口服抗氧化剂对特发性少精症男性精液质量指标、生殖激素和精子DNA完整性的有益影响

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Chaymae Rochdi, Meriem Ouadrhiri, Larbi Allai, Ibtissam Bellajdel, Samira Mamri, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri
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引用次数: 0

摘要

目的:最近,口服联合抗氧化剂被用于治疗男性特发性不育症。本研究旨在评估维生素 C、维生素 E、硒、锌、精氨酸、左旋肉碱和辅酶 Q10 对男性不育症和特发性少精症(OAT)患者的精子质量指标、DNA 完整性、生殖激素和妊娠率的影响:对420名患有不育症和特发性少精子症的男性进行了一项前瞻性研究,这些男性每天口服两次抗氧化剂SP-Power片剂,为期6个月。根据世界卫生组织2021年指南,在补充剂服用后的基线期、3个月和6个月对精液质量、生殖激素和DNA碎片指数(DFI)进行了评估:结果:在治疗过程中,精子数量和典型形态的比例均无明显差异。结果表明:治疗期间,精子数量和典型形态百分比无明显差异;补充 SP-Power 片剂后,精子浓度有明显改善(基线、3 个月和 6 个月时分别为 8.67±1.41、12.17±1.91 和 19.01±0.86,p):补充 SP-Power 片剂可改善不育症和特发性 OAT 男性患者的精子质量参数、精子 DFI、某些生殖激素和受孕率,这可能归功于补充剂的协同抗氧化作用。要确定补充剂对氧化应激指标的影响,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia.

Objective: Recently, oral antioxidants in combined forms have been used to treat men with idiopathic infertility. This study aimed to evaluate the effects of treatment with vitamin C, vitamin E, selenium, zinc, arginine, L-carnitine, and coenzyme Q10 on sperm quality parameters, DNA integrity, reproductive hormones, and pregnancy rates in men with infertility and idiopathic oligoasthenoteratozoospermia (OAT).

Methods: A prospective study was conducted on 420 men with infertility and idiopathic OAT who took an oral supplement of antioxidant SP-Power tablets twice daily for 6 months. Semen quality, reproductive hormones, and the DNA fragmentation index (DFI) were evaluated at baseline and at 3 and 6 months after supplementation, using the World Health Organization 2021 guidelines.

Results: No significant difference was observed in volume or the percentage of typical morphology during treatment. A significant improvement in sperm concentration was observed after supplementation (8.67±1.41, 12.17±1.91, and 19.01±0.86 at baseline, 3, and 6 months respectively, p<0.01). The total motility, progressive motility, and total motile sperm count also increased significantly (p<0.01), whereas the DFI decreased after 6 months. There was an increase in normal FSH levels and testosterone levels after 6 months of supplementation of antioxidant SP-Power but these differences were not statistically significant (p=not significant and p=0.06, respectively).

Conclusion: Supplementation with SP-Power tablets improved sperm quality parameters, sperm DFI, some reproductive hormones, and pregnancy rates in men with infertility and idiopathic OAT, which could be attributed to the supplement's synergistic antioxidant action. Further studies are needed to determine the effects of supplementation on oxidative stress markers.

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