Clinical and Experimental Reproductive Medicine-CERM最新文献_第6页

The effect of temperature and storage time on DNA integrity after freeze-drying sperm from individuals with normozoospermia. 温度和储存时间对正常精子症患者精子冷冻干燥后DNA完整性的影响。

IF 1.8

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-03-01 Epub Date: 2023-12-01 DOI: 10.5653/cerm.2023.06093

Farzaneh Mohammadzadeh Kazorgah, Azam Govahi, Ali Dadseresht, Fatemeh Nejat Pish Kenari, Marziyeh Ajdary, Rana Mehdizadeh, Roya Derakhshan, Mehdi Mehdizadeh

{"title":"The effect of temperature and storage time on DNA integrity after freeze-drying sperm from individuals with normozoospermia.","authors":"Farzaneh Mohammadzadeh Kazorgah, Azam Govahi, Ali Dadseresht, Fatemeh Nejat Pish Kenari, Marziyeh Ajdary, Rana Mehdizadeh, Roya Derakhshan, Mehdi Mehdizadeh","doi":"10.5653/cerm.2023.06093","DOIUrl":"10.5653/cerm.2023.06093","url":null,"abstract":"Objective: This study evaluated the effects of temperature and storage time on the quality and DNA integrity of freeze-dried sperm from individuals with normozoospermia.Methods: Normal sperm samples from 15 men aged 24 to 40 years were studied. Each sample was divided into six groups: fresh, freezing (frozen in liquid nitrogen), freeze-dried then preserved at room temperature for 1 month (FD-1m-RT), freeze-dried then preserved at room temperature for 2 months (FD-2m-RT), freeze-dried then preserved at 4 °C for 1 month (FD-1m-4 °C), and freeze-dried then preserved at 4 °C for 2 months (FD-2m-4 °C). The morphology, progressive motility, vitality, and DNA integrity of the sperm were evaluated in all groups.Results: In all freeze-dried groups, sperm cells were immotile after rehydration. The freeze-dried groups also showed significantly less sperm vitality than the fresh and frozen groups. Significantly more morphological sperm abnormalities were found in the freeze-dried groups, but freeze-drying did not lead to a significantly higher DNA fragmentation index (DFI). The DFI was significantly higher in the FD-2m-RT group than in the other freeze-dried groups.Conclusion: The freeze-drying method preserved the integrity of sperm DNA. The temperature and duration of storage were also identified as factors that influenced the DFI. Accordingly, more research is needed on ways to improve sperm quality in the freeze-drying process.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":" ","pages":"42-47"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of twin pregnancy in in vitro fertilization with intracytoplasmic sperm injection cycles with day 3 double embryo transfer. 卵胞浆内单精子注射体外受精周期第 3 天双胚胎移植中双胎妊娠的预测因素。

IF 1.8

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-03-01 Epub Date: 2023-12-27 DOI: 10.5653/cerm.2023.06156

Duy Le Nguyen, Hieu Le-Trung Hoang, Vu Ngoc-Anh Ho, Toan Duong Pham, Nam Thanh Nguyen, Van Thi-Thu Tran, Tuong Manh Ho, Lan Ngoc Vuong

{"title":"Predictors of twin pregnancy in in vitro fertilization with intracytoplasmic sperm injection cycles with day 3 double embryo transfer.","authors":"Duy Le Nguyen, Hieu Le-Trung Hoang, Vu Ngoc-Anh Ho, Toan Duong Pham, Nam Thanh Nguyen, Van Thi-Thu Tran, Tuong Manh Ho, Lan Ngoc Vuong","doi":"10.5653/cerm.2023.06156","DOIUrl":"10.5653/cerm.2023.06156","url":null,"abstract":"Objective: The purpose of this study was to identify factors associated with twin pregnancy following day 3 double embryo transfer (DET).Methods: This retrospective cohort study incorporated data from 16,972 day 3 DET cycles. The participants were women aged between 18 and 45 years who underwent in vitro fertilization with intracytoplasmic sperm injection (IVF/ICSI) at My Duc Assisted Reproduction Technique Unit (IVFMD), My Duc Hospital, located in Ho Chi Minh City, Vietnam.Results: Of the 16,972 day 3 DET cycles investigated, 8,812 (51.9%) resulted in pregnancy. Of these, 6,108 cycles led to clinical pregnancy, with 1,543 (25.3% of clinical pregnancies) being twin pregnancies. Factors associated with twin pregnancy included age under 35 years (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.32 to 1.71; p<0.001) and cycles involving the transfer of at least one grade I embryo. Relative to the transfer of two grade III embryos, the risk of twin pregnancy was significantly elevated following the transfer of two grade I embryos (OR, 1.40; 95% CI, 1.16 to 1.69; p<0.001) or a combination of one grade I and one grade II embryo (OR, 1.27; 95% CI, 1.05 to 1.55; p=0.001).Conclusion: By analyzing a large number of IVF/ICSI cycles, we identified several predictors of twin pregnancy. These findings can assist medical professionals in tailoring treatment strategies for couples with infertility.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":" ","pages":"69-74"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia. 咖啡因可减轻慢性阴囊高热小鼠的生精障碍

IF 1.8

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-03-01 Epub Date: 2024-02-29 DOI: 10.5653/cerm.2023.06142

Amir Raoofi, Omid Gholami, Hossein Mokhtari, Fatemeh Bagheri, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi

{"title":"Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia.","authors":"Amir Raoofi, Omid Gholami, Hossein Mokhtari, Fatemeh Bagheri, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi","doi":"10.5653/cerm.2023.06142","DOIUrl":"10.5653/cerm.2023.06142","url":null,"abstract":"Objective: Chronic scrotal hyperthermia (SHT) can lead to serious disorders of the male reproductive system, with oxidative stress playing a key role in the onset of these dysfunctions. Thus, we evaluated the impact of caffeine, a potent antioxidant, on cellular and tissue disorders in mice with chronic SHT.Methods: In this experimental study, 56 adult male NMRI mice were allocated into seven equal groups. Apart from the non-treated control group, all were exposed to heat stress. Two groups, termed \"preventive\" and \"curative,\" were orally administered caffeine. The preventive mice began receiving caffeine immediately prior to heat exposure, while for the curative group, a caffeine regimen was initiated 15 consecutive days following cessation of heat exposure. Each treated group was subdivided based on pairing with a positive control (Pre/curative [Cur]+PC) or a vehicle (Pre/Cur+vehicle). Upon conclusion of the study, we assessed sperm characteristics, testosterone levels, stereological parameters, apoptosis, antioxidant and oxidant levels, and molecular markers.Results: Sperm parameters, testosterone levels, stereological parameters, biochemical factors (excluding malondialdehyde [MDA]), and c-kit gene expression were significantly elevated in the preventive and curative groups, especially the former, relative to the other groups. Conversely, expression levels of the heat shock protein 72 (HSP72) and nuclear factor kappa beta (NF-κβ) genes, MDA levels, and apoptotic cell density were markedly lower in both caffeine-treated groups relative to the other groups, with more pronounced differences observed in the preventive group.Conclusion: Overall, caffeine attenuated cellular and molecular abnormalities induced by heat stress in the testis, particularly in the mice treated under the preventive condition.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":"51 1","pages":"28-41"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of preimplantation mouse embryo development with optimized in vitro culture dish via stabilization of medium osmolarity. 优化体外培养皿通过稳定培养基渗透压促进小鼠胚胎着床前发育。

IF 1.8

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.5653/cerm.2023.06436

Hyejin Yoon, Jongwoo Lee, Inyoung Kang, Kyoo Wan Choi, Jaewang Lee, Jin Hyun Jun

{"title":"Enhancement of preimplantation mouse embryo development with optimized in vitro culture dish via stabilization of medium osmolarity.","authors":"Hyejin Yoon, Jongwoo Lee, Inyoung Kang, Kyoo Wan Choi, Jaewang Lee, Jin Hyun Jun","doi":"10.5653/cerm.2023.06436","DOIUrl":"10.5653/cerm.2023.06436","url":null,"abstract":"Objective: We evaluated the efficacy of the newly developed optimized in vitro culture (OIVC) dish for cultivating preimplantation mouse embryos. This dish minimizes the need for mineral oil and incorporates microwells, providing a stable culture environment and enabling independent monitoring of individual embryos.Methods: Mouse pronuclear (PN) zygotes and two-cell-stage embryos were collected at 18 and 46 hours after human chorionic gonadotropin injection, respectively. These were cultured for 120 hours using potassium simplex optimized medium (KSOM) to reach the blastocyst stage. The embryos were randomly allocated into three groups, each cultured in one of three dishes: a 60-mm culture dish, a microdrop dish, and an OIVC dish that we developed.Results: The OIVC dish effectively maintained the osmolarity of the KSOM culture medium over a 5-day period using only 2 mL of mineral oil. This contrasts with the significant osmolarity increase observed in the 60-mm culture dish. Additionally, the OIVC dish exhibited higher blastulation rates from two-cell embryos (100%) relative to the other dish types. Moreover, blastocysts derived from both PN zygotes and two-cell embryos in the OIVC dish group demonstrated significantly elevated mean cell numbers.Conclusion: Use of the OIVC dish markedly increased the number of cells in blastocysts derived from the in vitro culture of preimplantation mouse embryos. The capacity of this dish to maintain medium osmolarity with minimal mineral oil usage represents a breakthrough that may advance embryo culture techniques for various mammals, including human in vitro fertilization and embryo transfer programs.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":"50 4","pages":"244-252"},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of berberine on ischemia-reperfusion injuries in an experimental model of ovarian torsion 小檗碱对卵巢扭转实验模型缺血再灌注损伤的影响

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-11-09 DOI: 10.5653/cerm.2023.06366

Filiz Yilmaz, Orkun Ilgen, Alper Mankan, Bayram Yilmaz, Sefa Kurt

{"title":"The effects of berberine on ischemia-reperfusion injuries in an experimental model of ovarian torsion","authors":"Filiz Yilmaz, Orkun Ilgen, Alper Mankan, Bayram Yilmaz, Sefa Kurt","doi":"10.5653/cerm.2023.06366","DOIUrl":"https://doi.org/10.5653/cerm.2023.06366","url":null,"abstract":"Objective: Ovarian torsion is a gynecological disorder that causes ischemia-reperfusion injuries in the ovary. Our study investigated berberine’s short- and long-term effects on ovarian ischemia-reperfusion injuries.Methods: This study included 28 Wistar albino female rats weighing 180 to 220 g, which were divided into four groups: sham (S), torsion/detorsion (T/D), torsion/ detorsion+single dose berberine (T/D+Bb), and torsion/detorsion+15 days berberine (T/D+15Bb). The torsion and detorsion model was applied in all non-sham groups. In the T/D+Bb group, a single dose of berberine was administered, while in the T/D+15Bb group, berberine was administered over a period of 15 days. After the rats were euthanized, their ovaries were excised. The left ovaries were used for histopathologic evaluation, which included ovarian injury scoring and follicle count, while the right ovaries were used for biochemical analyses (tissue transforming growth factor-β [TGF-β] and alpha-smooth muscle actin [α-SMA] levels).Results: The histopathologic evaluation scores for the ovaries were significantly lower in the T/D+B group (p<0.05) and the T/D+15B group (p<0.005) than in the T/D group. The follicle counts in the T/D group were lower than those in both the sham and treated groups (p<0.005). The TGF-β levels were significantly lower in the T/D+15B group (p<0.005), whereas the α-SMA levels did not show a significant difference.Conclusion: Both short- and long-term berberine use could potentially have therapeutic effects on ovarian torsion. Long-term berberine use exhibited anti-inflammatory effects by reducing TGF-β levels, thereby preventing ischemia-reperfusion injuries. Therefore, we suggest that long-term berberine use could be beneficial for ovarian torsion.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":" 33","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135192387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a short abstinence period on sperm quality in oligozoospermic men 短时间禁欲对少精子男性精子质量的影响

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-11-09 DOI: 10.5653/cerm.2023.06100

Nattaporn Poopaibool, Amornrat Tangprasittipap, Sukanya Chumchuen, Chonthicha Satirapod, Artitaya Singwongsa

{"title":"Effects of a short abstinence period on sperm quality in oligozoospermic men","authors":"Nattaporn Poopaibool, Amornrat Tangprasittipap, Sukanya Chumchuen, Chonthicha Satirapod, Artitaya Singwongsa","doi":"10.5653/cerm.2023.06100","DOIUrl":"https://doi.org/10.5653/cerm.2023.06100","url":null,"abstract":"Objective: The aim of this study was to compare semen parameters and sperm DNA fragmentation (SDF) and explore the relationship between semen parameters and SDF between 2 and 7 days of abstinence and a short abstinence period (within 4 hours) in oligozoospermic infertile patients.Methods: Two semen samples were collected from infertile oligozoospermic men (n=34) after an abstinence period of 2 to 7 days and within 4 hours, respectively. Sperm parameters were compared between the two abstinence duration groups, including semen volume, sperm concentration, total sperm count, sperm motility, total motile sperm count (TMSC), morphology, and SDF.Results: The semen volume, concentration, and total sperm count were significantly decreased after 4 hours of abstinence than after 2 to 7 days of abstinence, with median differences of 1.2 mL (p<0.001), 2×106/mL (p=0.011), and 9.6×106/ejaculation (p<0.001), respectively. TMSC was significantly lower after a short abstinence, with a median difference of 4.24×106/ejaculate (p<0.001). However, there were no significance differences in the percentage of motility, the SDF, and the percentage of sperm with normal morphology. Interestingly, volume, concentration, total sperm count, sperm motility, and SDF, but not TMSC, exhibited significant linear correlations between the two abstinence groups in univariate regression analysis, except for TMSC.Conclusion: In oligozoospermic men, the volume, concentration, and total sperm count were significantly lower after a short abstinence period, but without adverse effects on sperm motility and SDF.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":" 36","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135244543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beneficial effects of intraovarian injection of platelet-rich plasma in women with poor ovarian response 卵巢反应差的妇女卵巢内注射富血小板血浆的有益效果

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-10-24 DOI: 10.5653/cerm.2023.06086

Aida Najafian, Ashraf Alyasin, Marziyeh Aghahosseini, Sedigheh Hosseinimousa, Seyyedeh Neda Kazemi

{"title":"Beneficial effects of intraovarian injection of platelet-rich plasma in women with poor ovarian response","authors":"Aida Najafian, Ashraf Alyasin, Marziyeh Aghahosseini, Sedigheh Hosseinimousa, Seyyedeh Neda Kazemi","doi":"10.5653/cerm.2023.06086","DOIUrl":"https://doi.org/10.5653/cerm.2023.06086","url":null,"abstract":"Objective: Infertility can result from a diminished ovarian reserve, but a potential remedy exists in the form of platelet-rich plasma (PRP) administration. This treatment involves both biological factors and tissue trauma mechanisms, which stimulate folliculogenesis, making it a promising and effective strategy. We assessed the impact of direct PRP injections into the ovaries on the fertility outcomes of women classified as poor responders.Methods: A quasi-experimental study was conducted from April 2021 to December 2022, focusing on patients classified as POSEIDON grade 3 or 4. PRP injections were administered into both ovaries. After 3 months, data were collected on anti-Müllerian hormone (AMH) level, follicle-stimulating hormone (FSH) level, and the numbers of oocytes, mature oocytes, and good-quality embryos following ovarian stimulation. We then compared the data from before and after PRP injection.Results: This study included 50 women, with a mean of 39 years (interquartile range [IQR], 35 to 43) and 4 years (IQR, 2 to 6) for age and infertility duration, respectively. FSH levels decreased after treatment, while AMH levels and the numbers of oocytes, metaphase II oocytes, and high-quality embryos increased. However, only the increase in high-quality embryos was significant. The pregnancy and spontaneous pregnancy rates were 20% and 14%, respectively. Notably, women with secondary infertility exhibited a significantly higher pregnancy rate than those with primary infertility.Conclusion: Ample evidence suggests that PRP can enhance ovarian function. However, further studies are needed to identify the appropriate candidates for this procedure, establish the optimal PRP preparation method, and standardize the procedure for its adjuvant use in assisted reproductive technology cycles.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135220432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dienogest in endometriosis treatment: A narrative literature review 子宫内膜异位症治疗中的双孕激素:叙述性文献综述

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-10-24 DOI: 10.5653/cerm.2023.06128

Joowon Lee, Hyeon Ji Park, Kyong Wook Yi

{"title":"Dienogest in endometriosis treatment: A narrative literature review","authors":"Joowon Lee, Hyeon Ji Park, Kyong Wook Yi","doi":"10.5653/cerm.2023.06128","DOIUrl":"https://doi.org/10.5653/cerm.2023.06128","url":null,"abstract":"Endometriosis is characterized by the implantation of endometrial cells outside the uterus. This hormone-dependent disease is highly prevalent among women of reproductive age. Clinical symptoms of endometriosis include dysmenorrhea, pelvic pain, and infertility, which can negatively impact the overall quality of life of those affected. The medical treatment of endometriosis serves as an important therapeutic option, aimed at alleviating pain associated with the condition and suppressing the growth of endometriotic lesions. As such, it is employed as an adjuvant therapy following surgery or an empirical treatment after the clinical diagnosis of endometriosis. Dienogest, a fourth-generation progestin, has received approval for the treatment of endometriosis in many countries. A growing body of evidence has demonstrated its efficacy in managing endometriosis-associated pain, preventing symptoms, and reducing lesion recurrence. In this review, we examine the clinical efficacy, safety, and tolerability of dienogest in treating endometriosis. We also provide updated findings, drawing from clinical studies that focus on the long-term use of this medication in patients with endometriosis.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":"9 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135220081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between anthropometric and metabolic risk factors and testicular function in healthy young men 健康青年男性人体测量学和代谢危险因素与睾丸功能的关系

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-10-24 DOI: 10.5653/cerm.2023.06114

Hakkı Uzun, Merve Huner, Mehmet Kıvrak, Ertan Zengin, Yusuf Önder Ozsagir, Berat Sönmez, Görkem Akça

{"title":"The relationship between anthropometric and metabolic risk factors and testicular function in healthy young men","authors":"Hakkı Uzun, Merve Huner, Mehmet Kıvrak, Ertan Zengin, Yusuf Önder Ozsagir, Berat Sönmez, Görkem Akça","doi":"10.5653/cerm.2023.06114","DOIUrl":"https://doi.org/10.5653/cerm.2023.06114","url":null,"abstract":"Objective: This study investigated the relationship of anthropometric and metabolic risk factors with seminal and sex steroidal hormone parameters in a screened population of healthy males.Methods: The participants were healthy young men without chronic or congenital diseases. The body composition parameters that we investigated were measured weight, height, and waist circumference (WC), as well as bioelectrical impedance analysis. Semen samples were analyzed for semen volume, sperm concentration, sperm motility and morphology, seminal pH, and liquefaction time. Biochemistry analysis, including glucose and lipid metabolism parameters, was conducted on fasting blood samples. Testicular volume was calculated separately for each testis using ultrasonography.Results: Body mass index exhibited an inverse association with total sperm count. WC showed negative correlations with numerous seminal parameters, including sperm concentration, total sperm count, sperm morphology, and follicle-stimulating hormone levels. The basal metabolic rate was associated with seminal pH, liquefaction time, and sperm motility. WC, fat mass percentage, and triglyceride levels exhibited negative correlations with sex hormone binding globulin. The measures of glucose metabolism were associated with a greater number of seminal parameters than the measures of cholesterol metabolism. C-reactive protein levels were inversely associated with sperm concentration and total sperm count.Conclusion: Anthropometric and metabolic risk factors were found to predict semen quality and alterations in sex steroidal hormone levels.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":"23 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135220071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting the ongoing pregnancy rate in women with repeated implantation failure undergoing an endometrial receptivity array 子宫内膜容受性阵列对反复着床失败妇女持续妊娠率的影响因素

Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2023-10-19 DOI: 10.5653/cerm.2023.06184

Hyun Kyoung Lee, Kyoung Yong Moon, Haerin Paik, Byung Chul Jee

{"title":"Factors affecting the ongoing pregnancy rate in women with repeated implantation failure undergoing an endometrial receptivity array","authors":"Hyun Kyoung Lee, Kyoung Yong Moon, Haerin Paik, Byung Chul Jee","doi":"10.5653/cerm.2023.06184","DOIUrl":"https://doi.org/10.5653/cerm.2023.06184","url":null,"abstract":"OBJECTIVE\u0000In this retrospective study, we analyzed factors influencing the ongoing pregnancy rate (PR) in women with repeated implantation failure (RIF) undergoing embryo transfer with endometrial receptivity array (ERA).\u0000\u0000\u0000METHODS\u0000Eighty-three consecutive personalized embryo transfers (pETs) with ERA, from 54 women with RIF, were selected from June 2020 to April 2022. Vitrified blastocyst transfer was timed based on ERA results.\u0000\u0000\u0000RESULTS\u0000The ongoing PR per pET was 33.7%. Using ERA, the endometrium was identified as pre-receptive in 26 cycles, early receptive in 25 cycles, receptive in 31 cycles, and late receptive in one cycle. With cycles categorized into three receptivity phases (pre-receptive, early receptive, or receptive), no significant differences were found in the clinical PR (27.3%, 55.6%, and 40%, respectively) or ongoing PR (9.1%, 55.6%, and 40%, respectively) after a single blastocyst transfer. Similarly, no significant differences were observed in the clinical PR or ongoing PR after the transfer of two or more blastocysts. Among women with ongoing pregnancy relative to those without, age at first pET was significantly lower (35 years vs. 39 years, p=0.001), while blastocyst score (23 vs. 18, p=0.012) and the proportion of blastocyst scores >18 (71.4% vs. 38.9%, p=0.005) were significantly higher. In multiple logistic regression analysis, the woman's age (odds ratio [OR], 0.814; 95% confidence interval [CI], 0.706 to 0.940; p=0.005) and blastocyst score >18 (OR, 3.052; 95% CI, 1.075 to 8.665; p=0.036) were identified as significant factors influencing ongoing pregnancy.\u0000\u0000\u0000CONCLUSION\u0000In pET with ERA, ongoing pregnancy was closely associated with woman's age and blastocyst quality.","PeriodicalId":46409,"journal":{"name":"Clinical and Experimental Reproductive Medicine-CERM","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0