European Journal of Translational Myology最新文献

{"title":"Electrical stimulation in the therapy of dysphagia: current knowledge - a narrative review.","authors":"Aleksandra Kaczyńska","doi":"10.4081/ejtm.2025.14253","DOIUrl":"10.4081/ejtm.2025.14253","url":null,"abstract":"<p><p>Dysphagia, a sensorimotor disorder impairing swallowing, affects millions globally, compromising quality of life and increasing risks of malnutrition, aspiration pneumonia, and healthcare costs. Neuromuscular Electrical Stimulation (NMES) is an emerging adjunctive therapy delivering low-frequency electrical impulses to stimulate swallowing muscles, enhancing strength, coordination, and neuroplasticity. This narrative review synthesizes evidence on NMES efficacy in dysphagia treatment across pediatric and adult populations, emphasizing muscle-specific outcomes and translational myology applications. In pediatric patients with primary or neurological dysphagia, NMES improves suprahyoid, facial, and tongue muscle activation, enhances swallowing efficiency and reduces tube-feeding dependency In adults, particularly post-stroke, NMES improves laryngeal elevation, Upper Esophageal Sphincter (UES) opening, and quality of life, though efficacy in head and neck cancer patients is limited. Methodological limitations, including small sample sizes, protocol heterogeneity, and lack of assessor blinding, hinder generalizability. NMES is safe, with minor adverse effects such as erythema and holds promise as a valuable adjunct in dysphagia rehabilitation, but requires standardized protocols and robust trials to optimize its role in clinical myology.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proposed protocol for combining core stability and pelvic floor muscle training to prevent stress urinary incontinence in pregnant women: a preventive framework.","authors":"Lin Kou, Wenzhi Cai, Wenjuan Wang, Liang Surui","doi":"10.4081/ejtm.2025.14163","DOIUrl":"10.4081/ejtm.2025.14163","url":null,"abstract":"<p><p>Stress urinary incontinence is common during and after pregnancy and impacts women's health both physically and mentally. This protocol suggests a non-invasive preemptive training strategy which integrates pelvic floor muscle training and core stability exercises with nutrition counseling. This model provides a clear, systematic, evidence-based framework which can be incorporated into antenatal care arising from a literature and clinical guideline review. The objective is to equip healthcare professionals with tangible, multidisciplinary strategies for proactive urinary incontinence care during in pregnancy, this model underscores the importance of early, non-pharmacological interventions in preserving pelvic health and preventing postpartum dysfunction, offering a feasible and low-cost strategy to support the well-being of pregnant women.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic strategy with indirect spinal manipulations in C2-C3 segments for long-term treatment of cervicogenic headache.","authors":"Marieta Karadjova, Teodor Angelov, Julia Petrova, Fabio Antonaci","doi":"10.4081/ejtm.2025.13845","DOIUrl":"10.4081/ejtm.2025.13845","url":null,"abstract":"<p><p>Cervicogenic Headache (CGH) is a secondary type headache, associated with dysfunction in upper cervical segments (C1-C2-C3) and manifested by specific clinical features. It is unilateral, starting from one side of the posterior head and neck, migrating to the front, sometimes associated with ipsilateral arm discomfort and, in addition, neuralgia with ipsilateral conjunctival inection. Our research is based on 29 patients (with average age of 49.78 years ± 10.41 (34-73)) with headache: 19 females and 10 males. We examined the active range of motion (AROM). We used palpatory maneuvers, finding local symptoms (facet joints' tenderness) and symptoms in the segmental territory - cellulalgia in the supraorbital and submandibular region (found by the pinch-roll test - PR-SO and PR-SM). The clinical examination before and immediately after the indirect high velocity low amplitude (HVLA) manipulations, as well as at the end of treatment, showed a significant reduction in the Visual Analogue Scale (VAS) score, in local symptoms and especially in measurable indicators - skin fold (PR-SO and PR-SM) in mm. (p<0.01 and p<0.001). Our study shows that indirect HVLA-spine manipulations have an invariable place in the treatment of cervicogenic headache.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary.","authors":"Bahare Rafiee, Saied Karbalay-Doust, Seyed Mohammad Bagher Tabei, Negar Azarpira, Sanaz Alaee, Parvin Lohrasbi, Soghra Bahmanpour","doi":"10.4081/ejtm.2025.14616","DOIUrl":"10.4081/ejtm.2025.14616","url":null,"abstract":"<p><p>Retraction: Rafiee B, Karbalay-Doust S, Tabei SMB, Azarpira N, Alaee S, Lohrasbi P, Bahmanpour S. Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary. Eur J Transl Myol 2022; 32(2):10409. DOI: 10.4081/ejtm.2022.10409   The article has been retracted by the authors, in agreement with the Editor-in-Chief, Professor Ugo Carraro, and the Publisher, following an investigation into Figure 6 (specifically panels a and c). Although the image in question was not intentionally manipulated to mislead, and the error stemmed from an inadvertent mistake during figure preparation, the authors fully recognize the seriousness of the issue and the importance of maintaining the highest standards of scientific integrity. The authors apologize for this oversight and for any inconvenience it may have caused to the editorial board, reviewers, and readers, and are committed to learning from this experience and reinforcing stricter internal review processes to prevent such issues in future publications.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145394030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate effects of electrical stimulation on serratus anterior muscle activity in people with hemiplegia post-stroke.","authors":"Palak Anand Kakwani, Ramesh Debur","doi":"10.4081/ejtm.2025.14082","DOIUrl":"10.4081/ejtm.2025.14082","url":null,"abstract":"<p><p>Upper limb impairment occurs in approximately 80% of stroke survivors, with altered scapular kinematics playing a key role in dysfunction. Serratus anterior weakness post-stroke contributes to abnormal scapular motion, limiting shoulder and arm function. This study explored whether Electrical Stimulation (ES) could immediately enhance serratus anterior activity in individuals with post-stroke hemiplegia. A pre-post intervention design was used involving 19 individuals within three months post-stroke. Surface Electromyography (sEMG) recorded serratus anterior activity during a forward reach task. The Fugl-Meyer Assessment (FMA) was also administered. Participants received 20 minutes of ES targeting the serratus anterior, after which sEMG and FMA were reassessed. Wilcoxon signed rank test compared pre- and post-intervention sEMG values. Statistical analysis showed a significant change in the area under the curve value(p < 0.01) but no significant change in RMS value. There was no change in FMA scale. Electrical stimulation showed significant changes in the muscle activity of the serratus anterior, indicating a reduction in the cost of the muscle work done during the forward reach task.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of hyperbaric oxygen therapy in ligament and tendon injuries: a systematic review.","authors":"Shrinit Babel, Gerardo Bosco, Enrico Camporesi","doi":"10.4081/ejtm.2025.14016","DOIUrl":"10.4081/ejtm.2025.14016","url":null,"abstract":"<p><p>Ligament and tendon injuries are one of the major health concerns that affect over 1.71 billion people around the world. They cause functional limitations and affect the quality of life of people. As conventional methods have their limitations, Hyperbaric Oxygen Therapy (HBOT) is becoming a potential solution for the improvement and acceleration of the healing process in ligament and tendon injuries. This systematic review aims to evaluate efficacy and safety of HBOT for ligament and tendon injuries. This systematic review provides a comprehensive analysis by following PRISMA guidelines. We looked for articles published between March 1999 and May 2024 across 6 databases. The articles included investigated the use of hyperbaric oxygen therapy to treat ligament or tendon injuries. Animal studies, as well as human studies, were included in this review. Studies were evaluated for HBOT, and if they were not related or with insufficient data, they were excluded. Risk of bias has been assessed using the ROBINS-I tool. The studies measured outcomes across functional, histological, biomechanical, physicochemical, and even radiological aspects. A total of 13 studies were included in the review, with 693 participants. This study has analyzed the effectiveness of HBOT in two ways, namely, standalone treatment and combined methods like HBOT and other methods like platelet growth factor, steroid injections, intermittent oxygen therapy, or platelet-rich plasma. The pressure observed in this study is between 1.3 to 2.8 atmospheres absolute. The findings suggest that HBOT, whether used alone or as a complementary treatment, enhanced healing compared to controls. The ROBINS-I tool suggested low risk of bias for the majority of studies. Positive impacts in mechanical and histological outcomes were observed in both animal and human studies, such as increased collagen density, fiber alignment, and synthesis. The review highlights the potential of HBOT to especially reduce graft rejection post-ACL reconstruction, enhance functional recovery, and accelerate tendon healing. HBOT seems to be a safe and effective method for speeding up the healing process of tendons and ligaments. But, there is a need for more studies with more number of population for analyzing the effect of HBOT in a long run. It is necessary to make a standard protocol for the HBOT treatment method.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentric macro EMG role in electrodiagnostic evaluation of inflammatory myopathies.","authors":"Eman ElZamarany, Ayat Allah Farouk, Lamia Afifi, Sandra Ahmed, Eman Ashraf, Eman Attia, Marwa Shalaby","doi":"10.4081/ejtm.2025.13833","DOIUrl":"10.4081/ejtm.2025.13833","url":null,"abstract":"<p><p>Inflammatory Myopathies (IM) encompass a diverse group of systemic autoimmune muscle disorders, not easy to diagnose. Concentric-macro EMG is supposed to reflect electrical activity of the entire motor unit. It could help in electrophysiological characterization of inflammatory myopathies and recognizing earlier myopathic changes. Conventional EMG in our IM patients showed myopathic changes in all the cases, so it could be a golden tool for diagnosis. The degree of abnormalities was variable in different muscles in concentric macro EMG. Myopathic changes using concentric macro EMG was not so advanced as those seen in chronic stable relapsing phase. Pooling up the results of the conventional EMG, muscle enzyme tests, muscle ultrasound , and Con-Mac will give optimal results for diagnosis and could help in follow up of patients with IM.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative response of rat skeletal muscle to the implantation of a collagen-based bone graft substitute: an <i>in vivo</i> study.","authors":"Fernando Leiva-Cepas, Maria Jesus Gil-Belmonte, Ignacio Jimena, Maria Angeles Peña-Toledo, Rafael Villalba, Jose Peña-Amaro","doi":"10.4081/ejtm.2025.13574","DOIUrl":"10.4081/ejtm.2025.13574","url":null,"abstract":"<p><p>The application of implantable biomaterials in reconstructive grafting is a common practice in surgical fields such as orthopedics, maxillary and plastic surgery. This study explores the regenerative response of skeletal muscle to a porous bovine collagen-based matrix (Osteovit®) in a volumetric muscle loss injury model. Forty male Wistar rats were divided into four groups. Normal control underwent no procedure and regenerative control had mepivacaine injected in the tibialis anterior muscle to provoke a standard regenerative response. In the other two groups, a volumetric defect was created in the tibialis anterior muscle; the fibrosis control had no treatment, while the collagen-scaffolding group had a bone substitution matrix implanted. Animals were sacrificed at 21, 28, and 60 days post-procedure for histological, histochemical, immunohistochemical and histomorphometry analysis to evaluate muscle architecture and myogenic regenerative response. Significant changes in tissue architecture among groups, with a notable emphasis on the integration of the collagen scaffold, were demonstrated. This was also confirmed at the histomorphometry analysis, which found differences at the cross-sectional area, minor diameter and form factor values between groups The bone substitution matrix did not inhibit regeneration but promoted an abnormal one. This can be explained by the excessive formation of connective tissue, which led to the genesis of intramuscular tendons that may have interfered with the normal development of regenerative muscle fibers. The findings highlight the need for further investigation into the cellular mechanisms underlying skeletal muscle regeneration in response to implantable biomaterials.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Power Doppler in ultrasound-guided percutaneous procedures: the Jet sign.","authors":"Angelo Iovane, Francesco Mantia, Micol Terrasi, Eleonora Maria Iovane, Pietro Cataldo, Antonino Bianco","doi":"10.4081/ejtm.2025.13503","DOIUrl":"10.4081/ejtm.2025.13503","url":null,"abstract":"<p><p>In recent decades, ultrasound-guided percutaneous infiltrative procedures have gained prominence in treating musculoskeletal disorders, providing enhanced accuracy over traditional \"blind\" techniques. This study examines the utility of the Power Doppler ultrasound technique, specifically the \"Jet sign,\" in identifying needle placement during infiltrative treatments. A retrospective analysis was conducted involving 5,376 patients where procedures were performed under ultrasound guidance from January 2014 to January 2022. While the needle tip was successfully visualized in 7% of cases, the Jet sign facilitated accurate localization in 368 instances. This technique capitalizes on the creation of a high-pressure fluid flow, enabling real-time monitoring and precise targeting of the therapeutic agent while minimizing complications. The findings underscore the effectiveness of the Jet sign in enhancing procedural accuracy and suggest its incorporation into clinical practice to optimize outcomes in ultrasound-assisted infiltrative therapies.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized interventional study that compares treatments for vitiligo and anti-vitiligo cream.","authors":"Shahzad Shirzad, Mahdis Miladi","doi":"10.4081/ejtm.2025.13787","DOIUrl":"10.4081/ejtm.2025.13787","url":null,"abstract":"<p><p>This study aimed to evaluate the efficacy of a novel combination therapy, AVC (Anti-Vitiligo Cream), compared to common treatments for vitiligo. A randomized interventional study was conducted on 1,000 patients with confirmed vitiligo, aged 7-70 years. Participants were divided into five groups (200 patients each): oral prednisolone, Tofacitinib, Ruxolitinib, AVC (Anti-Vitiligo Cream), and AVC combined with Tofacitinib. Outcomes were assessed over two years using the Vitiligo Area Scoring Index (VASI), patient satisfaction scores, and clinical observations. AVC-based therapies (Groups 4 and 5) demonstrated superior efficacy and patient satisfaction compared to other treatments. Group 5 (AVC + Tofacitinib) achieved the highest outcomes, with a mean satisfaction score of 90 (IQR: 85-95) and treatment efficacy significantly higher than Group 1 (p < 0.001). Regression analysis identified treatment outcomes and therapy type as significant predictors of satisfaction. AVC (Anti-Vitiligo Cream), particularly in combination with Tofacitinib, represents a groundbreaking approach for managing vitiligo, providing enhanced efficacy and patient satisfaction. These findings support the potential of AVC-based therapies as a standard treatment option.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}