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European Journal of Translational Myology最新文献

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Tremella fuciformis polysaccharide: enhancing ischemic hypoxic adaptation of mesenchymal stem cells. 银耳多糖：增强间充质干细胞缺血缺氧适应能力。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2025-10-07 DOI: 10.4081/ejtm.2025.14289
Lei Yang, Shan Chen, Gang Zhao, Wei Gou, Weiwei Wang, Zhipeng Hu
{"title":"<i>Tremella fuciformis</i> polysaccharide: enhancing ischemic hypoxic adaptation of mesenchymal stem cells.","authors":"Lei Yang, Shan Chen, Gang Zhao, Wei Gou, Weiwei Wang, Zhipeng Hu","doi":"10.4081/ejtm.2025.14289","DOIUrl":"10.4081/ejtm.2025.14289","url":null,"abstract":"<p><p>Human Placenta-Derived Mesenchymal Stem Cells (HP-MSCs) are recognized for their potential in treating various diseases due to their multidirectional differentiation and immunomodulatory abilities. However, the therapeutic efficacy is often compromised in ischemic and hypoxic environments. Tremella Fuciformis Polysaccharide (TFP), a natural polysaccharide known for its immunomodulatory and anti-inflammatory properties, stands a good chance of overcoming this limitation. Our study investigates whether TFP enhances the therapeutic efficacy of HP-MSCs under ischemic-hypoxic conditions by inhibiting autophagy, with a focus on the role of the ERK signaling pathway. HP-MSCs were cultured under hypoxic conditions to simulate an ischemic environment and TFP was added to investigate its effects on MSC bioactivity, apoptosis, and proliferation. Mechanistic studies were conducted to assess the activation of the ERK signaling pathway and the expression of autophagy-related markers. TFP enhanced HP-MSC bioactivity under hypoxia by reducing apoptosis and promoting proliferation. Mechanistic analysis revealed that TFP enhanced the ability of HP-MSCs to adapt to hypoxic stress by activating the ERK signaling pathway. This activation led to the inhibition of autophagy-related markers, suggesting that TFP plays a protective role in hypoxia-induced cell stress. TFP enhances the therapeutic potential of HP-MSCs in ischemic-hypoxic conditions by inhibiting autophagy through ERK signaling pathway activation. These findings provide a theoretical foundation for the use of TFP in treating lower limb ischemia and highlight its potential to improve treatment protocols and outcomes.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute effects of movement-specific warm-up on force production and neuromuscular activation during maximal isometric squat in resistance-trained men: a pilot study. 在阻力训练的男性最大等距深蹲期间，运动特定热身对力量产生和神经肌肉激活的急性影响：一项初步研究。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2025-12-12 DOI: 10.4081/ejtm.2025.14653
Viktor Oliva, Julián E Smoliga, Matej Tóth, Gabriel Buzgó
{"title":"Acute effects of movement-specific warm-up on force production and neuromuscular activation during maximal isometric squat in resistance-trained men: a pilot study.","authors":"Viktor Oliva, Julián E Smoliga, Matej Tóth, Gabriel Buzgó","doi":"10.4081/ejtm.2025.14653","DOIUrl":"10.4081/ejtm.2025.14653","url":null,"abstract":"<p><p>Warm-up is a fundamental preparatory phase for optimizing performance, yet its acute effects may depend on the specificity of the protocol to the target task. This pilot study compared a General, mobility-based Warm-Up (GWU) with a low-intensity, bodyweight Movement-Specific Warm-Up (MSWU) replicating squat biomechanics on maximal isometric force and neuromuscular activation during isometric squat. Eight resistance-trained men (age 23.5 ± 1.2 years; height 182.9 ± 5.9 cm; body mass 84.3 ± 9.1 kg; 1RM back squat 146 ± 19 kg) completed two randomized, counterbalanced sessions. Each session included a standardized preliminary warm-up, baseline maximal isometric high-bar back squat at 90° knee flexion, and either the GWU or the MSWU, followed by a 2-min rest and reassessment. Peak force and surface EMG of vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF), gluteus maximus (GMax), and biceps femoris (BF) were measured. Completion time did not differ between protocols (~6-7 min; p = 0.806). Peak force significantly decreased after the GWU (-3.8%; p = 0.004; d = 1.47) but was maintained following the MSWU (-1.9%; p = 0.138; d = 0.59). Between-protocol differences in peak force were not significant (p = 0.186; d = 0.52). No significant changes were observed in normalized GMax activity or total integrated EMG. These results indicate that, for isometric, task-specific performance, a brief movement-specific warm-up better preserves force-generating capacity than a general mobility routine of similar duration, emphasizing the importance of biomechanical specificity in warm-up design.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of rapid palate expansion on body posture and motor functions in children with monolateral posterior crossbite are test and task-related. 快速上颚扩张对单侧后牙合儿童身体姿势和运动功能的影响是测试和任务相关的。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2026-01-13 DOI: 10.4081/ejtm.2026.14430
Chiara Lopes, Rossana Pipitone, Imena Rexhepi, Moreno D'Amico, Lucia Lazetera, Ludovica Valentino, Danilo Bondi, Edyta Kinel, Beatrice Di Carlo, Bruna Sinjari, Anacleto Navangione, Stefania Fulle, Tiziana Pietrangelo, Michele D'Attilio
{"title":"Effects of rapid palate expansion on body posture and motor functions in children with monolateral posterior crossbite are test and task-related.","authors":"Chiara Lopes, Rossana Pipitone, Imena Rexhepi, Moreno D'Amico, Lucia Lazetera, Ludovica Valentino, Danilo Bondi, Edyta Kinel, Beatrice Di Carlo, Bruna Sinjari, Anacleto Navangione, Stefania Fulle, Tiziana Pietrangelo, Michele D'Attilio","doi":"10.4081/ejtm.2026.14430","DOIUrl":"10.4081/ejtm.2026.14430","url":null,"abstract":"<p><p>Stomatognathic apparatus and the postural system interact through biomechanical chains, whose neuromuscular properties influence both gross and fine motor coordination. To evaluate changes in body posture and motor functions in children with malocclusion who are treated with palatal expanders, 8 right-handed children (6-12 years) with unilateral posterior crossbite were enrolled in this non-randomized pragmatic longitudinal study. Fine motor skills tests, handgrip strength, 3D body posture analysis, electromyography, thermography and stabilometry were performed before and after the treatment with a Rapid Palatal Expander (RPE) at T0pre (before using RPE), t0Post (immediately after using RPE), T1 (after 21 days of RPE use) and T3 (after 6 months). The positive effect on malocclusion, as demonstrated by reduced mandibular offset, did not result in changes in motor symmetries across time. Velocity variance of stabilometry was reduced during the treatment. The immediate wearing of device only slightly affected the results. The beneficial results at the occlusal level through RPE were not accompanied by changes at the neuromuscular and postural level. Clinicians and practitioners should consider that orthodontics treatments and devices which are adapted due to neuromuscular and posturometric tests may be task and test-related.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CN-macroEMG does not provide additional support for diagnosing inflammatory myopathies. CN-macroEMG不能为炎性肌病的诊断提供额外的支持。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2025-10-10 DOI: 10.4081/ejtm.2025.14239
Josef Finsterer
{"title":"CN-macroEMG does not provide additional support for diagnosing inflammatory myopathies.","authors":"Josef Finsterer","doi":"10.4081/ejtm.2025.14239","DOIUrl":"10.4081/ejtm.2025.14239","url":null,"abstract":"<p><p>We read with interest the article by ElZamarany et al. on a case-control study of the use of concentric needle macroelectromyography (CN-macroEMG) in 26 patients with Inflammatory Myopathies (IM) and 20 healthy control subjects.1 The study concludes that CN macroEMG provides optimal results in the diagnosis of IM and can be helpful in the follow-up of IM patients.1 The study is impressive, but some points should be discussed. The first point is that the objectives of the study were not specified.1 We should know whether the study was conducted to calculate the sensitivity and specificity of the method for diagnosing IM, or simply to document that CN-macroEMG may be abnormal in patients with IM. If the aim was to calculate sensitivity/specificity, we should know which gold standard for the diagnosis of IM was used to compare it with the CN-macroEMG findings. [...].</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parry-Romberg syndrome associated with ataxia: description of a patient improved after neurorehabilitation. 伴有共济失调的Parry-Romberg综合征：一位神经康复后改善的患者的描述。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2025-11-25 DOI: 10.4081/ejtm.2025.14103
Gianluca Regazzo, Francesco Piccione, Marco Marenghi, Paola Contessa, Stefano Masiero
{"title":"Parry-Romberg syndrome associated with ataxia: description of a patient improved after neurorehabilitation.","authors":"Gianluca Regazzo, Francesco Piccione, Marco Marenghi, Paola Contessa, Stefano Masiero","doi":"10.4081/ejtm.2025.14103","DOIUrl":"10.4081/ejtm.2025.14103","url":null,"abstract":"<p><p>Parry-Romberg Syndrome (PRS) is a rare condition that can affect the musculoskeletal system, resulting in progressive motor disabilities. The existing literature provides limited evidence regarding physical therapy interventions for PRS. We present a case of a 69-year-old woman diagnosed with PRS with associated ataxia treated with a neurorehabilitative program aimed at improving motor function and balance. We administered various functional scales (SPPB, Tampa Scale of Kinesiophobia, Berg Balance Scale, and Tinetti Scale). Additionally, a standardized gait analysis was conducted in our Gait and Motion Laboratory. Following neurorehabilitative therapy, the patient exhibited significant positive changes in various motor outcomes, as demonstrated by improvements in scores on standardized tests (SPBB, Berg, TSK and Tinetti scales when compared pre- and post-treatment), as well as enhancements in biomechanical parameters and quality of life (FIM, SF-12). This case report suggests that neurorehabilitative therapy can be beneficial in improving motor function and balance in PRS patient, as well as other rare condition associated with disabilities.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to The outcome of severe Guillain-Barré syndrome  after robotic or conventional rehabilitation also depends on the triggering agent and the neurophysiological subtype. 重型吉兰-巴罗综合征在机器人或常规康复后的预后也取决于触发因子和神经生理亚型。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2026-02-05 DOI: 10.4081/ejtm.2026.14916
Caterina Tramonti
{"title":"Reply to <i>The outcome of severe Guillain-Barré syndrome  after robotic or conventional rehabilitation also depends on the triggering agent and the neurophysiological subtype</i>.","authors":"Caterina Tramonti","doi":"10.4081/ejtm.2026.14916","DOIUrl":"10.4081/ejtm.2026.14916","url":null,"abstract":"<p><p>Dear Editor, We read the interesting letter to the Editor by Dr. Finsterer and appreciated the comments on our work. In this paper we aim at answering to the questions raised. For the first point, Dr Finsterer suggests to add information about Nerve Conduction Studies (NCS) and needle Electromyography (EMG); unfortunately, we are not able to give the neurophysiological investigations acquired during the first admission at the hospital. Anyway, as regards the type of GBS, we can point out that he was diagnosed with an Acute Motor Axonal Neuropathy (AMAN), as stated by previous medical documents. Furthermore, we can confirm that the patient presented cranial nerve involvement, as evidenced by the ascending paralysis which involved trunk and head control, swallowing problems, mimic musculature deficits and respiratory impairment.[...].</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute responses of isometric handgrip exercise combined with blood flow restriction in the elderly. 老年人等距握力运动联合血流限制的急性反应。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2026-01-22 DOI: 10.4081/ejtm.2026.14110
Thailson Fernandes da Silva, Leandro Lima de Sousa, Johnatan Campos Sousa Leite, Lucas Souza Martins, Robson Conceição Silva, Carlos Ernesto Santos Ferreira
{"title":"Acute responses of isometric handgrip exercise combined with blood flow restriction in the elderly.","authors":"Thailson Fernandes da Silva, Leandro Lima de Sousa, Johnatan Campos Sousa Leite, Lucas Souza Martins, Robson Conceição Silva, Carlos Ernesto Santos Ferreira","doi":"10.4081/ejtm.2026.14110","DOIUrl":"10.4081/ejtm.2026.14110","url":null,"abstract":"<p><p>This study aimed to investigate the influence of isometric handgrip exercise under different blood flow restriction times on acute responses related to safety and effectiveness in the elderly. Eleven physically active elderly people (70.1 ± 7.1 years) were subjected to three protocols (P1-1m), (P2-30s) and (P3-Control) of isometric handgrip contraction. Hemodynamic markers (SBP, DBP and HR), hematological markers (D-dimer, fibrinogen, APTT and ultrasensitive CRP) and surface electromyography (sEMG) of the flexor digitorum superficialis and extensor digitorum communis muscles were analyzed. The hemodynamic variables showed no significant difference P < 0.05 between the moments before, immediately after, after 15 minutes, and after 30 minutes. The hematological variables showed no significant difference P < 0.05 between the pre- and post-30 minute time points. The sEMG variables showed a significant difference of p< 0.01 at the beginning, middle and end of each series and between the complete series for both muscles analyzed. In line with the aim of this study, we can accept the hypothesis that the P1-1m, P2-30s and P3-Control protocols are safe. However, we reject the hypothesis that the BFR protocols result in greater muscle activation compared to the protocol without BFR.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum biomarkers in Duchenne muscular dystrophy: a leap toward precision diagnostics. 杜氏肌营养不良症的血清生物标志物：向精确诊断的飞跃。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2025-10-10 DOI: 10.4081/ejtm.2025.14257
Daniel Matovu
{"title":"Serum biomarkers in Duchenne muscular dystrophy: a leap toward precision diagnostics.","authors":"Daniel Matovu","doi":"10.4081/ejtm.2025.14257","DOIUrl":"10.4081/ejtm.2025.14257","url":null,"abstract":"<p><p>I was interested to read the article by Dowling et al.1 in the European Journal of Translational Myology, where the authors provide a comprehensive review of serum biomarkers for Duchenne Muscular Dystrophy (DMD), a devastating early-onset muscle wasting disease. The emphasis of research on liquid biopsy-based approaches, with the application of Mass Spectrometry (MS)-based proteomics for the identification of novel biomarkers like carbonic anhydrase CA3, fatty acid binding protein FABP3, and titin fragments, represents a revolutionary step towards minimally invasive diagnostics. As a neurologist and clinical pharmacologist working in Uganda, where diagnosis of DMD is delayed owing to the limited access to invasive tests, I find the prospects of these biofluid-based markers not only intriguing but also of immense worth in advancing precision medicine in resource-poor settings. [...].</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The outcome of severe Guillain-Barré syndrome after robotic or conventional rehabilitation also depends on the triggering agent and the electrophysiological subtype. 重型GBS在机器人或常规康复后的预后也取决于触发剂和电生理亚型。
IF 2
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2025-12-19 DOI: 10.4081/ejtm.2025.14516
Josef Finsterer
{"title":"The outcome of severe Guillain-Barré syndrome after robotic or conventional rehabilitation also depends on the triggering agent and the electrophysiological subtype.","authors":"Josef Finsterer","doi":"10.4081/ejtm.2025.14516","DOIUrl":"10.4081/ejtm.2025.14516","url":null,"abstract":"<p><p>Dear Editor, We read with interest the article by Tramonti et al. about a 54-year-old man with severe Guillain-Barré Syndrome (GBS) following a flu-like infection in April 2022, which required long-term intubation and mechanical ventilation.1 Despite immediate treatment with steroids, Intravenous Immunoglobulins (IVIG), and Plasma Exchange (PE), the patient was discharged to a rehabilitation facility after 9 months with severe quadruparesis and weakness of the axial, respiratory, and pharyngeal muscles.1 After intensive rehabilitation with conventional and robot-assisted approaches, the patient's condition improved significantly after another two months.1 The study is noteworthy, but some points require discussion. [...].</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does GABA supplementation modulate muscle cytokine expression and inflammatory status in aged rats?. 补充GABA是否能调节老年大鼠肌肉细胞因子表达和炎症状态？
IF 1.8
European Journal of Translational Myology Pub Date : 2026-03-31 Epub Date: 2026-02-10 DOI: 10.4081/ejtm.2026.14718
Elena Daskalova, Haridimos Tsibidakis
{"title":"Does GABA supplementation modulate muscle cytokine expression and inflammatory status in aged rats?<b />.","authors":"Elena Daskalova, Haridimos Tsibidakis","doi":"10.4081/ejtm.2026.14718","DOIUrl":"10.4081/ejtm.2026.14718","url":null,"abstract":"<p><p>Aging is a multifactorial process affecting all organs and systems in the body. Specific to aging is the establishment of a chronic subacute inflammatory state in tissues underlying age-related pathologies. GABA (Gamma-Aminobutyric Acid) is an inhibitory neurotransmitter in the central nervous system. Pharmaceutical properties of Gaba on non-neuronal peripheral tissues and organs were reported from anti-hypertension, anti-diabetes, anti-cancer, antioxidant, anti-inflammation, anti-microbial, anti-allergy, hepato-protection, reno-protection, and intestinal protection. GABA was indicated as an inflamation inhibitor via decreasing pro-inflammatory mediator production and ameliorating inflammatory symptoms. This study aimed to evaluate the effect of GABA supplementation on inflammatory status in the muscle tissue of aged rats. Male Wistar rats (n=24) were put in 3 groups: CY (3 month-old controls); CO (24 month-old controls); G (24 month-old rats supplemented with GABA at dosage of 10ml/kg for 3 months). At the experiment's end, skeletal muscle, small intestine and heart material was collected for immunohistochemical analysis. Comparative analysis of the intensity of IL-10, IL-4 and IL-1β immunoreaction in different muscle tissues showed that inflammatory responses varied with age and tissue. Aged animals showed higher IL-1β levels than young animals, and these effects amplified in IL-10- and IL-4-deficient rat muscles of same group. In group of GABA-supplemented animals, the intensity of IL-1β in skeletal muscle, heart and small intestine was reduced compared to adult controls. In conclusion, GABA supplementation can influence the inflammatory status of muscle tissue in old animals by modulating pro- and anti-inflammatory cytokine levels. GABA can be used to prevent the effects of ageing.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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