European Journal of Translational Myology最新文献

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Quantitative 3D-CT imaging of sarcopenia mitigation in the elderly: evidence from a case report. 老年人肌肉疏松症缓解的三维 CT 定量成像:一份病例报告的证据。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-06-28 DOI: 10.4081/ejtm.2024.12715
Marco Quadrelli, Tommaso Baccaglini, Aldo Morra
{"title":"Quantitative 3D-CT imaging of sarcopenia mitigation in the elderly: evidence from a case report.","authors":"Marco Quadrelli, Tommaso Baccaglini, Aldo Morra","doi":"10.4081/ejtm.2024.12715","DOIUrl":"10.4081/ejtm.2024.12715","url":null,"abstract":"<p><p>This case study examines the effectiveness of using combined CT imaging and 3D imaging in monitoring the prevention of sarcopenia through continuous daily exercises in an elderly patient. Using a 256-slice CT scanner with dose reduction technology and advanced muscle segmentation with the open-source software DAFNE, we compared changes in muscle mass and density in a 70-year-old patient in 2014 and in 2023. The obtained images allowed the creation of detailed 3D models for a more accurate and intuitive assessment of the leg musculature. Despite aging, the results of the scans performed at the beginning and end of the study period did not show significant changes in the patient's musculature, suggesting that a persistent Full-Body in-Bed Gym protocol (\"Gym Bed\" exercise routine) can effectively contribute to maintaining muscle mass and density in the elderly. These preliminary results highlight the potential of advanced imaging techniques not only to diagnose but also to quantify the effectiveness of non-pharmacological interventions against sarcopenia.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment and pain management using Ozoile as a hydrogel and cream formulation. Onychocryptosis:使用 Ozoile 作为水凝胶和乳膏配方进行临床方面、炎症治疗和疼痛控制的回顾性研究。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-06-26 DOI: 10.4081/ejtm.2024.12487
Vincenzo Francavilla, Giuseppe Secolo, Marianna D'Armetta, Rosario Toscano, Angelo Campo, Valentina Catanzaro, Marina Manno, Innocenzo Secolo, Giuseppe Messina
{"title":"Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment and pain management using Ozoile as a hydrogel and cream formulation.","authors":"Vincenzo Francavilla, Giuseppe Secolo, Marianna D'Armetta, Rosario Toscano, Angelo Campo, Valentina Catanzaro, Marina Manno, Innocenzo Secolo, Giuseppe Messina","doi":"10.4081/ejtm.2024.12487","DOIUrl":"10.4081/ejtm.2024.12487","url":null,"abstract":"<p><p>Ingrown toenails account for roughly 20% of all foot problems in primary care. It is most common in young men, with nail care habits and footwear being major contributors. Onychocryptosis is typically caused by self-treatment attempts to cure the condition in its early stages. Its clinical features are frequently confused with other osseous and soft tissue abnormalities. The goal of this study was to provide perspectives on the management of pain and inflammation in Onychocryptosis using an Ozoile-based hydrogel formulation in a semi-occlusive bandage for 14 days, while incorporating natural pharmacological solutions into established protocols. The primary outcomes measured were pain reduction on NRS and stadiation according to the Al Kline Classification. The reduction was statistically significant, with a mean decrease in VAS score from 10 to 4 (p < 0.05), and Al Kline classification decreased by an average of 1.6 stages. 42% of patients recovered within the first 15 days of treatment, and 93% by the end of the scheduled treatment.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stretching exercises in managing spasticity: effectiveness, risks, and adjunct therapies. 控制痉挛的伸展运动:有效性、风险和辅助疗法。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-06-13 DOI: 10.4081/ejtm.2024.12455
Mostafa Mehraban Jahromi, Přemysl Vlček, Marcela Grünerová Lippertová
{"title":"Stretching exercises in managing spasticity: effectiveness, risks, and adjunct therapies.","authors":"Mostafa Mehraban Jahromi, Přemysl Vlček, Marcela Grünerová Lippertová","doi":"10.4081/ejtm.2024.12455","DOIUrl":"10.4081/ejtm.2024.12455","url":null,"abstract":"<p><p>Spasticity is a component of upper motor neuron disorders and can be seen in neurological conditions like stroke and multiple sclerosis. Although the incidence rate of spasticity is unknown, it can put pressure on the health condition of those with spasticity, and there is no absolute effective way to control it. In the past, stretching exercises were an accessible tool for physical therapists to manage and control spasticity, but opinions on the optimal dose, aftereffects, and mechanism of effects were controversial. Therefore, this article tries to provide an overview of the effectiveness and risks of stretching exercises. Furthermore, there are several adjunct therapies, such as brain stimulation and botulinum injection, that can increase the effectiveness of a simple stretch by increasing cortical excitability and reducing muscle tone and their role is evaluated in this regard. The results of this study propose that several prospective and case studies have demonstrated the benefits of stretching to control spasticity, but it seems that other methods such as casting can be more effective than a simple stretch. Therefore, it is better to use stretching in combination with other therapeutic regimes to increase its effectivity of it.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the impact of oesophageal reflux disease on muscle fatigue. 评估食道反流病对患者肌肉疲劳的影响。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-30 DOI: 10.4081/ejtm.2024.12243
Wenming Hong, Hao Wang, Xuheng Yu
{"title":"Evaluation of the impact of oesophageal reflux disease on muscle fatigue.","authors":"Wenming Hong, Hao Wang, Xuheng Yu","doi":"10.4081/ejtm.2024.12243","DOIUrl":"10.4081/ejtm.2024.12243","url":null,"abstract":"<p><p>Gastroesophageal reflux disease (GERD) is a gastrointestinal tract disorder associated with regurgitation of gastric acid into the oesophagus. It can present itself as non-erosive reflux condition or erosive esophagitis. Our main objective was to evaluate the impact of oesophageal reflux disease on muscle fatigue among patients. The prospective study design was adopted using surveys performed at the South West China Medical University. All patients who were subjected to screening endoscopy at the South West China Medical University were prospectively enrolled in the study. Our study was conducted according to ethical guidelines involving animal and human subjects. Our study used Epworth Sleepiness Scale (ESS), Hospital Anxiety and Depression Scale (HADS), and the Multidimensional Fatigue Inventory (MFI) questionnaires to perform data collection on the levels of fatigue, depression, daytime hypersomnolence and anxiety. In the (HADS, Anxiety (β = 0.657, p < .001) and Depression (β = 2.927, p < .001) exhibited significant positive associations with the predicted fatigue. The Epworth Sleepiness Scale (ESS) showed no significant difference between individuals with and without reflux esophagitis (p = 0.787, power = 0.071). However, a significant difference was observed based on the presence of GERD symptoms (p = 0.003, power = 0.789), with higher mean scores for those with GERD symptoms (6.1±3.5) compared to those without (4.9±2.9). In MFI, significant differences were observed between the two groups for General and Physical Fatigue (p = 0.040, power = 0.823), Mental Fatigue (p = 0.002, power = 0.767), and MFI Total Score (p = 0.002, power = 0.981). In conclusion, GERD symptoms exhibited stronger associations with fatigue and daytime sleepiness than endoscopic findings, emphasizing the impact of symptomatic experiences on well-being.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing muscle architecture with ultrasound: implications for spasticity. 用超声波评估肌肉结构:对痉挛的影响。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-30 DOI: 10.4081/ejtm.2024.12397
Ève Boissonnault, April Jeon, Michael C Munin, Mirko Filippetti, Alessandro Picelli, Chloe Haldane, Rajiv Reebye
{"title":"Assessing muscle architecture with ultrasound: implications for spasticity.","authors":"Ève Boissonnault, April Jeon, Michael C Munin, Mirko Filippetti, Alessandro Picelli, Chloe Haldane, Rajiv Reebye","doi":"10.4081/ejtm.2024.12397","DOIUrl":"10.4081/ejtm.2024.12397","url":null,"abstract":"<p><p>Botulinum Neurotoxin Type A (BoNT-A) injections using Ultrasound (US) guidance have led to research evaluating changes in muscle architecture. Controversy remains as to what constitutes increased Echo-Intensity (EI) in spastic muscles and whether this may affect outcomes. We aim to provide a narrative review of US muscle architecture changes following Central Nervous System (CNS) lesions and explore their relationship to spasticity. Medline, CINAHL, and Embase databases were searched with keywords: ultrasonography, hypertonia, spasticity, fibrosis, and Heckmatt. Three physicians reviewed the results of the search to select relevant papers. Reviews identified in the search were used as a resource to identify additional studies. A total of 68 papers were included. Four themes were identified, including histopathological changes in spastic muscle, effects of BoNT-A on the muscle structure, available US modalities to assess the muscle, and utility of US assessment in clinical spasticity. Histopathological studies revealed atrophic and fibro-fatty changes after CNS lesions. Several papers described BoNT-A injections contributing to those modifications. These changes translated to increased EI. The exact significance of increased muscle EI remains unclear. The Modified Heckmatt Scale (MHS) is a validated tool for grading muscle EI in spasticity. The use of the US may be an important tool to assess muscle architecture changes in spasticity and improve spasticity management. Treatment algorithms may be developed based on the degree of EI. Further research is needed to determine the incidence and impact of these EI changes in spastic muscles.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins located in the sarcomere, cytoskeleton and the extracellular matrix. 用于肌肉疏松症研究的蛋白质组参考图:位于肌节、细胞骨架和细胞外基质中的关键肌肉蛋白质的质谱鉴定。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-24 DOI: 10.4081/ejtm.2024.12564
Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
{"title":"Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins located in the sarcomere, cytoskeleton and the extracellular matrix.","authors":"Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck","doi":"10.4081/ejtm.2024.12564","DOIUrl":"10.4081/ejtm.2024.12564","url":null,"abstract":"<p><p>Sarcopenia of old age is characterized by the progressive loss of skeletal muscle mass and concomitant decrease in contractile strength. Age-related skeletal muscle dysfunctions play a key pathophysiological role in the frailty syndrome and can result in a drastically diminished quality of life in the elderly. Here we have used mass spectrometric analysis of the mouse hindlimb musculature to establish the muscle protein constellation at advanced age of a widely used sarcopenic animal model. Proteomic results were further analyzed by systems bioinformatics of voluntary muscles. In this report, the proteomic survey of aged muscles has focused on the expression patterns of proteins involved in the contraction-relaxation cycle, membrane cytoskeletal maintenance and the formation of the extracellular matrix. This includes proteomic markers of the fast versus slow phenotypes of myosin-containing thick filaments and actin-containing thin filaments, as well as proteins that are associated with the non-sarcomeric cytoskeleton and various matrisomal layers. The bioanalytical usefulness of the newly established reference map was demonstrated by the comparative screening of normal versus dystrophic muscles of old age, and findings were verified by immunoblot analysis.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins of organelles, cellular signaling, bioenergetic metabolism and molecular chaperoning. 用于肌肉疏松症研究的蛋白质组参考图:对细胞器、细胞信号、生物能代谢和分子伴侣的关键肌肉蛋白质进行质谱鉴定。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-24 DOI: 10.4081/ejtm.2024.12565
Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
{"title":"Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins of organelles, cellular signaling, bioenergetic metabolism and molecular chaperoning.","authors":"Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck","doi":"10.4081/ejtm.2024.12565","DOIUrl":"10.4081/ejtm.2024.12565","url":null,"abstract":"<p><p>During the natural aging process, frailty is often associated with abnormal muscular performance. Although inter-individual differences exit, in most elderly the tissue mass and physiological functionality of voluntary muscles drastically decreases. In order to study age-related contractile decline, animal model research is of central importance in the field of biogerontology. Here we have analyzed wild type mouse muscle to establish a proteomic map of crude tissue extracts. Proteomics is an advanced and large-scale biochemical method that attempts to identify all accessible proteins in a given biological sample. It is a technology-driven approach that uses mass spectrometry for the characterization of individual protein species. Total protein extracts were used in this study in order to minimize the potential introduction of artefacts due to excess subcellular fractionation procedures. In this report, the proteomic survey of aged muscles has focused on organellar marker proteins, as well as proteins that are involved in cellular signaling, the regulation of ion homeostasis, bioenergetic metabolism and molecular chaperoning. Hence, this study has establish a proteomic reference map of a highly suitable model system for future aging research.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adoption of blockchain as a step forward in orthopedic practice. 采用区块链作为骨科实践的一个进步。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-24 DOI: 10.4081/ejtm.2024.12197
Giuseppe Rovere, Francesco Bosco, Angelo Miceli, Salvatore Ratano, Giuseppe Freddo, Lorenzo D'Itri, Massimo Ferruzza, Giulio Maccauro, Pasquale Farsetti, Lawrence Camarda
{"title":"Adoption of blockchain as a step forward in orthopedic practice.","authors":"Giuseppe Rovere, Francesco Bosco, Angelo Miceli, Salvatore Ratano, Giuseppe Freddo, Lorenzo D'Itri, Massimo Ferruzza, Giulio Maccauro, Pasquale Farsetti, Lawrence Camarda","doi":"10.4081/ejtm.2024.12197","DOIUrl":"10.4081/ejtm.2024.12197","url":null,"abstract":"<p><p>Blockchain technology has gained popularity since the invention of Bitcoin in 2008. It offers a decentralized and secure system for managing and protecting data. In the healthcare sector, where data protection and patient privacy are crucial, blockchain has the potential to revolutionize various aspects, including patient data management, orthopedic registries, medical imaging, research data, and the integration of Internet of Things (IoT) devices. This manuscript explores the applications of blockchain in orthopedics and highlights its benefits. Furthermore, the combination of blockchain with artificial intelligence (AI), machine learning, and deep learning can enable more accurate diagnoses and treatment recommendations. AI algorithms can learn from large datasets stored on the blockchain, leading to advancements in automated clinical decision-making. Overall, blockchain technology has the potential to enhance data security, interoperability, and collaboration in orthopedics. While there are challenges to overcome, such as adoption barriers and data sharing willingness, the benefits offered by blockchain make it a promising innovation for the field.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dirk Pette, remembered for his pioneering muscle research. 德克-佩特,因其开创性的肌肉研究而被世人铭记。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-22 DOI: 10.4081/ejtm.2024.12681
Kay Ohlendieck, Winfried Mayr, Helmut Kern, Carlo Reggiani, Giorgio Fanò-Illic, Ugo Carraro
{"title":"Dirk Pette, remembered for his pioneering muscle research.","authors":"Kay Ohlendieck, Winfried Mayr, Helmut Kern, Carlo Reggiani, Giorgio Fanò-Illic, Ugo Carraro","doi":"10.4081/ejtm.2024.12681","DOIUrl":"10.4081/ejtm.2024.12681","url":null,"abstract":"<p><p>It is with great sadness that we learned of the passing of Prof. Dr. Dr. h.c. Dirk Pette. He passed away suddenly and unexpectedly on June 4, 2022. Dirk was an outstanding professor of biochemistry at the University of Konstanz, Germany and an internationally renowned researcher in the field of skeletal muscle biology. His research on electrical stimulation has had a profound impact on our understanding of myofiber type specification and the enormous adaptive potential of skeletal muscle. Under Dirk's leadership, new biological questions in the field of neuromuscular biology have developed into multidisciplinary approaches using advanced physiological, cell biological, and biochemical techniques. Dirk's research laboratory was frequently visited by a large number of national and international collaborators who familiarized themselves with the technically demanding stimulation protocols and bioanalytical techniques to study the intricate details of the highly complex process of fast-to-slow muscle transitions. Importantly, fundamental studies on the physiological effects of changes in innervation patterns on muscle phenotype have provided the scientific evidence base for a variety of innovative clinical applications. The skeletal muscle research community has lost one of its leading figures and an outstanding teacher of protein biochemistry. He leaves an inspiring legacy in the field of basic and applied myology. Dirk will be missed by his colleagues and by many students of neuromuscular biology and beyond.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Botulinum toxin in the rehabilitation of painful syndromes: multiperspective literature analysis, lexical analysis and systematic review of randomized controlled trials. 肉毒杆菌毒素在疼痛综合征康复治疗中的应用:多视角文献分析、词法分析和随机对照试验的系统回顾。
IF 1.8
European Journal of Translational Myology Pub Date : 2024-05-20 DOI: 10.4081/ejtm.2024.12509
Daniele Coraci, Maria Chiara Maccarone, Lisa Ragazzo, Lucrezia Tognolo, Domenico Antonio Restivo, Gabriele Santilli, Ana Lucila Moreira, Paola Emilia Ferrara, Gianpaolo Ronconi, Stefano Masiero
{"title":"Botulinum toxin in the rehabilitation of painful syndromes: multiperspective literature analysis, lexical analysis and systematic review of randomized controlled trials.","authors":"Daniele Coraci, Maria Chiara Maccarone, Lisa Ragazzo, Lucrezia Tognolo, Domenico Antonio Restivo, Gabriele Santilli, Ana Lucila Moreira, Paola Emilia Ferrara, Gianpaolo Ronconi, Stefano Masiero","doi":"10.4081/ejtm.2024.12509","DOIUrl":"10.4081/ejtm.2024.12509","url":null,"abstract":"<p><p>Pain represents a common symptom of several diseases and is often associated with a reduction in rehabilitation outcomes and recovery. The effectiveness of pain alleviation by botulinum toxin has been recently demonstrated. We searched in PubMed the papers about this topic published in the last ten years, and we selected clinical trials, guidelines, meta-analyses, reviews, and systematic reviews. We used different approaches: multiperspective presentation, lexical evaluation, and systematic review. The systematic review was only performed for the randomized controlled trials. We predominantly found reviews and trials about the rehabilitation of stroke/brain injury and epicondylitis. The most common outcome measures were pain, function, and spasticity. Among the common words, pain was the most frequent and the terms were grouped into different families, especially concerning the outcomes. Rehabilitation showed a relatively low frequency. Finally, the systematic review showed moderate-low levels of bias which confirms the effectiveness of botulinum toxin for pain treatment. The current literature about botulinum toxin is wide and globally diffuse but with some limitations in study strategies and clearness in the formal presentation. The evidence justifies the use of botulinum toxin in treating pain in different diseases.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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