphological impact of physical activity and nutritional interventions to offset disuse-induced skeletal muscle atrophy.","authors":"Irfan Arif, Ayesha Rasheed, Sadia Nazeer, Fareeha Shahid","doi":"10.4081/ejtm.2025.13177","DOIUrl":"10.4081/ejtm.2025.13177","url":null,"abstract":"<p><p>Skeletal muscle tissue acts as a functional unit for physical movements, energy metabolism, thermogenesis, and metabolic homeostasis. In this literature review, the underlying mechanisms of skeletal muscle atrophy and the prevention strategies, including vigorous training and nutritional modifications are focused. Furthermore, the comparative analysis of multiple interventions is briefly explained. Ageing is an inevitable process often associated with cognitive impairment and physical decline due to muscular atrophy. Skeletal muscle atrophy is characterized by low muscle mass due to multiple underlying factors, i.e., genetic predisposition, ageing, inflammation, and trauma. The structural alterations include myofiber shrinkage, changes in myosin isoforms, decrease in myofiber diameter, and total protein loss. Furthermore, there is an imbalance in protein anabolic and catabolic reactions. This may be due to changes in multiple signal transduction pathways of protein degradation (i.e., caspase, calpain, ubiquitin protein degradation system, autophagy) and protein anabolism via the mTOR pathway. Consequently, certain pathophysiological factors associated with health disparities may reduce mobility and functional capacity to perform ADLs. To tackle this issue, novel strategies linked to physical movement, and dietary intake must be incorporated in life. Exercise poses multiple health benefits, including improved muscle mass and mobility. Diet diversification [particularly protein-rich meals] and the \"whole food\" approach (based on non-protein nutrients) may enhance intramuscular anabolic signaling and tissue remodeling. However, there is a pressing need to fund large-scale evidence-based trials based on modern machine learning techniques (AI-driven nutrition). Additionally, entrepreneurial platforms for commercialization of consumer-friendly food products must be initiated in future.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality and cognitive function rehabilitation after traumatic brain injury: a systematic review.","authors":"Nemanja Lakicevic, Bogdan Andjelic, Marko Manojlovic, Ambra Gentile, Antonino Bianco, Antonio Paoli, Sergey Leonov, Alexander Pashchenko, Patrik Drid","doi":"10.4081/ejtm.2025.13275","DOIUrl":"10.4081/ejtm.2025.13275","url":null,"abstract":"<p><p>Traumatic Brain Injury (TBI) is the leading cause of injury-related death worldwide. In recent years, Virtual Reality (VR) has emerged as a promising diagnostic and treatment tool capable of improving Cognitive Function (CF) after TBI. We sought to review the literature on this issue systematically. Web of Science, PubMed and PsycINFO were screened for relevant literature. Only randomized control trials whereby TBI-affected individuals underwent VR training and control groups received standard rehabilitative care were included. Screening, quality appraisal and data extraction were conducted by independent reviewers using a standardized protocol. Six studies of ~300 participants met the inclusion criteria and showed that both groups improved their overall CF post-intervention. However, non-immersive and semi-immersive VR groups had markedly better scores in all of the cognitive domains measured when compared to non-VR groups. VR is a potent post-TBI rehabilitative tool that can improve CF in this population and facilitate the return-to-work process. Future studies should adopt a similar design yet use fully immersive VR to enhance CF potentially to a greater degree.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the relationship between mediolateral episiotomy in vaginal delivery and pelvic organ prolapse in pregnant mothers.","authors":"Marzieh Savari, Mahdieh Rahmatipanah, Sepideh Miraj, Abolfazl Mohammadbeigi","doi":"10.4081/ejtm.2025.13822","DOIUrl":"10.4081/ejtm.2025.13822","url":null,"abstract":"<p><p>Pelvic Floor Disorders (PFDs) are a group of disorders of the female reproductive system that can cause a variety of problems for women. PFDs can include Urinary Incontinence (UI) and Pelvic Organ Prolapse (POP). This study evaluated the association between mediolateral episiotomy during pregnancy and POP in patients. A cross-sectional study with prospective follow-up was conducted on 150 pregnant women admitted for vaginal delivery at Furqani Hospital in Qom, Iran. Participants were divided into episiotomy and non-episiotomy groups based on clinical indications. Pelvic organ prolapse was assessed using the Pelvic Organ Prolapse Quantification (POP-Q) system at baseline and 3-6 months postpartum. Data were analyzed using SPSS version 26, with a significance level of 0.05. The study included 142 patients with a mean age of 29.67 years. No significant differences were observed in demographic or clinical variables between the episiotomy and non-episiotomy groups at baseline. Postpartum, the episiotomy group showed significant improvements in cystocele severity (P=0.038), rectocele severity (P=0.026), apical prolapse (P=0.011), levator tone (P=0.016), and perineal descent (P=0.016). However, the cough test results did not differ significantly (P=0.052). Mediolateral episiotomy during vaginal delivery was associated with reduced severity of POP and improved PFD. These findings suggest a potential protective effect of episiotomy against certain pelvic floor complications, although further studies with larger sample sizes and longer follow-up periods are needed to confirm these results.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}